ZA796244B - New derivatives of 3-quinoline-carboxylic acid,process for preparing them,their use as a medicament and the pharmaceutical compositions containing them - Google Patents
New derivatives of 3-quinoline-carboxylic acid,process for preparing them,their use as a medicament and the pharmaceutical compositions containing themInfo
- Publication number
- ZA796244B ZA796244B ZA00796244A ZA796244A ZA796244B ZA 796244 B ZA796244 B ZA 796244B ZA 00796244 A ZA00796244 A ZA 00796244A ZA 796244 A ZA796244 A ZA 796244A ZA 796244 B ZA796244 B ZA 796244B
- Authority
- ZA
- South Africa
- Prior art keywords
- quinoline
- medicament
- preparing
- carboxylic acid
- pharmaceutical compositions
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- DJXNJVFEFSWHLY-UHFFFAOYSA-N quinoline-3-carboxylic acid Chemical class C1=CC=CC2=CC(C(=O)O)=CN=C21 DJXNJVFEFSWHLY-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7834592A FR2443467A1 (fr) | 1978-12-08 | 1978-12-08 | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA796244B true ZA796244B (en) | 1980-11-26 |
Family
ID=9215841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA00796244A ZA796244B (en) | 1978-12-08 | 1979-11-19 | New derivatives of 3-quinoline-carboxylic acid,process for preparing them,their use as a medicament and the pharmaceutical compositions containing them |
Country Status (12)
Country | Link |
---|---|
US (1) | US4299831A (xx) |
EP (2) | EP0012639B1 (xx) |
JP (1) | JPS5581878A (xx) |
AU (1) | AU531501B2 (xx) |
CA (1) | CA1137985A (xx) |
DE (1) | DE2966142D1 (xx) |
DK (1) | DK149773C (xx) |
ES (1) | ES8103045A1 (xx) |
FR (1) | FR2443467A1 (xx) |
HU (1) | HU182570B (xx) |
IE (1) | IE49875B1 (xx) |
ZA (1) | ZA796244B (xx) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2482596A1 (fr) * | 1980-05-19 | 1981-11-20 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament |
HU190796B (en) * | 1981-06-12 | 1986-11-28 | Roussel Uclaf,Fr | Process for producing n-dihydrothiazolyl-3-quinoline-carboxamide derivatives |
FR2509728A1 (fr) * | 1981-07-17 | 1983-01-21 | Roussel Uclaf | Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
FR2537139B2 (fr) * | 1982-03-15 | 1985-09-20 | Roussel Uclaf | Nouveau derive de la n-dihydrothiazolyl 3-quinoleine carboxamide, procede de preparation, application a titre de medicament et compositions le renfermant |
FR2532314B1 (fr) * | 1982-08-25 | 1985-07-19 | Roussel Uclaf | Nouveau procede de preparation de derives de l'acide 3-quinoleine carboxylique, nouveaux derives halogenes de l'acide 3-quinoleine carboxylique, leur application comme medicaments, les compositions pharmaceutiques les renfermant et les intermediaires nouveaux obtenus |
FR2566405B1 (fr) * | 1984-06-25 | 1986-09-26 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus |
FR2612189B1 (fr) * | 1987-03-13 | 1989-06-23 | Roussel Uclaf | Nouveaux derives de la pyridine, leur procede de preparation et les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions les renfermant |
FR2636329B2 (fr) * | 1987-03-13 | 1990-11-02 | Roussel Uclaf | Nouveaux derives de la pyridine, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant |
US4966906A (en) * | 1987-11-27 | 1990-10-30 | Hoechst-Roussel Pharmaceuticals Inc. | 1-aryl-3-isoquinolinecarboxamides |
