ZA889711B - A process for the preparation of antibodies by genetic engineering - Google Patents
A process for the preparation of antibodies by genetic engineeringInfo
- Publication number
- ZA889711B ZA889711B ZA889711A ZA889711A ZA889711B ZA 889711 B ZA889711 B ZA 889711B ZA 889711 A ZA889711 A ZA 889711A ZA 889711 A ZA889711 A ZA 889711A ZA 889711 B ZA889711 B ZA 889711B
- Authority
- ZA
- South Africa
- Prior art keywords
- antibodies
- preparation
- genetic engineering
- hapten
- antigen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873744595 DE3744595A1 (de) | 1987-12-31 | 1987-12-31 | Verfahren zur gentechnischen herstellung von antikoerpern |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA889711B true ZA889711B (en) | 1989-09-27 |
Family
ID=6343878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA889711A ZA889711B (en) | 1987-12-31 | 1988-12-29 | A process for the preparation of antibodies by genetic engineering |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0324162B1 (xx) |
JP (1) | JP2771204B2 (xx) |
KR (1) | KR970007861B1 (xx) |
AT (1) | ATE102651T1 (xx) |
AU (1) | AU628310B2 (xx) |
DE (2) | DE3744595A1 (xx) |
DK (1) | DK732988A (xx) |
ES (1) | ES2063022T3 (xx) |
HU (1) | HU212592B (xx) |
IE (1) | IE62257B1 (xx) |
PT (1) | PT89362B (xx) |
ZA (1) | ZA889711B (xx) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5576195A (en) * | 1985-11-01 | 1996-11-19 | Xoma Corporation | Vectors with pectate lyase signal sequence |
US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
GB9015198D0 (en) * | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US6916605B1 (en) | 1990-07-10 | 2005-07-12 | Medical Research Council | Methods for producing members of specific binding pairs |
US7063943B1 (en) | 1990-07-10 | 2006-06-20 | Cambridge Antibody Technology | Methods for producing members of specific binding pairs |
GB9206318D0 (en) * | 1992-03-24 | 1992-05-06 | Cambridge Antibody Tech | Binding substances |
US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
SE9101433D0 (sv) * | 1991-05-13 | 1991-05-13 | Marianne Hansson | Recombinant dna sequence and its use |
US6492160B1 (en) | 1991-05-15 | 2002-12-10 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
US5871907A (en) | 1991-05-15 | 1999-02-16 | Medical Research Council | Methods for producing members of specific binding pairs |
US5858657A (en) * | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
US5962255A (en) * | 1992-03-24 | 1999-10-05 | Cambridge Antibody Technology Limited | Methods for producing recombinant vectors |
US6225447B1 (en) | 1991-05-15 | 2001-05-01 | Cambridge Antibody Technology Ltd. | Methods for producing members of specific binding pairs |
EP0861893A3 (en) * | 1991-09-19 | 1999-11-10 | Genentech, Inc. | High level expression of immunoglobulin polypeptides |
US5621083A (en) * | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
US6146850A (en) * | 1991-11-04 | 2000-11-14 | Xoma Corporation | Proteins encoding gelonin sequences |
US5837491A (en) * | 1991-11-04 | 1998-11-17 | Xoma Corporation | Polynucleotides encoding gelonin sequences |
DE69233782D1 (de) | 1991-12-02 | 2010-05-20 | Medical Res Council | Herstellung von Autoantikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken |
EP0618977A4 (en) * | 1991-12-18 | 1997-02-12 | Univ Calgary | Expression-secretion vectors for the production of biologically active fv fragments. |
US5733743A (en) * | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
US7368111B2 (en) | 1995-10-06 | 2008-05-06 | Cambridge Antibody Technology Limited | Human antibodies specific for TGFβ2 |
GB9705376D0 (en) * | 1997-03-14 | 1997-04-30 | Harris William J | Antibody fragment formulations and assay formats for detecting the presence an d concentration of analytes |
US6492497B1 (en) | 1999-04-30 | 2002-12-10 | Cambridge Antibody Technology Limited | Specific binding members for TGFbeta1 |
EP1908769A1 (en) * | 2001-08-27 | 2008-04-09 | Genentech, Inc. | A system for antibody expression and assembly |
US20030077739A1 (en) | 2001-08-27 | 2003-04-24 | Genentech, Inc. | System for antibody expression and assembly |
AU2008205632B2 (en) * | 2007-01-12 | 2013-10-24 | Dow Global Technologies Llc | Apparatus and methods for osmotically shocking cells |
RU2677925C1 (ru) | 2013-12-12 | 2019-01-22 | Конинклейке Филипс Н.В. | Способ обеспечения функционирования стандартных адаптеров электропитания, преобразующих переменный ток в постоянный ток, в сильных магнитных полях |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
