ZA974574B - Novel guanidine derivatives process for their preparations and their use as pharmaceuticals. - Google Patents

Novel guanidine derivatives process for their preparations and their use as pharmaceuticals.

Info

Publication number
ZA974574B
ZA974574B ZA9704574A ZA974574A ZA974574B ZA 974574 B ZA974574 B ZA 974574B ZA 9704574 A ZA9704574 A ZA 9704574A ZA 974574 A ZA974574 A ZA 974574A ZA 974574 B ZA974574 B ZA 974574B
Authority
ZA
South Africa
Prior art keywords
pharmaceuticals
preparations
guanidine derivatives
derivatives process
novel guanidine
Prior art date
Application number
ZA9704574A
Other languages
English (en)
Inventor
Eberhard Amtmann
Norbert Frank
Gerhard Sauer
Gerhard Schilling
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of ZA974574B publication Critical patent/ZA974574B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA9704574A 1996-05-24 1997-05-26 Novel guanidine derivatives process for their preparations and their use as pharmaceuticals. ZA974574B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19621038A DE19621038A1 (de) 1996-05-24 1996-05-24 Aminoguanidine, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen enthalten

Publications (1)

Publication Number Publication Date
ZA974574B true ZA974574B (en) 1998-03-03

Family

ID=7795277

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9704574A ZA974574B (en) 1996-05-24 1997-05-26 Novel guanidine derivatives process for their preparations and their use as pharmaceuticals.

Country Status (11)

Country Link
US (3) US6284798B1 (xx)
EP (1) EP0918750B1 (xx)
AR (1) AR007286A1 (xx)
AT (1) ATE222236T1 (xx)
AU (1) AU734871B2 (xx)
CA (1) CA2259033C (xx)
DE (2) DE19621038A1 (xx)
ES (1) ES2183180T3 (xx)
NZ (1) NZ333520A (xx)
WO (1) WO1997045401A1 (xx)
ZA (1) ZA974574B (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0005326D0 (en) * 2000-03-06 2000-04-26 Deutsches Krebsforsch Enzymes and uses relating thereto
WO2002051439A2 (en) * 2000-12-22 2002-07-04 Medlyte, Inc. Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
DE10149919A1 (de) * 2001-10-10 2003-04-24 Biosphings Ag Neue Salze von Guanidinderivaten und pharmazeutische Zubereitungen daraus
US7794713B2 (en) * 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
CA2585645C (en) * 2004-10-29 2014-10-21 Musc Foundation For Research Development Ceramides and apoptosis-signaling ligand
WO2006050264A1 (en) * 2004-10-29 2006-05-11 Musc Foundation For Research Development Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer
US9217749B2 (en) * 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
US9274129B2 (en) * 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US8796429B2 (en) * 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
BRPI0718118A2 (pt) * 2006-10-27 2017-05-30 Lpath Inc composições e métodos para ligação de sphingosine-1-fosfato
AU2007313822A1 (en) * 2006-10-27 2008-05-08 Lpath, Inc. Compositions and methods for treating ocular diseases and conditions
FI119513B (fi) 2007-03-07 2008-12-15 Dextech Medical Ab Muokatut hydroksipolymeerikonjugaatit, joilla on tappava vaikutus tuumorisoluihin
US8361465B2 (en) * 2007-10-26 2013-01-29 Lpath, Inc. Use of anti-sphingosine-1-phosphate antibodies in combination with chemotherapeutic agents
CN101990442B (zh) * 2008-04-07 2013-03-27 德克斯特克医疗公司 具有亲骨部分和肿瘤杀伤部分的改性羟基聚合物缀合物
WO2010048164A2 (en) * 2008-10-20 2010-04-29 University Of South Florida N,n'-di-p-bromophenyl guanidine treatment for stroke at delayed timepoints
US8871202B2 (en) 2008-10-24 2014-10-28 Lpath, Inc. Prevention and treatment of pain using antibodies to sphingosine-1-phosphate
RU2011117722A (ru) 2008-11-06 2012-12-20 Фонд Медицинского Университета Южной Каролины по развитию научных исследований Лизосомотропные ингибиторы кислой церамидазы
AU2009332952A1 (en) * 2008-12-30 2011-07-21 Musc Foundation For Research Development Sphingo-guanidines and their use as inhibitors of sphingosine kinase
AR105675A1 (es) 2016-08-11 2017-10-25 Consejo Nac De Investigaciones Científicas Y Técnicas (Conicet) Un compuesto antibacteriano
US11072610B2 (en) 2018-09-12 2021-07-27 Novartis Ag Antiviral pyridopyrazinedione compounds
US11667613B2 (en) 2019-09-26 2023-06-06 Novartis Ag Antiviral pyrazolopyridinone compounds
JP2023544448A (ja) * 2020-09-22 2023-10-23 ライセラ セラピューティクス，インコーポレイテッド 皮膚放射線傷害の予防及び治療のための組成物及び方法
CN118141793A (zh) * 2022-05-17 2024-06-07 中国医学科学院基础医学研究所 二甲双胍及其它含胍化合物溶解夏科-莱登结晶并缓解急性肺损伤炎症中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB932951A (en) * 1959-02-02 1963-07-31 May & Baker Ltd Improvements in or relating to guanidines
US3914308A (en) * 1969-11-20 1975-10-21 Texaco Inc Solubilizing process
JPS5815913A (ja) * 1981-07-21 1983-01-29 Mitsubishi Chem Ind Ltd 強心剤
US4709094A (en) 1986-07-10 1987-11-24 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Sigma brain receptor ligands and their use
US5093525A (en) 1986-07-10 1992-03-03 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
DE3990965C2 (xx) 1988-08-18 1993-01-07 Kabushiki Kaisha Sankyo Seiki Seisakusho, Nagano, Jp
DE3924129A1 (de) 1989-07-20 1991-01-31 Bosch Gmbh Robert Ueberwachungseinrichtung fuer eine zuendungsendstufe an einer brennkraftmaschine
US5002365A (en) 1989-10-16 1991-03-26 Eastman Kodak Company Beam splitter for color imaging apparatus
DE69131482T2 (de) 1990-07-11 1999-11-18 New York University, New York Phosphotyrosin phosphatase als neuer rezeptor-typ

Also Published As

Publication number Publication date
WO1997045401A1 (de) 1997-12-04
CA2259033C (en) 2011-07-05
CA2259033A1 (en) 1997-12-04
DE59707976D1 (de) 2002-09-19
ATE222236T1 (de) 2002-08-15
DE19621038A1 (de) 1997-11-27
ES2183180T3 (es) 2003-03-16
US6444706B2 (en) 2002-09-03
AR007286A1 (es) 1999-10-27
NZ333520A (en) 2000-10-27
US6284798B1 (en) 2001-09-04
EP0918750A1 (de) 1999-06-02
US20010023251A1 (en) 2001-09-20
AU734871B2 (en) 2001-06-21
AU3028897A (en) 1998-01-05
EP0918750B1 (de) 2002-08-14
US20010025055A1 (en) 2001-09-27

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