ZA855740B - 11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives - Google Patents

11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives

Info

Publication number: ZA855740B
Authority: ZA; South Africa
Prior art keywords: phenoxy; substituted; hydrogen; acid derivatives; lower alkyl
Prior art date: 1984-07-31

Application number

ZA855740A

Other languages

English (en)

Inventor

Gary Francis Cooper

John Hans Fried

Lowell David Waterbury

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-31

Filing date

1985-07-30

Publication date

1987-03-25

1985-07-30 Application filed by Syntex Inc filed Critical Syntex Inc

1987-03-25 Publication of ZA855740B publication Critical patent/ZA855740B/xx

Links

-1 16-substituted phenoxy-prostatrienoic acid Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Ophthalmology & Optometry (AREA)
Pulmonology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA855740A 1984-07-31 1985-07-30 11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives ZA855740B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US63597084A	1984-07-31	1984-07-31

Publications (1)

Publication Number	Publication Date
ZA855740B true ZA855740B (en)	1987-03-25

Family

ID=24549856

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA855740A ZA855740B (en)	1984-07-31	1985-07-30	11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives

Country Status (10)

Country	Link
EP (1)	EP0170258B1 (xx)
JP (1)	JPS6147459A (xx)
AT (1)	ATE48991T1 (xx)
AU (1)	AU573018B2 (xx)
DE (1)	DE3574968D1 (xx)
DK (1)	DK346085A (xx)
ES (1)	ES8607921A1 (xx)
HU (1)	HU196174B (xx)
NZ (1)	NZ212914A (xx)
ZA (1)	ZA855740B (xx)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4804787A (en) *	1983-12-22	1989-02-14	Syntex (U.S.A.) Inc.	Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
US4600785A (en) *	1983-12-22	1986-07-15	Syntex (U.S.A.) Inc.	Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
US4912235A (en) *	1983-12-22	1990-03-27	Syntex (U.S.A.) Inc.	Processes and intermediates for making 16-phenoxy- and 16-substituted phenoxy-prostatrienoic acid derivatives and their stereoisomers
US5057621A (en) *	1984-07-31	1991-10-15	Syntex (U.S.A.) Inc.	11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
US4618696A (en) *	1984-07-31	1986-10-21	Syntex (U.S.A.) Inc.	9-oxo-15α-hydroxy-16-phenoxy and 16-substituted phenoxy 17,18,19,20-tetranorprosta-4,5,13,(E)-trienoates
DE3570073D1 (en) *	1984-10-09	1989-06-15	Syntex Inc	Intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
AU586658B2 (en) *	1984-12-24	1989-07-20	Syntex (U.S.A.) Inc.	Uses for enprostil
US5236907A (en) *	1988-10-01	1993-08-17	R-Tech Ueno Ltd.	Ocular hypotensive agents
US6420422B1 (en)	1987-09-18	2002-07-16	Sucampo Pharmaceuticals, Inc.	Ocular hypotensive agents
US5296504A (en) *	1988-09-06	1994-03-22	Kabi Pharmacia	Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
EP1300151A3 (en) *	1988-09-06	2003-05-14	Pharmacia Aktiebolag	Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5321128A (en) *	1988-09-06	1994-06-14	Kabi Pharmacia Ab	Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US6187813B1 (en)	1990-04-10	2001-02-13	Pharmacia & Upjohn Aktiebolag	Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
DE68929435T2 (de) *	1988-09-06	2003-07-17	Pharmacia Ab	Prostaglandinderivate zur Behandlung des grünen Stars oder einer okularen Hypertension
JP3164368B2 (ja) *	1990-03-08	2001-05-08	塩野義製薬株式会社	１５―デオキシプロスタグランジン誘導体
CA2138181A1 (en) *	1993-12-15	1995-06-16	Verney L. Sallee	Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
DE69823852T2 (de)	1997-02-04	2005-05-19	Johnstone, Murray A., Seattle	Verfahren zur förderung des haarwuchses und entwicklung des haarsystems
AU2211700A (en) *	1998-12-24	2000-07-31	Alcon Laboratories, Inc.	Prostaglandin e agonists for treatment of glaucoma
HUP0200258A2 (hu)	1999-03-05	2002-05-29	The Procter & Gamble Co.	C16-telítetlen FP-szelektív prosztaglandin analógok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
US20020172693A1 (en)	2000-03-31	2002-11-21	Delong Michell Anthony	Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020037914A1 (en)	2000-03-31	2002-03-28	Delong Mitchell Anthony	Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en)	2000-03-31	2002-01-31	Delong Mitchell Anthony	Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US7351404B2 (en)	2002-02-04	2008-04-01	Allergan, Inc.	Method of enhancing hair growth
US8758733B2 (en)	2002-02-04	2014-06-24	Allergan, Inc.	Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US9216183B2 (en)	2002-02-04	2015-12-22	Allergan, Inc.	Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US20050239872A1 (en) *	2002-06-06	2005-10-27	Xavier Billot	1,5-distributed pyrrolid-2-one derivatives for use as ep4 receptor agonists in the teatment of eye diseases such as glaucoma
US7642370B2 (en)	2006-08-07	2010-01-05	Daiichi Fine Chemical Co., Ltd.	Method for preparing prostaglandin derivative
US8623918B2 (en)	2008-10-29	2014-01-07	Novaer Holdings, Inc.	Amino acid salts of prostaglandins
US8722739B2 (en)	2008-10-29	2014-05-13	Novaer Holdings, Inc.	Amino acid salts of prostaglandins
US9149484B2 (en)	2009-11-09	2015-10-06	Allergan, Inc.	Compositions and methods for stimulating hair growth
MX361709B (es)	2009-11-09	2018-12-07	Allergan Inc	Composiciones y metodos para estimular el crecimiento del cabello.
US8859616B2 (en)	2011-01-21	2014-10-14	Allergan, Inc.	Compounds and methods for enhancing hair growth

