ZA814523B - Salt of furosemide or piretanide as the acid component and penbutolol or (-).3-(4)-(3-(3,4-dimethoxyphenylethylamino)-2-hydroxy-proposy)-phenyl)crotononitrile as the base component,process for its prepration,composition in which it is present and its use - Google Patents

Salt of furosemide or piretanide as the acid component and penbutolol or (-).3-(4)-(3-(3,4-dimethoxyphenylethylamino)-2-hydroxy-proposy)-phenyl)crotononitrile as the base component,process for its prepration,composition in which it is present and its use

Info

Publication number
ZA814523B
ZA814523B ZA814523A ZA814523A ZA814523B ZA 814523 B ZA814523 B ZA 814523B ZA 814523 A ZA814523 A ZA 814523A ZA 814523 A ZA814523 A ZA 814523A ZA 814523 B ZA814523 B ZA 814523B
Authority
ZA
South Africa
Prior art keywords
piretanide
penbutolol
furosemide
proposy
dimethoxyphenylethylamino
Prior art date
Application number
ZA814523A
Other languages
English (en)
Inventor
R Muschaweck
W Fuelberth
A Sickmueller
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA814523B publication Critical patent/ZA814523B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA814523A 1980-07-04 1981-07-03 Salt of furosemide or piretanide as the acid component and penbutolol or (-).3-(4)-(3-(3,4-dimethoxyphenylethylamino)-2-hydroxy-proposy)-phenyl)crotononitrile as the base component,process for its prepration,composition in which it is present and its use ZA814523B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803025367 DE3025367A1 (de) 1980-07-04 1980-07-04 Salz aus furosemid oder piretanid als saeurekomponente und penbutolol oder (-)-3-(4- (3-(3,4-dimethoxyphenylaethylamino)-2-hydroxy-propoxy) -phenyl ) -crotonsaeurenitril als basenkomponente, verfahren zu seiner herstellung, dieses enthaltendes mittel und dessen verwendung

Publications (1)

Publication Number Publication Date
ZA814523B true ZA814523B (en) 1982-07-28

Family

ID=6106415

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA814523A ZA814523B (en) 1980-07-04 1981-07-03 Salt of furosemide or piretanide as the acid component and penbutolol or (-).3-(4)-(3-(3,4-dimethoxyphenylethylamino)-2-hydroxy-proposy)-phenyl)crotononitrile as the base component,process for its prepration,composition in which it is present and its use

Country Status (8)

Country Link
US (1) US4564625A (xx)
EP (1) EP0043548B1 (xx)
JP (1) JPS5756426A (xx)
AT (1) ATE8627T1 (xx)
AU (1) AU538612B2 (xx)
CA (1) CA1161449A (xx)
DE (2) DE3025367A1 (xx)
ZA (1) ZA814523B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663348A (en) * 1985-07-02 1987-05-05 Warner-Lambert Co. Furosemide salts and pharmaceutical preparations thereof
US5256687A (en) * 1985-09-09 1993-10-26 Hoechst Aktiengesellschaft Pharmaceutical composition for the treatment of high blood pressure
DE3617824A1 (de) * 1986-05-27 1987-12-03 Hoechst Ag Zusammensetzung fuer transdermale therapeutische systeme von schleifendiuretika
US4698361A (en) * 1986-05-28 1987-10-06 Schiena Michele G Di Tris-chydroxymethyl) aminomethane salt of 4-chloro-N-furfuryl-5-sulfamoyl anthranilic acid and diuretic compositions containing the same
US5013761A (en) * 1988-06-03 1991-05-07 Eli Lilly And Company Serotonin antagonists
JPH0720862B2 (ja) * 1989-01-27 1995-03-08 ヘキスト・アクチエンゲゼルシヤフト 吸入用喘息治療剤
IT1237115B (it) * 1989-10-24 1993-05-18 Sali della furosemide, procedimento per la loro preparazione e composizionni farmaceutiche che li contengono

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3839321A (en) * 1966-07-21 1974-10-01 Smithkline Corp 5-sulfamoyl-n-(2-substituted-ethyl) anthranilic acids
US4139633A (en) * 1971-06-15 1979-02-13 Ciba-Geigy Corporation Pharmaceutical preparations for the treatment of hypertonia
DE2227423A1 (de) * 1971-06-15 1972-12-21 Ciba-Geigy Ag, Basel (Schweiz) Neue pharmazeutische Präparate
AT356095B (de) * 1975-04-24 1980-04-10 Hoechst Ag Verfahren zur herstellung von neuen, heterocyclisch substituierten 5-sulfamoyl- benzoesaeurederivaten und ihren salzen
US4118587A (en) * 1976-03-22 1978-10-03 Hoffmann-La Roche Inc. Novel 4-phenoxy-5-sulfamylbenzoic acid derivatives
US4191765A (en) * 1976-05-25 1980-03-04 Hoechst Aktiengesellschaft 1-Aryloxy-2-hydroxy-3-aminopropanes
DE2638716A1 (de) * 1976-08-27 1978-03-02 Ici Gmbh Antihypertensiva

Also Published As

Publication number Publication date
CA1161449A (en) 1984-01-31
EP0043548B1 (de) 1984-07-25
US4564625A (en) 1986-01-14
AU538612B2 (en) 1984-08-23
AU7252581A (en) 1982-01-07
EP0043548A1 (de) 1982-01-13
JPS5756426A (en) 1982-04-05
ATE8627T1 (de) 1984-08-15
DE3025367A1 (de) 1982-01-28
DE3165050D1 (en) 1984-08-30
JPH0148245B2 (xx) 1989-10-18

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ZA814523B (en) Salt of furosemide or piretanide as the acid component and penbutolol or (-).3-(4)-(3-(3,4-dimethoxyphenylethylamino)-2-hydroxy-proposy)-phenyl)crotononitrile as the base component,process for its prepration,composition in which it is present and its use
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