DE602005015174D1 - Verfahren zur herstellung von montelukast-natrium - Google Patents
Verfahren zur herstellung von montelukast-natriumInfo
- Publication number
- DE602005015174D1 DE602005015174D1 DE602005015174T DE602005015174T DE602005015174D1 DE 602005015174 D1 DE602005015174 D1 DE 602005015174D1 DE 602005015174 T DE602005015174 T DE 602005015174T DE 602005015174 T DE602005015174 T DE 602005015174T DE 602005015174 D1 DE602005015174 D1 DE 602005015174D1
- Authority
- DE
- Germany
- Prior art keywords
- montelucasts
- sodium
- producing
- present
- provides processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56450404P | 2004-04-21 | 2004-04-21 | |
US58223704P | 2004-06-22 | 2004-06-22 | |
PCT/US2005/014011 WO2005105751A1 (en) | 2004-04-21 | 2005-04-21 | Processes for preparing montelukast sodium |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005015174D1 true DE602005015174D1 (de) | 2009-08-13 |
Family
ID=34966501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005015174T Active DE602005015174D1 (de) | 2004-04-21 | 2005-04-21 | Verfahren zur herstellung von montelukast-natrium |
Country Status (11)
Country | Link |
---|---|
US (1) | US7547787B2 (de) |
EP (1) | EP1646612B1 (de) |
JP (1) | JP2007532686A (de) |
KR (1) | KR100815670B1 (de) |
AT (1) | ATE435209T1 (de) |
CA (1) | CA2563776A1 (de) |
DE (1) | DE602005015174D1 (de) |
ES (1) | ES2327762T3 (de) |
IL (1) | IL176142A (de) |
MX (1) | MXPA06012220A (de) |
WO (1) | WO2005105751A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100486807C (zh) * | 2003-09-09 | 2009-05-13 | 三菱树脂株式会社 | 脱模薄片和粘合体 |
WO2005075427A2 (en) * | 2004-01-30 | 2005-08-18 | Teva Pharmaceutical Industries Ltd. | Montelukast sodium polymorphs |
EP1708708A1 (de) * | 2004-01-30 | 2006-10-11 | Teva Pharmaceutical Industries Ltd. | Montelukast-freie säure-polymorphen |
KR20090015186A (ko) * | 2005-07-05 | 2009-02-11 | 테바 파마슈티컬 인더스트리즈 리미티드 | 몬테루카스트의 정제 |
CA2616129A1 (en) * | 2005-07-20 | 2007-01-25 | Dr. Reddy's Laboratories Ltd. | Preparation of montelukast |
US7528254B2 (en) | 2006-02-27 | 2009-05-05 | Chemagis Ltd. | Process for preparing montelukast and salts thereof |
US20090326232A1 (en) * | 2006-06-26 | 2009-12-31 | Uttam Kumar Ray | Process for the Preparation of Leukotriene Receptor Antagonist (Montelukast Sodium) |
EP1886998A1 (de) | 2006-08-09 | 2008-02-13 | Esteve Quimica, S.A. | Verfahren zur Reinigung von Montelukast und dessen Aminesalzen |
US7700776B2 (en) | 2006-10-24 | 2010-04-20 | Formosa Laboratories, Inc. | Compounds and preparation for montelukast sodium |
KR100774088B1 (ko) * | 2006-12-14 | 2007-11-06 | 한미약품 주식회사 | 몬테루카스트의 제조방법 및 이에 사용되는 중간체 |
CZ302238B6 (cs) * | 2007-01-09 | 2011-01-05 | Zentiva, A. S. | Zpusob prípravy montelukastu |
US20080188664A1 (en) * | 2007-01-15 | 2008-08-07 | Chemagis Ltd. | Process for preparing montelukast sodium containing controlled levels of impurities |
CZ302518B6 (cs) * | 2007-07-09 | 2011-06-29 | Zentiva, A. S. | Zpusob izolace a cištení montelukastu |
KR20100061571A (ko) | 2007-09-28 | 2010-06-07 | 코덱시스, 인코포레이티드 | 케토리덕타제 폴리펩티드 및 이의 용도 |
KR101072896B1 (ko) | 2007-10-09 | 2011-10-17 | 한미홀딩스 주식회사 | 이온성 액체 매개체를 이용한 몬테루카스트산의 제조 방법 |
DE102007061630B4 (de) | 2007-12-20 | 2013-07-04 | Formosa Laboratories, Inc. | Neue Verbindungen und Herstellung von Montelukast-Natrium |
WO2009138993A1 (en) * | 2008-05-13 | 2009-11-19 | Macleods Pharmaceuticals Limited | A process for preparation of montelukast sodium salt |
EP2288595B1 (de) * | 2008-05-26 | 2016-11-02 | Laurus Labs Private Limited | Verbessertes verfahren zur herstellung von montelukast und salzen daraus |
KR101123292B1 (ko) * | 2008-09-26 | 2012-03-19 | 주식회사 엘지생명과학 | 몬테루카스트 나트륨염의 제조방법 |
