ZA200908751B - ACE2 polypeptide - Google Patents

ACE2 polypeptide

Info

Publication number: ZA200908751B
Authority: ZA; South Africa
Prior art keywords: ace2 polypeptide; ace2; polypeptide
Prior art date: 2007-06-12

Application number

ZA200908751A

Other languages

English (en)

Inventor

Manfred Schuster

Hans Loibner

Evelyne Janzek-Hawlat

Bernhard Peball

Stefan Stranner

Bettina Wagner

Robert Weik

Original Assignee

Apeiron Biologics Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-12

Filing date

2009-01-01

Publication date

2010-07-28

2008-04-08 Priority claimed from EP08450052A external-priority patent/EP2108695A1/de

2009-01-01 Application filed by Apeiron Biologics Ag filed Critical Apeiron Biologics Ag

2010-07-28 Publication of ZA200908751B publication Critical patent/ZA200908751B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/485—Exopeptidases (3.4.11-3.4.19)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/17—Metallocarboxypeptidases (3.4.17)
- C12Y304/17023—Angiotensin-converting enzyme 2 (3.4.17.23)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Cardiology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Toxicology (AREA)
Biophysics (AREA)
Cell Biology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

ZA200908751A 2007-06-12 2009-01-01 ACE2 polypeptide ZA200908751B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT0091307A AT505262A1 (de)	2007-06-12	2007-06-12	Rekombinantes ace2 polypeptid
EP08450052A EP2108695A1 (de)	2008-04-08	2008-04-08	Ace2 Polypeptid

Publications (1)

Publication Number	Publication Date
ZA200908751B true ZA200908751B (en)	2010-07-28

Family

ID=39720296

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200908751A ZA200908751B (en)	2007-06-12	2009-01-01	ACE2 polypeptide

Country Status (35)

Country	Link
US (3)	US8586319B2 (hu)
EP (3)	EP2155871B1 (hu)
JP (1)	JP5731193B2 (hu)
KR (2)	KR101682240B1 (hu)
CN (2)	CN101796183A (hu)
AT (1)	AT505262A1 (hu)
AU (1)	AU2008261591B2 (hu)
BR (1)	BRPI0813942B8 (hu)
CA (1)	CA2692854C (hu)
CO (1)	CO6270265A2 (hu)
CR (1)	CR11213A (hu)
CY (2)	CY1116873T1 (hu)
DK (2)	DK2155871T3 (hu)
DO (1)	DOP2009000282A (hu)
EA (1)	EA027399B1 (hu)
EG (1)	EG27095A (hu)
ES (2)	ES2670938T3 (hu)
HK (2)	HK1136602A1 (hu)
HR (2)	HRP20151120T1 (hu)
HU (2)	HUE037877T2 (hu)
IL (1)	IL202653B (hu)
LT (1)	LT2543724T (hu)
MA (1)	MA31472B1 (hu)
MX (1)	MX2009013472A (hu)
MY (1)	MY180672A (hu)
NO (1)	NO2543724T3 (hu)
NZ (1)	NZ581704A (hu)
PL (2)	PL2543724T3 (hu)
PT (2)	PT2155871E (hu)
RS (2)	RS54340B1 (hu)
SI (2)	SI2155871T1 (hu)
TR (1)	TR201808117T4 (hu)
UA (1)	UA106869C2 (hu)
WO (1)	WO2008151347A1 (hu)
ZA (1)	ZA200908751B (hu)

Families Citing this family (37)

