ZA968470B - Antiadhesive peripidine- and pyrrolidinecarboxylic acids - Google Patents
Antiadhesive peripidine- and pyrrolidinecarboxylic acidsInfo
- Publication number
- ZA968470B ZA968470B ZA968470A ZA968470A ZA968470B ZA 968470 B ZA968470 B ZA 968470B ZA 968470 A ZA968470 A ZA 968470A ZA 968470 A ZA968470 A ZA 968470A ZA 968470 B ZA968470 B ZA 968470B
- Authority
- ZA
- South Africa
- Prior art keywords
- peripidine
- antiadhesive
- piperidine
- ring
- linked
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19537334A DE19537334A1 (de) | 1995-10-09 | 1995-10-09 | Antiadhäsive Piperidin- und Pyrrolidin-Carbonsäuren |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA968470B true ZA968470B (en) | 1997-04-09 |
Family
ID=7774241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA968470A ZA968470B (en) | 1995-10-09 | 1996-10-08 | Antiadhesive peripidine- and pyrrolidinecarboxylic acids |
Country Status (20)
Country | Link |
---|---|
US (1) | US5739300A (no) |
EP (1) | EP0787739B1 (no) |
JP (1) | JPH09110834A (no) |
KR (1) | KR970021071A (no) |
CN (1) | CN1150155A (no) |
AT (1) | ATE231877T1 (no) |
AU (1) | AU6799796A (no) |
BR (1) | BR9605024A (no) |
CA (1) | CA2187392A1 (no) |
CZ (1) | CZ294096A3 (no) |
DE (2) | DE19537334A1 (no) |
HR (1) | HRP960459A2 (no) |
HU (1) | HUP9602745A3 (no) |
MX (1) | MX9604657A (no) |
NO (1) | NO964268L (no) |
PL (1) | PL316429A1 (no) |
SI (1) | SI9600296A (no) |
SK (1) | SK127796A3 (no) |
TR (1) | TR199600799A2 (no) |
ZA (1) | ZA968470B (no) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999029705A2 (en) * | 1997-12-08 | 1999-06-17 | Glycomed Incorporated | Sialyl lewis x and sialyl lewis a glycomimetics |
JP5183010B2 (ja) | 2002-05-16 | 2013-04-17 | グリコミメティクス, インコーポレイテッド | セレクチンによって媒介される機能を阻害するための化合物および方法 |
CA2485346C (en) * | 2002-06-12 | 2013-05-28 | Exelixis, Inc. | Human adam-10 inhibitors |
AU2003245595A1 (en) * | 2002-07-03 | 2004-01-23 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
DE602004011272T2 (de) * | 2003-11-19 | 2008-12-24 | Glycomimetics, Inc. | Spezifischer antagonist sowohl für e- als auch p-selektine |
JP2007524658A (ja) * | 2003-11-19 | 2007-08-30 | グリコミメティクス, インコーポレイテッド | E−およびp−セレクチンの両方のための糖模倣物アンタゴニスト |
US8201377B2 (en) * | 2004-11-05 | 2012-06-19 | Faus Group, Inc. | Flooring system having multiple alignment points |
US20090036386A1 (en) * | 2005-05-25 | 2009-02-05 | Glycomimetics, Inc | Heterobifunctional compounds for selectin inhibition |
US7517980B2 (en) * | 2005-08-09 | 2009-04-14 | Glycomimetics, Inc. | Glycomimetric inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas |
EP2264043B1 (en) * | 2005-09-02 | 2017-11-08 | GlycoMimetics, Inc. | Heterobifunctional pan-selectin inhibitors |
WO2007143052A1 (en) * | 2006-06-01 | 2007-12-13 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
WO2008060378A2 (en) | 2006-10-12 | 2008-05-22 | Glycomimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
JP5511390B2 (ja) * | 2007-02-09 | 2014-06-04 | グリコミメティクス, インコーポレイテッド | ヘキソースおよびn−アセチルヘキソサミンの置換体を有する糖模倣体の使用方法 |
US8039442B2 (en) * | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
WO2009152245A1 (en) * | 2008-06-13 | 2009-12-17 | Glycomimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
CN102421441B (zh) * | 2009-05-01 | 2015-04-01 | 糖模拟物有限公司 | E-选择蛋白和cxcr4趋化因子受体的异双功能抑制剂 |
WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
