ZA200905116B - Macrocyclic compound - Google Patents
Macrocyclic compoundInfo
- Publication number
- ZA200905116B ZA200905116B ZA200905116A ZA200905116A ZA200905116B ZA 200905116 B ZA200905116 B ZA 200905116B ZA 200905116 A ZA200905116 A ZA 200905116A ZA 200905116 A ZA200905116 A ZA 200905116A ZA 200905116 B ZA200905116 B ZA 200905116B
- Authority
- ZA
- South Africa
- Prior art keywords
- macrocyclic compound
- macrocyclic
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/20—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007052072 | 2007-03-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200905116B true ZA200905116B (en) | 2010-07-28 |
Family
ID=39721348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200905116A ZA200905116B (en) | 2007-03-01 | 2009-07-22 | Macrocyclic compound |
Country Status (18)
Country | Link |
---|---|
US (1) | US8362236B2 (ja) |
EP (1) | EP2119718B1 (ja) |
JP (1) | JP5235859B2 (ja) |
KR (1) | KR20090125155A (ja) |
CN (1) | CN101675059A (ja) |
AR (1) | AR065583A1 (ja) |
AT (1) | ATE553107T1 (ja) |
AU (1) | AU2008220009A1 (ja) |
BR (1) | BRPI0808524A2 (ja) |
CA (1) | CA2679126A1 (ja) |
CL (1) | CL2008000629A1 (ja) |
IL (1) | IL200009A0 (ja) |
MX (1) | MX2009008756A (ja) |
PE (1) | PE20090110A1 (ja) |
RU (1) | RU2009136343A (ja) |
TW (1) | TW200904435A (ja) |
WO (1) | WO2008105526A1 (ja) |
ZA (1) | ZA200905116B (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR061185A1 (es) * | 2006-05-26 | 2008-08-13 | Chugai Pharmaceutical Co Ltd | Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas. |
BRPI0808524A2 (pt) | 2007-03-01 | 2014-11-11 | Chugai Pharmaceutical Co Ltd | Composto macrocíclico |
AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
SI2822953T1 (sl) | 2012-03-06 | 2017-04-26 | Pfizer Inc. | Makrociklični derivati za zdravljenje proliferativnih bolezni |
NZ630901A (en) * | 2012-03-17 | 2015-09-25 | Polyphor Ag | Conformationally constrained, fully synthetic macrocyclic compounds |
WO2014143672A1 (en) * | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Macrocyclic compounds as irak4 inhibitors for the treatment of inflammatory diseases |
PL3053578T3 (pl) | 2013-09-30 | 2021-06-14 | Taiho Pharmaceutical Co., Ltd. | Skojarzona terapia przeciwnowotworowa z zastosowaniem związku azabicyklicznego |
EP3623378A4 (en) * | 2017-05-12 | 2021-03-03 | Chugai Seiyaku Kabushiki Kaisha | METHOD OF MAKING A CYCLIC ORGANIC COMPOUND |
WO2022089449A1 (zh) * | 2020-10-26 | 2022-05-05 | 山东大学 | 一种特异性热休克蛋白90α亚型抑制剂制备及其应用 |
CN115124550B (zh) * | 2020-10-26 | 2024-04-02 | 山东大学 | 一种特异性热休克蛋白90α亚型抑制剂制备及其应用 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5170780A (ja) | 1974-12-17 | 1976-06-18 | Nippon Shinyaku Co Ltd | Shinkinabenzoguanidoruino seiho |
JPS60208968A (ja) | 1984-03-07 | 1985-10-21 | イー・アイ・デユポン・デ・ニモアス・アンド・カンパニー | 除草剤性フルオロエトキシピリミジン類及びトリアジン類 |
AU585761B2 (en) | 1984-03-07 | 1989-06-22 | E.I. Du Pont De Nemours And Company | Herbicidal fluoroethoxy triazines |
TW440563B (en) | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
CA2263301A1 (en) | 1996-11-01 | 1998-05-14 | Warner-Lambert Company | Isoquinolones |
US5968921A (en) | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
AU3378599A (en) | 1998-04-03 | 1999-10-25 | University Of Pittsburgh | Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke |
JP2001226358A (ja) | 1999-10-12 | 2001-08-21 | Japan Tobacco Inc | Lpl活性増強剤 |
BR0108611A (pt) | 2000-02-25 | 2003-05-06 | Hoffmann La Roche | Moduladores de receptor de adenosina |
AU2001271567A1 (en) | 2000-06-29 | 2002-01-14 | Trustees Of Boston University | Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders |
KR20030046397A (ko) | 2000-07-28 | 2003-06-12 | 슬로안-케테링인스티튜트퍼캔서리서치 | 세포증식성 질환 및 바이러스 감염의 치료 방법 |
CN1501928A (zh) | 2000-11-02 | 2004-06-02 | 斯隆-凯特林癌症研究所 | 结合hsp90的小分子组合物 |
JP2004512381A (ja) | 2000-11-02 | 2004-04-22 | スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ | Hsp90インヒビターの使用により細胞毒性剤の効力を増強させる方法 |
AU2002343604C1 (en) | 2001-10-30 | 2009-09-17 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