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Publication number	Priority date	Publication date	Assignee	Title
US20150038413A1 (en)	2006-02-03	2015-02-05	Opko Biologics Ltd.	Long-acting polypeptides and methods of producing and administering same
US9249407B2 (en)	2006-02-03	2016-02-02	Opko Biologics Ltd.	Long-acting coagulation factors and methods of producing same
US10221228B2 (en)	2006-02-03	2019-03-05	Opko Biologics Ltd.	Long-acting polypeptides and methods of producing and administering same
US20140113860A1 (en)	2006-02-03	2014-04-24	Prolor Biotech Ltd.	Long-acting polypeptides and methods of producing and administering same
US8946155B2 (en)	2006-02-03	2015-02-03	Opko Biologics Ltd.	Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en)	2006-02-03	2016-10-04	Opko Biologics Ltd.	Long-acting coagulation factors and methods of producing same
US8048849B2 (en)	2006-02-03	2011-11-01	Modigene, Inc.	Long-acting polypeptides and methods of producing same
US10351615B2 (en)	2006-02-03	2019-07-16	Opko Biologics Ltd.	Methods of treatment with long-acting growth hormone
AT505262A1 (de) *	2007-06-12	2008-12-15	Apeiron Biolog Forschungs Und	Rekombinantes ace2 polypeptid
EP2077119A1 (de) *	2007-12-21	2009-07-08	Apeiron Biologics Forschungs- und Entwicklungsgesellschaft M.B.H.	Behandlung von Fibrosen und Lebererkrankungen
AT506632A1 (de) *	2008-04-09	2009-10-15	Apeiron Biolog Forschungs Und	Behandlung von tumorerkrankungen
US9663778B2 (en)	2009-07-09	2017-05-30	OPKO Biologies Ltd.	Long-acting coagulation factors and methods of producing same
WO2013157002A1 (en)	2012-04-19	2013-10-24	Prolor Biotech Inc.	Long-acting oxyntomodulin variants and methods of producing same
JP6388581B2 (ja)	2012-08-02	2018-09-12	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	単量体および多量体分子を生産するための方法およびその使用
EP3848386A1 (en)	2012-11-20	2021-07-14	OPKO Biologics Ltd.	Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides
US9757433B2 (en)	2013-01-14	2017-09-12	Apeiron Biologicals AG	Modified ACE2 polypeptides
US20150158926A1 (en)	2013-10-21	2015-06-11	Opko Biologics, Ltd.	Long-acting polypeptides and methods of producing and administering same
US10960058B2 (en)	2015-06-19	2021-03-30	Opko Biologics Ltd.	Long-acting coagulation factors and methods of producing same
HUE064463T2 (hu)	2016-07-11	2024-03-28	Opko Biologics Ltd	Hosszantartó hatású VII. koagulációs faktor és az elõállítására vonatkozó eljárások
US11518788B2 (en) *	2020-07-10	2022-12-06	Avirus, Inc.	Methods and compositions for treating and preventing viral infection
WO2021190980A1 (en)	2020-03-22	2021-09-30	Quadrucept Bio Limited	Multimers for viral strain evolution
EP3884957A1 (en)	2020-03-26	2021-09-29	The University of British Columbia	Methods for treatment of virus and methods for screening of anti-virus reagent using organoids
US20230174611A1 (en) *	2020-04-24	2023-06-08	Administrators Of The Tulane Educational Fund	Compositions and methods for preventing or reducing the effects of infections by coronaviruses that bind the extracellular domain of the ace2 receptor
CN113667016A (zh) *	2020-05-15	2021-11-19	普米斯生物技术(珠海)有限公司	一种构建冠状病毒抗体的平台
WO2021247675A1 (en)	2020-06-02	2021-12-09	Ngm Biopharmaceuticals, Inc.	Coronavirus-binding agents and uses thereof
DE102020207224A1 (de)	2020-06-09	2021-12-09	Christoph Karle	Protein oder Peptid, insbesondere zur Prophylaxe und/oder Behandlung einer durch Coronaviren, insbesondere SARS-CoV-2-Viren, hervorgerufenen Infektion oder Infektionskrankheit und/oder einer Folgekrankheit davon
CA3179834A1 (en) *	2020-06-25	2021-12-30	David S. Block	Ace2-fc fusion proteins and methods of use
WO2022008642A1 (en)	2020-07-08	2022-01-13	Apeiron Biologics Ag	Treatment of sars-cov-2 infection with a combination of targets
MX2023000504A (es) *	2020-07-10	2023-04-14	Biomolecular Holdings Llc	Anticuerpos tetrahedricos.
US20240035012A1 (en) *	2020-08-21	2024-02-01	Westlake University	Engineered ace2 oligomers and uses thereof
CN112280764A (zh) *	2020-11-18	2021-01-29	通用生物***（安徽）有限公司	一种新冠重组ace2蛋白在哺乳动物细胞中的生产方法
EP4011387A1 (en)	2020-12-11	2022-06-15	IMBA-Institut für Molekulare Biotechnologie GmbH	Superior neutralization of sars-cov-2 by deglycosylated human angiotensin converting enzyme 2
WO2022159433A1 (en)	2021-01-20	2022-07-28	Singh Biotechnology, Llc	Therapeutics directed against coronavirus
WO2022184659A1 (en)	2021-03-01	2022-09-09	Quadrucept Bio Limited	Antibody domains & multimers
WO2022207918A1 (en)	2021-04-02	2022-10-06	Apeiron Biologics Ag	COVID-19 Therapy
WO2023023424A1 (en)	2021-08-19	2023-02-23	Phenom Pharmaceuticals, Inc.	Compositions and methods for treatment of sars cov-2
CN113897346A (zh) *	2021-09-16	2022-01-07	四川大学	能够提高与SARS-CoV-2 S蛋白亲和力的ACE2突变组合及应用

