AR006690A1 - PIPERIDINES AND PYRROLIDINS, PROCEDURE TO PREPARE THEM, CONTAINING PHARMACEUTICAL PREPARATIONS AND PROCEDURE TO PREPARE THESE PHARMACEUTICAL PREPARATIONS. - Google Patents

PIPERIDINES AND PYRROLIDINS, PROCEDURE TO PREPARE THEM, CONTAINING PHARMACEUTICAL PREPARATIONS AND PROCEDURE TO PREPARE THESE PHARMACEUTICAL PREPARATIONS.

Info

Publication number
AR006690A1
AR006690A1 ARP970101562A ARP970101562A AR006690A1 AR 006690 A1 AR006690 A1 AR 006690A1 AR P970101562 A ARP970101562 A AR P970101562A AR P970101562 A ARP970101562 A AR P970101562A AR 006690 A1 AR006690 A1 AR 006690A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical preparations
prepare
procedure
hal
mono
Prior art date
Application number
ARP970101562A
Other languages
Spanish (es)
Original Assignee
Merck Patent Ges Mit Beschränkter Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Beschränkter Haftung filed Critical Merck Patent Ges Mit Beschränkter Haftung
Publication of AR006690A1 publication Critical patent/AR006690A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Derivados de la piperidina y pirrolidina de fórmula (I), en donde: R1 es fenilo no sustituido, o bien mono-, di o trisustituido con A, A-O-, Hal, CN,NO2, NH2, Ph,-O-SO2A y/o -O-SO2CF3, 2- o 3-indolilo no sustituido, o bien mono o disustituido con A, A-O-, OH, Hal y/o CN, 1,4-benzodioxan-5- o 6-ilo, o1- o 2-naftilo; R2 es fenilo o piridilo no sustituido, o bien mono o disustituido con A, A-O, OH, Hal y/o CN; R3 es H, A, A-O-, Ph, NHR4 o NR5R6;k, l son independientemente 0 o1; m es 0, 1 o 2 y n es 1 o 2 o sus sales y productos intermedios. También se refiere a un procedimiento para prepararestos compuestos y sus sales aceptables desde el punto de vista fisiológico, a preparaciones farmacéuticas que los contieneny al empleo de los mismospara combatir los trastornos alimenticios, trastornos en el aprendizaje, los trastornos de la memoria dependientes de la edad, la discinesia taría y paraejercer una influencia positiva sobre el comportamiento en situaciones de tensión. Los compuestos de fórmula (I) presentan una acción antagonista dereceptor 5-HT1A e inhiben la reabsorción de 5-HT. Estos compuestos pueden ser empleados para preparar medicamentos.Derivatives of piperidine and pyrrolidine of formula (I), where: R1 is unsubstituted phenyl, or mono-, di or trisubstituted with A, AO-, Hal, CN, NO2, NH2, Ph, -O-SO2A and / or -O-SO2CF3, 2- or 3-indolyl unsubstituted, either mono or disubstituted with A, AO-, OH, Hal and / or CN, 1,4-benzodioxan-5- or 6-yl, or1- or 2-naphthyl; R2 is unsubstituted phenyl or pyridyl, either mono or disubstituted with A, A-O, OH, Hal and / or CN; R3 is H, A, A-O-, Ph, NHR4 or NR5R6: k, l are independently 0 or 1; m is 0, 1 or 2 and n is 1 or 2 or their salts and intermediates. It also refers to a process for preparing these compounds and their physiologically acceptable salts, pharmaceutical preparations containing them and the use of them to combat eating disorders, learning disorders, age-dependent memory disorders. , dyskinesia, and to exert a positive influence on behavior in stressful situations. The compounds of formula (I) exhibit a 5-HT1A receptor antagonist action and inhibit 5-HT reuptake. These compounds can be used to prepare medicines.

ARP970101562A 1996-04-18 1997-04-18 PIPERIDINES AND PYRROLIDINS, PROCEDURE TO PREPARE THEM, CONTAINING PHARMACEUTICAL PREPARATIONS AND PROCEDURE TO PREPARE THESE PHARMACEUTICAL PREPARATIONS. AR006690A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19615232A DE19615232A1 (en) 1996-04-18 1996-04-18 New carbamoyl derivatives and their use as 5-HT ¶1¶¶A¶ antagonists

Publications (1)

Publication Number Publication Date
AR006690A1 true AR006690A1 (en) 1999-09-08

Family

ID=7791576

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101562A AR006690A1 (en) 1996-04-18 1997-04-18 PIPERIDINES AND PYRROLIDINS, PROCEDURE TO PREPARE THEM, CONTAINING PHARMACEUTICAL PREPARATIONS AND PROCEDURE TO PREPARE THESE PHARMACEUTICAL PREPARATIONS.