WO2003037346A1 (en) | 2001-10-31 | 2003-05-08 | Cell Therapeutics, Inc. | 6-phenyl-n-phenyl-(1,3,5) -triazine-2,4-diamine derivatives and related compounds with lysophphosphatidic acid acyltransferase beta (lpaat-beta) inhibitory activity for use in the treatment of cancer |
EP1321169A1 (en) | 2001-12-18 | 2003-06-25 | Biofrontera Pharmaceuticals AG | Combination of a serotonin receptor antagonist with a histidine decarboxylase inhibitor as a medicament |
DE60222804T2 (de) | 2001-12-21 | 2008-07-03 | Vernalis (Cambridge) Ltd., Abington | 3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung |
AU2003217393B8 (en) * | 2002-02-08 | 2009-06-25 | Conforma Therapeutics Corporation | Ansamycins having improved pharmacological and biological properties |
US7419984B2 (en) | 2002-10-17 | 2008-09-02 | Cell Therapeutics, Inc. | Pyrimidines and uses thereof |
GB0228417D0 (en) | 2002-12-05 | 2003-01-08 | Cancer Rec Tech Ltd | Pyrazole compounds |
NZ546044A (en) | 2003-08-29 | 2009-09-25 | Vernalis Cambridge Ltd | Pyrimidothiophene compounds |
JP2005225787A (ja) | 2004-02-12 | 2005-08-25 | Nippon Kayaku Co Ltd | Hsp90阻害剤 |
GB0416168D0 (en) | 2004-07-20 | 2004-08-18 | Vernalis Cambridge Ltd | Pyrmidothiophene compounds |
WO2006123165A2 (en) | 2005-05-19 | 2006-11-23 | Astex Therapeutics Limited | Pyrimidine derivatives as hsp90 inhibitors |
DE102005022977A1 (de) | 2005-05-19 | 2006-12-07 | Merck Patent Gmbh | Phenylchinazolinderivate |
WO2007058627A1 (en) | 2005-11-16 | 2007-05-24 | S*Bio Pte Ltd | Oxygen linked pyrimidine derivatives |
AR061185A1 (es) | 2006-05-26 | 2008-08-13 | Chugai Pharmaceutical Co Ltd | Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas. |
BRPI0808524A2 (pt) | 2007-03-01 | 2014-11-11 | Chugai Pharmaceutical Co Ltd | Composto macrocíclico |
JP2009067729A (ja) | 2007-09-14 | 2009-04-02 | Kyowa Hakko Kirin Co Ltd | Hsp90ファミリー蛋白質阻害剤 |
ES2475206T3 (es) | 2008-02-01 | 2014-07-10 | Takeda Pharmaceutical Company Limited | Derivados de oxima como inhibidores de HSP90 |
-
2008
- 2008-02-29 BR BRPI0808524-2A2A patent/BRPI0808524A2/pt not_active IP Right Cessation
- 2008-02-29 AR ARP080100884A patent/AR065583A1/es unknown
- 2008-02-29 US US12/529,222 patent/US8362236B2/en not_active Expired - Fee Related
- 2008-02-29 KR KR1020097020448A patent/KR20090125155A/ko not_active Application Discontinuation
- 2008-02-29 PE PE2008000409A patent/PE20090110A1/es not_active Application Discontinuation
- 2008-02-29 AU AU2008220009A patent/AU2008220009A1/en not_active Abandoned
- 2008-02-29 RU RU2009136343/04A patent/RU2009136343A/ru unknown
- 2008-02-29 CL CL200800629A patent/CL2008000629A1/es unknown
- 2008-02-29 CA CA002679126A patent/CA2679126A1/en not_active Abandoned
- 2008-02-29 CN CN200880014171A patent/CN101675059A/zh not_active Withdrawn
- 2008-02-29 MX MX2009008756A patent/MX2009008756A/es not_active Application Discontinuation
- 2008-02-29 EP EP08721047A patent/EP2119718B1/en not_active Not-in-force
- 2008-02-29 TW TW097107103A patent/TW200904435A/zh unknown
- 2008-02-29 AT AT08721047T patent/ATE553107T1/de active
- 2008-02-29 WO PCT/JP2008/053599 patent/WO2008105526A1/ja active Application Filing
- 2008-02-29 JP JP2009501315A patent/JP5235859B2/ja not_active Expired - Fee Related
-
2009
- 2009-07-22 IL IL200009A patent/IL200009A0/en unknown
- 2009-07-22 ZA ZA200905116A patent/ZA200905116B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP2119718A1 (en) | 2009-11-18 |
EP2119718B1 (en) | 2012-04-11 |
CA2679126A1 (en) | 2008-09-04 |
RU2009136343A (ru) | 2011-04-10 |
AR065583A1 (es) | 2009-06-17 |
US20100056510A1 (en) | 2010-03-04 |
AU2008220009A1 (en) | 2008-09-04 |
CL2008000629A1 (es) | 2008-08-29 |
TW200904435A (en) | 2009-02-01 |
PE20090110A1 (es) | 2009-04-04 |
KR20090125155A (ko) | 2009-12-03 |
EP2119718A4 (en) | 2010-12-15 |
IL200009A0 (en) | 2010-04-15 |
BRPI0808524A2 (pt) | 2014-11-11 |
JPWO2008105526A1 (ja) | 2010-06-03 |
WO2008105526A1 (ja) | 2008-09-04 |
CN101675059A (zh) | 2010-03-17 |
ATE553107T1 (de) | 2012-04-15 |
JP5235859B2 (ja) | 2013-07-10 |
MX2009008756A (es) | 2009-08-27 |
US8362236B2 (en) | 2013-01-29 |
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