ZA834888B - Allyloxy-and allylthio-2,3,4,5-tetrahydro-1h-3-benzazepines - Google Patents

Allyloxy-and allylthio-2,3,4,5-tetrahydro-1h-3-benzazepines

Info

Publication number
ZA834888B
ZA834888B ZA834888A ZA834888A ZA834888B ZA 834888 B ZA834888 B ZA 834888B ZA 834888 A ZA834888 A ZA 834888A ZA 834888 A ZA834888 A ZA 834888A ZA 834888 B ZA834888 B ZA 834888B
Authority
ZA
South Africa
Prior art keywords
allylthio
allyloxy
benzazepines
tetrahydro
hydrogen
Prior art date
Application number
ZA834888A
Other languages
English (en)
Inventor
Robert Michael Demarinis
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of ZA834888B publication Critical patent/ZA834888B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
ZA834888A 1982-07-29 1983-07-05 Allyloxy-and allylthio-2,3,4,5-tetrahydro-1h-3-benzazepines ZA834888B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/403,229 US4469634A (en) 1982-07-29 1982-07-29 Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines

Publications (1)

Publication Number Publication Date
ZA834888B true ZA834888B (en) 1984-03-28

Family

ID=23594994

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA834888A ZA834888B (en) 1982-07-29 1983-07-05 Allyloxy-and allylthio-2,3,4,5-tetrahydro-1h-3-benzazepines

Country Status (13)

Country Link
US (1) US4469634A (de)
EP (1) EP0103961B1 (de)
JP (1) JPS5942371A (de)
AT (1) ATE18906T1 (de)
AU (1) AU558321B2 (de)
CA (1) CA1193254A (de)
DE (1) DE3362789D1 (de)
DK (1) DK339383A (de)
ES (1) ES524515A0 (de)
GR (1) GR77558B (de)
IE (1) IE55669B1 (de)
PT (1) PT77068B (de)
ZA (1) ZA834888B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659706A (en) * 1985-12-20 1987-04-21 Smithkline Beckman Corporation Sulfinyl and sulfonyl substituted 3-benzazepines
US4683229A (en) * 1986-03-17 1987-07-28 Smithkline Beckman Corporation 6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists
US4959360A (en) * 1988-06-01 1990-09-25 Smithkline Beecham Corporation α-adrenergic receptor antagonists
US4978660A (en) * 1988-06-01 1990-12-18 Smithkline Beecham Corporation α-adrenergic receptor antagonists
US4963547A (en) * 1988-06-01 1990-10-16 Smithkline Beecham Corporation Alpha-andrenergic receptor antagonists and use thereas
US5006521A (en) * 1988-06-01 1991-04-09 Smithkline Beecham Corporation α-adrenergic receptor antagonists and methods of use thereas
US4981848A (en) * 1989-02-23 1991-01-01 Smithkline Beecham Corporation Alpha-adrenergic receptor antagonists
US4981849A (en) * 1989-02-23 1991-01-01 Smithkline Beecham Corporation Alpha-adrenergic receptor antagonists
GB9116824D0 (en) * 1991-08-05 1991-09-18 Smithkline Beecham Corp Chemical compounds
US5639748A (en) * 1991-08-05 1997-06-17 Smithkline Beecham Corporation 6,9-disubstituted benzazepines having α-adrenoceptor blocking activity
GB9119467D0 (en) * 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3483185A (en) * 1966-08-16 1969-12-09 American Home Prod N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
CA974989A (en) * 1968-03-11 1975-09-23 Wallace And Tiernan Inc. Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US4233217A (en) * 1968-03-11 1980-11-11 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H, 3 benzazepines
US3963725A (en) * 1973-07-20 1976-06-15 Fujisawa Pharmaceutical Co., Ltd. 1,2,3,4-Tetrahydroisoquinoline derivatives and the preparation thereof
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
ZA792785B (en) * 1978-07-07 1980-08-27 Smithkline Corp Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines

Also Published As

Publication number Publication date
DE3362789D1 (en) 1986-05-07
IE55669B1 (en) 1990-12-19
EP0103961A1 (de) 1984-03-28
ATE18906T1 (de) 1986-04-15
EP0103961B1 (de) 1986-04-02
DK339383A (da) 1984-01-30
GR77558B (de) 1984-09-24
PT77068A (en) 1983-08-01
AU558321B2 (en) 1987-01-29
PT77068B (en) 1986-01-27
CA1193254A (en) 1985-09-10
IE831784L (en) 1984-01-29
DK339383D0 (da) 1983-07-25
ES8502095A1 (es) 1984-12-16
US4469634A (en) 1984-09-04
JPS5942371A (ja) 1984-03-08
ES524515A0 (es) 1984-12-16
AU1649483A (en) 1984-02-02

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