ZA88642B - 1-(4-hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine,various derivatives thereof,processes for the preparation of these compounds,medicaments containing them,and their use - Google Patents

1-(4-hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine,various derivatives thereof,processes for the preparation of these compounds,medicaments containing them,and their use

Info

Publication number: ZA88642B
Authority: ZA; South Africa
Prior art keywords: homopiperazine; tert; hydroxy; butylbenzoyl; compounds
Prior art date: 1987-01-30

Application number

ZA88642A

Other languages

English (en)

Inventor

Erhard Wolf

Wolf Erhard

Erhard Rossmanith

Rossmanith Erhard

Robert R Bartlett

R Bartlett Robert

Rudolf Chleyerbach

Chleyerbach Rudolf

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-30

Filing date

1988-01-29

Publication date

1988-09-28

1988-01-29 Application filed by Hoechst Ag filed Critical Hoechst Ag

1988-09-28 Publication of ZA88642B publication Critical patent/ZA88642B/xx

Links

LYRRSBJFMOFHBF-UHFFFAOYSA-N 1,4-diazepan-1-yl-(3,5-ditert-butyl-4-hydroxyphenyl)methanone Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(C(=O)N2CCNCCC2)=C1 LYRRSBJFMOFHBF-UHFFFAOYSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
230000002757 inflammatory effect Effects 0.000 abstract 2
FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical compound C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 abstract 1
208000025747 Rheumatic disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
230000000552 rheumatic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polyesters Or Polycarbonates (AREA)
Lubricants (AREA)
Fats And Perfumes (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA88642A 1987-01-30 1988-01-29 1-(4-hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine,various derivatives thereof,processes for the preparation of these compounds,medicaments containing them,and their use ZA88642B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19873702755 DE3702755A1 (de)	1987-01-30	1987-01-30	3,5-di-tert.-butyl-4-hydroxybenzoesaeureamid, verschiedene von dessen derivaten, verfahren zur herstellung dieser verbindungen, die sie enthaltenden arzneimittel und ihre verwendung

Publications (1)

Publication Number	Publication Date
ZA88642B true ZA88642B (en)	1988-09-28

Family

ID=6319853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA88642A ZA88642B (en)	1987-01-30	1988-01-29	1-(4-hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine,various derivatives thereof,processes for the preparation of these compounds,medicaments containing them,and their use

Country Status (20)

