ZA908386B - N-substituted derivatives of 3r,4r-ethyl-((1-methyl-1h-imidazol-5-yl)methyl)-2-pyrrolidinone - Google Patents

N-substituted derivatives of 3r,4r-ethyl-((1-methyl-1h-imidazol-5-yl)methyl)-2-pyrrolidinone

Info

Publication number
ZA908386B
ZA908386B ZA908386A ZA908386A ZA908386B ZA 908386 B ZA908386 B ZA 908386B ZA 908386 A ZA908386 A ZA 908386A ZA 908386 A ZA908386 A ZA 908386A ZA 908386 B ZA908386 B ZA 908386B
Authority
ZA
South Africa
Prior art keywords
methyl
pyrrolidinone
imidazol
ethyl
substituted derivatives
Prior art date
Application number
ZA908386A
Other languages
English (en)
Inventor
Pamela Albaugh
Albaugh Pamela
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of ZA908386B publication Critical patent/ZA908386B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA908386A 1989-11-13 1990-10-19 N-substituted derivatives of 3r,4r-ethyl-((1-methyl-1h-imidazol-5-yl)methyl)-2-pyrrolidinone ZA908386B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/434,929 US5264449A (en) 1989-11-13 1989-11-13 N-substituted derivatives of 3R,4R-ethyl-[(1-methyl-1H-imidazol-5-yl)methyl]-2-pyrrolidinone

Publications (1)

Publication Number Publication Date
ZA908386B true ZA908386B (en) 1991-08-28

Family

ID=23726283

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA908386A ZA908386B (en) 1989-11-13 1990-10-19 N-substituted derivatives of 3r,4r-ethyl-((1-methyl-1h-imidazol-5-yl)methyl)-2-pyrrolidinone

Country Status (15)

Country Link
US (1) US5264449A (fi)
EP (1) EP0429232A1 (fi)
JP (1) JPH03188075A (fi)
CN (1) CN1026589C (fi)
AU (1) AU631025B2 (fi)
CA (1) CA2027604A1 (fi)
FI (1) FI905589A0 (fi)
HU (1) HU207512B (fi)
IE (1) IE904067A1 (fi)
IL (1) IL96088A (fi)
NO (1) NO177056C (fi)
NZ (1) NZ235735A (fi)
PT (1) PT95874A (fi)
RU (1) RU2015978C1 (fi)
ZA (1) ZA908386B (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453434A (en) * 1989-11-13 1995-09-26 Allergan, Inc. N-substituted derivatives of 3R,4R-ethyl-[(1-methyl-1H-imidazol-5-yl)methyl]-2-pyrrolidone
DE69212844T2 (de) * 1991-12-18 1997-01-09 Schering Corp., Kenilworth, N.J. Imidazolyl oder imidazolylalkyl substituiert mit einem 4- oder 5-gliedrigen stickstoff enthaltenden heterozyklischen ring
CA2125060C (en) * 1993-07-02 1999-03-30 Henry P. Dabrowski Ophthalmic solution for artificial tears
US5895645A (en) * 1995-01-31 1999-04-20 Bausch & Lomb Incorporated Opthalmic solution for artificial tears
US5677327A (en) * 1995-06-22 1997-10-14 Allergan Method for identifying muscarinic agents lacking miotic side effects
US6001835A (en) * 1996-04-03 1999-12-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2000507597A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシルタンパク質トランスフェラーゼ阻害剤
CA2250353A1 (en) * 1996-04-03 1997-10-09 Christopher J. Dinsmore Inhibitors of farnesyl-protein transferase
US5675019A (en) * 1996-07-18 1997-10-07 Allergan Process for making piloloctam and derivatives thereof
US5675038A (en) * 1996-07-18 1997-10-07 Allergan Lithium and amine dissolving metal reduction
US5800807A (en) * 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
WO2003057131A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Novel process for the preparation of trans-3- ethyl-2,5- dihydro-4- methyl-n-[2-[ 4-[[[[(4-methyl cyclohexyl) amino]carbonyl] amino]sulfonyl] phenyl]ethyl] -2-oxo-1h-pyrrole -1-carboxamide
CN104211638A (zh) * 2014-08-13 2014-12-17 李增 一种脂肪氨基取代的芸香碱类衍生物及其制备和作为抗阿尔兹海默症的药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470197A (en) * 1967-08-30 1969-09-30 Miles Lab 1-substituted derivatives of 3-ethyl-4 - (1-methylimidazolyl-(5)-methyl)-2-pyrrolidinone
US5055467A (en) * 1989-11-13 1991-10-08 Allergan, Inc. Pharmaceutical epinephrine-pilocarpine compounds

Also Published As

Publication number Publication date
NO904901D0 (no) 1990-11-12
EP0429232A1 (en) 1991-05-29
NO904901L (no) 1991-05-14
US5264449A (en) 1993-11-23
CA2027604A1 (en) 1991-05-14
JPH03188075A (ja) 1991-08-16
NO177056B (no) 1995-04-03
IL96088A0 (en) 1991-07-18
HUT56360A (en) 1991-08-28
HU207512B (en) 1993-04-28
IE904067A1 (en) 1991-05-22
AU631025B2 (en) 1992-11-12
PT95874A (pt) 1991-09-13
HU907116D0 (en) 1991-05-28
FI905589A0 (fi) 1990-11-12
RU2015978C1 (ru) 1994-07-15
CN1051730A (zh) 1991-05-29
NO177056C (no) 1995-07-12
CN1026589C (zh) 1994-11-16
NZ235735A (en) 1992-03-26
AU6652890A (en) 1991-05-16
IL96088A (en) 1995-03-30

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