AR020001A1 - COMPUESTOS ACTIVADORES DE hPPARGAMMA Y hPPARALFA, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN, METODO PARA EL TRATAMIENTO Y/O PREVENCION DE UNAENFERMEDAD MEDIADA POR LOS MISMOS, Y SU USO PARA LA ELABORACION DE UN MEDICAMENTO - Google Patents

COMPUESTOS ACTIVADORES DE hPPARGAMMA Y hPPARALFA, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN, METODO PARA EL TRATAMIENTO Y/O PREVENCION DE UNAENFERMEDAD MEDIADA POR LOS MISMOS, Y SU USO PARA LA ELABORACION DE UN MEDICAMENTO

Info

Publication number
AR020001A1
AR020001A1 ARP990103874A ARP990103874A AR020001A1 AR 020001 A1 AR020001 A1 AR 020001A1 AR P990103874 A ARP990103874 A AR P990103874A AR P990103874 A ARP990103874 A AR P990103874A AR 020001 A1 AR020001 A1 AR 020001A1
Authority
AR
Argentina
Prior art keywords
hpparalfa
hppargamma
treatment
disease mediated
prevention
Prior art date
Application number
ARP990103874A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AR020001A1 publication Critical patent/AR020001A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compuestos de la formula (I), y las formas tautoméricas, sales farmacéuticamente aceptables, o solvatos de la misma, donde R1 a R6 y n tienen lossignificados que constan en la descripcion. Composicion farmacéutica que los comprende. Un método para eltratamiento o prevencion de una enfermedad mediadapor hPPARgamma y/o hPPARalfa que comprende la administracion de una composicion de los mismos. El uso de los compuestos para la elaboracion de un medicamentopara el tratamiento de una enfermedad mediada por hPPARgamma y hPPARalfa, factor de riesgo o condicion. Preferentemente, los compuestos de la formula (I), ylas formas tautoméricas, sales farmacéuticamente aceptables, o solvatos de la misma son activadores dobles de hPPARgamma y hPPARalfa.
ARP990103874A 1998-08-07 1999-08-04 COMPUESTOS ACTIVADORES DE hPPARGAMMA Y hPPARALFA, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN, METODO PARA EL TRATAMIENTO Y/O PREVENCION DE UNAENFERMEDAD MEDIADA POR LOS MISMOS, Y SU USO PARA LA ELABORACION DE UN MEDICAMENTO AR020001A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9817118.4A GB9817118D0 (en) 1998-08-07 1998-08-07 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
AR020001A1 true AR020001A1 (es) 2002-03-27

Family

ID=10836805

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990103874A AR020001A1 (es) 1998-08-07 1999-08-04 COMPUESTOS ACTIVADORES DE hPPARGAMMA Y hPPARALFA, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN, METODO PARA EL TRATAMIENTO Y/O PREVENCION DE UNAENFERMEDAD MEDIADA POR LOS MISMOS, Y SU USO PARA LA ELABORACION DE UN MEDICAMENTO

Country Status (31)

Country Link
US (1) US6498174B1 (es)
EP (1) EP1102757B1 (es)
JP (1) JP2002522426A (es)
KR (1) KR20010085340A (es)
CN (1) CN1321152A (es)
AP (1) AP2001002066A0 (es)
AR (1) AR020001A1 (es)
AT (1) ATE264313T1 (es)
AU (1) AU5731099A (es)
BR (1) BR9912866A (es)
CA (1) CA2339773A1 (es)
CO (1) CO5070570A1 (es)
CZ (1) CZ2001490A3 (es)
DE (1) DE69916457T2 (es)
EA (1) EA200100105A1 (es)
EE (1) EE200100074A (es)
ES (1) ES2220110T3 (es)
GB (1) GB9817118D0 (es)
HR (1) HRP20010095A2 (es)
HU (1) HUP0103469A3 (es)
ID (1) ID29543A (es)
IL (1) IL141248A0 (es)
IS (1) IS5840A (es)
MA (1) MA26668A1 (es)
NO (1) NO20010628L (es)
PE (1) PE20000947A1 (es)
PL (1) PL345882A1 (es)
SK (1) SK1962001A3 (es)
TR (1) TR200100372T2 (es)
WO (1) WO2000008002A1 (es)
ZA (1) ZA200100983B (es)

