AR007299A1 - 1-naftoilguanidinas sustituidas, procedimiento para su preparacion, su empleo para la preparacion de un medicamento y agente curativo y terapeuticoque las contiene - Google Patents
1-naftoilguanidinas sustituidas, procedimiento para su preparacion, su empleo para la preparacion de un medicamento y agente curativo y terapeuticoque las contieneInfo
- Publication number
- AR007299A1 AR007299A1 ARP970102252A ARP970102252A AR007299A1 AR 007299 A1 AR007299 A1 AR 007299A1 AR P970102252 A ARP970102252 A AR P970102252A AR P970102252 A ARP970102252 A AR P970102252A AR 007299 A1 AR007299 A1 AR 007299A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- substituted
- ischemia
- naftoilguanidines
- employment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
1-naftoilguanidina sustituídos de la fórmula (I) en donde R2, R3, R4, R5, R6 y R7 son independientemente uno de otro H, F, Cl, Br. I, CN, NO2, CF3, C2F5o XaYbZ; X siginfica O, S, NR(10), CR(11)R(12), C=O, C(=O)NR(10), C(=O), SO, SO2,SO2NR(1 0), OC=O, NR(10)C=O o NR(10)SO, efectuándose el enlace con elanillo de naftalina en cadda caso a través del átomo situado a la izquierda, o Z significa un heterciclo con contenido en N con 1, 2, 3, 4, 5, 6, 7, 8 o 9átomos de C estandoenlazado el he terociclo con contenido en N a través de N ó C y no estando sustituído o estando sustituido con 1-3 sustituyentes elegidosdel grupo consistente en F, Cl, Br, CF3, metilo, metoxi, y NR(21R(22); en donde sin embargo, para el caso deque R(4) represent e un radical alcoxi, al menosuno de los sustituyentes R(2), R(3), R(5), R(6), R(7) y R(8) son distintos de hidrógeno; así como sales farmacéuticamente compatibles. Son adecuados, comoconsecuencia como medicamentos antirrítmicoscon un componente ca rdioprotector para la profilaxis del infarto y el tratamiento del infarto, así como para eltratamiento de la angina de pecho. Inhiben también de forma preventiva los procesos pato-fisiológicos en la aparición de lesionesinducidas por isquemias ,en particular en el desencadenamiento de arritmias del corazón inducidas por isquemias. Concierne, además a un procedimiento para la preparación delcompuesto 1, uso del mismo para la preparación de un medicamento, yagente curativo y terapéu tico que contiene dichos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19621482A DE19621482A1 (de) | 1996-05-29 | 1996-05-29 | Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR007299A1 true AR007299A1 (es) | 1999-10-27 |
Family
ID=7795548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970102252A AR007299A1 (es) | 1996-05-29 | 1997-05-27 | 1-naftoilguanidinas sustituidas, procedimiento para su preparacion, su empleo para la preparacion de un medicamento y agente curativo y terapeuticoque las contiene |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6600072B2 (es) |
| EP (1) | EP0810205B1 (es) |
| JP (1) | JP4039587B2 (es) |
| KR (1) | KR970074753A (es) |
| CN (1) | CN1062859C (es) |
| AR (1) | AR007299A1 (es) |
| AT (1) | ATE200076T1 (es) |
| AU (1) | AU710258B2 (es) |
| BR (1) | BR9703342A (es) |
| CA (1) | CA2206362C (es) |
| CZ (1) | CZ292441B6 (es) |
| DE (2) | DE19621482A1 (es) |
| DK (1) | DK0810205T3 (es) |
| ES (1) | ES2155223T3 (es) |
| GR (1) | GR3035811T3 (es) |
| HR (1) | HRP970294B1 (es) |
| HU (1) | HUP9700954A3 (es) |
| ID (1) | ID17348A (es) |
| IL (1) | IL120925A0 (es) |
| NO (1) | NO308528B1 (es) |
| NZ (1) | NZ314914A (es) |
| PL (1) | PL185755B1 (es) |
| PT (1) | PT810205E (es) |
| RU (1) | RU2182901C2 (es) |
| SI (1) | SI0810205T1 (es) |
| SK (1) | SK282356B6 (es) |
| TR (1) | TR199700427A2 (es) |
| TW (1) | TW372955B (es) |
