ZA918120B - Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists - Google Patents

Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists

Info

Publication number
ZA918120B
ZA918120B ZA918120A ZA918120A ZA918120B ZA 918120 B ZA918120 B ZA 918120B ZA 918120 A ZA918120 A ZA 918120A ZA 918120 A ZA918120 A ZA 918120A ZA 918120 B ZA918120 B ZA 918120B
Authority
ZA
South Africa
Prior art keywords
leukotriene antagonists
unsaturated
acids
hydroxyalkylquinoline acids
unsaturated hydroxyalkylquinoline
Prior art date
Application number
ZA918120A
Other languages
English (en)
Inventor
Michel L Belley
L Belley Michel
Yi Bin Xiang
Bin Xiang Yi
Patrick Roy
Roy Patrick
Serge Leger
Leger Serge
Marc Labelle
Labelle Marc
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Publication of ZA918120B publication Critical patent/ZA918120B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
ZA918120A 1990-10-12 1991-10-11 Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists ZA918120B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59684490A 1990-10-12 1990-10-12

Publications (1)

Publication Number Publication Date
ZA918120B true ZA918120B (en) 1992-06-24

Family

ID=24388953

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA918120A ZA918120B (en) 1990-10-12 1991-10-11 Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists

Country Status (16)

Country Link
US (1) US5428033A (pt)
EP (1) EP0480716A1 (pt)
JP (1) JP2538155B2 (pt)
KR (1) KR920008004A (pt)
CN (1) CN1061408A (pt)
AU (1) AU639611B2 (pt)
CA (1) CA2053216C (pt)
CS (1) CS309391A3 (pt)
FI (1) FI914797A (pt)
HU (1) HUT61980A (pt)
IE (1) IE913611A1 (pt)
IL (1) IL99725A0 (pt)
MX (1) MX9101557A (pt)
NO (1) NO914002L (pt)
PT (1) PT99212B (pt)
ZA (1) ZA918120B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856322A (en) * 1990-10-12 1999-01-05 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
CA2111372C (en) * 1992-12-22 2007-01-16 Robert N. Young Diaryl 5,6-fusedheterocyclic acids as leukotriene antagonists
US5472964A (en) * 1992-12-22 1995-12-05 Merck Frosst Canada, Inc. Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists
US5438141A (en) * 1993-05-21 1995-08-01 Merck Frosst Canada, Inc. Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists
ES2080656B1 (es) * 1993-07-19 1996-10-16 Merck Frosst Canada Inc Acidos de hidroxialquilquinolina fluorados como antagonistas del leucotrieno.
TW416948B (en) * 1993-12-28 2001-01-01 Merck & Co Inc Process for the preparation of leukotriene antagonists
US5750539A (en) * 1995-06-07 1998-05-12 Merck Frosst Canada Heteroaryl diol acids as leukotriene antagonists
US6696466B1 (en) * 2000-09-07 2004-02-24 Leslie Joe Dunaway Methods of treating select neuronal inflammatory disorders using hydroxyalkylquinolines
WO2002058690A2 (en) 2001-01-26 2002-08-01 Chugai Seiyaku Kabushiki Kaisha Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors
CA2435067C (en) * 2001-01-26 2011-11-15 Chugai Seiyaku Kabushiki Kaisha Malonyl-coa decarboxylase inhibitors useful as metabolic modulators
JP4267920B2 (ja) * 2001-01-26 2009-05-27 中外製薬株式会社 代謝調節剤として有用なマロニル−ＣｏＡ脱炭酸酵素阻害剤
HU229431B1 (en) 2001-02-20 2013-12-30 Chugai Pharmaceutical Co Ltd Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators
US7709510B2 (en) * 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
ES2309563T3 (es) * 2003-08-01 2008-12-16 Chugai Seiyaku Kabushiki Kaisha Compuestos de piperidina utiles como inhibidores de malonil coenzima a descarboxilasa.
DE602004009582T2 (de) * 2003-08-01 2009-01-02 Chugai Seiyaku K.K. Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer
ATE407673T1 (de) * 2003-08-01 2008-09-15 Chugai Pharmaceutical Co Ltd Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer
CA2533747C (en) * 2003-08-01 2012-11-13 Chugai Seiyaku Kabushiki Kaisha Heterocyclic compounds useful as malonyl-coa decarboxylase inhibitors
ES2371549T3 (es) * 2003-10-10 2012-01-05 Synthon B.V. Montelukast en estado sólido.
EP1709002A2 (en) * 2004-01-30 2006-10-11 Teva Pharmaceutical Industries Ltd. Montelukast sodium polymorphs
US20050187243A1 (en) * 2004-01-30 2005-08-25 Valerie Niddam-Hildesheim Montelukast free acid polymorphs
DE602005015174D1 (de) * 2004-04-21 2009-08-13 Teva Pharma Verfahren zur herstellung von montelukast-natrium
CA2608369A1 (en) * 2005-07-05 2007-01-11 Teva Pharmaceutical Industries Ltd. Purification of montelukast
AR057909A1 (es) * 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico.
WO2009001374A2 (en) * 2007-06-25 2008-12-31 Aptuit Laurus Pvt Ltd Preparation of ethyl-3'-[((7-chloro-2-quinolinyl)ethenyl)phenyl]-3-oxopropanoate, a key intermediate for montelukast sodium
WO2009130056A1 (en) * 2008-04-25 2009-10-29 Synthon B.V. Process for making montelukast intermediates
JP6038914B2 (ja) * 2011-07-26 2016-12-07 スン プハルマ アドバンセド リサーチ カンパニー リミテド キノリン−、キノキサリン、又はベンゾチアゾールベースのシステイニルロイコトリエンアンタゴニスト（ｌｔｃ４）
KR20210114962A (ko) * 2019-01-10 2021-09-24 장인 무코케어 파마슈티컬 컴퍼니 리미티드 류코트리엔 수용체 길항제를 함유하는 신규 제제