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US6194556B1 (en) *	1997-12-11	2001-02-27	Millennium Pharmaceuticals, Inc.	Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therfor
US6989363B1 (en) *	1997-12-11	2006-01-24	Millennium Pharmaceuticals, Inc.	Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
US6610497B1 (en) *	1997-12-11	2003-08-26	Millennium Pharmaceuticals, Inc.	Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
EP2047867B1 (en)	2002-06-19	2013-05-22	Apeiron Biologics AG	ACE2 activation for treatment of heart, lung and kidney disease and hypertension
US20040209344A1 (en)	2002-09-09	2004-10-21	Pantoliano Michael W.	Crystal structure of angiotensin-converting enzyme-related carboxypeptidase
EP1723962A1 (en) *	2005-05-19	2006-11-22	IMBA-Institut für Molekulare Biotechnologie GmbH	Use of inhibitors of the renin-angiotensin system for the treatment of lung injuries
AT504443B1 (de) *	2006-10-19	2008-11-15	Apeiron Biolog Forschungs Und	Verfahren zur bestimmung der aktivität von ace2
EP2108695A1 (de)	2008-04-08	2009-10-14	Apeiron Biologics Forschungs- und Entwicklungsgesellschaft M.B.H.	Ace2 Polypeptid
AT505262A1 (de) *	2007-06-12	2008-12-15	Apeiron Biolog Forschungs Und	Rekombinantes ace2 polypeptid
AT506258A1 (de) *	2007-12-18	2009-07-15	Apeiron Biolog Forschungs Und	Behandlung inflammatorischer krankheiten
AT506632A1 (de) *	2008-04-09	2009-10-15	Apeiron Biolog Forschungs Und	Behandlung von tumorerkrankungen

