CO4980854A1 - Inhibidores de celulas b particularmente amidas, proceso par su produccion y composiciones farmaceuticas que los contiene - Google Patents
Inhibidores de celulas b particularmente amidas, proceso par su produccion y composiciones farmaceuticas que los contieneInfo
- Publication number
- CO4980854A1 CO4980854A1 CO99007017A CO99007017A CO4980854A1 CO 4980854 A1 CO4980854 A1 CO 4980854A1 CO 99007017 A CO99007017 A CO 99007017A CO 99007017 A CO99007017 A CO 99007017A CO 4980854 A1 CO4980854 A1 CO 4980854A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- carbon atoms
- terminal position
- amided
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona con un compuesto de lafórmula A: en donde cualquiera de: 1) Z es O; n es 0; T es un residuo: en donde: R6 es H; alquilo de 1 a 6 átomos de carbono opcionalmente sustituido en la posición terminal por halógeno, OH, NR7 R8 , COOH, CO-O-alquilo de 1 a 4 átomos de carbono, o CO-NR7 R8 ; alquilo de 1 a 6 átomos de carbono interrumpido por uno o más heteroátomos seleccionados a partir de N, o ó S, y sustituido en la posición terminal por halógeno, OH, NR7 R8 , COOH, CO-O-alquilo de 1 a 4 átomos de carbono, o CO-NR7 R8 ; OR9 ; NHR10 ; ciano; o formilo; Cada uno de R7 y R8 es independientemente H, alquilo de 1 a 4 átomos de carbono, ?-HO-alquilo de 1 a 4 átomos de carbono, CHO ó heterocicloalquilo de 1 a 4 átomos de carbono, o R7 y R8 forman junto con el átomo de nitrógeno con el que están enlazados, un anillo heterocíclico; R9 es alquilo de 1 a 6 átomos de carbono sustituido en la posición terminal por OH ó NR7 R8 ; R10 es un alquilo de 1 a 6 átomos de carbono sustituido en la posición terminal por OH ó NR7 R8 ; y W es un residuo: en donde: i) X es -CR1 =, en donde R1 es H, F, CF3 , alquilo de 1 a 4 átomos de carbono, ó NH2 ; ...
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9802842.6A GB9802842D0 (en) | 1998-02-10 | 1998-02-10 | Organic compounds |
GBGB9810688.3A GB9810688D0 (en) | 1998-05-19 | 1998-05-19 | Organic compounds |
GBGB9826553.1A GB9826553D0 (en) | 1998-12-02 | 1998-12-02 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4980854A1 true CO4980854A1 (es) | 2000-11-27 |
Family
ID=27269204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO99007017A CO4980854A1 (es) | 1998-02-10 | 1999-02-08 | Inhibidores de celulas b particularmente amidas, proceso par su produccion y composiciones farmaceuticas que los contiene |
Country Status (5)
Country | Link |
---|---|
AR (1) | AR015514A1 (es) |
AU (1) | AU2832399A (es) |
CO (1) | CO4980854A1 (es) |
PE (1) | PE20000281A1 (es) |
WO (1) | WO1999041239A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7112594B2 (en) | 2000-08-09 | 2006-09-26 | Mitsubishi Pharma Corporation | Fused bicyclic amide compounds and medicinal use thereof |
CA2430951A1 (en) * | 2000-12-07 | 2002-06-13 | Cv Therapeutics, Inc. | Substituted 1, 3, 5-triazines and pyrimidines as abca-1 elevating compounds against coronary artery disease or atherosclerosis |
EP1377549A1 (en) * | 2001-03-12 | 2004-01-07 | Millennium Pharmaceuticals, Inc. | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor |
MXPA04001286A (es) * | 2001-08-15 | 2004-05-27 | Du Pont | Arilamidas orto-heterociclicas sustituidas para controlar plagas de invertebrados. |
JP4361800B2 (ja) | 2001-12-21 | 2009-11-11 | サイトキネティックス, インコーポレイテッド | 心不全を処置するための組成物および方法 |
WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
US8686048B2 (en) | 2010-05-06 | 2014-04-01 | Rhizen Pharmaceuticals Sa | Immunomodulator and anti-inflammatory compounds |
CA2804225C (en) * | 2010-07-02 | 2018-05-01 | Aska Pharmaceutical Co., Ltd. | Heterocyclic compound and p27kip1 degradation inhibitor |
EP2672963A4 (en) | 2011-02-08 | 2015-06-24 | Childrens Medical Center | METHOD FOR THE TREATMENT OF MELANOMA |
US9499484B2 (en) * | 2012-04-02 | 2016-11-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Indole, indoline derivatives, compositions comprising them and uses thereof |
ES2682493T3 (es) | 2013-10-25 | 2018-09-20 | Novartis Ag | Compuestos derivados de piridilo bicíclicos fusionados a anillo como inhibidores de FGFR4 |
US20180185341A1 (en) | 2014-10-03 | 2018-07-05 | Novartis Ag | Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
US9802917B2 (en) | 2015-03-25 | 2017-10-31 | Novartis Ag | Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide |
US10730839B2 (en) * | 2016-11-27 | 2020-08-04 | Russell Dahl | Quinolines as cytoprotective agents |
CN111164075A (zh) * | 2017-09-20 | 2020-05-15 | 北京加科思新药研发有限公司 | 用作fgfr4抑制剂的稠环衍生物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1305458A (es) * | 1969-02-26 | 1973-01-31 | ||
US3699123A (en) * | 1970-03-24 | 1972-10-17 | Sandoz Ltd | 4-(3-amino-2-hydroxy-propoxy) indole derivatives |
FR2121394A1 (fr) * | 1971-01-08 | 1972-08-25 | Anvar | Procédé d'obtention de dérivés d'acides indole carboxyliques et produits préparables par ce procédé. |
US5484944A (en) * | 1993-10-27 | 1996-01-16 | Neurogen Corporation | Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands |
-
1999
- 1999-02-08 WO PCT/EP1999/000817 patent/WO1999041239A1/en active Application Filing
- 1999-02-08 AU AU28323/99A patent/AU2832399A/en not_active Abandoned
- 1999-02-08 AR ARP990100525A patent/AR015514A1/es unknown
- 1999-02-08 CO CO99007017A patent/CO4980854A1/es unknown
- 1999-02-09 PE PE1999000110A patent/PE20000281A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PE20000281A1 (es) | 2000-05-15 |
AU2832399A (en) | 1999-08-30 |
AR015514A1 (es) | 2001-05-02 |
WO1999041239A1 (en) | 1999-08-19 |
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