UY26308A1 - NEW SUBSTITUTED INDOLINONES, THEIR PREPARATION AND THEIR USE AS MEDICINES - Google Patents

NEW SUBSTITUTED INDOLINONES, THEIR PREPARATION AND THEIR USE AS MEDICINES

Info

Publication number
UY26308A1
UY26308A1 UY26308A UY26308A UY26308A1 UY 26308 A1 UY26308 A1 UY 26308A1 UY 26308 A UY26308 A UY 26308A UY 26308 A UY26308 A UY 26308A UY 26308 A1 UY26308 A1 UY 26308A1
Authority
UY
Uruguay
Prior art keywords
preparation
medicines
substituted indolinones
new substituted
salts
Prior art date
Application number
UY26308A
Other languages
Spanish (es)
Inventor
Dr Gerald Jurgen Roth D Walter
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of UY26308A1 publication Critical patent/UY26308A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a indolinonas sustituidas de la fórmula general (i), en la que r1 a r6 y x están definidos como en la reivindicación 1, a sus isómeros y sus sales, en particular sus sales fisiológicamente compatibles, que presentan valiosas propiedades farmacológicas, en particular un efecto inhibidor sobre diferentes tirosinquinasas de receptor y complejos de ciclina/cdk, así como sobre la proliferación de células endoteliales y diferentes células tumorales, a medicamentos que contienen estos compuestos, a su empleo y a procedimientos para su preparación.The present invention relates to substituted indolinones of the general formula (i), in which r1 to r6 and x are defined as in claim 1, to their isomers and their salts, in particular their physiologically compatible salts, which have valuable pharmacological properties , in particular an inhibitory effect on different receptor tyrosine kinases and cyclin / cdk complexes, as well as on the proliferation of endothelial cells and different tumor cells, to medicines containing these compounds, to their use and to procedures for their preparation.

UY26308A 1999-08-27 2000-08-23 NEW SUBSTITUTED INDOLINONES, THEIR PREPARATION AND THEIR USE AS MEDICINES UY26308A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1999140829 DE19940829A1 (en) 1999-08-27 1999-08-27 New 3-(anilino-methylidene)-2-indolinone derivatives, are kinase inhibitors and cell proliferation inhibitors, useful e.g. for treating tumors, metastasis, rheumatoid arthritis or psoriasis

Publications (1)

Publication Number Publication Date
UY26308A1 true UY26308A1 (en) 2001-04-30

Family

ID=7919897

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26308A UY26308A1 (en) 1999-08-27 2000-08-23 NEW SUBSTITUTED INDOLINONES, THEIR PREPARATION AND THEIR USE AS MEDICINES

Country Status (2)

Country Link
DE (1) DE19940829A1 (en)
UY (1) UY26308A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1370527A1 (en) 2001-03-06 2003-12-17 AstraZeneca AB Indolone derivatives having vascular-damaging activity
DE10117204A1 (en) 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma Indolinones substituted in the 6-position, their preparation and their use as medicaments
JP2010529161A (en) * 2007-06-12 2010-08-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Indolinone derivatives and their use in treating symptoms such as cancer

Also Published As

Publication number Publication date
DE19940829A1 (en) 2001-03-01

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20110531