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3989744A (en) *	1973-07-30	1976-11-02	Miles Laboratories, Inc.	11-Substitute d-11-desoxy-pge analogues
US4178457A (en) *	1978-07-10	1979-12-11	Syntex (U.S.A.) Inc.	(dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives and processes for the production thereof
US4618696A (en) *	1984-07-31	1986-10-21	Syntex (U.S.A.) Inc.	9-oxo-15α-hydroxy-16-phenoxy and 16-substituted phenoxy 17,18,19,20-tetranorprosta-4,5,13,(E)-trienoates

1985
- 1985-07-30 HU HU852917A patent/HU196174B/hu not_active IP Right Cessation
- 1985-07-30 DK DK346085A patent/DK346085A/da not_active Application Discontinuation
- 1985-07-30 ZA ZA855740A patent/ZA855740B/xx unknown
- 1985-07-30 AU AU45620/85A patent/AU573018B2/en not_active Ceased
- 1985-07-30 AT AT85109580T patent/ATE48991T1/de not_active IP Right Cessation
- 1985-07-30 ES ES545700A patent/ES8607921A1/es not_active Expired
- 1985-07-30 NZ NZ212914A patent/NZ212914A/xx unknown
- 1985-07-30 DE DE8585109580T patent/DE3574968D1/de not_active Expired - Fee Related
- 1985-07-30 EP EP85109580A patent/EP0170258B1/en not_active Expired
- 1985-07-30 JP JP60169653A patent/JPS6147459A/ja active Pending

Also Published As

Publication number	Publication date
HU196174B (en)	1988-10-28
ES545700A0 (es)	1986-06-16
ES8607921A1 (es)	1986-06-16
DK346085A (da)	1986-02-01
EP0170258B1 (en)	1989-12-27
ATE48991T1 (de)	1990-01-15
NZ212914A (en)	1988-08-30
EP0170258A3 (en)	1986-09-10
DK346085D0 (da)	1985-07-30
EP0170258A2 (en)	1986-02-05
JPS6147459A (ja)	1986-03-07
DE3574968D1 (de)	1990-02-01
AU573018B2 (en)	1988-05-26
HUT38309A (en)	1986-05-28
AU4562085A (en)	1986-02-06

Publication	Publication Date	Title
EP0170258A3 (en)	1986-09-10	11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
PH23448A (en)	1989-08-07	Quinoline compounds
ZA858699B (en)	1986-07-30	Quinolonecarboxylic acid derivatives
GR3007460T3 (xx)	1993-07-30
ES8606283A1 (es)	1986-04-16	Procedimiento para preparar derivados de acidos quinolon- carboxilicos
AU7388487A (en)	1987-12-10	2-benzoyl-1,3,5-cyclohexanetriones
ES8607922A1 (es)	1986-06-16	Procedimiento para preparar 9-oxo-15 a-hidroxi-16-fenoxi y 16-fenoxi sustituido-17,18,19,20-tetranorprosta-4,5,13 (e)- trienoatos
NO903514L (no)	1991-02-11	Imidazolderivat og fremgangsmaate til dets fremstilling.
ES2001676A6 (es)	1988-06-01	Procedimiento para la preparacion de derivados propionamidinos
EP0147788A3 (en)	1986-06-25	Phenylacetanilide derivatives
AU650630B2 (en)	1994-06-30	Novel benzoxazolone compounds and the use thereof as microbicides
EP0443474A3 (en)	1992-04-22	1-phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents