ZA200505684B - N-(indolethyl-)cycloamine compounds - Google Patents

N-(indolethyl-)cycloamine compounds Download PDF

Info

Publication number: ZA200505684B
Authority: ZA; South Africa
Prior art keywords: denotes; formula; ratios; pharmaceutically usable; compounds
Prior art date: 2002-12-17

Application number

ZA200505684A

Other languages

English (en)

Inventor

Timo Heinrich

Kai Schiemann

Christoph Van Amsterdam

Joachim Leibrock

Henning Boettcher

Guenter Hoeltzemann

Gerd Bartoszyk

Christoph Seyfried

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-17

Filing date

2005-07-14

Publication date

2006-04-26

2005-07-14 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2006-04-26 Publication of ZA200505684B publication Critical patent/ZA200505684B/en

Links

150000001875 compounds Chemical class 0.000 title claims description 98
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238000002360 preparation method Methods 0.000 claims description 23
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238000007911 parenteral administration Methods 0.000 description 1
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230000000144 pharmacologic effect Effects 0.000 description 1
150000003016 phosphoric acids Chemical class 0.000 description 1
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229930006728 pinane Natural products 0.000 description 1
IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
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239000003755 preservative agent Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
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230000001681 protective effect Effects 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000010992 reflux Methods 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
239000004576 sand Substances 0.000 description 1
230000007017 scission Effects 0.000 description 1
125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
229940076279 serotonin Drugs 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
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235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
238000003797 solvolysis reaction Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
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238000003756 stirring Methods 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
125000003107 substituted aryl group Chemical group 0.000 description 1
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150000003460 sulfonic acids Chemical class 0.000 description 1
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239000000829 suppository Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
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239000000454 talc Substances 0.000 description 1
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238000002560 therapeutic procedure Methods 0.000 description 1
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229960002622 triacetin Drugs 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
SMBZJSVIKJMSFP-UHFFFAOYSA-N trifluoromethyl hypofluorite Chemical compound FOC(F)(F)F SMBZJSVIKJMSFP-UHFFFAOYSA-N 0.000 description 1
229940099259 vaseline Drugs 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
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239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
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- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

ZA200505684A 2002-12-17 2005-07-14 N-(indolethyl-)cycloamine compounds ZA200505684B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10259244A DE10259244A1 (de)	2002-12-17	2002-12-17	N-(Indolethyl-)cycloamin-Verbindungen

Publications (1)

Publication Number	Publication Date
ZA200505684B true ZA200505684B (en)	2006-04-26

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ZA200505684A ZA200505684B (en)	2002-12-17	2005-07-14	N-(indolethyl-)cycloamine compounds

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US (1)	US20060122191A1 (zh)
EP (1)	EP1572646A1 (zh)
JP (1)	JP2006511522A (zh)
KR (1)	KR20050085697A (zh)
CN (1)	CN1729173A (zh)
AU (1)	AU2003298145A1 (zh)
BR (1)	BR0317422A (zh)
CA (1)	CA2510169A1 (zh)
DE (1)	DE10259244A1 (zh)
MX (1)	MXPA05006385A (zh)
PL (1)	PL377519A1 (zh)
RU (1)	RU2005122615A (zh)
WO (1)	WO2004054972A1 (zh)
ZA (1)	ZA200505684B (zh)

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DE10326940A1 (de) *	2003-06-16	2005-01-05	Merck Patent Gmbh	Indol-Derivate
DE10326939A1 (de) *	2003-06-16	2005-01-05	Merck Patent Gmbh	Indol-Derivate
PE20060373A1 (es)	2004-06-24	2006-04-29	Smithkline Beecham Corp	Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2
CN1989115B (zh) *	2004-07-26	2012-03-21	伊莱利利公司	作为组胺h3受体药物的噁唑衍生物及其制备和制药用途
TW200626142A (en)	2004-09-21	2006-08-01	Glaxo Group Ltd	Chemical compounds
US7371769B2 (en)	2004-12-07	2008-05-13	Solvay Pharmaceuticals B.V.	Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
ATE425754T1 (de) *	2004-12-07	2009-04-15	Solvay Pharm Bv	Bezdioxan-piperazin-derivate mit einer kombination aus affinitat fur dopamin-d2- rezeptoren und serotonin-wiederaufnahme-stellen
US20070072870A2 (en)	2004-12-08	2007-03-29	Solvay Pharmeceuticals B.V.	Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
DE102004063797A1 (de) *	2004-12-30	2006-07-13	Schwarz Pharma Ag	Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide
US8063071B2 (en)	2007-10-31	2011-11-22	GlaxoSmithKline, LLC	Chemical compounds
AR065804A1 (es)	2007-03-23	2009-07-01	Smithkline Beecham Corp	Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
JP2012520257A (ja)	2009-03-10	2012-09-06	グラクソグループリミテッド	Ｉｋｋ２阻害剤としてのインドール誘導体
US8367676B2 (en) *	2009-06-30	2013-02-05	Astrazeneca Ab	2-carboxamide-7-piperazinyl-benzofuran derivatives 774
CN104337812B (zh)	2013-07-29	2018-09-14	广东东阳光药业有限公司	取代的杂芳基化合物及其使用方法和用途
US9714232B2 (en)	2013-12-20	2017-07-25	Sunshine Lake Pharma Co., Ltd.	Substituted piperazine compounds and methods of use thereof
CN106243088B (zh)	2015-06-03	2019-01-04	广东东阳光药业有限公司	取代的哌嗪化合物及其使用方法和用途
US11285153B2 (en)	2017-09-29	2022-03-29	Sunshine Lake Pharma Co., Ltd.	Substituted pyrimidine piperazine compound and use thereof

