CR11213A - Ace2 polypeptide - Google Patents

Ace2 polypeptide

Info

Publication number
CR11213A
CR11213A CR11213A CR11213A CR11213A CR 11213 A CR11213 A CR 11213A CR 11213 A CR11213 A CR 11213A CR 11213 A CR11213 A CR 11213A CR 11213 A CR11213 A CR 11213A
Authority
CR
Costa Rica
Prior art keywords
ace2 polypeptide
dimer
present
polypeptide
ace2
Prior art date
Application number
CR11213A
Other languages
English (en)
Inventor
Manfred Schuster
Hans Loibner
Janzek-Hawlat
Bernhard Peball
Stefan Stranner
Bettina Wagner
Original Assignee
Apeiron Biologics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP08450052A external-priority patent/EP2108695A1/de
Application filed by Apeiron Biologics Ag filed Critical Apeiron Biologics Ag
Publication of CR11213A publication Critical patent/CR11213A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485—Exopeptidases (3.4.11-3.4.19)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/17—Metallocarboxypeptidases (3.4.17)
    • C12Y304/17023—Angiotensin-converting enzyme 2 (3.4.17.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invencion se relaciona al polipeptido ACE2 recombinante, donde el polipeptido ACE2esta presente como un dImero. El dimero se forma especificamente de monomeros glicosilados y se usa para producir productos farmaceuticos con una vida media prolongada.
CR11213A 2007-06-12 2010-01-12 Ace2 polypeptide CR11213A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0091307A AT505262A1 (de) 2007-06-12 2007-06-12 Rekombinantes ace2 polypeptid
EP08450052A EP2108695A1 (de) 2008-04-08 2008-04-08 Ace2 Polypeptid

Publications (1)

Publication Number Publication Date
CR11213A true CR11213A (es) 2010-04-20

Family

ID=39720296

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11213A CR11213A (es) 2007-06-12 2010-01-12 Ace2 polypeptide

Country Status (35)