EP0196864A3 (en) * | 1985-03-25 | 1988-03-23 | Cetus Corporation | Alkaline phosphatase-mediated processing and secretion of recombinant proteins, dna sequences for use therein and cells transformed using such sequences |
EP0234592A1 (en) * | 1986-02-28 | 1987-09-02 | Teijin Limited | Plasmid containing DNA fragment coding for human immunoglobulin G Fc region protein and use thereof for production of said protein |
JPS62201581A (ja) * | 1986-02-28 | 1987-09-05 | Rikagaku Kenkyusho | 新規プラスミド、微生物細胞及びヒト免疫グロブリンG Fc領域蛋白質の製造方法 |
EP0368926A4 (en) * | 1987-07-16 | 1991-11-27 | Codon | Transfected cells containing plasmids having genes oriented in opposing directions and methods of obtaining the same |
CA1341235C (en) * | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
-
1987
- 1987-12-31 DE DE19873744595 patent/DE3744595A1/de not_active Ceased
-
1988
- 1988-12-24 ES ES88121675T patent/ES2063022T3/es not_active Expired - Lifetime
- 1988-12-24 AT AT88121675T patent/ATE102651T1/de not_active IP Right Cessation
- 1988-12-24 EP EP88121675A patent/EP0324162B1/de not_active Revoked
- 1988-12-24 DE DE88121675T patent/DE3888337D1/de not_active Revoked
- 1988-12-28 JP JP63335695A patent/JP2771204B2/ja not_active Expired - Lifetime
- 1988-12-29 PT PT89362A patent/PT89362B/pt not_active IP Right Cessation
- 1988-12-29 ZA ZA889711A patent/ZA889711B/xx unknown
- 1988-12-29 KR KR1019880017762A patent/KR970007861B1/ko not_active IP Right Cessation
- 1988-12-30 IE IE389388A patent/IE62257B1/en not_active IP Right Cessation
- 1988-12-30 HU HU886680A patent/HU212592B/hu not_active IP Right Cessation
- 1988-12-30 AU AU27617/88A patent/AU628310B2/en not_active Ceased
- 1988-12-30 DK DK732988A patent/DK732988A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PT89362B (pt) | 1993-08-31 |
IE62257B1 (en) | 1995-01-11 |
HU212592B (en) | 1996-08-29 |
JP2771204B2 (ja) | 1998-07-02 |
PT89362A (pt) | 1989-12-29 |
DE3744595A1 (de) | 1989-07-13 |
DK732988A (da) | 1989-07-01 |
KR890010203A (ko) | 1989-08-07 |
ATE102651T1 (de) | 1994-03-15 |
DK732988D0 (da) | 1988-12-30 |
IE883893L (en) | 1989-06-30 |
EP0324162B1 (de) | 1994-03-09 |
AU2761788A (en) | 1989-07-06 |
JPH02799A (ja) | 1990-01-05 |
EP0324162A1 (de) | 1989-07-19 |
KR970007861B1 (ko) | 1997-05-17 |
ES2063022T3 (es) | 1995-01-01 |
DE3888337D1 (de) | 1994-04-14 |
HUT49169A (en) | 1989-08-28 |
AU628310B2 (en) | 1992-09-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA889711B (en) | A process for the preparation of antibodies by genetic engineering | |
Russell | Wall-associated protein antigens of Streptococcus mutans | |
US4948874A (en) | Purified protein G from streptococcal bacteria | |
EP0807683A3 (en) | Endothelial cell-leukocyte adhesion molecules (elams) and molecules involved in leukocyte adhesion (milas) | |
IL87255A (en) | Dna constructs containing a kluyveromycesalpha- factorleader sequence for directingsecretion of heterologouspolypeptides | |
WO1998027114A3 (en) | Mammalian cell surface antigens; related reagents | |
AU4055697A (en) | Mammalian cell surface antigens; related reagents | |
EP0325045A3 (en) | Immunoassay method for detecting antigens | |
EP0352761A3 (de) | Antigenkonstrukte von "Major Histocompatibility Complex" Klasse I Antigenen mit spezifischen Trägermolekülen, ihre Herstellung und Verwendung | |
ATE44768T1 (de) | Verfahren zur mikrobiologischen herstellung von menschlichem serum-albumin. | |
KR19990044528A (ko) | 세포 표면에 세포성분의 부착 및 표현과 관련된 물질 및 방법 | |
MY157028A (en) | Mammalian cytokine, related reagents | |
WO1997021812A3 (en) | Mammalian chemokine ccf8 and chemokine receptor cckr3 | |
WO1998025958A3 (en) | Mammalian cell surface antigens comprising structural motifs characteristic of a member of the TNF ligand family | |
WO1998011226A3 (en) | Mammalian chemokines, related reagents | |
JPH07504090A (ja) | 触媒性部分の発現および触媒性部分の濃縮に係わる反応−ベース選別 | |
WO1992007939A3 (en) | Polypeptide with 46kd hmfg differentiation antigen binding specificity | |
WO1998023750A3 (en) | Mammalian chemokines | |
MX9603266A (es) | Genes de timocina de mamiferos. | |
EP0276984A3 (en) | Measuring anti-dna antibodies | |
Wu et al. | Artificial antibodies for affinity chromatography of homologous proteins: application to blood clotting proteins | |
SE8802939D0 (sv) | A method for the production and isolation of a fusion protein in eukaryotic cells | |
EP0335567A3 (en) | Controlled release of periplasmic proteins into the medium | |
Grange et al. | Serum angiotensin-converting enzyme and delayed hypersensitivity in pulmonary tuberculosis | |
SKERRA et al. | Sy (IGS) ARE A FAM |