Country	Link
US (1)	US4829061A (xx)
EP (1)	EP0276803B1 (xx)
JP (1)	JPS63192758A (xx)
KR (1)	KR880008997A (xx)
AT (1)	ATE68488T1 (xx)
AU (1)	AU600793B2 (xx)
CA (1)	CA1300619C (xx)
DE (2)	DE3702755A1 (xx)
DK (1)	DK47888A (xx)
ES (1)	ES2041705T3 (xx)
FI (1)	FI85469C (xx)
GR (1)	GR3003523T3 (xx)
HU (1)	HU200334B (xx)
IE (1)	IE880249L (xx)
IL (1)	IL85228A (xx)
NO (1)	NO170332C (xx)
NZ (1)	NZ223336A (xx)
PH (1)	PH24649A (xx)
PT (1)	PT86657B (xx)
ZA (1)	ZA88642B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE951044C (de) *	1954-08-24	1956-10-18	Heinrich Gueltig	Verfahren zum UEberziehen zugeschnittener Flaschenkorken mit einem mindestens vorwiegend Paraffin enthaltenden UEberzug
DE3834532A1 (de) *	1988-10-11	1990-04-12	Behringwerke Ag	Verwendung von homopiperazinen zur herstellung eines arzneimittels fuer das vorbeugen gegen und die behandlung von organabstossungsreaktionen
CA2049481A1 (en) *	1990-08-27	1992-02-28	Jill Ann Panetta	Method of treating inflammatory bowel disease
US5281623A (en) *	1990-08-27	1994-01-25	Eli Lilly And Company	Method for treating inflammation
US5280046A (en) *	1991-02-22	1994-01-18	The University Of Colorado Foundation, Inc.	Method of treating type I diabetes
WO1993000095A2 (en) *	1991-06-28	1993-01-07	Smithkline Beecham Corporation	Bicyclic fibrinogen antagonists
US5939412A (en) *	1992-06-26	1999-08-17	Smithkline Beecham Corporation	Bicyclic fibrinogen antagonists
AU689762B2 (en) *	1992-12-21	1998-04-09	Smithkline Beecham Corporation	Bicyclic fibrinogen antagonists
US6403578B1 (en)	1993-12-21	2002-06-11	Smithkline Beecham Corporation	Bicyclic fibrinogen antagonists
MA23420A1 (fr) *	1994-01-07	1995-10-01	Smithkline Beecham Corp	Antagonistes bicycliques de fibrinogene.
US6458784B1 (en)	1994-06-29	2002-10-01	Smithkline Beecham Corporation	Vitronectin receptor antagonists
US5977101A (en) *	1995-06-29	1999-11-02	Smithkline Beecham Corporation	Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
DE19737334A1 (de) *	1997-08-27	1999-03-04	Solvay Pharm Gmbh	7-Phenyl-1,4-diazepan-Derivate, sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19747644C2 (de) *	1997-10-29	2001-02-22	Inst Polymerforschung Dresden	Sterisch gehinderte Phenole und Verfahren zu ihrer Herstellung
WO2002080928A1 (en) *	2001-04-03	2002-10-17	Merck & Co., Inc.	N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
WO2006115509A2 (en)	2004-06-24	2006-11-02	Novartis Vaccines And Diagnostics Inc.	Small molecule immunopotentiators and assays for their detection
US10449198B2 (en)	2016-07-01	2019-10-22	The University Of Liverpool	Method for treating pain
RU2020114523A (ru) *	2017-10-27	2021-12-01	Эстеве Фармасьютикалз, С.А.	Новые алкоксиаминопроизводные для лечения боли и связанных с болью состояний

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4066614A (en) *	1974-12-30	1978-01-03	American Cyanamid Company	Heterocyclicamides of hindered 3,5-dialkyl-4-hydroxybenzoic acids and use as light stabilizers in polyolefins
US4404302A (en) *	1982-05-27	1983-09-13	Ferro Corporation	Acylated hindered hexahydropyrimidines and their use as light stabilizing agents
DE3685829T2 (de) *	1985-02-04	1992-12-17	Searle & Co	Heterocyclische amide.

1987
- 1987-01-30 DE DE19873702755 patent/DE3702755A1/de not_active Withdrawn
1988
- 1988-01-26 AT AT88101054T patent/ATE68488T1/de not_active IP Right Cessation
- 1988-01-26 DE DE8888101054T patent/DE3865443D1/de not_active Expired - Fee Related
- 1988-01-26 ES ES198888101054T patent/ES2041705T3/es not_active Expired - Lifetime
- 1988-01-26 EP EP88101054A patent/EP0276803B1/de not_active Expired - Lifetime
- 1988-01-28 IL IL85228A patent/IL85228A/xx not_active IP Right Cessation
- 1988-01-28 FI FI880387A patent/FI85469C/fi not_active IP Right Cessation
- 1988-01-28 US US07/149,602 patent/US4829061A/en not_active Expired - Fee Related
- 1988-01-28 PT PT86657A patent/PT86657B/pt active IP Right Grant
- 1988-01-28 HU HU88390A patent/HU200334B/hu not_active IP Right Cessation
- 1988-01-28 NZ NZ223336A patent/NZ223336A/xx unknown
- 1988-01-29 JP JP63017514A patent/JPS63192758A/ja active Pending
- 1988-01-29 PH PH36433A patent/PH24649A/en unknown
- 1988-01-29 AU AU10999/88A patent/AU600793B2/en not_active Ceased
- 1988-01-29 NO NO880407A patent/NO170332C/no unknown
- 1988-01-29 KR KR1019880000766A patent/KR880008997A/ko not_active Application Discontinuation
- 1988-01-29 ZA ZA88642A patent/ZA88642B/xx unknown
- 1988-01-29 CA CA000557741A patent/CA1300619C/en not_active Expired - Fee Related
- 1988-01-29 IE IE880249A patent/IE880249L/xx unknown
- 1988-01-29 DK DK047888A patent/DK47888A/da not_active Application Discontinuation
1992
- 1992-01-08 GR GR910401655T patent/GR3003523T3/el unknown

