ZA817772B - 4-pregnene-derivatives,their preparation and use - Google Patents

4-pregnene-derivatives,their preparation and use

Info

Publication number
ZA817772B
ZA817772B ZA817772A ZA817772A ZA817772B ZA 817772 B ZA817772 B ZA 817772B ZA 817772 A ZA817772 A ZA 817772A ZA 817772 A ZA817772 A ZA 817772A ZA 817772 B ZA817772 B ZA 817772B
Authority
ZA
South Africa
Prior art keywords
compounds
preparation
formula
pregnene
derivatives
Prior art date
Application number
ZA817772A
Inventor
Bror Arne Thalen
Ralph Lennart Brattsand
Original Assignee
Draco Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Draco Ab filed Critical Draco Ab
Publication of ZA817772B publication Critical patent/ZA817772B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Treating Waste Gases (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The invention refers to compounds having anti-inflammatory activity, characterized by the formula <IMAGE> (I) in the form of a stereoisomeric mixture or an epimer of the R or S type regarding the orientation of the substituents at the carbon atom in position 22, in which formula A is n-propyl or n-butyl and Z is hydroxyl or hydroxyl esterified with a fatty acid with a straight or branched hydrocarbon chain having 1-5 carbon atoms. The invention also refers to a process for the preparation of these compounds, a pharmaceutical preparation containing one of the compounds and a method for the treatment and control of inflammatory conditions.
ZA817772A 1980-12-04 1981-11-10 4-pregnene-derivatives,their preparation and use ZA817772B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8008524A SE8008524L (en) 1980-12-04 1980-12-04 4-PREGNEN DERIVATIVES, A PROCEDURE FOR THEIR PREPARATION, PREPARATION AND METHOD OF TREATMENT OF INFLAMMATORY CONDITIONS

Publications (1)

Publication Number Publication Date
ZA817772B true ZA817772B (en) 1982-08-25

Family

ID=20342392

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA817772A ZA817772B (en) 1980-12-04 1981-11-10 4-pregnene-derivatives,their preparation and use

Country Status (26)