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1144905A (en) 1965-03-25 1969-03-12 Fisons Pharmaceuticals Ltd Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3630200A (en) 1969-06-09 1971-12-28 Alza Corp Ocular insert
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4325961A (en) 1977-06-01 1982-04-20 Merck & Co., Inc. Fluorinated amino acids
PT68303A (en) 1977-07-26 1978-08-01 Merck & Co Inc Process for the preparation of dibenzo/b,f/thiepin
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
PH16099A (en) 1979-03-06 1983-06-24 Yamanouchi Pharma Co Ltd Guanidinothiazole compounds,process for preparing them and medical composition containing them
JPS6056143B2 (ja) 1979-08-02 1985-12-09 山之内製薬株式会社 アミジン誘導体ならびにその製造法
GB2058785B (en) 1979-09-05 1983-05-25 Glaxo Group Ltd Phenol derivatives
US4237160A (en) 1979-11-27 1980-12-02 Merck Sharp & Dohme (I.A.) Corp. 3-Hydroxymethyldibenzo[b,f]thiepins as prostaglandin antagonists
EP0040696B1 (en) 1980-04-30 1986-08-27 Merck & Co. Inc. Aminothiadiazoles as gastric secretion inhibitors
US4394508A (en) 1980-06-07 1983-07-19 Bristol-Myers Company Chemical compounds
EP0056172B1 (en) 1981-01-09 1985-04-03 FISONS plc Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them
EP0061800B1 (en) 1981-03-24 1985-08-28 FISONS plc Anti srs-a carboxylic acid derivatives, processes for their production and pharmaceutical formulations containing them
IL69691A (en) 1982-09-23 1988-01-31 Merck Frosst Canada Inc Leukotriene antagonists,their preparation and pharmaceutical compositions containing them
EP0106565B1 (en) 1982-09-30 1986-09-10 Merck Frosst Canada Inc. Leukotriene antagonists, their production, and compositions containing them
NZ206795A (en) 1983-01-21 1987-08-31 Merck Frosst Canada Inc Phenothiazines, analogues and pharmaceutical compositions
EP0136893B1 (en) 1983-10-05 1989-08-16 Merck Frosst Canada Inc. Benzo[a]phenothiazines and hydro-derivatives and pharmaceutical compositions containing them
DE3484745D1 (de) 1983-10-05 1991-08-01 Merck Frosst Canada Inc Inhibitoren fuer die leukotrien-biosynthese.
ES8602818A1 (es) 1983-10-31 1985-12-01 Merck Frosst Canada Inc Una composicion farmaceutica
ES8801209A1 (es) 1985-06-18 1988-01-01 Merck Frosst Canada Inc Un procedimiento para la preparacion de quinolinas 2-sustituidas.
IE59889B1 (en) * 1986-02-14 1994-04-20 Merck Frosst Canada Inc 2-substituted quinoline dioic acids
US4851409A (en) * 1986-02-14 1989-07-25 Merck Frosst Canada Inc. 2-substituted quinoline dioic acids and pharmaceutical compositions
EP0271287A3 (en) * 1986-12-11 1990-06-13 Merck Frosst Canada Inc. Quinoline dioic acids and amides
DE3700732A1 (de) * 1987-01-13 1988-07-21 Boehringer Mannheim Gmbh Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
IL88433A0 (en) * 1987-11-25 1989-06-30 Merck Frosst Canada Inc Diarylstyrylquinoline diacids and pharmaceutical compositions containing them
US5104882A (en) * 1987-11-25 1992-04-14 Merck Frosst Canada, Inc. Diarylstrylquinoline diacids and pharmaceutical compositions thereof
NZ233752A (en) * 1989-05-24 1993-05-26 Merck Frosst Canada Inc Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
MX9101557A (es) 1994-05-31
EP0480716A1 (en) 1992-04-15
HU913216D0 (en) 1992-01-28
FI914797A (fi) 1992-04-13
IL99725A0 (en) 1992-08-18
US5428033A (en) 1995-06-27
JPH06206868A (ja) 1994-07-26
CN1061408A (zh) 1992-05-27
CS309391A3 (en) 1992-05-13
CA2053216A1 (en) 1992-04-13
AU8579691A (en) 1992-04-16
FI914797A0 (fi) 1991-10-11
CA2053216C (en) 2003-04-08
AU639611B2 (en) 1993-07-29
HUT61980A (en) 1993-03-29
PT99212A (pt) 1992-09-30
NO914002D0 (no) 1991-10-11
KR920008004A (ko) 1992-05-27
JP2538155B2 (ja) 1996-09-25
NO914002L (no) 1992-04-13
PT99212B (pt) 1999-04-30
IE913611A1 (en) 1992-04-22