Country Status (15)

Country Link
EP (1) EP0898569A1 (en)
JP (1) JP2000508670A (en)
KR (1) KR20000005505A (en)
AR (1) AR006690A1 (en)
AU (1) AU2696797A (en)
BR (1) BR9708677A (en)
CA (1) CA2252385A1 (en)
CZ (1) CZ330598A3 (en)
DE (1) DE19615232A1 (en)
HU (1) HUP9901389A3 (en)
NO (1) NO984861L (en)
PL (1) PL329351A1 (en)
SK (1) SK141998A3 (en)
WO (1) WO1997040038A1 (en)
ZA (1) ZA973301B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19756036A1 (en) 1997-12-17 1999-06-24 Merck Patent Gmbh New indole amide derivatives
DE69903930T2 (en) * 1998-04-08 2003-07-17 Wyeth Corp N-ARYLOXYETHYL-INDOLYL-ALKYLAMINE FOR TREATING DEPRESSIONS
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
AU3765899A (en) * 1998-04-29 1999-11-16 American Home Products Corporation Serotonergic agents
JP2002518382A (en) * 1998-06-15 2002-06-25 アメリカン・ホーム・プロダクツ・コーポレイション Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonin agonists
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
BR9916220A (en) * 1998-12-17 2001-09-11 American Home Prod Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine urea derivatives having 5ht1a receptor activity
US6326381B1 (en) 1998-12-17 2001-12-04 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates
PT1140830E (en) * 1998-12-17 2005-08-31 Wyeth Corp ARILPIPERIDINE AND ARIL-1,2,5,6-TETRAHYDRO-PYRIDINE AMIDA DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY
US6239126B1 (en) 1998-12-17 2001-05-29 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetra-hydropyridine urea derivatives
EP1146871A4 (en) * 1999-01-28 2002-04-17 Bristol Myers Squibb Co Antidepressant heterocyclic compounds
CA2431197C (en) * 2000-12-27 2012-03-13 Axiogenesis Ag System for the cell-specific and development-specific selection of differentiating embryonic stem cells, adult stem cells and embryonic germline cells
KR100459917B1 (en) * 2001-12-14 2004-12-03 (주)바이오뉴트리젠 Phenolic acid derivatives and composition for preventing or treating blood lipid level-related diseases comprising same
DE10337184A1 (en) * 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituted 3-pyrrolidine-indole derivatives
EP3215141A4 (en) 2014-11-05 2018-06-06 Flexus Biosciences, Inc. Immunoregulatory agents
UY36390A (en) * 2014-11-05 2016-06-01 Flexus Biosciences Inc MODULATING COMPOUNDS OF INDOLAMINE ENZYME 2,3-DIOXYGENASE (IDO), ITS SYNTHESIS METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO2023144764A1 (en) 2022-01-29 2023-08-03 Suven Life Sciences Limited Benzoisothiazole and benzoisoxazole compounds for the treatment of mental disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226392A (en) * 1960-03-07 1965-12-28 Sterling Drug Inc 1-[n-aryl-n-acylaminoalkyl]-4-aryl-1,2,3,6-tetrahydropyridines, the corresponding piperidines and their salts
US3647790A (en) * 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines
US4782071A (en) * 1986-11-03 1988-11-01 Warner-Lambert Company Tetrasubstituted urea cholinergic agents
IL101722A (en) * 1991-05-02 1996-05-14 Wyeth John & Brother Ltd Piperazine derivatives their preparation and pharmaceutical compositions containing them
FR2706894A1 (en) * 1993-06-22 1994-12-30 Synthelabo N-Phenyl-N-(piperidinoalkyl)arylamide derivatives, their preparation and their application in therapeutics
GB9314758D0 (en) * 1993-07-16 1993-08-25 Wyeth John & Brother Ltd Heterocyclic derivatives
EP0661266A1 (en) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives

Also Published As

Publication number Publication date
NO984861D0 (en) 1998-10-16
NO984861L (en) 1998-10-16
SK141998A3 (en) 1999-03-12
HUP9901389A2 (en) 1999-08-30
KR20000005505A (en) 2000-01-25
DE19615232A1 (en) 1997-10-23
HUP9901389A3 (en) 2000-09-28
JP2000508670A (en) 2000-07-11
PL329351A1 (en) 1999-03-29
CZ330598A3 (en) 1999-01-13
EP0898569A1 (en) 1999-03-03
BR9708677A (en) 1999-08-03
ZA973301B (en) 1997-10-24
WO1997040038A1 (en) 1997-10-30
AU2696797A (en) 1997-11-12
CA2252385A1 (en) 1997-10-30

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