WO2011004298A1 (en) | 2009-07-09 | 2011-01-13 | Alembic Limited | Montelukast hexamethylenediamine salt and its use for the preparation of montelukast sodium |
EP2552892A1 (de) | 2010-03-31 | 2013-02-06 | KRKA, D.D., Novo Mesto | Effiziente synthese zur herstellung von montelukast und neue kristalline form von zwischenprodukten darin |
HUP1000425A2 (en) | 2010-08-11 | 2012-03-28 | Richter Gedeon Nyrt | Process for the production of montelukast sodium |
US8471030B2 (en) | 2010-12-06 | 2013-06-25 | Orochem Technologies Inc. | Purification of montelukast using simulated moving bed |
CN105541710B (zh) * | 2016-02-22 | 2018-06-19 | 齐鲁天和惠世制药有限公司 | 一种孟鲁司特的合成方法 |
CN105541711B (zh) * | 2016-02-22 | 2018-06-19 | 齐鲁天和惠世制药有限公司 | 一种孟鲁司特的制备方法 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5856322A (en) | 1990-10-12 | 1999-01-05 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
US5565473A (en) | 1990-10-12 | 1996-10-15 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
HUT61980A (en) | 1990-10-12 | 1993-03-29 | Merck Frosst Canada Inc | Process for producing saturated hydroxyalkylquinoline acids and pharmaceutical compositions comprising such compounds as active ingredient |
EP0480717B1 (de) * | 1990-10-12 | 1998-04-15 | Merck Frosst Canada Inc. | Ungesättigte Hydroxyalkylchinolinsäuren als Leukotrien-Antagonisten |
IE920499A1 (en) * | 1991-02-21 | 1992-08-26 | Merck Frosst Canada Inc | Quinoline-containing ketoacids as leukotriene antagonists |
TW416948B (en) * | 1993-12-28 | 2001-01-01 | Merck & Co Inc | Process for the preparation of leukotriene antagonists |
US5523477A (en) | 1995-01-23 | 1996-06-04 | Merck & Co., Inc. | Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid |
US5750539A (en) | 1995-06-07 | 1998-05-12 | Merck Frosst Canada | Heteroaryl diol acids as leukotriene antagonists |
US5952347A (en) | 1997-03-13 | 1999-09-14 | Merck & Co., Inc. | Quinoline leukotriene antagonists |
GB9812413D0 (en) | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
FI104718B (fi) | 1998-06-18 | 2000-03-31 | Orion Yhtymae Oyj | [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä |
US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
WO2003066598A1 (en) | 2002-02-07 | 2003-08-14 | Dr. Reddy's Laboratories Ltd. | Novel anhydrous amorphous forms of montelukast sodium salt |
US20050107612A1 (en) | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
US7560559B2 (en) | 2003-04-15 | 2009-07-14 | Merck & Co., Inc. | Polymorphic form of montelukast sodium |
WO2004108679A1 (en) * | 2003-06-06 | 2004-12-16 | Morepen Laboratories Limited | An improved method for the preparation of montelukast acid and sodium salt thereof in amorphous form |
PT1678139E (pt) | 2003-10-10 | 2011-11-28 | Synhton B V | Montelucaste em estado sólido |
US20070225325A1 (en) | 2004-01-28 | 2007-09-27 | Pliva-Istrazivanje I Razvoj D.O.O. | Solid Forms of Montelukast Acid |
EP1708708A1 (de) | 2004-01-30 | 2006-10-11 | Teva Pharmaceutical Industries Ltd. | Montelukast-freie säure-polymorphen |
WO2005074893A1 (en) | 2004-02-03 | 2005-08-18 | Chemagis Ltd. | Stable amorphous forms of montelukast sodium |
US7189853B2 (en) | 2004-04-15 | 2007-03-13 | Dr. Reddy's Laboratories Limited | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts |
DE602004031678D1 (de) | 2004-07-19 | 2011-04-14 | Matrix Lab Ltd | Verfahren zur herstellung von montelukast und salzen davon |
PL205637B1 (pl) | 2004-10-22 | 2010-05-31 | Inst Farmaceutyczny | Sposób wytwarzania kwasu (R,E)-(1-{1-{3-[2-(7-chlorochinolin-2-ylo)etenylo]fenylo}-3-[2-(1-hydroksy-1-metyloetylo)fenylo] propylosulfanylometylo}cyklopropylo)octowego i/lub jego farmaceutycznie dopuszczalnych soli |
CA2589936A1 (en) | 2004-11-30 | 2006-06-08 | Medichem S.A. | New process for the preparation of a leukotriene antagonist |
