AR015426A1 - Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacion - Google Patents
Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacionInfo
- Publication number
- AR015426A1 AR015426A1 ARP980104363A ARP980104363A AR015426A1 AR 015426 A1 AR015426 A1 AR 015426A1 AR P980104363 A ARP980104363 A AR P980104363A AR P980104363 A ARP980104363 A AR P980104363A AR 015426 A1 AR015426 A1 AR 015426A1
- Authority
- AR
- Argentina
- Prior art keywords
- cr8r8
- alkyl
- optionally substituted
- alkenyl
- heteroaryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- 238000000034 method Methods 0.000 title 2
- 108090001007 Interleukin-8 Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- -1 (CR8R8) qS ( O) tR4 Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 150000001540 azides Chemical group 0.000 abstract 1
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004447 heteroarylalkenyl group Chemical group 0.000 abstract 1
- 125000005114 heteroarylalkoxy group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 102000010681 interleukin-8 receptors Human genes 0.000 abstract 1
- 108010038415 interleukin-8 receptors Proteins 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos de benzotiazol antagonistas del receptor de IL-8 caracterizado porque tienen la formula (I), en la que R es -NH-C(X)-NH-(CR13R14)v-Z; Z es W,heteroarilo opcionalmente sustituido, cicloalquilo C5-8 opcionalmente sustituido, alquilo C1-10op cionalmente sustituido, alquenilo C2-10 opcionalmentesustituido,o un alquinilo C2-10 opcionalmente sustituido; X es =O o =S; A es CR20R21; R1 se selecciona independientemente de hidrogeno, halogeno, nitro, ciano,alquilo C1-10 sustituido conhalogeno, alquilo C1-10, alquenilo C2-10, alcoxi C1-10, alcoxi C1-10 sustituido con halogeno, azida, (CR8R8)qS(O)tR4, hidroxi,hidroxi-alquilo C1-4, arilo, aril-alquilo C1-4, ariloxi, aril-alquiloxi C1-4, heteroarilo, heteroaril-alquilo, radicalheterocíclico, radical heterocíclico-alquilo C1-4, heteroaril-alquiloxi C1-4, aril-alquenilo C2-10, heteroaril-alquenilo C2-10, radical heterocícico-alquenilo C2-10, (CR8R8)qNR4R5, alquenil C2-10-C(O)NR4R5, (CR8R8)qC(O)NR4R5, (CR8R8)qC(O)NR4R10,S(O)3R8, (CR8R8)qC (O)R11, alquenil C2-10-C(O)R11, alquenil C2-10-C(O)OR11, (CR8R8)qC(O)R11, (CR8R8)qC(O)OR11,(CR8R8)qC(O)OR12, (CR8R8)qOC(O)R11, (CR8R8)qNR4C(O)R11, (CR8R8)qC(NR4)NR4R5, (CR8R8)qNR4C(NR5)R11, (CR8R8)qNHS(O)2R17, (CR8R8)qS(O)2NR4R5,o dos restos de R1ju ntos pueden formar O-(CH2)s-O o un anillo saturado o no saturado de 5-6 miembros, y en el que los anillos que contienen arilo, heteroarilo y radicalesheterocíclicos pueden estar opcionalmente sustituidos; n es un numero enteroque tiene un valor de 1 a 3; m es un numero entero que tiene un valor de 1 o 3; qes 0, o un numero entero que tiene un valor de 1 a 10; t es 0, o un numero entero que tiene un valor de 1 o 2; s es un numero entero que tiene un valor de 1 a3; v es 0,o un numero entero que tiene un valor de 1 a 4; R4 y R5 son independientemente hidrogeno, alquilo C1-4 opcionalmente sustituido, arilo opcionalmentesustituido, aril-alquilo C1-4 opcionalmente sustituido, heteroarilo opcionalmente sustituido,heteroaril-alquilo C1-4 opciona lmente sustituido, radicalheterocíclico, radical heterocíclico-alquilo C1-4, o R4 y R5 junto con el átomo de nitrogeno al que están unidos forman un anillo de 5-7 miembros que puede
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5799797P | 1997-09-05 | 1997-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015426A1 true AR015426A1 (es) | 2001-05-02 |
Family
ID=22014018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980104363A AR015426A1 (es) | 1997-09-05 | 1998-09-01 | Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacion |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6316478B1 (es) |
| EP (1) | EP1003497B1 (es) |
| JP (1) | JP2001514217A (es) |
| KR (1) | KR20010023673A (es) |
| CN (1) | CN1278721A (es) |
| AR (1) | AR015426A1 (es) |
| AT (1) | ATE303370T1 (es) |
| AU (1) | AU731182B2 (es) |
| BR (1) | BR9811751A (es) |
| CA (1) | CA2302364A1 (es) |
| CO (1) | CO4970746A1 (es) |
| DE (1) | DE69831413T2 (es) |
| ES (1) | ES2248916T3 (es) |
| HK (1) | HK1028730A1 (es) |
| HU (1) | HUP0003581A3 (es) |
| IL (1) | IL134854A0 (es) |
| NO (1) | NO315467B1 (es) |
| NZ (1) | NZ503125A (es) |
| PL (1) | PL339133A1 (es) |
| TR (1) | TR200000610T2 (es) |
| WO (1) | WO1999011253A1 (es) |
| ZA (1) | ZA988101B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR008331A1 (es) * | 1997-01-23 | 1999-12-29 | Smithkline Beecham Corp | Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen |
| US6664259B2 (en) * | 2000-03-16 | 2003-12-16 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| DE10038709A1 (de) * | 2000-08-09 | 2002-02-28 | Aventis Pharma Gmbh | Substituierte und unsubstituierte Benzooxathiazole sowie daraus abgeleitete Verbindungen |
| MY143477A (en) * | 2002-10-29 | 2011-05-31 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| WO2005113534A2 (en) | 2004-05-12 | 2005-12-01 | Schering Corporation | Cxcr1 and cxcr2 chemokine antagonists |
| JP2008517054A (ja) * | 2004-10-20 | 2008-05-22 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体アンタゴニスト |
| AU2007240364A1 (en) * | 2006-04-21 | 2007-11-01 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| DK2009992T3 (da) * | 2006-04-21 | 2012-08-13 | Glaxosmithkline Llc | Il-8 receptor-antagonister |
| CL2007001829A1 (es) * | 2006-06-23 | 2008-01-25 | Smithkline Beecham Corp | P-toluensulfonato de n-[4-cloro-2-hidroxi-3-(piperazina-1-sulfonil)fenil]-n-(2-cloro-3-fluorofenil)urea;procedimiento de preparacion;composicion farmaceutica;combinacion farmaceutica;y uso en el tratamiento de una enfermedad mediada por la quiimioquina il-8, tales como asma y epoc. |
| KR101182114B1 (ko) * | 2010-03-05 | 2012-09-12 | 한림제약(주) | 유효성분으로서 레바미피드를 함유하는 골관절염 예방 또는 치료용 약학 조성물 |
| WO2018007323A1 (en) * | 2016-07-04 | 2018-01-11 | Bayer Cropscience Aktiengesellschaft | Benzosultams and analogues and their use as fungicides |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1327482A (en) * | 1970-06-30 | 1973-08-22 | Leo Pharm Prod Ltd | 1,2-benzisothiazole-1,1-dioxide derivatives |
| US5593993A (en) * | 1991-08-02 | 1997-01-14 | Medivir Ab | Method for inhibition of HIV related viruses |
| AR008331A1 (es) * | 1997-01-23 | 1999-12-29 | Smithkline Beecham Corp | Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen |
-
1998
- 1998-09-01 AR ARP980104363A patent/AR015426A1/es unknown
- 1998-09-04 KR KR1020007002326A patent/KR20010023673A/ko not_active Application Discontinuation
- 1998-09-04 JP JP2000508356A patent/JP2001514217A/ja active Pending
- 1998-09-04 EP EP98944775A patent/EP1003497B1/en not_active Expired - Lifetime
- 1998-09-04 WO PCT/US1998/018563 patent/WO1999011253A1/en active IP Right Grant
- 1998-09-04 ZA ZA988101A patent/ZA988101B/xx unknown
- 1998-09-04 CA CA002302364A patent/CA2302364A1/en not_active Abandoned
- 1998-09-04 ES ES98944775T patent/ES2248916T3/es not_active Expired - Lifetime
- 1998-09-04 AU AU92233/98A patent/AU731182B2/en not_active Ceased
- 1998-09-04 IL IL13485498A patent/IL134854A0/xx unknown
- 1998-09-04 DE DE69831413T patent/DE69831413T2/de not_active Expired - Fee Related
- 1998-09-04 PL PL98339133A patent/PL339133A1/xx unknown
- 1998-09-04 TR TR2000/00610T patent/TR200000610T2/xx unknown
- 1998-09-04 CN CN98810929A patent/CN1278721A/zh active Pending
- 1998-09-04 HU HU0003581A patent/HUP0003581A3/hu unknown
- 1998-09-04 US US09/486,986 patent/US6316478B1/en not_active Expired - Fee Related
- 1998-09-04 BR BR9811751-3A patent/BR9811751A/pt not_active Application Discontinuation
- 1998-09-04 CO CO98050794A patent/CO4970746A1/es unknown
- 1998-09-04 AT AT98944775T patent/ATE303370T1/de not_active IP Right Cessation
-
2000
- 2000-02-29 NZ NZ503125A patent/NZ503125A/en unknown
- 2000-03-03 NO NO20001099A patent/NO315467B1/no not_active IP Right Cessation
- 2000-11-13 HK HK00107224A patent/HK1028730A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9811751A (pt) | 2001-11-13 |
| US6316478B1 (en) | 2001-11-13 |
| ZA988101B (en) | 1999-03-05 |
| TR200000610T2 (tr) | 2000-09-21 |
| AU9223398A (en) | 1999-03-22 |
| WO1999011253A1 (en) | 1999-03-11 |
| DE69831413T2 (de) | 2006-06-14 |
| HUP0003581A3 (en) | 2002-11-28 |
| DE69831413D1 (de) | 2005-10-06 |
| CA2302364A1 (en) | 1999-03-11 |
| HUP0003581A2 (hu) | 2001-09-28 |
| JP2001514217A (ja) | 2001-09-11 |
| EP1003497B1 (en) | 2005-08-31 |
| ATE303370T1 (de) | 2005-09-15 |
| EP1003497A1 (en) | 2000-05-31 |
| CN1278721A (zh) | 2001-01-03 |
| AU731182B2 (en) | 2001-03-22 |
| EP1003497A4 (en) | 2002-11-13 |
| NO20001099L (no) | 2000-03-03 |
| PL339133A1 (en) | 2000-12-04 |
| NO315467B1 (no) | 2003-09-08 |
| KR20010023673A (ko) | 2001-03-26 |
| IL134854A0 (en) | 2001-05-20 |
| CO4970746A1 (es) | 2000-11-07 |
| NO20001099D0 (no) | 2000-03-03 |
| NZ503125A (en) | 2002-05-31 |
| HK1028730A1 (en) | 2001-03-02 |
| ES2248916T3 (es) | 2006-03-16 |
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