2007
- 2007-06-12 AT AT0091307A patent/AT505262A1/de not_active Application Discontinuation
2008
- 2008-06-12 JP JP2010511445A patent/JP5731193B2/ja active Active
- 2008-06-12 DK DK08756821.8T patent/DK2155871T3/en active
- 2008-06-12 ES ES12165189.7T patent/ES2670938T3/es active Active
- 2008-06-12 RS RS20150709A patent/RS54340B1/en unknown
- 2008-06-12 SI SI200831514T patent/SI2155871T1/sl unknown
- 2008-06-12 EP EP08756821.8A patent/EP2155871B1/de active Active
- 2008-06-12 KR KR1020097027569A patent/KR101682240B1/ko active IP Right Grant
- 2008-06-12 RS RS20180677A patent/RS57292B1/sr unknown
- 2008-06-12 HU HUE12165189A patent/HUE037877T2/hu unknown
- 2008-06-12 EA EA201000002A patent/EA027399B1/ru unknown
- 2008-06-12 AU AU2008261591A patent/AU2008261591B2/en active Active
- 2008-06-12 PT PT87568218T patent/PT2155871E/pt unknown
- 2008-06-12 NZ NZ581704A patent/NZ581704A/en unknown
- 2008-06-12 MY MYPI20095316A patent/MY180672A/en unknown
- 2008-06-12 PL PL12165189T patent/PL2543724T3/pl unknown
- 2008-06-12 DK DK12165189.7T patent/DK2543724T3/en active
- 2008-06-12 CA CA2692854A patent/CA2692854C/en active Active
- 2008-06-12 CN CN200880100650A patent/CN101796183A/zh active Pending
- 2008-06-12 WO PCT/AT2008/000211 patent/WO2008151347A1/de active Application Filing
- 2008-06-12 PL PL08756821T patent/PL2155871T3/pl unknown
- 2008-06-12 EP EP18161541.0A patent/EP3375872A1/de not_active Withdrawn
- 2008-06-12 TR TR2018/08117T patent/TR201808117T4/tr unknown
- 2008-06-12 SI SI200831961T patent/SI2543724T1/en unknown
- 2008-06-12 ES ES08756821.8T patent/ES2550390T3/es active Active
- 2008-06-12 EP EP12165189.7A patent/EP2543724B1/de active Active
- 2008-06-12 UA UAA200912888A patent/UA106869C2/uk unknown
- 2008-06-12 LT LTEP12165189.7T patent/LT2543724T/lt unknown
- 2008-06-12 NO NO12165189A patent/NO2543724T3/no unknown
- 2008-06-12 BR BRPI0813942A patent/BRPI0813942B8/pt active IP Right Grant
- 2008-06-12 CN CN201410412672.3A patent/CN104450654A/zh active Pending
- 2008-06-12 HU HUE08756821A patent/HUE028012T2/hu unknown
- 2008-06-12 US US12/664,641 patent/US8586319B2/en active Active
- 2008-06-12 PT PT121651897T patent/PT2543724T/pt unknown
- 2008-06-12 KR KR1020167011786A patent/KR20160054045A/ko not_active Application Discontinuation
- 2008-06-12 MX MX2009013472A patent/MX2009013472A/es active IP Right Grant
2009
- 2009-01-01 ZA ZA200908751A patent/ZA200908751B/xx unknown
- 2009-12-10 EG EG2009121812A patent/EG27095A/xx active
- 2009-12-10 IL IL202653A patent/IL202653B/en active IP Right Grant
- 2009-12-11 DO DO2009000282A patent/DOP2009000282A/es unknown
- 2009-12-30 MA MA32464A patent/MA31472B1/fr unknown
2010
- 2010-01-08 CO CO10001879A patent/CO6270265A2/es not_active Application Discontinuation
- 2010-01-12 CR CR11213A patent/CR11213A/es unknown
- 2010-04-28 HK HK10104145.4A patent/HK1136602A1/xx unknown
- 2010-04-28 HK HK18114676.2A patent/HK1255493A1/zh unknown
2013
- 2013-09-13 US US14/026,887 patent/US20140099297A1/en not_active Abandoned
2015
- 2015-10-23 HR HRP20151120TT patent/HRP20151120T1/hr unknown
- 2015-10-26 CY CY20151100955T patent/CY1116873T1/el unknown
2017
- 2017-12-06 US US15/833,243 patent/US10716833B2/en active Active
2018
- 2018-05-23 CY CY20181100549T patent/CY1120426T1/el unknown
- 2018-05-30 HR HRP20180856TT patent/HRP20180856T1/hr unknown