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DE4333254A1 (de) *	1993-09-30	1995-04-06	Merck Patent Gmbh	Piperidine und Piperazine
DE19730989A1 (de) *	1997-07-18	1999-01-21	Merck Patent Gmbh	Piperazin-Derivate
US20030040639A1 (en) *	1999-12-30	2003-02-27	H. Lundbeck A/S	Method for the preparation of substituted benzene derivatives
WO2001049678A1 (en) *	1999-12-30	2001-07-12	H. Lundbeck A/S	Substituted phenyl-piperazine derivatives, their preparation and use
DE10112151A1 (de) *	2001-03-14	2002-09-19	Merck Patent Gmbh	Substituierte Benzofuran-2-carbonsäureamide
UA76758C2 (uk) *	2001-06-19	2006-09-15	Мерк Патент Гмбх	Поліморфні форми гідрохлориду 1-'4-(5-ціаноіндол-3-іл)бутил-4-(2-карбамоїлбензофуран-5-іл)піперазину
DE10217006A1 (de) *	2002-04-16	2003-11-06	Merck Patent Gmbh	Substituierte Indole

2002
- 2002-12-17 DE DE10259244A patent/DE10259244A1/de not_active Withdrawn
2003
- 2003-11-27 JP JP2004559727A patent/JP2006511522A/ja active Pending
- 2003-11-27 US US10/539,516 patent/US20060122191A1/en not_active Abandoned
- 2003-11-27 MX MXPA05006385A patent/MXPA05006385A/es unknown
- 2003-11-27 AU AU2003298145A patent/AU2003298145A1/en not_active Abandoned
- 2003-11-27 WO PCT/EP2003/013374 patent/WO2004054972A1/de not_active Application Discontinuation
- 2003-11-27 KR KR1020057011051A patent/KR20050085697A/ko not_active Application Discontinuation
- 2003-11-27 CA CA002510169A patent/CA2510169A1/en not_active Abandoned
- 2003-11-27 PL PL377519A patent/PL377519A1/pl unknown
- 2003-11-27 EP EP03795848A patent/EP1572646A1/de not_active Withdrawn
- 2003-11-27 CN CNA2003801067371A patent/CN1729173A/zh active Pending
- 2003-11-27 RU RU2005122615/04A patent/RU2005122615A/ru not_active Application Discontinuation
- 2003-11-27 BR BR0317422-0A patent/BR0317422A/pt not_active Application Discontinuation
2005
- 2005-07-14 ZA ZA200505684A patent/ZA200505684B/en unknown

Also Published As

Publication number	Publication date
EP1572646A1 (de)	2005-09-14
RU2005122615A (ru)	2006-01-20
WO2004054972A1 (de)	2004-07-01
KR20050085697A (ko)	2005-08-29
AU2003298145A1 (en)	2004-07-09
US20060122191A1 (en)	2006-06-08
JP2006511522A (ja)	2006-04-06
CN1729173A (zh)	2006-02-01
BR0317422A (pt)	2005-11-08
PL377519A1 (pl)	2006-02-06
DE10259244A1 (de)	2004-07-01
CA2510169A1 (en)	2004-07-01
MXPA05006385A (es)	2005-08-29

Publication	Publication Date	Title
ZA200505684B (en)	2006-04-26	N-(indolethyl-)cycloamine compounds
JP3022951B2 (ja)	2000-03-21	アロイル−ピペリジン誘導体
JP4727925B2 (ja)	2011-07-20	統合失調症およびうつ病等の疾患を処置するためのフェノキシピペリジン
EP1725555B1 (en)	2010-10-06	Pyrrolopyridine-2-carboxylic acid hydrazides as inhibitors of glycogen phosphorylase
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