ZA974234B - Adhesion receptor antagonists. - Google Patents

Adhesion receptor antagonists.

Info

Publication number
ZA974234B
ZA974234B ZA9704234A ZA974234A ZA974234B ZA 974234 B ZA974234 B ZA 974234B ZA 9704234 A ZA9704234 A ZA 9704234A ZA 974234 A ZA974234 A ZA 974234A ZA 974234 B ZA974234 B ZA 974234B
Authority
ZA
South Africa
Prior art keywords
receptor antagonists
adhesion receptor
adhesion
antagonists
receptor
Prior art date
Application number
ZA9704234A
Inventor
Horst Juraszyk
Hanns Wurziger
Guido Melzer
Joachim Gante
Sabine Bernotat-Danielowski
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA974234B publication Critical patent/ZA974234B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA9704234A 1996-05-17 1997-05-15 Adhesion receptor antagonists. ZA974234B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19620041A DE19620041A1 (en) 1996-05-17 1996-05-17 Adhesion receptor antagonists

Publications (1)

Publication Number Publication Date
ZA974234B true ZA974234B (en) 1997-12-11

Family

ID=7794651

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9704234A ZA974234B (en) 1996-05-17 1997-05-15 Adhesion receptor antagonists.

Country Status (5)

Country Link
AR (1) AR007160A1 (en)
AU (1) AU2957997A (en)
DE (1) DE19620041A1 (en)
WO (1) WO1997044333A1 (en)
ZA (1) ZA974234B (en)

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CA2263998A1 (en) * 1996-08-29 1998-03-05 Michael F. Sugrue Compositions and methods for administering integrin receptor antagonists
HUP0103304A3 (en) 1998-01-28 2002-10-28 Shionogi & Co Novel tricyclic compounds and pharmaceutical compositions thereof
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JP2003504301A (en) * 1998-04-01 2003-02-04 ブリストル−マイヤーズ スクイブ ファーマ カンパニー Integrin antagonist
GB9814414D0 (en) 1998-07-03 1998-09-02 Celltech Therapeutics Ltd Chemical compounds
JP2002521450A (en) * 1998-07-29 2002-07-16 メルク エンド カムパニー インコーポレーテッド Integrin receptor antagonist
GB9821061D0 (en) 1998-09-28 1998-11-18 Celltech Therapeutics Ltd Chemical compounds
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
GB9826174D0 (en) 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
US6534513B1 (en) 1999-09-29 2003-03-18 Celltech R&D Limited Phenylalkanoic acid derivatives
US6455539B2 (en) 1999-12-23 2002-09-24 Celltech R&D Limited Squaric acid derivates
WO2001079173A2 (en) 2000-04-17 2001-10-25 Celltech R & D Limited Enamine derivatives as cell adhesion molecules
US6403608B1 (en) 2000-05-30 2002-06-11 Celltech R&D, Ltd. 3-Substituted isoquinolin-1-yl derivatives
US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
JP2004511434A (en) 2000-06-15 2004-04-15 ファルマシア・コーポレーション Heteroarylalkanoic acids as integrin receptor antagonists
JP2004502762A (en) 2000-07-07 2004-01-29 セルテック　アール　アンド　ディ　リミテッド Squaric acid derivatives as integrin antagonists containing bicyclic heteroaromatic rings
EP1305291A1 (en) 2000-08-02 2003-05-02 Celltech R&D Limited 3-substituted isoquinolin-1-yl derivatives
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
CN1638776A (en) * 2001-06-08 2005-07-13 西托维亚公司 Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs
CA2488117A1 (en) 2002-06-17 2003-12-24 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
JP2006516144A (en) 2002-12-20 2006-06-22 ファルマシア・コーポレーション Thiazole compounds as integrin receptor antagonist derivatives
MXPA05006727A (en) * 2002-12-20 2005-09-08 Pharmacia Corp Heteroarylalkanoic acids as integrin receptor antagonists.
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
EP1618098B1 (en) 2003-04-11 2014-11-19 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
EP1697333A4 (en) 2003-12-17 2009-07-08 Merck & Co Inc (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists
US9051342B2 (en) 2004-10-13 2015-06-09 Ptc Therapeutics, Inc. Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation related diseases
BRPI0612028A2 (en) * 2005-06-08 2010-10-13 Novartis Ag polycyclic oxadiazoles or isodiazoles and their use as s1p receptor ligands
WO2007003960A1 (en) * 2005-06-30 2007-01-11 Prosidion Limited Gpcr agonists
CA2647903C (en) 2006-03-30 2016-12-13 Ptc Therapeutics, Inc. Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith
KR101130592B1 (en) 2006-06-26 2012-04-02 워너 칠콧 컴퍼니 엘엘씨 Prolyl hydroxylase inhibitors and methods of use
JO2701B1 (en) 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Compounds
KR101273765B1 (en) * 2008-06-24 2013-06-12 아이알엠 엘엘씨 Compounds and methods for modulating g protein-coupled receptors
EP2717870B1 (en) 2011-06-06 2017-09-27 Akebia Therapeutics Inc. Composition for stabilizing hypoxia inducible factor-2 alpha useful for treating cancer
NO2686520T3 (en) 2011-06-06 2018-03-17
NZ753904A (en) 2013-06-13 2020-07-31 Akebia Therapeutics Inc Compositions and methods for treating anemia
RU2021125455A (en) 2013-11-15 2021-10-05 Экебиа Терапьютикс, Инк. SOLID FORMS {[5- (3-CHLOROPHENYL) -3-HYDROXYPIRIDINE-2-CARBONYL] AMINO} ACETIC ACID, THEIR COMPOSITIONS AND APPLICATIONS
CN112979575A (en) 2014-03-06 2021-06-18 Ptc医疗公司 Pharmaceutical compositions and salts of 1,2, 4-oxadiazole benzoic acids
EP3247355A4 (en) 2015-01-23 2018-06-13 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
LT3277270T (en) 2015-04-01 2022-01-10 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
WO2017075312A1 (en) 2015-10-30 2017-05-04 Ptc Therapeutics, Inc. Methods for treating epilepsy
MX2020011845A (en) 2018-05-09 2021-01-15 Akebia Therapeutics Inc Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino]acetic acid.
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
GB202209228D0 (en) * 2022-06-23 2022-08-10 Univ Strathclyde Modified amino acids and uses thereof

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GB935523A (en) * 1961-06-17 1963-08-28 Acraf New sulphamido-oxadiazoles
JPS51143669A (en) * 1975-06-06 1976-12-10 Takeda Chem Ind Ltd A process for preparing 1,2,4- oxadiazole derivatives
JPS52272A (en) * 1975-10-17 1977-01-05 Takeda Chem Ind Ltd Process for preparing 1,2,4-oxadiazole derivatives
US4135910A (en) * 1977-05-12 1979-01-23 Monsanto Company Oxadiazol-3-yl-benzoates as plant growth regulants
WO1994022846A1 (en) * 1993-03-30 1994-10-13 Pfizer Inc. Compounds enhancing antitumor activity of other cytotoxic agents

Also Published As

Publication number Publication date
DE19620041A1 (en) 1998-01-29
WO1997044333A1 (en) 1997-11-27
AU2957997A (en) 1997-12-09
AR007160A1 (en) 1999-10-13

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