| ZA (1) | ZA974664B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19621483A1 (de) * | 1996-05-29 | 1997-12-04 | Hoechst Ag | Substituierte 2-Naphthoylguanidine, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE10023405A1 (de) * | 2000-05-12 | 2001-11-15 | Merck Patent Gmbh | Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen |
| PE20040167A1 (es) * | 2002-03-28 | 2004-05-26 | Novartis Ag | Amidas del acido sulfamico |
| ATE440827T1 (de) | 2002-12-04 | 2009-09-15 | Ore Pharmaceuticals Inc | Melanocortin-rezeptormodulatoren |
| CA2529949C (en) * | 2003-06-26 | 2013-08-06 | Biotron Limited | Antiviral compounds and methods |
| WO2010005783A1 (en) * | 2008-07-08 | 2010-01-14 | Boehringer Ingelheim International Gmbh | Pyrrolidinyl and piperidinyl compounds useful as nhe-1 inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4251545A (en) * | 1979-09-19 | 1981-02-17 | Gaf Corporation | Fungicidal process using 1-(alkoxyaroyl)guanidines |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
| DE4415873A1 (de) | 1994-05-05 | 1995-11-09 | Hoechst Ag | Substituierte bizyklische Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| JPH08225513A (ja) * | 1994-12-21 | 1996-09-03 | Kanebo Ltd | ナフトイルグアニジン誘導体 |
| JPH08225135A (ja) | 1995-02-21 | 1996-09-03 | Mitsubishi Heavy Ind Ltd | スクリユ−式土砂搬送機 |
| DE19621483A1 (de) | 1996-05-29 | 1997-12-04 | Hoechst Ag | Substituierte 2-Naphthoylguanidine, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1996
- 1996-05-29 DE DE19621482A patent/DE19621482A1/de not_active Withdrawn
-
1997
- 1997-02-28 PL PL97318724A patent/PL185755B1/pl not_active IP Right Cessation
- 1997-05-16 SI SI9730125T patent/SI0810205T1/xx unknown
- 1997-05-16 DK DK97108012T patent/DK0810205T3/da active
- 1997-05-16 AT AT97108012T patent/ATE200076T1/de not_active IP Right Cessation
- 1997-05-16 PT PT97108012T patent/PT810205E/pt unknown
- 1997-05-16 EP EP97108012A patent/EP0810205B1/de not_active Expired - Lifetime
- 1997-05-16 ES ES97108012T patent/ES2155223T3/es not_active Expired - Lifetime
- 1997-05-16 DE DE59703220T patent/DE59703220D1/de not_active Expired - Lifetime
- 1997-05-27 TW TW086107121A patent/TW372955B/zh active
- 1997-05-27 HR HR970294A patent/HRP970294B1/xx not_active IP Right Cessation
- 1997-05-27 NZ NZ314914A patent/NZ314914A/en unknown
- 1997-05-27 CN CN97113186A patent/CN1062859C/zh not_active Expired - Fee Related
- 1997-05-27 AR ARP970102252A patent/AR007299A1/es unknown
- 1997-05-27 CZ CZ19971631A patent/CZ292441B6/cs not_active IP Right Cessation
- 1997-05-27 AU AU23713/97A patent/AU710258B2/en not_active Ceased
- 1997-05-27 IL IL12092597A patent/IL120925A0/xx not_active IP Right Cessation
- 1997-05-27 SK SK669-97A patent/SK282356B6/sk unknown
- 1997-05-27 HU HU9700954A patent/HUP9700954A3/hu unknown
- 1997-05-27 TR TR97/00427A patent/TR199700427A2/xx unknown
- 1997-05-28 CA CA002206362A patent/CA2206362C/en not_active Expired - Fee Related
- 1997-05-28 JP JP13822697A patent/JP4039587B2/ja not_active Expired - Fee Related
- 1997-05-28 KR KR1019970021106A patent/KR970074753A/ko not_active Application Discontinuation
- 1997-05-28 RU RU97109002/04A patent/RU2182901C2/ru not_active IP Right Cessation
- 1997-05-28 NO NO972434A patent/NO308528B1/no not_active IP Right Cessation
- 1997-05-28 ZA ZA9704664A patent/ZA974664B/xx unknown
- 1997-05-28 ID IDP971813A patent/ID17348A/id unknown
- 1997-05-30 BR BR9703342A patent/BR9703342A/pt not_active IP Right Cessation
-
2001
- 2001-04-30 GR GR20010400659T patent/GR3035811T3/el not_active IP Right Cessation
-
2002
- 2002-08-14 US US10/217,457 patent/US6600072B2/en not_active Expired - Fee Related
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