Country Link
US (1) US4404200A (en)
EP (1) EP0054010B1 (en)
JP (1) JPS57122100A (en)
KR (1) KR870001904B1 (en)
AT (1) ATE11920T1 (en)
AU (1) AU546379B2 (en)
CA (1) CA1183835A (en)
CS (1) CS229923B2 (en)
CY (1) CY1413A (en)
DD (1) DD202034A5 (en)
DE (1) DE3169108D1 (en)
DK (1) DK163003C (en)
ES (1) ES507670A0 (en)
FI (1) FI70582C (en)
GR (1) GR76919B (en)
HK (1) HK11688A (en)
HU (1) HU183717B (en)
IE (1) IE51923B1 (en)
MY (1) MY8600139A (en)
NO (1) NO158508C (en)
NZ (1) NZ199141A (en)
PH (1) PH17826A (en)
PT (1) PT74078B (en)
SE (1) SE8008524L (en)
SU (1) SU1156600A3 (en)
ZA (1) ZA817772B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5866866A (en) * 1981-10-16 1983-04-21 Advantest Corp Display device for waveform or the like
JPS5866867A (en) * 1981-10-16 1983-04-21 Advantest Corp Display device for waveform or the like
US4482539A (en) * 1983-05-13 1984-11-13 Schering Corporation Betamethasone dipropionate cream
US4489070A (en) * 1983-05-13 1984-12-18 Schering Corporation Betamethasone dipropionate cream
IT1196142B (en) * 1984-06-11 1988-11-10 Sicor Spa PROCEDURE FOR THE PREPARATION OF 16.17-ACETALS OF PREGNANIC DERIVATIVES AND NEW COMPOUNDS OBTAINED
SE8604059D0 (en) * 1986-09-25 1986-09-25 Astra Pharma Prod A METHOD OF CONTROLLING THE EPIMERIC DISTRIBUTION IN THE PREPARATION OF 16,17-ACETALS OF PREGNANE DERIVATIVES
HU203769B (en) * 1989-03-09 1991-09-30 Richter Gedeon Vegyeszet Process for producing new steroide derivatives and pharmaceutical compositions containing them
SE8903219D0 (en) * 1989-10-02 1989-10-02 Astra Ab PROCESS FOR THE MANUFACTURE OF BUDESONIDE
SE8903914D0 (en) 1989-11-22 1989-11-22 Draco Ab ORAL COMPOSITION FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES
US5643602A (en) * 1989-11-22 1997-07-01 Astra Aktiebolag Oral composition for the treatment of inflammatory bowel disease
GR1001529B (en) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Process for the obtainment of a new pregna-1,4-diene-3,20-dione -16-17-acetal-21 esters
SE9100342D0 (en) * 1991-02-04 1991-02-04 Astra Ab NOVEL STEROID ESTERS
SE9100341D0 (en) * 1991-02-04 1991-02-04 Astra Ab NOVEL STEROIDS
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
ES2107806T3 (en) * 1992-12-24 1997-12-01 Rhone Poulenc Rorer Ltd NEW STEROIDS.
CZ171095A3 (en) * 1993-01-08 1996-01-17 Astra Ab Novel steroidal derivatives specific for colon or ilium
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
TW200417371A (en) * 2003-02-21 2004-09-16 Upjohn Co A continuous process for the production of R-rofleponide
CA2936740C (en) 2014-10-31 2017-10-10 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US11011063B2 (en) * 2018-11-16 2021-05-18 Toyota Motor North America, Inc. Distributed data collection and processing among vehicle convoy members
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB909126A (en) * 1958-03-11 1962-10-24 American Cyanamid Co 16ª--17ª--alkylidenedioxy steroids and process for preparation
US2990401A (en) * 1958-06-18 1961-06-27 American Cyanamid Co 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3549498A (en) * 1968-04-02 1970-12-22 Squibb & Sons Inc 11alpha-substituted steroids and process
CH513843A (en) * 1969-04-23 1971-10-15 Lark Spa Microbiological oxhydrilation process in position 11B
SE378110B (en) * 1972-05-19 1975-08-18 Bofors Ab
SE378109B (en) * 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
ES8107308A3 (en) 1979-12-19 1980-12-01 Espanola Esteroide Procedure for obtaining steroids 11 replaced (Machine-translation by Google Translate, not legally binding)

Also Published As

Publication number Publication date
EP0054010B1 (en) 1985-02-20
AU546379B2 (en) 1985-08-29
CY1413A (en) 1988-04-22
ES8306164A1 (en) 1983-05-01
SE8008524L (en) 1982-06-05
DK163003B (en) 1992-01-06
KR870001904B1 (en) 1987-10-21
NO158508B (en) 1988-06-13
IE812827L (en) 1982-06-04
FI813807L (en) 1982-06-05
SU1156600A3 (en) 1985-05-15
JPS6261599B2 (en) 1987-12-22
KR830007715A (en) 1983-11-04
NO158508C (en) 1988-09-28
DK163003C (en) 1992-06-01
GR76919B (en) 1984-09-04
DD202034A5 (en) 1983-08-24
JPS57122100A (en) 1982-07-29
PT74078B (en) 1983-12-19
NZ199141A (en) 1984-09-28
EP0054010A1 (en) 1982-06-16
CA1183835A (en) 1985-03-12
US4404200A (en) 1983-09-13
DK535981A (en) 1982-06-05
CS229923B2 (en) 1984-07-16
MY8600139A (en) 1986-12-31
FI70582B (en) 1986-06-06
ATE11920T1 (en) 1985-03-15
AU7816981A (en) 1982-06-10
NO814098L (en) 1982-06-07
PT74078A (en) 1982-01-01
DE3169108D1 (en) 1985-03-28
HU183717B (en) 1984-05-28
ES507670A0 (en) 1983-05-01
PH17826A (en) 1985-01-07
FI70582C (en) 1986-09-24
IE51923B1 (en) 1987-04-29
HK11688A (en) 1988-02-16

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