ZA201803749B - Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method - Google Patents
Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation methodInfo
- Publication number
- ZA201803749B ZA201803749B ZA2018/03749A ZA201803749A ZA201803749B ZA 201803749 B ZA201803749 B ZA 201803749B ZA 2018/03749 A ZA2018/03749 A ZA 2018/03749A ZA 201803749 A ZA201803749 A ZA 201803749A ZA 201803749 B ZA201803749 B ZA 201803749B
- Authority
- ZA
- South Africa
- Prior art keywords
- carboxypropionyl
- biphenyl
- salts
- amino
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ2015-891A CZ2015891A3 (cs) | 2015-12-11 | 2015-12-11 | Krystalická forma draselné soli ethylesteru (2R,4S)-5-(bifenyl-4-yl)-4-[(3-karboxypropionyl)amino]-2-methylpentanové kyseliny a průmyslově použitelný způsob její přípravy |
CZ2015-896A CZ2015896A3 (cs) | 2015-12-14 | 2015-12-14 | Pevné formy ethyl esteru (2R,4S)-5-(bifenyl-4-yl)-4-[3-karboxypropionyl)amino]-2--methylpentanové kyseliny, její sole a způsob přípravy |
PCT/CZ2016/000130 WO2017097275A1 (en) | 2015-12-11 | 2016-12-12 | Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA201803749B true ZA201803749B (en) | 2019-04-24 |
Family
ID=57614098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA2018/03749A ZA201803749B (en) | 2015-12-11 | 2018-06-06 | Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP3386945A1 (pt) |
BR (1) | BR112018011788A2 (pt) |
CO (1) | CO2018005941A2 (pt) |
MX (1) | MX2018007129A (pt) |
WO (1) | WO2017097275A1 (pt) |
ZA (1) | ZA201803749B (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018045505A1 (zh) * | 2016-09-07 | 2018-03-15 | 诺瑞特国际药业股份有限公司 | 沙库比曲钠盐新晶型 |
US10857132B2 (en) | 2016-10-10 | 2020-12-08 | Laurus Labs Limited | Stable amorphous form of sacubitril valsartan trisodium complex and processes for preparation thereof |
EP3532454A4 (en) | 2016-10-28 | 2020-11-25 | Biocon Limited | AMORPHIC TRINATRIUM SACUBITRIL VALSARTAN AND THE PROCESS FOR THE PREPARATION |
CN107311909A (zh) * | 2017-06-22 | 2017-11-03 | 东南大学 | 一种lcz696杂质对照品的制备方法 |
WO2019020706A1 (en) * | 2017-07-28 | 2019-01-31 | Synthon B.V. | PHARMACEUTICAL COMPOSITION COMPRISING SACUBITRIL AND VALSARTAN |
CN109400493B (zh) * | 2017-08-15 | 2021-07-09 | 成都博腾药业有限公司 | 沙库比曲及其中间体的制备方法 |
CN107602410A (zh) * | 2017-09-13 | 2018-01-19 | 浙江三门恒康制药有限公司 | 沙库比曲钠盐的晶型ii及其制备方法 |
WO2019127994A1 (zh) * | 2017-12-27 | 2019-07-04 | 浙江天宇药业股份有限公司 | 一种沙库比曲钠盐、沙库比曲游离酸与乙酸的共晶物、其晶型、晶型的制备方法及用途 |
CN108558693A (zh) * | 2018-04-24 | 2018-09-21 | 南京双科医药开发有限公司 | 一种沙库巴曲游离酸及其金属盐在药物制备中应用的方法 |
GB201810326D0 (en) * | 2018-06-22 | 2018-08-08 | Johnson Matthey Plc | Crystalline form of sacubitril, its preparation and use |
CN109912486B (zh) * | 2019-04-25 | 2022-09-27 | 东北制药集团股份有限公司 | 一种联苯甲基内酰胺化合物的制备方法 |
CN110878039A (zh) * | 2019-12-18 | 2020-03-13 | 株洲千金药业股份有限公司 | 一种沙库巴曲缬沙坦钠杂质的制备方法 |
CN115677521B (zh) * | 2022-11-16 | 2024-02-02 | 迪嘉药业集团股份有限公司 | 一种高纯度沙库巴曲钙的制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5217996A (en) | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
CN1615134A (zh) | 2002-01-17 | 2005-05-11 | 诺瓦提斯公司 | 含有缬沙坦和nep抑制剂的药物组合物 |
WO2007045663A2 (en) | 2005-10-19 | 2007-04-26 | Novartis Ag | Combination of an ati receptor antagonist and a np inhibitor fro treating ia hypertension and heartfailure |
AR057882A1 (es) | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
EP1903027A1 (en) | 2006-09-13 | 2008-03-26 | Novartis AG | Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors |
JP5715339B2 (ja) | 2007-01-12 | 2015-05-07 | ノバルティス アーゲー | 5−ビフェニル−4−アミノ−2−メチルペンタン酸の製造方法 |
AR070176A1 (es) | 2008-01-17 | 2010-03-17 | Novartis Ag | Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis |
PT2526088E (pt) | 2010-01-22 | 2015-11-03 | Novartis Ag | Intermediários dos inibidores da endopeptidase neutra e método de preparação dos mesmos |
WO2012025501A1 (en) | 2010-08-23 | 2012-03-01 | Novartis Ag | Process for the preparation of intermediates for the manufacture of nep inhibitors |
CN103080072B (zh) | 2010-08-23 | 2016-03-16 | 诺华有限公司 | 制备可用于生产nep抑制剂的中间体的新方法 |
AR092278A1 (es) | 2012-08-31 | 2015-04-08 | Novartis Ag | Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados |
US20160206597A1 (en) | 2013-08-26 | 2016-07-21 | Toni Lynne Bransford | New Use |
WO2016029828A1 (zh) * | 2014-08-27 | 2016-03-03 | 上海翰森生物医药科技有限公司 | AHU-377结晶型游离酸、半钙盐、α﹣苯乙胺盐及其制备方法和应用 |
CN105622452A (zh) * | 2014-08-27 | 2016-06-01 | 上海翰森生物医药科技有限公司 | Ahu-377结晶型游离酸及其制备方法和应用 |
CN105461587A (zh) * | 2014-08-27 | 2016-04-06 | 上海翰森生物医药科技有限公司 | Ahu-377半钙盐晶型及其制备方法和应用 |
DK3218351T3 (da) * | 2014-11-14 | 2019-09-16 | Zentiva Ks | Fremgangsmåde til fremstilling, isolering og oprensning af farmaceutisk anvendelige former af ahu-377 |
CN105837464A (zh) * | 2015-01-15 | 2016-08-10 | 四川海思科制药有限公司 | 沙库比曲钠的晶型及其制备方法和用途 |
-
2016
- 2016-12-12 MX MX2018007129A patent/MX2018007129A/es unknown
- 2016-12-12 EP EP16818971.0A patent/EP3386945A1/en not_active Withdrawn
- 2016-12-12 BR BR112018011788A patent/BR112018011788A2/pt not_active Application Discontinuation
- 2016-12-12 WO PCT/CZ2016/000130 patent/WO2017097275A1/en active Application Filing
-
2018
- 2018-06-06 ZA ZA2018/03749A patent/ZA201803749B/en unknown
- 2018-06-12 CO CONC2018/0005941A patent/CO2018005941A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2017097275A1 (en) | 2017-06-15 |
EP3386945A1 (en) | 2018-10-17 |
MX2018007129A (es) | 2018-11-09 |
CO2018005941A2 (es) | 2018-07-10 |
BR112018011788A2 (pt) | 2018-12-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA201803749B (en) | Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method | |
IL258636A (en) | Acc inhibitors and uses thereof | |
EP3331530A4 (en) | Mthfd2 inhibitors and uses thereof | |
HUE053175T2 (hu) | ACC-gátló észterek és azok alkalmazása | |
IL287604A (en) | Formulations of pthrp analogs, their transdermal dressings and their uses | |
EP3284738A4 (en) | 5-aromatic alkynyl substituted benzamide compound and preparation method, pharmaceutical composition, and use thereof | |
HK1245772A1 (zh) | (2r,4r)-5-(5'-氯-2'-氟聯苯-4-基)-2-羥基-4-[(5-甲基惡唑-2-羰基)氨基]戊酸 | |
EP3292860A4 (en) | Cabazitaxel fat emulsion injection, and preparation method and use thereof | |
IL253601A0 (en) | (2-5-(r4,s (5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as a neprilysin inhibitor | |
IL258820B (en) | System and method for contacting a seam | |
PL3621948T3 (pl) | Amino(met)akrylany | |
SG11201707248XA (en) | Management system and management method for packages of shuffled playing cards | |
EP3389664A4 (en) | MTHFD2 CAFFEIN INHIBITORS AND USES THEREOF | |
GB201507325D0 (en) | Method for application of a suture and suturing guides | |
PL3448946T3 (pl) | Sposób wytwarzania organopolisiloksanów z grupami funkcyjnymi (met)akrylanu | |
HK1245094A1 (zh) | 一種治療抑鬱症的藥物組合物及其製備方法 | |
HK1246172A1 (zh) | 配混了氨基酸的面部用皮膚外用劑 | |
HK1244224B (zh) | Mek抑制劑的藥物組合物及其製備方法 | |
SI3408264T1 (sl) | Nilotinibijev dinitrat (V) in njegove kristalne oblike | |
IL255024A0 (en) | Hydroxamic acids and their uses | |
GB201504936D0 (en) | Suture anchor delivery tool | |
GB201621139D0 (en) | Agent and method for temporarily deforming keratin-containing fibers | |
GB201621141D0 (en) | Agent and method for temporarily deforming keratin-containing fibers | |
HUE051157T2 (hu) | Akrilsavszármazékot tartalmazó készítmény és eljárás akrilsavszármazék stabilizálására | |
EP3156051A4 (en) | Pharmaceutical composition combining an anticonvulsant and a derivate of nicotinic acid |