KR20090015186A (ko) | 2005-07-05 | 2009-02-11 | 테바 파마슈티컬 인더스트리즈 리미티드 | 몬테루카스트의 정제 |
-
2005
- 2005-04-21 MX MXPA06012220A patent/MXPA06012220A/es not_active Application Discontinuation
- 2005-04-21 DE DE602005015174T patent/DE602005015174D1/de active Active
- 2005-04-21 JP JP2007508649A patent/JP2007532686A/ja active Pending
- 2005-04-21 WO PCT/US2005/014011 patent/WO2005105751A1/en active Application Filing
- 2005-04-21 CA CA002563776A patent/CA2563776A1/en not_active Abandoned
- 2005-04-21 ES ES05739023T patent/ES2327762T3/es active Active
- 2005-04-21 US US11/112,790 patent/US7547787B2/en not_active Expired - Fee Related
- 2005-04-21 EP EP05739023A patent/EP1646612B1/de not_active Not-in-force
- 2005-04-21 KR KR1020067024379A patent/KR100815670B1/ko not_active IP Right Cessation
- 2005-04-21 AT AT05739023T patent/ATE435209T1/de not_active IP Right Cessation
-
2006
- 2006-06-06 IL IL176142A patent/IL176142A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2007532686A (ja) | 2007-11-15 |
ES2327762T3 (es) | 2009-11-03 |
EP1646612A1 (de) | 2006-04-19 |
US20050256156A1 (en) | 2005-11-17 |
EP1646612B1 (de) | 2009-07-01 |
IL176142A (en) | 2010-12-30 |
MXPA06012220A (es) | 2007-07-18 |
ATE435209T1 (de) | 2009-07-15 |
WO2005105751A1 (en) | 2005-11-10 |
CA2563776A1 (en) | 2005-11-10 |
IL176142A0 (en) | 2006-10-05 |
KR20070004114A (ko) | 2007-01-05 |
US7547787B2 (en) | 2009-06-16 |
KR100815670B1 (ko) | 2008-03-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE602005015174D1 (de) | Verfahren zur herstellung von montelukast-natrium | |
DE602005016292D1 (de) | Verfahren zur herstellung von glatiramer | |
DE502006001614D1 (de) | Verfahren zur herstellung von 1-alkyl-3-phenyluracilen | |
DE502006000218D1 (de) | Verfahren zur Herstellung von SiOC-verknüpften, linearen Polydialkylsiloxan-Polyoxyalkylen-Blockcopolymeren | |
ATE443038T1 (de) | Verfahren zur herstellung von cinacalcet hydrochlorid | |
DE502005010038D1 (de) | Verfahren zur herstellung von 3-pentennitril | |
DE502004009763D1 (de) | Verfahren zur herstellung von 1-buten | |
ATE425136T1 (de) | Verfahren zur herstellung substituierter 3-aryl- butyl-aminverbindungen | |
DE502006000138D1 (de) | Verfahren zur Herstellung von Triorganosiloxygruppen aufweisenden Organopolysiloxanen | |
DE502006006498D1 (de) | Verfahren zur Herstellung von Organopolysiloxanen | |
DE602006010302D1 (de) | Verfahren zur Herstellung von 5-methyl-2-furfural | |
DE502005001841D1 (de) | Verfahren zur herstellung von 1,4-diphenylazetidinon-derivaten | |
DE502005000428D1 (de) | Verfahren zur Herstellung von 1,2-Diaminocyclohexan-Platin(II)-Komplexen | |
DE602005013895D1 (de) | Vorrichtung zur Herstellung von Reifenbestandteilen. | |
DE602006009562D1 (de) | Verfahren zur herstellung von ferrisuccinylcasein | |
DE602005021110D1 (de) | Verfahren zur herstellung von n-piperidino-1,5-diphenylpyrazol-3-carboxamid-derivaten | |
DE60302139D1 (de) | Verfahren zur herstellung von aripiprazole | |
DE502005007702D1 (de) | Verfahren zur herstellung von terrylen-3,4:11,12-t | |
DE502006004187D1 (de) | Verfahren zur herstellung von diorganopolysiloxanen | |
ATE516290T1 (de) | Verfahren zur herstellung von buprenorphin und derivaten von buprenorphin | |
DE502004005626D1 (de) | Verfahren zur herstellung von organoacylphosphiten | |
DE502006004524D1 (de) | Verfahren zur herstellung von 3,7-diaza-bicycloä3.3.1ünonan-verbindungen | |
ATE405374T1 (de) | Verfahren zur herstellung von brillengläsern | |
ATE474842T1 (de) | Neues verfahren zur herstellung von 5-amino-3h- thiazoloä4,5-düpyrimidin-2-on | |
DE602005026841D1 (de) | Verfahren zur herstellung von 1,2,2,2-tetrafluor-ethyl-difluor-methylether |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |