ZA933766B - Novel thio-substituted, nitrogen-containing, heterocyclic phosphonate compounds, pharmaceutical compositions and methods of treating abnormal calcium and phosphate metabolism. - Google Patents

Novel thio-substituted, nitrogen-containing, heterocyclic phosphonate compounds, pharmaceutical compositions and methods of treating abnormal calcium and phosphate metabolism.

Info

Publication number: ZA933766B
Authority: ZA; South Africa
Prior art keywords: substituted; nitrogen; methods; pharmaceutical compositions; treating abnormal
Prior art date: 1992-05-29

Application number

ZA933766A

Other languages

English (en)

Inventor

Susan Mary Kaas

Frank Hallock Ebetino

Marion David Francis

Original Assignee

Procter & Gamble Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-29

Filing date

1993-05-28

Publication date

1994-01-20

1993-05-28 Application filed by Procter & Gamble Pharmaceutical filed Critical Procter & Gamble Pharmaceutical

1994-01-20 Publication of ZA933766B publication Critical patent/ZA933766B/xx

Links

OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title 1
229910019142 PO4 Inorganic materials 0.000 title 1
230000002159 abnormal effect Effects 0.000 title 1
229910052791 calcium Inorganic materials 0.000 title 1
239000011575 calcium Substances 0.000 title 1
-1 heterocyclic phosphonate compounds Chemical class 0.000 title 1
230000004060 metabolic process Effects 0.000 title 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title 1
239000010452 phosphate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5532—Seven-(or more) membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA933766A 1992-05-29 1993-05-28 Novel thio-substituted, nitrogen-containing, heterocyclic phosphonate compounds, pharmaceutical compositions and methods of treating abnormal calcium and phosphate metabolism. ZA933766B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US89149092A	1992-05-29	1992-05-29

Publications (1)

Publication Number	Publication Date
ZA933766B true ZA933766B (en)	1994-01-20

Family

ID=25398279

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA933766A ZA933766B (en)	1992-05-29	1993-05-28	Novel thio-substituted, nitrogen-containing, heterocyclic phosphonate compounds, pharmaceutical compositions and methods of treating abnormal calcium and phosphate metabolism.

Country Status (20)

Country	Link
US (1)	US5856314A (ja)
EP (1)	EP0642521A1 (ja)
JP (1)	JPH07507317A (ja)
KR (1)	KR100266484B1 (ja)
CN (1)	CN1039327C (ja)
AU (1)	AU666741B2 (ja)
CA (1)	CA2136820C (ja)
CZ (1)	CZ295994A3 (ja)
FI (1)	FI945595A0 (ja)
HU (1)	HUT69731A (ja)
IL (1)	IL105832A (ja)
MX (1)	MX9303249A (ja)
NO (1)	NO305398B1 (ja)
NZ (1)	NZ253526A (ja)
PL (1)	PL175046B1 (ja)
RU (1)	RU2124019C1 (ja)
SG (1)	SG47603A1 (ja)
SK (1)	SK144694A3 (ja)
WO (1)	WO1993024500A1 (ja)
ZA (1)	ZA933766B (ja)

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WO2001044257A1 (en) *	1999-12-17	2001-06-21	Ariad Pharmaceuticals, Inc.	Proton pump inhibitors
JP2003519183A (ja) *	2000-01-04	2003-06-17	ザリージェンツオブザユニバーシティオブカリフォルニア	心臓および動脈の石灰化を抑制する低用量ビスホスホネートの使用
EP1482897A2 (en) *	2002-02-19	2004-12-08	Ilex Products, Inc.	Aminodiphosphonate apolipoprotein e modulators
WO2005090370A1 (en)	2004-02-05	2005-09-29	The Regents Of The University Of California	Pharmacologically active agents containing esterified phosphonates and methods for use thereof
EP2842559A3 (en)	2005-04-08	2015-03-18	Chimerix, Inc.	Compounds, compositions and methods for the treatment of viral infections and other medical disorders
EP1868628B1 (en)	2005-04-08	2014-06-11	Chimerix, Inc.	Compounds, compositions and methods for the treatment of poxvirus infections
DK2155851T3 (da)	2007-06-06	2014-09-29	Basf Se	Anvendelse af et n-vinylimidazol-polymerisat til forbedring af biologiske fermenterede opløsningers værdibestemmende egenskaber
EP2254582B1 (en) *	2008-01-25	2016-01-20	Chimerix, Inc.	Methods of treating viral infections
WO2011011519A1 (en)	2009-07-21	2011-01-27	Chimerix, Inc.	Compounds, compositions and methods for treating ocular conditions
EP2462152A4 (en)	2009-08-03	2013-02-13	Chimerix Inc	COMPOSITION AND METHODS FOR TREATING VIRAL INFECTIONS AND TUMORS OF VIRAL ORIGIN
US9006218B2 (en)	2010-02-12	2015-04-14	Chimerix Inc.	Nucleoside phosphonate salts
EP2563367A4 (en)	2010-04-26	2013-12-04	Chimerix Inc	METHODS OF TREATING RETROVIRAL INFECTIONS AND ASSOCIATED DOSAGE REGIMES
RU2506085C1 (ru) *	2013-01-30	2014-02-10	Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" (ФБУН ГНЦ ВБ "Вектор")	Тетраэтил-2-(2,2,6,6-тетраметилпиперидин-4-иламино)-этилен-1,1-бисфосфонат, обладающий противоопухолевой активностью
DE202015000809U1 (de)	2015-02-02	2015-02-16	Basf Se	Copolymere enthaltend Alkylaminoalkylalkoxy(meth)acrylate und deren Verwendung zur Wasserbehandlung
US10865220B2 (en)	2016-06-03	2020-12-15	Biovinc, Llc	Bisphosphonate quinolone conjugates and uses thereof
JP2019518792A (ja) *	2016-06-03	2019-07-04	バイオビンクエルエルシー	ビスホスホネート・キノロン複合体及びそれらの用途