Similar Documents

Publication Publication Date Title
ZA918120B (en) Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
AP9200416A0 (en) Imidazolyl-alkenoic acids
ZA882421B (en) Leukotriene antagonists
EP0441235A3 (en) Process for the continuous preparation of imidoperoxycarbonic acids
EP0439829A3 (en) Process for the preparation of copolyestercarbonates
EP0541705A4 (en) Substituted 1h-imidazol-5-yl)alkanoic acids
HUT71732A (en) General purpose aqueous cleaning composition
EP0563238A4 (en) Imidazolyl-alkenoic acids
ZA911111B (en) Leukotriene antagonists
DE3463653D1 (en) Substituted unsaturated mercaptocarboxylic acids and derivatives as leukotriene antagonists
AU640328B2 (en) Sulfimidoperoxycarboxylic acids
AU110435S (en) Sprayer hood
PL308473A1 (en) Enabntiomeric cis-3-(4,6-dihydoxychroman-3-yl methyl)bezoic acids
EP0543343A3 (en) Process for the preparation of alpha-hydroxy-beta-aminocarboxylic acids
EP0421439A3 (en) Ultrasonic atomiser
EP0502199A4 (en) Ultrasonic microscope
ZA964645B (en) Heteroaryl diol acids as leukotriene antagonists
ZA918119B (en) Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
GB9103134D0 (en) Process for the preparation of n-acyl-alpha-amino acids
AU639610C (en) Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
ZW9390A1 (en) Imidazolyl-alkenoic acids
IE900361L (en) Saccharoascorbic acids
IE900337L (en) Heteroaryl-1-alkyl-pyrrole-2-carboxylic acids
IE900338L (en) Heteroaryl-1-alkyl-pyrrole-2-carboxylic acids
IE901193L (en) 5-alkylquinolone carboxylic acids