AP2015008656A0 - Antibody drug conjugates - Google Patents
Antibody drug conjugatesInfo
- Publication number
- AP2015008656A0 AP2015008656A0 AP2015008656A AP2015008656A AP2015008656A0 AP 2015008656 A0 AP2015008656 A0 AP 2015008656A0 AP 2015008656 A AP2015008656 A AP 2015008656A AP 2015008656 A AP2015008656 A AP 2015008656A AP 2015008656 A0 AP2015008656 A0 AP 2015008656A0
- Authority
- AP
- ARIPO
- Prior art keywords
- drug conjugates
- antibody drug
- antibody
- conjugates
- drug
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- 2014-03-12 EP EP18188339.8A patent/EP3514178A1/fr not_active Withdrawn
- 2014-03-12 BR BR112015021134A patent/BR112015021134A2/pt not_active Application Discontinuation
- 2014-03-12 US US14/205,915 patent/US9498543B2/en active Active
- 2014-03-12 US US14/774,512 patent/US9789203B2/en active Active
- 2014-03-12 WO PCT/US2014/024597 patent/WO2014150937A1/fr active Application Filing
- 2014-03-12 CA CA2903772A patent/CA2903772A1/fr not_active Abandoned
- 2014-03-12 EA EA201591801A patent/EA035253B1/ru not_active IP Right Cessation
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- 2014-03-12 EP EP14723915.6A patent/EP2968590B1/fr active Active
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- 2014-03-12 AP AP2015008656A patent/AP2015008656A0/xx unknown
- 2014-03-12 MA MA38396A patent/MA38396B1/fr unknown
- 2014-03-12 KR KR1020157028519A patent/KR20150131173A/ko not_active Application Discontinuation
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