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US4933472A (en) *	1988-04-08	1990-06-12	Yamanouchi Pharmaceutical Co., Ltd.	Substituted aminomethylenebis(phosphonic acid) derivatives
TW198039B (ja) *	1988-11-28	1993-01-11	Ciba Geigy Ag
CA2046905A1 (en) *	1989-04-03	1990-10-04	Colin John Dunn	Germinal bisphosphonic acids and derivatives as anti-arthritic agents
DE4011777A1 (de) *	1989-04-14	1990-10-18	Ciba Geigy Ag	N-trisubstituierte aminoalkandiphosphonsaeuren
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US5763611A (en) *	1992-05-29	1998-06-09	The Procter & Gamble Company	Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
ES2118967T3 (es) *	1992-05-29	1998-10-01	Procter & Gamble Pharma	Compuestos de fosfonato que contienen nitrogeno cuaternario para tratar un metabolismo anormal del calcio y fosfato asi como el calculo y la placa dentales.
NZ253524A (en) *	1992-05-29	1997-01-29	Procter & Gamble Pharma	Sulphur-containing phosphonate derivatives and medicaments (for treating abnormal calcium and phosphate metabolism)

1993
- 1993-05-26 RU RU94046146A patent/RU2124019C1/ru active
- 1993-05-26 AU AU43919/93A patent/AU666741B2/en not_active Ceased
- 1993-05-26 EP EP93914153A patent/EP0642521A1/en not_active Ceased
- 1993-05-26 CZ CZ942959A patent/CZ295994A3/cs unknown
- 1993-05-26 HU HU9403407A patent/HUT69731A/hu unknown
- 1993-05-26 CA CA002136820A patent/CA2136820C/en not_active Expired - Fee Related
- 1993-05-26 KR KR1019940704305A patent/KR100266484B1/ko not_active IP Right Cessation
- 1993-05-26 NZ NZ253526A patent/NZ253526A/en unknown
- 1993-05-26 WO PCT/US1993/004979 patent/WO1993024500A1/en not_active Application Discontinuation
- 1993-05-26 SK SK1446-94A patent/SK144694A3/sk unknown
- 1993-05-26 JP JP6500724A patent/JPH07507317A/ja active Pending
- 1993-05-26 PL PL93306141A patent/PL175046B1/pl unknown
- 1993-05-26 SG SG1996003070A patent/SG47603A1/en unknown
- 1993-05-28 IL IL10583293A patent/IL105832A/en not_active IP Right Cessation
- 1993-05-28 ZA ZA933766A patent/ZA933766B/xx unknown
- 1993-05-29 CN CN93108277A patent/CN1039327C/zh not_active Expired - Fee Related
- 1993-05-31 MX MX9303249A patent/MX9303249A/es not_active Application Discontinuation
1994
- 1994-05-09 US US08/240,303 patent/US5856314A/en not_active Expired - Fee Related
- 1994-11-24 NO NO944501A patent/NO305398B1/no not_active IP Right Cessation
- 1994-11-28 FI FI945595A patent/FI945595A0/fi unknown

Also Published As

Publication number	Publication date
CN1039327C (zh)	1998-07-29
SK144694A3 (en)	1995-06-07
CZ295994A3 (en)	1995-10-18
HUT69731A (en)	1995-09-28
SG47603A1 (en)	1998-04-17
RU2124019C1 (ru)	1998-12-27
IL105832A (en)	1998-08-16
JPH07507317A (ja)	1995-08-10
CA2136820A1 (en)	1993-12-09
NO944501L (no)	1995-01-27
RU94046146A (ru)	1996-11-27
KR950701932A (ko)	1995-05-17
HU9403407D0 (en)	1995-02-28
IL105832A0 (en)	1993-09-22
MX9303249A (es)	1994-05-31
FI945595A (fi)	1994-11-28
NO944501D0 (no)	1994-11-24
KR100266484B1 (ko)	2000-09-15
FI945595A0 (fi)	1994-11-28
CN1085907A (zh)	1994-04-27
NZ253526A (en)	1997-01-29
PL175046B1 (pl)	1998-10-30
AU4391993A (en)	1993-12-30
AU666741B2 (en)	1996-02-22
NO305398B1 (no)	1999-05-25
EP0642521A1 (en)	1995-03-15
CA2136820C (en)	1997-09-09
WO1993024500A1 (en)	1993-12-09
US5856314A (en)	1999-01-05

Publication	Publication Date	Title
ZA933768B (en)	1994-01-20	Novel phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism metabolism.
ZA933766B (en)	1994-01-20	Novel thio-substituted, nitrogen-containing, heterocyclic phosphonate compounds, pharmaceutical compositions and methods of treating abnormal calcium and phosphate metabolism.
BG104599A (en)	2001-03-30	Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas
ZA969248B (en)	1997-05-06	New aminoacid derivatives process for the manufacture thereof and pharmaceutical compositions containing thesse compounds
HUT40331A (en)	1986-12-28	Process for preparing pharmaceutical compositions containing a combination of dihidro-pyridines and ace-inhibitors
MY115310A (en)	2003-05-31	Substance p antagonists for the treatment of emesis
IL117656A0 (en)	1996-07-23	Pharmaceutical compositions for the treatment of travellers diarrhea
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