ZA968930B - Preparations and processes for stablizing biological materials by means of drying processes without freezing. - Google Patents

Preparations and processes for stablizing biological materials by means of drying processes without freezing.

Info

Publication number
ZA968930B
ZA968930B ZA9608930A ZA968930A ZA968930B ZA 968930 B ZA968930 B ZA 968930B ZA 9608930 A ZA9608930 A ZA 9608930A ZA 968930 A ZA968930 A ZA 968930A ZA 968930 B ZA968930 B ZA 968930B
Authority
ZA
South Africa
Prior art keywords
processes
solution
freezing
stablizing
preparations
Prior art date
Application number
ZA9608930A
Other languages
English (en)
Inventor
Markus Mattern
Gerhard Winter
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7775640&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA968930(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of ZA968930B publication Critical patent/ZA968930B/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1816Erythropoietin [EPO]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/193Colony stimulating factors [CSF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44Oxidoreductases (1)
    • A61K38/443Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Drying Of Solid Materials (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Storage Of Fruits Or Vegetables (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
ZA9608930A 1995-10-25 1996-10-24 Preparations and processes for stablizing biological materials by means of drying processes without freezing. ZA968930B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19539574A DE19539574A1 (de) 1995-10-25 1995-10-25 Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren

Publications (1)

Publication Number Publication Date
ZA968930B true ZA968930B (en) 1998-04-24

Family

ID=7775640

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9608930A ZA968930B (en) 1995-10-25 1996-10-24 Preparations and processes for stablizing biological materials by means of drying processes without freezing.

Country Status (25)