Also Published As

Publication number	Publication date
HK1255493A1 (zh)	2019-08-16
EP3375872A1 (de)	2018-09-19
EP2543724A3 (de)	2013-02-20
US8586319B2 (en)	2013-11-19
AU2008261591A1 (en)	2008-12-18
EA201000002A1 (ru)	2010-08-30
PL2155871T3 (pl)	2015-12-31
US20140099297A1 (en)	2014-04-10
HUE037877T2 (hu)	2018-09-28
CY1120426T1 (el)	2019-07-10
KR20160054045A (ko)	2016-05-13
AT505262A1 (de)	2008-12-15
ES2550390T3 (es)	2015-11-06
LT2543724T (lt)	2018-06-25
MX2009013472A (es)	2010-06-25
EP2155871B1 (de)	2015-08-12
EP2543724B1 (de)	2018-03-21
AU2008261591B2 (en)	2014-08-07
EA027399B1 (ru)	2017-07-31
ES2670938T3 (es)	2018-06-04
MA31472B1 (fr)	2010-06-01
HRP20180856T1 (hr)	2018-08-24
CA2692854A1 (en)	2008-12-18
NZ581704A (en)	2012-05-25
BRPI0813942A2 (pt)	2014-12-30
CY1116873T1 (el)	2017-04-05
CA2692854C (en)	2017-07-04
HRP20151120T1 (en)	2015-11-20
IL202653B (en)	2018-01-31
WO2008151347A1 (de)	2008-12-18
PT2155871E (pt)	2015-10-26
BRPI0813942B8 (pt)	2021-05-25
EP2543724A2 (de)	2013-01-09
KR20100040809A (ko)	2010-04-21
BRPI0813942B1 (pt)	2019-08-20
CN101796183A (zh)	2010-08-04
NO2543724T3 (hu)	2018-08-18
RS54340B1 (en)	2016-02-29
US10716833B2 (en)	2020-07-21
SI2155871T1 (sl)	2015-11-30
HUE028012T2 (hu)	2016-11-28
RS57292B1 (sr)	2018-08-31
US20180289779A1 (en)	2018-10-11
JP2011519264A (ja)	2011-07-07
CO6270265A2 (es)	2011-04-20
CN104450654A (zh)	2015-03-25
PT2543724T (pt)	2018-06-11
HK1136602A1 (en)	2010-07-02
TR201808117T4 (tr)	2018-07-23
SI2543724T1 (en)	2018-07-31
DK2543724T3 (en)	2018-05-28
JP5731193B2 (ja)	2015-06-10
CR11213A (es)	2010-04-20
EG27095A (en)	2015-05-28
MY180672A (en)	2020-12-05
DOP2009000282A (es)	2010-03-31
EP2155871A1 (de)	2010-02-24
IL202653A0 (en)	2011-08-01
DK2155871T3 (en)	2015-11-09
US20100310546A1 (en)	2010-12-09
PL2543724T3 (pl)	2018-08-31
UA106869C2 (uk)	2014-10-27
KR101682240B1 (ko)	2016-12-06

Publication	Publication Date	Title
HRP20151120T1 (en)	2015-11-20	Ace2 polypeptide
ZA200810738B (en)	2018-11-28	Polypeptide
DE602007008470D1 (en)	2010-09-23	Off
GB0721686D0 (en)	2007-12-12	Polypeptides
EP2360172A4 (en)	2012-03-07	BIPODAL PEPTIDE BINDER
ZA201000283B (en)	2011-06-29	Reinigung pegylierter polypeptide
GB0723712D0 (en)	2008-01-16	Peptides
GB201009543D0 (en)	2010-07-21	Geothermiesystem
EP2123666A4 (en)	2011-01-05	PEPTIDE
GB0723387D0 (en)	2008-01-09	Improved dehumldifier
GB0809659D0 (en)	2008-07-02	Polypeptides
GB0712302D0 (en)	2007-08-01	Chrondroitinase polypeptides
GB0703945D0 (en)	2007-04-11	Peptide
GB0713585D0 (en)	2007-08-22	Equivalent
IL197675A0 (en)	2009-12-24	Peptides
GB0703927D0 (en)	2007-04-11	Fuel
KG1098C1 (en)	2008-11-29	Towel-drying construction
GB0705251D0 (en)	2007-04-25	Peptides
GB0705115D0 (en)	2007-04-25	Peptides
GB0707626D0 (en)	2007-05-30	Peptides
GB0721702D0 (en)	2007-12-12	Hydrogienic globaltechnology limited
GB0609691D0 (en)	2006-06-28	Corcost 5a
GB0706942D0 (en)	2007-05-16	Fuel store-2
GB0717492D0 (en)	2007-10-24	Turn case
GB0705748D0 (en)	2007-05-02	Finally finally