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TWI260321B (en) 1999-09-22 2006-08-21 Bristol Myers Squibb Co Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
GB0002667D0 (en) * 2000-02-04 2000-03-29 Glaxo Group Ltd medicamesnts
GB0031103D0 (en) * 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
US20040072838A1 (en) 2000-12-20 2004-04-15 Pierette Banker Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
EP1394154A4 (en) 2001-03-23 2005-05-18 Takeda Pharmaceutical HETEROCYCLIC DERIVATIVE WITH FIVE MEMBERS OF ALKANOIC ACID
GB0111523D0 (en) * 2001-05-11 2001-07-04 Glaxo Group Ltd Chemical compounds
AU2002342244B2 (en) * 2001-05-15 2005-06-16 F. Hoffmann-La Roche Ag Carboxylic acid substituted oxazole derivatives for use as PPAR-alpha and -gamma activators in the treatment of diabetes
CZ20033450A3 (cs) * 2001-05-29 2004-05-12 Kyotoápharmaceuticaláindustriesźáltd Heterocyklická sloučenina a její lékařské použití
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TW200300681A (en) 2001-11-12 2003-06-16 Ono Pharmaceutical Co Carboxylic acid derivative compound and medicament containing same as active ingredient
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US20050119314A1 (en) * 2002-04-05 2005-06-02 Sankyo Company, Limited Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
KR100474202B1 (ko) * 2002-05-04 2005-03-08 강헌중 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체
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DK1638970T3 (da) 2003-06-20 2011-01-03 Hoffmann La Roche Pyrid (2, 1-A)-isoquinolinderivater som DPP-IV-inhibitorer
KR100744893B1 (ko) 2003-06-20 2007-08-01 에프. 호프만-라 로슈 아게 Ｄｐｐ-ｉｖ 저해제로서 헥사하이드로피리도아이소퀴놀린
US7825278B2 (en) 2004-05-06 2010-11-02 The Regents Of The University Of California Substituted enaminones, their derivatives and uses thereof
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CN100344618C (zh) 2004-05-24 2007-10-24 北京摩力克科技有限公司 作为hPPARα和hPPARγ激动剂的N－芳丙烯酰基取代的酪氨酸衍生物
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Also Published As

Publication number Publication date
NO20010628L (no) 2001-04-06
SK1962001A3 (en) 2001-11-06
CZ2001490A3 (cs) 2001-08-15
PE20000947A1 (es) 2000-09-22
ATE264313T1 (de) 2004-04-15
ES2220110T3 (es) 2004-12-01
IS5840A (is) 2001-02-05
BR9912866A (pt) 2001-10-30
PL345882A1 (en) 2002-01-14
TR200100372T2 (tr) 2001-09-21
CA2339773A1 (en) 2000-02-17
EP1102757B1 (en) 2004-04-14
MA26668A1 (fr) 2004-12-20
WO2000008002A1 (en) 2000-02-17
EP1102757A1 (en) 2001-05-30
KR20010085340A (ko) 2001-09-07
ID29543A (id) 2001-09-06
ZA200100983B (en) 2002-03-05
AP2001002066A0 (en) 2001-03-31
HRP20010095A2 (en) 2002-02-28
CN1321152A (zh) 2001-11-07
JP2002522426A (ja) 2002-07-23
US6498174B1 (en) 2002-12-24
EE200100074A (et) 2002-06-17
IL141248A0 (en) 2002-03-10
CO5070570A1 (es) 2001-08-28
DE69916457D1 (de) 2004-05-19
GB9817118D0 (en) 1998-10-07
AU5731099A (en) 2000-02-28
HUP0103469A3 (en) 2002-08-28
EA200100105A1 (ru) 2001-08-27
DE69916457T2 (de) 2005-04-14
NO20010628D0 (no) 2001-02-06
HUP0103469A2 (hu) 2002-01-28

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