Also Published As

Publication number	Publication date
FI85469B (fi)	1992-01-15
NZ223336A (en)	1989-09-27
US4829061A (en)	1989-05-09
NO170332C (no)	1992-10-07
ES2041705T3 (es)	1993-12-01
DK47888A (da)	1988-07-31
CA1300619C (en)	1992-05-12
AU600793B2 (en)	1990-08-23
JPS63192758A (ja)	1988-08-10
DE3865443D1 (de)	1991-11-21
PH24649A (en)	1990-09-07
IL85228A0 (en)	1988-07-31
KR880008997A (ko)	1988-09-13
FI85469C (fi)	1992-04-27
DK47888D0 (da)	1988-01-29
NO880407D0 (no)	1988-01-29
IL85228A (en)	1993-08-18
ATE68488T1 (de)	1991-11-15
FI880387A0 (fi)	1988-01-28
AU1099988A (en)	1988-08-04
IE880249L (en)	1988-07-30
FI880387A (fi)	1988-07-31
EP0276803A1 (de)	1988-08-03
PT86657B (pt)	1992-02-28
EP0276803B1 (de)	1991-10-16
DE3702755A1 (de)	1988-08-11
PT86657A (pt)	1988-02-01
GR3003523T3 (xx)	1993-03-16
NO170332B (no)	1992-06-29
HUT46683A (en)	1988-11-28
NO880407L (no)	1988-08-01
HU200334B (en)	1990-05-28

Publication	Publication Date	Title
ZA88642B (en)	1988-09-28	1-(4-hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine,various derivatives thereof,processes for the preparation of these compounds,medicaments containing them,and their use
ES2032382T3 (es)	1993-02-16	Metodo para preparar un medicamento para la prevencion o tratamiento de la endometriosis.
EP0379806A3 (en)	1991-05-29	Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines
PL262105A1 (en)	1988-08-18	The method of manufacture of new derivatives of benzimidazole
IL94267A0 (en)	1991-03-10	Compositions for treating skin disorders containing ketoconazole and their preparation
IE880061L (en)	1988-07-12	1,2,4,5-tetrasubstituted benzene derivatives
JPS56110679A (en)	1981-09-01	55aminootetrazole derivative of retinoic acid* its manufacture and medicine containing it
AU2126288A (en)	1989-02-13	Thiosulphinic acid derivatives, their use in the treatment of inflammatory diseases, and drugs containing them
IT8519907A0 (it)	1985-03-14	Prodotto farmaceutico cosmetico, in particolare per la cura di acne e seborrea.
ATE112276T1 (de)	1994-10-15	Aryl-chinolyl-substituierte 1,4-dihydropyridin- dicarbonsäurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
ES2032476T3 (es)	1993-02-16	Un procedimiento para preparar nuevos derivados de 2-anilinotiazolina.
EP0523013A3 (en)	1993-01-27	Use of benzimidazoline-2-oxo-1-carboxylic acid derivatives in the treatment of organic mental diseases
ZA898274B (en)	1990-07-25	2-aminocarboxylic acids and their derivatives,processes for their preparation and their use as medicaments
IL101953A0 (en)	1992-12-30	The use of 1-(5-oxohexyl)-3-methyl-7-n-propylxanthine in vascular surgery and pharmaceutical compositions containing this compound
IT8741690A0 (it)	1987-10-02	Farmaco per la profilassi e per la cura delle disbatteriosi vaginali.
IT8519776A0 (it)	1985-03-06	Preparato per la cura esterna delle emorroidi.
IL86647A (en)	1992-02-16	Pharmaceutical composition comprising 6-(1-imidazolylmethyl)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid
IT8919872A0 (it)	1989-03-22	Prodotto farmaceutico analgesico e anti infiammatorio per la cura delle affezioni dell'apparato muscolo scheletrico e metodo per ottenere detto prodotto.
IT7926323A0 (it)	1979-10-08	Farmaco per la cura delle leucosi e di sindroni nevrotiche.