ZA852874B - 1-(substituted-aryl)-dihydro-1h-pyrrolizine 3,5(2h,6h)-diones as cognition activators - Google Patents
1-(substituted-aryl)-dihydro-1h-pyrrolizine 3,5(2h,6h)-diones as cognition activatorsInfo
- Publication number
- ZA852874B ZA852874B ZA852874A ZA852874A ZA852874B ZA 852874 B ZA852874 B ZA 852874B ZA 852874 A ZA852874 A ZA 852874A ZA 852874 A ZA852874 A ZA 852874A ZA 852874 B ZA852874 B ZA 852874B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrrolizine
- diones
- dihydro
- aryl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
- C07C205/53—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/607,375 US4548947A (en) | 1984-05-07 | 1984-05-07 | 1-(Substituted-aryl)-dihydro-1H-pyrrolizine-3,5-[2H,6H-]diones and use for reversing amnesia |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA852874B true ZA852874B (en) | 1986-11-26 |
Family
ID=24431993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA852874A ZA852874B (en) | 1984-05-07 | 1985-04-17 | 1-(substituted-aryl)-dihydro-1h-pyrrolizine 3,5(2h,6h)-diones as cognition activators |
Country Status (10)
Country | Link |
---|---|
US (1) | US4548947A (fr) |
EP (1) | EP0164852B1 (fr) |
JP (1) | JPS60239487A (fr) |
AT (1) | ATE35546T1 (fr) |
AU (1) | AU564866B2 (fr) |
CA (1) | CA1252105A (fr) |
DE (1) | DE3563626D1 (fr) |
DK (1) | DK201585A (fr) |
ES (1) | ES8609326A1 (fr) |
ZA (1) | ZA852874B (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4663464A (en) * | 1986-03-21 | 1987-05-05 | Warner-Lambert Company | Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione |
CN107188808A (zh) * | 2017-05-22 | 2017-09-22 | 江苏斯威森生物医药工程研究中心有限公司 | 一种4‑氨基‑3‑苯基丁酸盐酸盐的合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1350582A (en) * | 1970-07-24 | 1974-04-18 | Ucb Sa | Cerivatives of 2-pyrrolidinone |
DE2413935A1 (de) * | 1974-03-20 | 1975-10-16 | Schering Ag | 4-(polyalkoxy-phenyl)-2-pyrrolidone |
US4372966A (en) * | 1980-09-15 | 1983-02-08 | Warner-Lambert Company | Use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator |
US4547519A (en) * | 1982-05-24 | 1985-10-15 | Warner-Lambert Company | Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acid and benzyl esters and amides thereof and their use in reversing amnesia |
-
1984
- 1984-05-07 US US06/607,375 patent/US4548947A/en not_active Expired - Fee Related
-
1985
- 1985-04-17 ZA ZA852874A patent/ZA852874B/xx unknown
- 1985-04-17 AU AU41340/85A patent/AU564866B2/en not_active Ceased
- 1985-04-23 CA CA000479812A patent/CA1252105A/fr not_active Expired
- 1985-04-26 EP EP85302948A patent/EP0164852B1/fr not_active Expired
- 1985-04-26 DE DE8585302948T patent/DE3563626D1/de not_active Expired
- 1985-04-26 AT AT85302948T patent/ATE35546T1/de not_active IP Right Cessation
- 1985-05-02 JP JP60093951A patent/JPS60239487A/ja active Pending
- 1985-05-03 ES ES542810A patent/ES8609326A1/es not_active Expired
- 1985-05-06 DK DK201585A patent/DK201585A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU4134085A (en) | 1985-11-14 |
JPS60239487A (ja) | 1985-11-28 |
ES542810A0 (es) | 1986-07-16 |
DK201585A (da) | 1985-11-08 |
ATE35546T1 (de) | 1988-07-15 |
DE3563626D1 (en) | 1988-08-11 |
DK201585D0 (da) | 1985-05-06 |
EP0164852B1 (fr) | 1988-07-06 |
CA1252105A (fr) | 1989-04-04 |
AU564866B2 (en) | 1987-08-27 |
EP0164852A1 (fr) | 1985-12-18 |
US4548947A (en) | 1985-10-22 |
ES8609326A1 (es) | 1986-07-16 |
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