ZA9810788B - Method and composition for the treatment and prevention of hyperuricemia - Google Patents

Method and composition for the treatment and prevention of hyperuricemia

Info

Publication number: ZA9810788B
Authority: ZA; South Africa
Prior art keywords: hyperuricemia; prevention; treatment; composition
Prior art date: 1997-11-25

Application number

ZA9810788A

Other languages

English (en)

Inventor

Toshihiko Fujiwara

Koichi Iwasaki

Hiroyoshi Horikoshi

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-25

Filing date

1998-11-25

Publication date

1999-05-25

1998-11-25 Application filed by Sankyo Co filed Critical Sankyo Co

1999-05-25 Publication of ZA9810788B publication Critical patent/ZA9810788B/xx

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Biological Depolymerization Polymers (AREA)

ZA9810788A 1997-11-25 1998-11-25 Method and composition for the treatment and prevention of hyperuricemia ZA9810788B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP32318297		1997-11-25

Publications (1)

Publication Number	Publication Date
ZA9810788B true ZA9810788B (en)	1999-05-25

Family

ID=18151987

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9810788A ZA9810788B (en)	1997-11-25	1998-11-25	Method and composition for the treatment and prevention of hyperuricemia

Country Status (23)

Country	Link
US (1)	US6353009B1 (de)
EP (1)	EP0919232B1 (de)
KR (1)	KR19990045531A (de)
AR (1)	AR011231A1 (de)
AT (1)	ATE278400T1 (de)
AU (1)	AU744653B2 (de)
BR (1)	BR9805012A (de)
CA (1)	CA2254394C (de)
CZ (1)	CZ378898A3 (de)
DE (2)	DE69826811T4 (de)
ES (1)	ES2230657T3 (de)
HK (1)	HK1020259A1 (de)
HU (2)	HUP9902721A2 (de)
ID (1)	ID21332A (de)
IL (1)	IL127219A (de)
NO (1)	NO985484L (de)
NZ (1)	NZ332895A (de)
PL (1)	PL329893A1 (de)
RU (1)	RU2190425C2 (de)
SA (1)	SA99191266A (de)
TR (1)	TR199802441A3 (de)
TW (1)	TW592697B (de)
ZA (1)	ZA9810788B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6489344B1 (en)	1998-06-19	2002-12-03	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
DK1180686T3 (da) *	1999-05-27	2010-01-04	Cmic Co Ltd	Lægemidler til nyresygdomme og fremgangsmåde til screening deraf
US6768008B2 (en)	2000-04-24	2004-07-27	Aryx Therapeutics	Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
US6784199B2 (en)	2000-09-21	2004-08-31	Aryx Therapeutics	Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis in mammals
US6958355B2 (en)	2000-04-24	2005-10-25	Aryx Therapeutics, Inc.	Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
US6680387B2 (en)	2000-04-24	2004-01-20	Aryx Therapeutics	Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
CN101597262A (zh) *	2002-03-05	2009-12-09	特兰斯泰克制药公司	抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物
MXPA05012350A (es) *	2003-05-20	2006-05-25	Transtech Pharma Inc	Antagonistas rage como agentes para la amiloidosis inversa y enfermedades asociadas con la misma.
US20050025823A1 (en) *	2003-07-29	2005-02-03	Fong Andy A.T.	Methods of use of herbal compositions
JP2005092923A (ja) *	2003-09-12	2005-04-07	Renesas Technology Corp	半導体記憶装置
WO2006012438A2 (en) *	2004-07-21	2006-02-02	University Of Florida Research Foundation, Inc.	Compositions and methods for treatment and prevention of insulin resistance
WO2007018687A1 (en) *	2005-07-21	2007-02-15	University Of Florida Research Foundation, Inc.	Compositions and methods for treatment and prevention of hyperuricemia related health consequences
CN101679298B (zh) *	2007-04-05	2013-10-23	第一三共株式会社	稠合二环杂芳基衍生物
JPWO2010101164A1 (ja)	2009-03-05	2012-09-10	第一三共株式会社	ピリジン誘導体
EP2470510B1 (de)	2009-09-30	2014-05-14	TransTech Pharma, LLC	Substituierte imidazol-derivate für die behandlung von alzheimers krankheit.
US8822464B2 (en)	2011-11-28	2014-09-02	Boehringer Ingelheim International Gmbh	N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
US8741892B2 (en)	2011-12-05	2014-06-03	Boehringer Ingelheim International Gmbh	Compounds
US8796467B2 (en)	2011-12-13	2014-08-05	Boehringer Ingelheim International Gmbh	Compounds
US8846948B2 (en)	2011-12-13	2014-09-30	Boehringer Ingelheim International Gmbh	Compounds
US8716277B2 (en) *	2011-12-14	2014-05-06	Boehringer Ingelheim International Gmbh	Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity
US8883789B2 (en)	2011-12-14	2014-11-11	Boehringer Ingelheim International Gmbh	Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
US8937176B2 (en)	2011-12-14	2015-01-20	Boehringer Ingelheim International Gmbh	Compounds
US8889677B2 (en)	2012-01-17	2014-11-18	Boehringer Ingellheim International GmbH	Substituted triazoles useful as mGlu5 receptor modulators
AR089812A1 (es) *	2012-01-27	2014-09-17	Teijin Pharma Ltd	Agente terapeutico para la diabetes mellitus
CA2912216A1 (en)	2013-05-22	2014-11-27	Telomere Diagnostics, Inc.	Measures of short telomere abundance
WO2017176770A1 (en) *	2016-04-04	2017-10-12	The Schepens Eye Research Institute, Inc.	Peroxisome proliferator-activated receptor gamma selective agonists for inhibition of retinal pigment epithelium degeneration or geographic atrophy

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5522636A (en)	1978-08-04	1980-02-18	Takeda Chem Ind Ltd	Thiazoliding derivative
JPS58118577A (ja)	1982-01-07	1983-07-14	Takeda Chem Ind Ltd	チアゾリジン誘導体
JPS6051189A (ja)	1983-08-30	1985-03-22	Sankyo Co Ltd	チアゾリジン誘導体およびその製造法
CN1003445B (zh)	1984-10-03	1989-03-01	武田药品工业株式会社	噻唑烷二酮衍生物，其制备方法和用途
AR240698A1 (es) *	1985-01-19	1990-09-28	Takeda Chemical Industries Ltd	Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
US4703052A (en)	1985-05-21	1987-10-27	Pfizer Inc.	Hypoglycemic thiazolidinediones
ZA873745B (en)	1986-06-04	1988-10-26	Daiichi Seiyaku Co	Benzopyran derivatives
US4873255A (en)	1987-02-04	1989-10-10	Sankyo Company Limited	Thiazolidinone derivatives, their preparation and their use
FI91869C (fi)	1987-03-18	1994-08-25	Tanabe Seiyaku Co	Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi
EP0295828A1 (de)	1987-06-13	1988-12-21	Beecham Group Plc	Chemische Verbindungen
US5194443A (en)	1987-09-04	1993-03-16	Beecham Group P.L.C.	Compounds
ES2137915T3 (es)	1987-09-04	2000-01-01	Beecham Group Plc	Derivados de tiazolidindiona sustituida.
US5260445A (en)	1987-09-04	1993-11-09	Beecham Group P.L.C.	2,4-thiazolidinediones
US5232925A (en)	1987-09-04	1993-08-03	Beecham Group P.L.C.	Compounds
US5120754A (en)	1988-03-08	1992-06-09	Pfizer Inc.	Thiazolidinedione hypoglycemic agents
US5223522A (en)	1988-03-08	1993-06-29	Pfizer Inc.	Thiazolidinedione hypoglycemic agents
US5061717A (en)	1988-03-08	1991-10-29	Pfizer Inc.	Thiazolidinedione hypoglycemic agents
MX15171A (es)	1988-03-08	1993-05-01	Pfizer	Derivados de tiazolidinodiona hipoglicemicos
US5155114A (en) *	1989-01-23	1992-10-13	Fujisawa Pharmaceutical Company, Ltd.	Method of treatment using pyrazolopyridine compound
US4897405A (en)	1989-04-21	1990-01-30	American Home Products Corporation	Novel naphthalenylalkyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents
GB8919434D0 (en)	1989-08-25	1989-10-11	Beecham Group Plc	Novel compounds
WO1991007107A1 (en)	1989-11-13	1991-05-30	Pfizer Inc.	Oxazolidinedione hypoglycemic agents
JPH0469383A (ja)	1990-07-06	1992-03-04	Yamanouchi Pharmaceut Co Ltd	置換チアゾリジン誘導体
GB9017218D0 (en)	1990-08-06	1990-09-19	Beecham Group Plc	Novel compounds
DE69310365T2 (de) *	1992-07-02	1997-09-11	Novonordisk As	Polymerisation von lignin bei alkalischem ph-wert
GB9223059D0 (en)	1992-11-04	1992-12-16	Bamford Excavators Ltd	Intercooler apparatus
JP2845743B2 (ja)	1992-12-28	1999-01-13	三菱化学株式会社	新規なナフタレン誘導体
JPH06211657A (ja)	1993-01-21	1994-08-02	Mochida Pharmaceut Co Ltd	尿酸***剤
ATE376829T1 (de)	1993-09-15	2007-11-15	Daiichi Sankyo Co Ltd	Verwendung von thiazolidindionen zur vorbeugung oder verzögerung des auftretens des nichtinsulinabhängigen diabetes mellitus (niddm)
EP0684242B1 (de)	1993-12-27	1999-05-06	Japan Tobacco Inc.	Isoxazolidindionderivate und deren verwendung
CA2146701A1 (en) *	1994-04-11	1995-10-12	Takashi Fujita	Heterocyclic compounds having anti-diabetic activity, their preparation and their use
CA2159938A1 (en)	1994-10-07	1996-04-08	Hiroaki Yanagisawa	Oxime derivatives, their preparation and their therapeutic use
CZ293016B6 (cs)	1995-06-01	2004-01-14	Sankyo Company Limited	Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem
US5929055A (en)	1997-06-23	1999-07-27	The Research Foundation Of State University Of New York	Therapeutic method for management of diabetes mellitus

1997
- 1997-03-25 HU HU9902721A patent/HUP9902721A2/hu unknown
1998
- 1998-11-18 AT AT98309426T patent/ATE278400T1/de not_active IP Right Cessation
- 1998-11-18 ES ES98309426T patent/ES2230657T3/es not_active Expired - Lifetime
- 1998-11-18 DE DE69826811T patent/DE69826811T4/de not_active Expired - Lifetime
- 1998-11-18 US US09/195,031 patent/US6353009B1/en not_active Expired - Fee Related
- 1998-11-18 EP EP98309426A patent/EP0919232B1/de not_active Expired - Lifetime
- 1998-11-18 DE DE69826811A patent/DE69826811D1/de not_active Expired - Lifetime
- 1998-11-19 NZ NZ332895A patent/NZ332895A/en unknown
- 1998-11-20 CZ CZ983788A patent/CZ378898A3/cs unknown
- 1998-11-23 IL IL12721998A patent/IL127219A/en not_active IP Right Cessation
- 1998-11-24 BR BR9805012A patent/BR9805012A/pt not_active Application Discontinuation
- 1998-11-24 ID IDP981528A patent/ID21332A/id unknown
- 1998-11-24 RU RU98121310/14A patent/RU2190425C2/ru not_active IP Right Cessation
- 1998-11-24 CA CA002254394A patent/CA2254394C/en not_active Expired - Fee Related
- 1998-11-24 NO NO985484A patent/NO985484L/no not_active Application Discontinuation
- 1998-11-24 TW TW087119452A patent/TW592697B/zh not_active IP Right Cessation
- 1998-11-24 KR KR1019980050484A patent/KR19990045531A/ko not_active Application Discontinuation
- 1998-11-25 PL PL98329893A patent/PL329893A1/xx unknown
- 1998-11-25 TR TR1998/02441A patent/TR199802441A3/tr unknown
- 1998-11-25 HU HU9802721A patent/HUP9802721A1/hu unknown
- 1998-11-25 AU AU94102/98A patent/AU744653B2/en not_active Ceased
- 1998-11-25 ZA ZA9810788A patent/ZA9810788B/xx unknown
- 1998-11-25 AR ARP980105979A patent/AR011231A1/es unknown
1999
- 1999-04-06 SA SA99191266A patent/SA99191266A/ar unknown
- 1999-11-22 HK HK99105394A patent/HK1020259A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
US6353009B1 (en)	2002-03-05
ATE278400T1 (de)	2004-10-15
NO985484L (no)	1999-05-26
KR19990045531A (ko)	1999-06-25
HUP9902721A2 (hu)	1999-12-28
HUP9802721A1 (hu)	2000-03-28
SA99191266A (ar)	2005-12-03
AU9410298A (en)	1999-06-17
HK1020259A1 (en)	2000-04-07
AR011231A1 (es)	2000-08-02
CZ378898A3 (cs)	1999-07-14
DE69826811T2 (de)	2005-06-16
HU9802721D0 (en)	1999-01-28
NZ332895A (en)	2001-04-27
ID21332A (id)	1999-05-27
DE69826811D1 (de)	2004-11-11
ES2230657T3 (es)	2005-05-01
PL329893A1 (en)	1999-06-07
IL127219A0 (en)	1999-09-22
DE69826811T4 (de)	2006-09-21
AU744653B2 (en)	2002-02-28
BR9805012A (pt)	2000-03-21
NO985484D0 (no)	1998-11-24
TR199802441A2 (xx)	1999-10-21
RU2190425C2 (ru)	2002-10-10
TR199802441A3 (tr)	1999-10-21
EP0919232B1 (de)	2004-10-06
EP0919232A1 (de)	1999-06-02
IL127219A (en)	2001-08-08
TW592697B (en)	2004-06-21
CA2254394A1 (en)	1999-05-25
CA2254394C (en)	2009-11-17

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HU9802721D0 (en)	1999-01-28	Method and composition for the treatment and prevention of hyperuricemia
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HK1048949A1 (en)	2003-04-25	Method and composition for the treatment of scars
HK1040944A1 (en)	2002-06-28	Methods and compositions for the prevention and treatment of anemia
EP0717592A4 (de)	1997-12-29	Verfahren und zusammensetzung zur behandlung des apathie-demotivations-syndroms
IL142906A0 (en)	2002-04-21	Methods and compositions for treating or preventing peripheral neuropathies
HK1031174A1 (en)	2001-06-08	Compositions and methods for treating diabetes
GB0015235D0 (en)	2000-08-16	Compositions for the treatment of skin and anorectal conditions
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