ZA889597B - Macrocyclic chelating agents and chelates thereof - Google Patents

Macrocyclic chelating agents and chelates thereof

Info

Publication number
ZA889597B
ZA889597B ZA889597A ZA889597A ZA889597B ZA 889597 B ZA889597 B ZA 889597B ZA 889597 A ZA889597 A ZA 889597A ZA 889597 A ZA889597 A ZA 889597A ZA 889597 B ZA889597 B ZA 889597B
Authority
ZA
South Africa
Prior art keywords
group
alkyl
alkoxyhydroxyalkyl
alkoxyalkyl
hydroxyalkyl
Prior art date
Application number
ZA889597A
Other languages
English (en)
Inventor
Ernst Felder
Felder Ernst
Carlo Musu
Musu Carlo
Luciano Fumagalli
Fumagalli Luciano
Fulvio Uggeri
Uggeri Fulvio
Original Assignee
Bracco Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Ind Chimica Spa filed Critical Bracco Ind Chimica Spa
Publication of ZA889597B publication Critical patent/ZA889597B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
ZA889597A 1987-12-24 1988-12-22 Macrocyclic chelating agents and chelates thereof ZA889597B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23217/87A IT1224416B (it) 1987-12-24 1987-12-24 Chelanti macrociclici e loro chelati

Publications (1)

Publication Number Publication Date
ZA889597B true ZA889597B (en) 1989-09-27

Family

ID=11204998

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA889597A ZA889597B (en) 1987-12-24 1988-12-22 Macrocyclic chelating agents and chelates thereof

Country Status (14)

Country Link
EP (2) EP0440606A1 (xx)
JP (1) JP2744920B2 (xx)
KR (1) KR900700467A (xx)
AT (1) ATE120191T1 (xx)
DE (1) DE3853415T2 (xx)
ES (1) ES2070845T3 (xx)
IE (1) IE67551B1 (xx)
IL (1) IL88762A (xx)
IT (1) IT1224416B (xx)
MX (1) MX9203262A (xx)
NZ (1) NZ227421A (xx)
PH (1) PH26255A (xx)
WO (1) WO1989005802A1 (xx)
ZA (1) ZA889597B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0466200B1 (en) * 1987-07-16 1996-04-24 Nycomed Imaging As Aminocarboxylic acids and derivatives thereof
DE4001655A1 (de) 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US6039931A (en) * 1989-06-30 2000-03-21 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
US5695739A (en) * 1989-06-30 1997-12-09 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5162109A (en) * 1990-09-13 1992-11-10 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US6875864B2 (en) 1991-08-01 2005-04-05 Bracco International B.V. Aminocarboxylate ligands having substituted aromatic amide moieties
EP0565930A1 (en) * 1992-03-27 1993-10-20 Nihon Medi-Physics Co., Ltd. Tetraazacyclododecane tetraacetic acid derivatives and the use thereof as diagnostic agents
US5310535A (en) * 1992-04-24 1994-05-10 The Dow Chemical Company Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies
EP0588229A3 (en) * 1992-09-12 1994-06-15 Hoechst Ag Macrocyclic chelating agents for the preparation of technetium or rhenium complexes
WO1995001346A1 (en) * 1993-06-30 1995-01-12 Akzo Nobel N.V. Chelating compounds
EP0702677A1 (en) * 1994-04-08 1996-03-27 BRACCO International B.V. Aromatic amide compounds and metal chelates thereof
US6693190B1 (en) 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
IT1274038B (it) * 1994-07-29 1997-07-14 Bracco Spa Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
DE19507820A1 (de) * 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
IT1291624B1 (it) * 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
IT1293777B1 (it) * 1997-07-25 1999-03-10 Bracco Spa Processo per la preparazione di tetraazamacrocicli
IT1293778B1 (it) * 1997-07-25 1999-03-10 Bracco Spa 1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6495118B1 (en) 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
IT1297034B1 (it) 1997-12-30 1999-08-03 Bracco Spa Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
DE3316703A1 (de) * 1983-05-04 1984-11-08 Schering AG, 1000 Berlin und 4709 Bergkamen Orales kontrastmittel fuer die kernspintomographie und dessen herstellung
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
DE3772785D1 (de) * 1986-01-23 1991-10-17 Squibb & Sons Inc 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga.
FR2596992B1 (fr) * 1986-04-11 1988-12-16 Guerbet Sa Sel de lysine du complexe gadolinium-dota et ses applications au diagnostic
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
DE3851070T3 (de) * 1987-02-28 2006-12-28 Sumitomo Electric Industries, Ltd. Verfahren zur Herstellung eines Oxid-Verbindungssupraleiterfadens.
EP0503746B1 (en) * 1987-03-13 1997-05-14 Kabushiki Kaisha Toshiba Superconducting wire and method of manufacturing the same

Also Published As

Publication number Publication date
KR900700467A (ko) 1990-08-13
EP0440606A1 (en) 1991-08-14
ES2070845T3 (es) 1995-06-16
DE3853415D1 (de) 1995-04-27
IT8723217A0 (it) 1987-12-24
EP0325762B1 (en) 1995-03-22
IL88762A (en) 1995-07-31
JPH03501848A (ja) 1991-04-25
MX9203262A (es) 1992-07-01
IT1224416B (it) 1990-10-04
ATE120191T1 (de) 1995-04-15
IE883844L (en) 1989-06-24
WO1989005802A1 (en) 1989-06-29
PH26255A (en) 1992-04-01
IL88762A0 (en) 1989-07-31
NZ227421A (en) 1990-10-26
DE3853415T2 (de) 1995-08-31
JP2744920B2 (ja) 1998-04-28
IE67551B1 (en) 1996-04-17
EP0325762A1 (en) 1989-08-02

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