AR009937A1 - PIRIMIDO [5,4-D] PIRIMIDINAS, MEDICINES CONTAINING THESE COMPOUNDS, THEIR USE AND PROCEDURE FOR THE PREPARATION - Google Patents
PIRIMIDO [5,4-D] PIRIMIDINAS, MEDICINES CONTAINING THESE COMPOUNDS, THEIR USE AND PROCEDURE FOR THE PREPARATIONInfo
- Publication number
- AR009937A1 AR009937A1 ARP970100874A ARP970100874A AR009937A1 AR 009937 A1 AR009937 A1 AR 009937A1 AR P970100874 A ARP970100874 A AR P970100874A AR P970100874 A ARP970100874 A AR P970100874A AR 009937 A1 AR009937 A1 AR 009937A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- pirimidinas
- pirimido
- compounds
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Pirimido [5,4-d] pirimidinas de la formula general (I) en la que A2, A4, A6 y A8 están definidos como en la reivindicacion 1, a sus tautomeros,estereoisomeros y sus sales, en particular sus sales fisiologicamente compatibles con ácidoss ob ases inorgánicos u orgánicos, que presentanvaliosas propiedades farmacologicas, en particular un efecto inhibidor sobre la transduccion de senalels inducida por tirosinquinasas, a su empleo para eltratamiento de enfermedades, en particularenfermedad es tumorales y a su preparacion.Pyrimido [5,4-d] pyrimidines of the general formula (I) in which A2, A4, A6 and A8 are defined as in claim 1, their tautomers, stereoisomers and their salts, in particular their physiologically compatible salts with inorganic or organic acids or aces, which have valuable pharmacological properties, in particular an inhibitory effect on the transduction of senalels induced by tyrosine kinase, its use for the treatment of diseases, in particular disease and its preparation.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19608653A DE19608653A1 (en) | 1996-03-06 | 1996-03-06 | Pyrimido [5,4-d] pyrimidines, medicaments containing these compounds, their use and processes for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
AR009937A1 true AR009937A1 (en) | 2000-05-17 |
Family
ID=7787391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970100874A AR009937A1 (en) | 1996-03-06 | 1997-03-05 | PIRIMIDO [5,4-D] PIRIMIDINAS, MEDICINES CONTAINING THESE COMPOUNDS, THEIR USE AND PROCEDURE FOR THE PREPARATION |
Country Status (23)
Country | Link |
---|---|
US (1) | US5977102A (en) |
EP (1) | EP0885227A1 (en) |
JP (1) | JP2000506153A (en) |
KR (1) | KR19990087551A (en) |
CN (1) | CN1212696A (en) |
AR (1) | AR009937A1 (en) |
AU (1) | AU712072B2 (en) |
BG (1) | BG102790A (en) |
BR (1) | BR9708004A (en) |
CA (1) | CA2248316A1 (en) |
CO (1) | CO4650044A1 (en) |
CZ (1) | CZ281698A3 (en) |
DE (1) | DE19608653A1 (en) |
EE (1) | EE9800289A (en) |
HU (1) | HUP9901750A2 (en) |
IL (1) | IL125341A0 (en) |
NO (1) | NO984081D0 (en) |
NZ (1) | NZ331382A (en) |
PL (1) | PL328776A1 (en) |
SK (1) | SK120498A3 (en) |
TR (1) | TR199801753T2 (en) |
WO (1) | WO1997032882A1 (en) |
ZA (1) | ZA971886B (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR199801530T2 (en) | 1996-02-13 | 1998-11-23 | Zeneca Limited | Quinazoline derivatives as VEGF inhibitors. |
JP4464466B2 (en) | 1996-03-05 | 2010-05-19 | アストラゼネカ・ユーケイ・リミテッド | 4-anilinoquinazoline derivatives |
UA71945C2 (en) * | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
JP3270834B2 (en) * | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | Heteroaromatic bicyclic derivatives useful as anticancer agents |
DE19911510A1 (en) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation |
CZ20013608A3 (en) | 1999-04-09 | 2002-05-15 | Astrazeneca Ab | Adamantane derivatives |
AU5003200A (en) | 1999-05-14 | 2000-12-05 | United States Of America As Represented By The Department Of Veterans Affairs, The | Isolation and characterization of epidermal growth factor related protein |
US7049410B2 (en) * | 1999-05-14 | 2006-05-23 | Majumdar Adhip P N | Antibodies to a novel EGF-receptor related protein (ERRP) |
UA72946C2 (en) | 1999-11-05 | 2005-05-16 | Астразенека Аб | Quinasoline derivatives as inhibitors of vascular endothelial growth factor (vegf) |
SE9904505D0 (en) | 1999-12-09 | 1999-12-09 | Astra Pharma Prod | Novel compounds |
TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
JP2004509875A (en) * | 2000-09-20 | 2004-04-02 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 4-aminoquinazoline |
AU2001293817A1 (en) * | 2000-09-20 | 2002-04-02 | Merck Patent Gmbh | 4-amino-quinazolines |
AU2002245709A1 (en) * | 2001-03-23 | 2002-10-08 | Bayer Corporation | Rho-kinase inhibitors |
AR035791A1 (en) * | 2001-03-23 | 2004-07-14 | Bayer Corp | COMPOUND N, N-DIHETEROCICLICO OF AMINA, INHIBITOR OF THE RHO-KINASE, ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND PROCESS FOR THE PREPARATION OF THE COMPOUND |
US7829566B2 (en) * | 2001-09-17 | 2010-11-09 | Werner Mederski | 4-amino-quinazolines |
AU2003202263A1 (en) * | 2002-01-10 | 2003-07-30 | Bayer Healthcare Ag | Roh-kinase inhibitors |
US6943172B2 (en) * | 2002-01-23 | 2005-09-13 | Bayer Pharmaceuticals Corporation | Rho-kinase inhibitors |
CA2473510A1 (en) * | 2002-01-23 | 2003-07-31 | Bayer Pharmaceuticals Corporation | Pyrimidine derivatives as rho-kinase inhibitors |
KR101139038B1 (en) * | 2005-06-28 | 2012-05-02 | 삼성전자주식회사 | Pyrimidopyrimidine Derivatives and Organic Thin Film Transistor Using The Same |
AR073501A1 (en) * | 2008-09-08 | 2010-11-10 | Boehringer Ingelheim Int | PYRIMID DERIVATIVES [5,4-D] PYRIMIDINE INHIBITORS OF THYROSINOQUINASE |
WO2010094695A1 (en) | 2009-02-17 | 2010-08-26 | Boehringer Ingelheim International Gmbh | Pyrimido [5,4-d] pyrimidine derivatives for the inhibition of tyrosine kinases |
CN102369186B (en) * | 2009-04-02 | 2014-07-09 | 默克专利有限公司 | Piperidine and piperazine derivatives as autotaxin inhibitors |
US20130023531A1 (en) | 2011-01-27 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors |
WO2014175370A1 (en) * | 2013-04-25 | 2014-10-30 | 塩野義製薬株式会社 | Pyrrolidine derivative and pharmaceutical composition containing same |
TW201607923A (en) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | Substituted azaspiro (4.5) decane derivatives |
CA2955071A1 (en) | 2014-07-15 | 2016-01-21 | Grunenthal Gmbh | Substituted azaspiro(4.5)decane derivatives |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3031450A (en) * | 1959-04-30 | 1962-04-24 | Thomae Gmbh Dr K | Substituted pyrimido-[5, 4-d]-pyrimidines |
EP0023559B1 (en) * | 1979-07-03 | 1984-09-19 | Dr. Karl Thomae GmbH | 2-(perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them |