Country Link
US (3) US8586319B2 (es)
EP (3) EP2155871B1 (es)
JP (1) JP5731193B2 (es)
KR (2) KR20160054045A (es)
CN (2) CN101796183A (es)
AT (1) AT505262A1 (es)
AU (1) AU2008261591B2 (es)
BR (1) BRPI0813942B8 (es)
CA (1) CA2692854C (es)
CO (1) CO6270265A2 (es)
CR (1) CR11213A (es)
CY (2) CY1116873T1 (es)
DK (2) DK2155871T3 (es)
DO (1) DOP2009000282A (es)
EA (1) EA027399B1 (es)
EG (1) EG27095A (es)
ES (2) ES2670938T3 (es)
HK (2) HK1255493A1 (es)
HR (2) HRP20151120T1 (es)
HU (2) HUE037877T2 (es)
IL (1) IL202653B (es)
LT (1) LT2543724T (es)
MA (1) MA31472B1 (es)
MX (1) MX2009013472A (es)
MY (1) MY180672A (es)
NO (1) NO2543724T3 (es)
NZ (1) NZ581704A (es)
PL (2) PL2155871T3 (es)
PT (2) PT2155871E (es)
RS (2) RS54340B1 (es)
SI (2) SI2543724T1 (es)
TR (1) TR201808117T4 (es)
UA (1) UA106869C2 (es)
WO (1) WO2008151347A1 (es)
ZA (1) ZA200908751B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
AT505262A1 (de) * 2007-06-12 2008-12-15 Apeiron Biolog Forschungs Und Rekombinantes ace2 polypeptid
EP2077119A1 (de) * 2007-12-21 2009-07-08 Apeiron Biologics Forschungs- und Entwicklungsgesellschaft M.B.H. Behandlung von Fibrosen und Lebererkrankungen
AT506632A1 (de) * 2008-04-09 2009-10-15 Apeiron Biolog Forschungs Und Behandlung von tumorerkrankungen
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
SG11201406671RA (en) 2012-04-19 2014-11-27 Opko Biolog Ltd Long-acting oxyntomodulin variants and methods of producing same
EP2880169B1 (en) 2012-08-02 2017-05-17 F. Hoffmann-La Roche AG Method for producing monomeric and multimeric molecules and uses thereof
MY172997A (en) 2012-11-20 2019-12-18 Opko Biologics Ltd Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides
CN105263512A (zh) * 2013-01-14 2016-01-20 阿派隆生物制剂股份公司 经修饰的ace2多肽
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
IL301728A (en) 2015-06-19 2023-05-01 Opko Biologics Ltd Long-term coagulation factors and methods for their preparation
BR112019000610A2 (pt) 2016-07-11 2019-07-02 Opko Biologics Ltd fator vii de coagulação de longa ação e métodos de produção do mesmo
US11518788B2 (en) * 2020-07-10 2022-12-06 Avirus, Inc. Methods and compositions for treating and preventing viral infection
WO2021190980A1 (en) 2020-03-22 2021-09-30 Quadrucept Bio Limited Multimers for viral strain evolution
EP3884957A1 (en) 2020-03-26 2021-09-29 The University of British Columbia Methods for treatment of virus and methods for screening of anti-virus reagent using organoids
US20230174611A1 (en) * 2020-04-24 2023-06-08 Administrators Of The Tulane Educational Fund Compositions and methods for preventing or reducing the effects of infections by coronaviruses that bind the extracellular domain of the ace2 receptor
CN113667016A (zh) * 2020-05-15 2021-11-19 普米斯生物技术(珠海)有限公司 一种构建冠状病毒抗体的平台
WO2021247675A1 (en) 2020-06-02 2021-12-09 Ngm Biopharmaceuticals, Inc. Coronavirus-binding agents and uses thereof
DE102020207224A1 (de) 2020-06-09 2021-12-09 Christoph Karle Protein oder Peptid, insbesondere zur Prophylaxe und/oder Behandlung einer durch Coronaviren, insbesondere SARS-CoV-2-Viren, hervorgerufenen Infektion oder Infektionskrankheit und/oder einer Folgekrankheit davon
WO2021263128A1 (en) * 2020-06-25 2021-12-30 Gliknik Inc. Ace2-fc fusion proteins and methods of use
WO2022008642A1 (en) 2020-07-08 2022-01-13 Apeiron Biologics Ag Treatment of sars-cov-2 infection with a combination of targets
TW202216777A (zh) * 2020-07-10 2022-05-01 美商生質分子控股有限責任公司 四面體抗體
CN116710560A (zh) * 2020-08-21 2023-09-05 西湖大学 工程化ace2寡聚物及其用途
CN112280764A (zh) * 2020-11-18 2021-01-29 通用生物***（安徽）有限公司 一种新冠重组ace2蛋白在哺乳动物细胞中的生产方法
EP4011387A1 (en) 2020-12-11 2022-06-15 IMBA-Institut für Molekulare Biotechnologie GmbH Superior neutralization of sars-cov-2 by deglycosylated human angiotensin converting enzyme 2
US20220226489A1 (en) 2021-01-20 2022-07-21 Singh Biotechnology, Llc Therapeutics directed against coronavirus
WO2022184659A1 (en) 2021-03-01 2022-09-09 Quadrucept Bio Limited Antibody domains & multimers
WO2022207918A1 (en) 2021-04-02 2022-10-06 Apeiron Biologics Ag COVID-19 Therapy
EP4387732A1 (en) 2021-08-19 2024-06-26 Phenom Pharmaceuticals, inc. Compositions and methods for treatment of sars cov-2
CN113897346A (zh) * 2021-09-16 2022-01-07 四川大学 能够提高与SARS-CoV-2 S蛋白亲和力的ACE2突变组合及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194556B1 (en) * 1997-12-11 2001-02-27 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therfor
US6989363B1 (en) * 1997-12-11 2006-01-24 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
US6610497B1 (en) * 1997-12-11 2003-08-26 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
JP4598518B2 (ja) 2002-06-19 2010-12-15 ユニバーシティー ヘルス ネットワーク 心臓、肺および腎臓疾患および高血圧症の治療のためのａｃｅ２活性化
US20040209344A1 (en) 2002-09-09 2004-10-21 Pantoliano Michael W. Crystal structure of angiotensin-converting enzyme-related carboxypeptidase
EP1723962A1 (en) * 2005-05-19 2006-11-22 IMBA-Institut für Molekulare Biotechnologie GmbH Use of inhibitors of the renin-angiotensin system for the treatment of lung injuries
AT504443B1 (de) * 2006-10-19 2008-11-15 Apeiron Biolog Forschungs Und Verfahren zur bestimmung der aktivität von ace2
EP2108695A1 (de) 2008-04-08 2009-10-14 Apeiron Biologics Forschungs- und Entwicklungsgesellschaft M.B.H. Ace2 Polypeptid
AT505262A1 (de) * 2007-06-12 2008-12-15 Apeiron Biolog Forschungs Und Rekombinantes ace2 polypeptid
AT506258A1 (de) * 2007-12-18 2009-07-15 Apeiron Biolog Forschungs Und Behandlung inflammatorischer krankheiten
AT506632A1 (de) * 2008-04-09 2009-10-15 Apeiron Biolog Forschungs Und Behandlung von tumorerkrankungen