US5028707A (en) * | 1989-11-20 | 1991-07-02 | Board Of Regents, University Of Texas | 4-hydroxyquinaldic acid derivatives |
GB9108547D0 (en) * | 1991-04-22 | 1991-06-05 | Fujisawa Pharmaceutical Co | Quinoline derivatives |
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
WO2005035484A1 (ja) * | 2003-10-10 | 2005-04-21 | Toyo Kasei Kogyo Company Limited | 1-アリール-5-(トリフルオロメチル)-1h-テトラゾールの製造方法 |
CA2571949C (en) | 2004-06-24 | 2015-05-12 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
HUE049976T2 (hu) | 2005-12-28 | 2020-11-30 | Vertex Pharma | N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid amorf alakjának gyógyászati kompozíciói |
KR101852173B1 (ko) | 2009-03-20 | 2018-04-27 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법 |
MX2014010253A (es) | 2012-02-27 | 2014-11-12 | Vertex Pharma | Composicion farmaceutica y administraciones de la misma. |
JP6746569B2 (ja) | 2014-10-07 | 2020-08-26 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | 嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4044138A (en) * | 1972-10-21 | 1977-08-23 | John Wyeth & Brother Limited | Pharmaceutical compositions containing 5,6,7,8-tetrahydroquinoline derivatives and related compounds |
FR2281761A1 (fr) * | 1974-08-13 | 1976-03-12 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
FR2324304A2 (fr) * | 1975-09-22 | 1977-04-15 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
JPS5291876A (en) * | 1976-01-27 | 1977-08-02 | Roussel Uclaf | Novel derivatives of 33quinolinecarboxylic acid and medicine comprising same |
FR2340735A1 (fr) * | 1976-02-11 | 1977-09-09 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
-
1978
- 1978-12-08 FR FR7834592A patent/FR2443467A1/fr active Granted
-
1979
- 1979-11-14 EP EP79400871A patent/EP0012639B1/fr not_active Expired
- 1979-11-14 EP EP81201342A patent/EP0049555B1/fr not_active Expired
- 1979-11-14 DE DE7979400871T patent/DE2966142D1/de not_active Expired
- 1979-11-19 ZA ZA00796244A patent/ZA796244B/xx unknown
- 1979-11-23 HU HU79RO1046A patent/HU182570B/hu not_active IP Right Cessation
- 1979-11-27 US US06/097,711 patent/US4299831A/en not_active Expired - Lifetime
- 1979-12-07 CA CA000341502A patent/CA1137985A/fr not_active Expired
- 1979-12-07 ES ES486671A patent/ES8103045A1/es not_active Expired
- 1979-12-07 DK DK520679A patent/DK149773C/da not_active IP Right Cessation
- 1979-12-07 AU AU53585/79A patent/AU531501B2/en not_active Ceased
- 1979-12-07 JP JP15822779A patent/JPS5581878A/ja active Granted
- 1979-12-07 IE IE2367/79A patent/IE49875B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA1137985A (fr) | 1982-12-21 |
JPS5581878A (en) | 1980-06-20 |
EP0049555A1 (fr) | 1982-04-14 |
US4299831A (en) | 1981-11-10 |
ES486671A0 (es) | 1981-02-16 |
EP0012639B1 (fr) | 1983-09-07 |
HU182570B (en) | 1984-02-28 |
JPS6330914B2 (xx) | 1988-06-21 |
ES8103045A1 (es) | 1981-02-16 |
IE49875B1 (en) | 1986-01-08 |
EP0012639A3 (en) | 1980-11-12 |
EP0049555B1 (fr) | 1984-02-22 |
DK149773C (da) | 1987-03-23 |
AU531501B2 (en) | 1983-08-25 |
DK520679A (da) | 1980-06-09 |
DK149773B (da) | 1986-09-29 |
DE2966142D1 (en) | 1983-10-13 |
FR2443467B1 (xx) | 1981-08-14 |
IE792367L (en) | 1980-06-08 |
AU5358579A (en) | 1980-06-12 |
FR2443467A1 (fr) | 1980-07-04 |
EP0012639A2 (fr) | 1980-06-25 |
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