DE3049207A1 (en) * | 1980-12-27 | 1982-07-29 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW TRISUBSTITUTED PYRIMIDO (5,4-D) PYRIMIDINE, THEIR PRODUCTION AND USE AS A MEDICINAL PRODUCT |
DE3423092A1 (en) * | 1984-06-22 | 1986-01-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW 8-ALKYLTHIO-2-PIPERAZINO-PYRIMIDO (5,4-D) PYRIMIDINE, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
US5034393A (en) * | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
DE4325900A1 (en) * | 1993-08-02 | 1995-02-09 | Thomae Gmbh Dr K | Trisubstituted pyrimido[5,4-d]pyrimidines for the modulation of multi-drug resistance, medicaments containing these compounds and processes for their production |
IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
TW414798B (en) * | 1994-09-07 | 2000-12-11 | Thomae Gmbh Dr K | Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation |
DE4431867A1 (en) * | 1994-09-07 | 1996-03-14 | Thomae Gmbh Dr K | New 4-amino-pyrimido-pyrimidine derivs. |
-
1996
- 1996-03-06 DE DE19608653A patent/DE19608653A1/en not_active Withdrawn
-
1997
- 1997-03-03 NZ NZ331382A patent/NZ331382A/en unknown
- 1997-03-03 BR BR9708004A patent/BR9708004A/en unknown
- 1997-03-03 KR KR1019980706988A patent/KR19990087551A/en not_active Application Discontinuation
- 1997-03-03 JP JP9531445A patent/JP2000506153A/en active Pending
- 1997-03-03 CZ CZ982816A patent/CZ281698A3/en unknown
- 1997-03-03 CA CA002248316A patent/CA2248316A1/en not_active Abandoned
- 1997-03-03 WO PCT/EP1997/001058 patent/WO1997032882A1/en not_active Application Discontinuation
- 1997-03-03 IL IL12534197A patent/IL125341A0/en unknown
- 1997-03-03 PL PL97328776A patent/PL328776A1/en unknown
- 1997-03-03 EP EP97907067A patent/EP0885227A1/en not_active Withdrawn
- 1997-03-03 TR TR1998/01753T patent/TR199801753T2/en unknown
- 1997-03-03 EE EE9800289A patent/EE9800289A/en unknown
- 1997-03-03 HU HU9901750A patent/HUP9901750A2/en unknown
- 1997-03-03 SK SK1204-98A patent/SK120498A3/en unknown
- 1997-03-03 AU AU19252/97A patent/AU712072B2/en not_active Ceased
- 1997-03-03 CN CN97192789A patent/CN1212696A/en active Pending
- 1997-03-05 ZA ZA971886A patent/ZA971886B/en unknown
- 1997-03-05 AR ARP970100874A patent/AR009937A1/en unknown
- 1997-03-05 US US08/812,002 patent/US5977102A/en not_active Expired - Fee Related
- 1997-03-06 CO CO97012273A patent/CO4650044A1/en unknown
-
1998
- 1998-09-04 NO NO984081A patent/NO984081D0/en unknown
- 1998-09-24 BG BG102790A patent/BG102790A/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO984081L (en) | 1998-09-04 |
KR19990087551A (en) | 1999-12-27 |
ZA971886B (en) | 1998-09-07 |
SK120498A3 (en) | 1999-04-13 |
DE19608653A1 (en) | 1997-09-11 |
BR9708004A (en) | 1999-07-27 |
CA2248316A1 (en) | 1997-09-12 |
NZ331382A (en) | 1999-08-30 |
IL125341A0 (en) | 1999-03-12 |
WO1997032882A1 (en) | 1997-09-12 |
EE9800289A (en) | 1999-02-15 |
BG102790A (en) | 1999-09-30 |
JP2000506153A (en) | 2000-05-23 |
NO984081D0 (en) | 1998-09-04 |
CO4650044A1 (en) | 1998-09-03 |
AU712072B2 (en) | 1999-10-28 |
CN1212696A (en) | 1999-03-31 |
US5977102A (en) | 1999-11-02 |
EP0885227A1 (en) | 1998-12-23 |
TR199801753T2 (en) | 1998-12-21 |
HUP9901750A2 (en) | 1999-09-28 |
CZ281698A3 (en) | 1999-02-17 |
PL328776A1 (en) | 1999-02-15 |
AU1925297A (en) | 1997-09-22 |
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