Also Published As

Publication number Publication date
AT505262A1 (de) 2008-12-15
IL202653A0 (en) 2011-08-01
PT2543724T (pt) 2018-06-11
DK2155871T3 (en) 2015-11-09
EA027399B1 (ru) 2017-07-31
JP5731193B2 (ja) 2015-06-10
IL202653B (en) 2018-01-31
LT2543724T (lt) 2018-06-25
DK2543724T3 (en) 2018-05-28
ES2670938T3 (es) 2018-06-04
NZ581704A (en) 2012-05-25
MY180672A (en) 2020-12-05
HRP20180856T1 (hr) 2018-08-24
EP2543724A3 (de) 2013-02-20
ZA200908751B (en) 2010-07-28
CY1116873T1 (el) 2017-04-05
HUE028012T2 (en) 2016-11-28
PL2543724T3 (pl) 2018-08-31
UA106869C2 (uk) 2014-10-27
US10716833B2 (en) 2020-07-21
RS57292B1 (sr) 2018-08-31
PT2155871E (pt) 2015-10-26
CO6270265A2 (es) 2011-04-20
CA2692854A1 (en) 2008-12-18
US8586319B2 (en) 2013-11-19
DOP2009000282A (es) 2010-03-31
KR20160054045A (ko) 2016-05-13
EP2543724A2 (de) 2013-01-09
AU2008261591A1 (en) 2008-12-18
ES2550390T3 (es) 2015-11-06
CN101796183A (zh) 2010-08-04
US20180289779A1 (en) 2018-10-11
WO2008151347A1 (de) 2008-12-18
AU2008261591B2 (en) 2014-08-07
EP2543724B1 (de) 2018-03-21
EP2155871A1 (de) 2010-02-24
BRPI0813942B8 (pt) 2021-05-25
EP3375872A1 (de) 2018-09-19
EA201000002A1 (ru) 2010-08-30
RS54340B1 (en) 2016-02-29
CY1120426T1 (el) 2019-07-10
HUE037877T2 (hu) 2018-09-28
SI2155871T1 (sl) 2015-11-30
JP2011519264A (ja) 2011-07-07
US20140099297A1 (en) 2014-04-10
TR201808117T4 (tr) 2018-07-23
KR20100040809A (ko) 2010-04-21
BRPI0813942A2 (pt) 2014-12-30
US20100310546A1 (en) 2010-12-09
EG27095A (en) 2015-05-28
PL2155871T3 (pl) 2015-12-31
HRP20151120T1 (en) 2015-11-20
HK1255493A1 (zh) 2019-08-16
MA31472B1 (fr) 2010-06-01
HK1136602A1 (en) 2010-07-02
KR101682240B1 (ko) 2016-12-06
BRPI0813942B1 (pt) 2019-08-20
NO2543724T3 (es) 2018-08-18
CN104450654A (zh) 2015-03-25
CA2692854C (en) 2017-07-04
EP2155871B1 (de) 2015-08-12
MX2009013472A (es) 2010-06-25
SI2543724T1 (en) 2018-07-31

Similar Documents

Publication Publication Date Title
CR11213A (es) Ace2 polypeptide
EA201171325A1 (ru) Нуклеиновые кислоты, связывающиеся с гепсидином
ECSP12011577A (es) Produccion recombinante de péptidos
CR11203S (es) Botella
PT3516966T (pt) Uma fração concentrada de hidrolisado de proteína de krill
CL2007003849A1 (es) Compuestos derivados de nafto[c]pirrol sustituidos con aminoacidos, utiles para tratar el cancer.
CR9280S (es) Botella
NI201000004S (es) Botella
BR112012007990A2 (pt) preparado farmacêutico compreendendo hcg recombinante
CR10633S (es) Botella
WO2010119455A3 (en) An injectable sustained release pharmaceutical composition
TWD147577S (zh) 發光二極體封裝
ES2415029A8 (es) Composición farmacéutica y uso de un anticuerpo para preparar un medicamento destinado a inhibir la producción o amplificar la eliminación de la proteína P24.
CY1113641T1 (el) Φαρμακευτικη συνθεση που περιλαμβανει aleglitazar
JP2012204677A5 (es)
DE602006019567D1 (de) Peptide, die die collagen- oder hyaluronsäureproduktion erhöhen
NI201300116A (es) Formulaciones de liberación sostenida de paracetamol
USD682450S1 (en) Head-mountable LED illuminator
NI201000007S (es) Parte mas alta de la botella
BR112012026016A2 (pt) combinação de um inibidor macrocíclico de hcv, um não-nucleosídeo e um nucleosídeo
IT1396316B1 (it) Proiettore ad ampia diffusione con sorgenti leds precollimate.
NI201000009S (es) Parte mas baja de la botella
TR201200639A2 (tr) Tek parçalı yapısı haiz bir terlik.
TH131841S (th) โคมไฟ
TH103871S (th) ตะไบแต่งเล็บสัตว์เลี้ยง