WO2013096926A1 (en) | 2011-12-22 | 2013-06-27 | Glycomimetics, Inc. | E-selectin antagonist compounds, compositions, and methods of use |
EP2928476B1 (en) | 2012-12-07 | 2018-02-14 | GlycoMimetics, Inc. | Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells |
ES2754549T3 (es) | 2014-12-03 | 2020-04-20 | Glycomimetics Inc | Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4 |
WO2017127422A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
EP3497131B1 (en) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4. |
US11072625B2 (en) | 2016-10-07 | 2021-07-27 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
WO2018169853A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
EP3717013A1 (en) | 2017-11-30 | 2020-10-07 | GlycoMimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
EP3732186A1 (en) | 2017-12-29 | 2020-11-04 | GlycoMimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
CN111867601A (zh) | 2018-03-05 | 2020-10-30 | 糖模拟物有限公司 | 用于治疗急性髓系白血病及相关病症的方法 |
WO2020139962A1 (en) | 2018-12-27 | 2020-07-02 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0671409A3 (de) * | 1994-03-11 | 1996-06-12 | Hoechst Ag | Malonsäurederivate mit antiadhäsiven Eigenschaften. |
-
1995
- 1995-10-09 DE DE19537334A patent/DE19537334A1/de not_active Withdrawn
-
1996
- 1996-09-26 AT AT96115414T patent/ATE231877T1/de not_active IP Right Cessation
- 1996-09-26 EP EP96115414A patent/EP0787739B1/de not_active Expired - Lifetime
- 1996-09-26 DE DE59610093T patent/DE59610093D1/de not_active Expired - Lifetime
- 1996-10-04 SK SK1277-96A patent/SK127796A3/sk unknown
- 1996-10-04 US US08/726,142 patent/US5739300A/en not_active Expired - Fee Related
- 1996-10-07 HR HR19537334.0A patent/HRP960459A2/hr not_active Application Discontinuation
- 1996-10-07 TR TR96/00799A patent/TR199600799A2/xx unknown
- 1996-10-07 CZ CZ962940A patent/CZ294096A3/cs unknown
- 1996-10-07 PL PL96316429A patent/PL316429A1/xx unknown
- 1996-10-07 HU HU9602745A patent/HUP9602745A3/hu unknown
- 1996-10-07 CN CN96113073A patent/CN1150155A/zh active Pending
- 1996-10-07 AU AU67997/96A patent/AU6799796A/en not_active Abandoned
- 1996-10-08 JP JP8267002A patent/JPH09110834A/ja active Pending
- 1996-10-08 CA CA002187392A patent/CA2187392A1/en not_active Abandoned
- 1996-10-08 BR BR9605024A patent/BR9605024A/pt not_active Application Discontinuation
- 1996-10-08 ZA ZA968470A patent/ZA968470B/xx unknown
- 1996-10-08 NO NO964268A patent/NO964268L/no unknown
- 1996-10-08 SI SI9600296A patent/SI9600296A/sl unknown
- 1996-10-08 MX MX9604657A patent/MX9604657A/es unknown
- 1996-10-09 KR KR1019960044663A patent/KR970021071A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1150155A (zh) | 1997-05-21 |
BR9605024A (pt) | 1998-06-30 |
DE59610093D1 (de) | 2003-03-06 |
ATE231877T1 (de) | 2003-02-15 |
DE19537334A1 (de) | 1997-04-10 |
AU6799796A (en) | 1997-04-17 |
NO964268L (no) | 1997-04-10 |
HUP9602745A2 (en) | 1997-05-28 |
TR199600799A2 (tr) | 1997-04-22 |
CZ294096A3 (en) | 1997-04-16 |
PL316429A1 (en) | 1997-04-14 |
SI9600296A (en) | 1997-04-30 |
SK127796A3 (en) | 1997-05-07 |
CA2187392A1 (en) | 1997-04-10 |
EP0787739A1 (de) | 1997-08-06 |
MX9604657A (es) | 1998-04-30 |
HUP9602745A3 (en) | 1998-03-02 |
US5739300A (en) | 1998-04-14 |
NO964268D0 (no) | 1996-10-08 |
HRP960459A2 (en) | 1998-02-28 |
JPH09110834A (ja) | 1997-04-28 |
EP0787739B1 (de) | 2003-01-29 |
HU9602745D0 (en) | 1996-11-28 |
KR970021071A (ko) | 1997-05-28 |
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