Country Link
US (3) US7172999B2 (xx)
EP (1) EP0857060B1 (xx)
JP (2) JPH11513700A (xx)
KR (1) KR100466670B1 (xx)
CN (1) CN1130196C (xx)
AT (1) ATE212541T1 (xx)
AU (1) AU712489B2 (xx)
BR (1) BR9611265A (xx)
CA (1) CA2235243C (xx)
CZ (1) CZ293456B6 (xx)
DE (2) DE19539574A1 (xx)
DK (1) DK0857060T3 (xx)
ES (1) ES2170274T3 (xx)
HU (1) HU222601B1 (xx)
IL (1) IL124204A (xx)
MX (1) MX9803264A (xx)
NO (1) NO324728B1 (xx)
NZ (1) NZ320276A (xx)
PL (1) PL190657B1 (xx)
PT (1) PT857060E (xx)
RU (1) RU2191003C2 (xx)
SK (1) SK283664B6 (xx)
TR (1) TR199800715T2 (xx)
WO (1) WO1997015288A2 (xx)
ZA (1) ZA968930B (xx)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
DE19539574A1 (de) * 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
EP0852951A1 (de) * 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
EP0913178A1 (en) * 1997-11-03 1999-05-06 Boehringer Mannheim Gmbh Process for the manufacture of dry, amorphous products comprising biologically active material by means of convection drying and products obtainable by the process
EP0913177A1 (de) * 1997-11-03 1999-05-06 Roche Diagnostics GmbH Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung
BR9905867A (pt) * 1998-11-06 2001-01-23 Bio Sidus S A Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula
MXPA01010208A (es) * 1999-04-09 2003-07-21 Johnson & Johnson Composiciones farmaceuticas de eritropoyetina.
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
WO2001094867A1 (en) * 2000-06-07 2001-12-13 Universal Preservation Technologies, Inc. Industrial scale barrier technology for preservation of sensitive biological materials
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
DE60224096T3 (de) * 2002-01-16 2012-01-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur herstellung einer zweischichtigen pharmazeutischen tablette enthaltend telmisartan und hydrochlorothiazid
KR100556503B1 (ko) * 2002-11-26 2006-03-03 엘지전자 주식회사 건조기의 건조 시간제어 방법
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US20060099567A1 (en) * 2004-04-08 2006-05-11 Biomatrica, Inc. Integration of sample storage and sample management for life science
US20080176209A1 (en) * 2004-04-08 2008-07-24 Biomatrica, Inc. Integration of sample storage and sample management for life science
RU2418633C2 (ru) * 2004-04-08 2011-05-20 Байоматрика, Инк. Объединение процессов хранения образцов и управление образцами в медико-биологических науках
GB0517688D0 (en) * 2005-08-31 2005-10-05 Cambridge Biostability Ltd Improvements in the stabilisation of biological materials
GB2430880A (en) * 2005-10-04 2007-04-11 Cambridge Biostability Ltd Pharmaceutical compositions stabilized in glassy particles
GB0523638D0 (en) * 2005-11-21 2005-12-28 Cambridge Biostability Ltd Pharmaceutical device for the administration of substances to patients
DK1973406T3 (da) 2005-12-28 2014-06-23 Advanced Bionutrition Corp Fremføringsmiddel til probiotiske bakerier omfattende en tør blanding af polysaccharider, saccharider, polyoler i glasform
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
EP2117354B1 (en) 2006-12-18 2018-08-08 Advanced BioNutrition Corp. A dry food product containing live probiotic
US8466187B2 (en) * 2007-09-18 2013-06-18 Thermolife International, Llc Amino acid compositions
CA2756883C (en) 2009-03-27 2018-01-09 Advanced Bionutrition Corp. Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish
EP2236520A1 (en) * 2009-03-31 2010-10-06 Leukocare Ag Stabilizing composition for immobilized biomolecules
US20120135017A1 (en) * 2009-05-26 2012-05-31 Moti Harel Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making
AR080428A1 (es) 2010-01-20 2012-04-11 Chugai Pharmaceutical Co Ltd Formulaciones liquidas estabilizadas contentivas de anticuerpos
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
WO2011094469A2 (en) 2010-01-28 2011-08-04 Advanced Bionutrition Corporation Dry glassy composition comprising a bioactive material
CA2806734A1 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
US9376709B2 (en) 2010-07-26 2016-06-28 Biomatrica, Inc. Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures
CN103140145B (zh) 2010-08-13 2014-08-20 高级生物营养公司 用于生物材料的干的贮存稳定用组合物
CN102408467B (zh) * 2010-09-26 2014-03-05 海口维瑅瑷生物研究院 真空干燥蛋白的方法、制得的蛋白产品和试剂盒
HUE032165T2 (en) 2011-04-13 2017-09-28 Thermolife Int Llc Methods of using N-actyl-beta-alanine
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
EP3656215B1 (en) 2014-06-10 2021-08-04 Biomatrica, INC. Stabilization of thrombocytes at ambient temperatures
US9868944B2 (en) * 2014-12-19 2018-01-16 Roche Molecular Systems, Inc. Reaction mixtures
US20180030400A1 (en) * 2015-02-11 2018-02-01 Prevtec Microbia Inc. Improved dry matrix for embedding viable escherichia coli, method of making same and use thereof
CN108024540B (zh) 2015-04-29 2021-09-17 雷迪厄斯制药公司 用于治疗癌症的方法
CN108347982A (zh) 2015-07-29 2018-07-31 高级生物营养公司 用于特殊饮食用途的稳定的干燥益生菌组合物
KR102589056B1 (ko) 2015-12-08 2023-10-12 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
CN106831466B (zh) * 2016-12-28 2018-05-22 安徽省虹升生物股份有限公司 一种β-丙氨酸的常规储存方法
EP3565542B1 (en) 2017-01-05 2024-04-10 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl
CN112165951A (zh) * 2018-04-16 2021-01-01 默克专利股份有限公司 用于改善热稳定性的蛋白质制剂添加剂
WO2020010216A1 (en) 2018-07-04 2020-01-09 Radius Pharmaceuticals, Inc. Polymorphic forms of rad 1901-2hcl
MX2023000557A (es) * 2020-07-13 2023-02-13 Merck Patent Gmbh Excipientes reductores de la viscosidad y combinaciones de los mismos para formulaciones proteicas altamente concentradas.
US11865139B2 (en) 2020-11-12 2024-01-09 Thermolife International, Llc Method of treating migraines and headaches
CN114480129A (zh) * 2022-01-13 2022-05-13 力因精准医疗产品(上海)有限公司 一种人粪便保存液及使用方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714353A (en) * 1959-08-11 1973-01-30 Upjohn Co THERAPEUTIC COMPOSITIONS COMPRISING A 6 alpha ; 9 alpha -DIFLUORO-11 beta ,17 alpha ,21-TRIHYDROXY-16 alpha -METHYL-1,4-PREGNADIENE-3,20-DIONE AND 21-ACYLATES
US3852461A (en) * 1971-08-04 1974-12-03 Upjohn Co Benzodiapines used as minor tranquilizers
JPS5836954B2 (ja) * 1980-03-31 1983-08-12 栄研化学株式会社 酵素の安定化剤
JPS5967228A (ja) 1982-10-07 1984-04-16 Green Cross Corp:The 寒冷不溶性グロブリンの凍結乾燥方法
JPS6197229A (ja) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd 安定なエリトロポエチン製剤
US4732889A (en) * 1985-02-06 1988-03-22 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for the treatment of the anemia of rheumatoid arthritis
US4788072A (en) * 1985-08-15 1988-11-29 Toshimitsu Kawamura Method of dehydrating foods
US4808617A (en) 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
EP0326618A1 (en) * 1987-03-04 1989-08-09 Nippon Hypox Laboratories Incorporated Medicinal composition containing albumin as carrier and process for its preparation
DE3729863A1 (de) 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh Stabilisierte erythropoietin-lyophilisate
US4886742A (en) * 1987-06-15 1989-12-12 Coulter Corporation Enzyme immunoassay for detecting HIV antigens in human sera
DE3801179A1 (de) 1988-01-18 1989-07-27 Hoechst Ag Stabilisierung von cephalosporinderivaten durch trocknung mit einem stabilisator sowie stabile zubereitungsformen mit cephalosporinderivaten
JPH0761955B2 (ja) 1988-04-28 1995-07-05 国立予防衛生研究所長 凍結乾燥a型肝炎ワクチン
CA1339071C (en) 1988-08-24 1997-07-29 Koichiro Tsuji Thrombus control agent
JPH0296536A (ja) 1988-09-29 1990-04-09 Green Cross Corp:The プラスミノゲン乾燥製剤
JP2739584B2 (ja) 1989-01-06 1998-04-15 株式会社ミドリ十字 ウロキナーゼ型プラスミノーゲンアクチベーター乾燥製剤
US5186944A (en) * 1989-02-15 1993-02-16 Eimei Company Ltd. Therapeutic medicament for thrombosis
WO1990012029A1 (en) * 1989-04-11 1990-10-18 Immunobiology Research Institute, Inc. Lyophilized peptide formulations
JPH0775519B2 (ja) 1989-10-06 1995-08-16 東洋製罐株式会社 ドライパック包装食品の製造方法
GB9001987D0 (en) * 1990-01-29 1990-03-28 Janssen Pharmaceutica Nv Improved cyclodextrin based erythropietin formulation
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
US5200399A (en) * 1990-09-14 1993-04-06 Boyce Thompson Institute For Plant Research, Inc. Method of protecting biological materials from destructive reactions in the dry state
US5217741A (en) 1991-01-25 1993-06-08 Snow Brand Milk Products Co., Ltd. Solution containing whey protein, whey protein gel, whey protein powder and processed food product produced by using the same
AU659645B2 (en) 1991-06-26 1995-05-25 Inhale Therapeutic Systems Storage of materials
JP2818834B2 (ja) * 1991-08-12 1998-10-30 大塚製薬株式会社 IL−1α安定化医薬製剤
DE4141351A1 (de) * 1991-12-14 1993-06-17 Basf Ag Stabile pulverfoermige vitamin- und/oder carotinoid-praeparate und verfahren zu deren herstellung
SE9201073D0 (sv) 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
IL105553A (en) 1992-05-06 1998-01-04 Janssen Pharmaceutica Inc Solid dosage forms consisting of a porous network of matrix that releases a substance that dissipates rapidly in water
IT1254359B (it) 1992-05-11 1995-09-14 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti il-6
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
JP3168550B2 (ja) * 1992-12-02 2001-05-21 株式会社林原生物化学研究所 脱水剤およびそれを用いる含水物の脱水方法並びにその方法で得られる脱水物品
DE4242863A1 (de) * 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF
US5354934A (en) * 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
EP0748213B1 (en) 1994-03-07 2004-04-14 Nektar Therapeutics Methods and compositions for pulmonary delivery of insulin
US5955448A (en) * 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
FR2719479B1 (fr) 1994-05-04 1996-07-26 Sanofi Elf Formulation stable lyophilisée comprenant une protéine: kit de dosage.
CA2190502A1 (en) 1994-05-18 1995-11-23 Robert M. Platz Methods and compositions for the dry powder formulation of interferons
IL116085A (en) * 1994-12-16 1999-12-31 Ortho Pharma Corp Spray dried erythropoietin
ES2237767T3 (es) 1995-04-14 2005-08-01 Nektar Therapeutics Composiciones farmaceuticas en polvo que tienen una dispersabilidad mejorada.
US5728678A (en) 1995-06-06 1998-03-17 Nestec Ltd. Method and composition for providing nutrition to a renal failure patient
DE19538687A1 (de) 1995-10-17 1997-04-24 Boehringer Mannheim Gmbh Stabile pharmazeutische Darreichungsformen enthaltend Parathormon
DE19539574A1 (de) * 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren

Also Published As

Publication number Publication date
CN1205628A (zh) 1999-01-20
EP0857060B1 (de) 2002-01-30
BR9611265A (pt) 1999-05-04
IL124204A (en) 2001-10-31
ES2170274T3 (es) 2002-08-01
US20070020289A1 (en) 2007-01-25
US20030059468A1 (en) 2003-03-27
SK50998A3 (en) 1998-12-02
CA2235243C (en) 2003-04-22
NO981868D0 (no) 1998-04-24
JP2007236975A (ja) 2007-09-20
CZ117998A3 (cs) 1998-11-11
KR100466670B1 (ko) 2005-09-07
KR19990067082A (ko) 1999-08-16
MX9803264A (es) 1998-09-30
TR199800715T2 (xx) 1998-08-21
PL190657B1 (pl) 2005-12-30
DE19539574A1 (de) 1997-04-30
RU2191003C2 (ru) 2002-10-20
PL326358A1 (en) 1998-09-14
CZ293456B6 (cs) 2004-05-12
HUP9901314A2 (hu) 1999-07-28
AU7298496A (en) 1997-05-15
AU712489B2 (en) 1999-11-11
CA2235243A1 (en) 1997-05-01
EP0857060A2 (de) 1998-08-12
US7172999B2 (en) 2007-02-06
CN1130196C (zh) 2003-12-10
DE59608684D1 (de) 2002-03-14
NO981868L (no) 1998-06-25
PT857060E (pt) 2002-07-31
NO324728B1 (no) 2007-12-03
ATE212541T1 (de) 2002-02-15
HU222601B1 (hu) 2003-08-28
DK0857060T3 (da) 2002-05-13
WO1997015288A3 (de) 1997-05-29
US20010055617A1 (en) 2001-12-27
NZ320276A (en) 1999-11-29
HUP9901314A3 (en) 2000-02-28
SK283664B6 (sk) 2003-11-04
WO1997015288A2 (de) 1997-05-01
JPH11513700A (ja) 1999-11-24

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