ZA200300619B - 3,4-dihyroisoquinoline derivative compounds and drugs containing these compounds as the active ingredient. - Google Patents

3,4-dihyroisoquinoline derivative compounds and drugs containing these compounds as the active ingredient.

Info

Publication number: ZA200300619B
Authority: ZA; South Africa
Prior art keywords: compounds; active ingredient; dihyroisoquinoline; drugs containing; formula
Prior art date: 2000-08-01

Application number

ZA200300619A

Other languages

English (en)

Inventor

Mikio Ogawa

Akira Ohhata

Yoshikazu Takaoka

Original Assignee

Ono Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-01

Filing date

2003-01-22

Publication date

2004-05-20

2003-01-22 Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co

2004-05-20 Publication of ZA200300619B publication Critical patent/ZA200300619B/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 3
239000004480 active ingredient Substances 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
-1 3,4-dihydroisoquinoline derivative compound Chemical class 0.000 abstract 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
102000009135 CB2 Cannabinoid Receptor Human genes 0.000 abstract 1
108010073376 CB2 Cannabinoid Receptor Proteins 0.000 abstract 1
206010012438 Dermatitis atopic Diseases 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
208000004550 Postoperative Pain Diseases 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000007815 allergy Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
201000008937 atopic dermatitis Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
239000008177 pharmaceutical agent Substances 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

ZA200300619A 2000-08-01 2003-01-22 3,4-dihyroisoquinoline derivative compounds and drugs containing these compounds as the active ingredient. ZA200300619B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2000232911		2000-08-01

Publications (1)

Publication Number	Publication Date
ZA200300619B true ZA200300619B (en)	2004-05-20

Family

ID=18725515

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200300619A ZA200300619B (en)	2000-08-01	2003-01-22	3,4-dihyroisoquinoline derivative compounds and drugs containing these compounds as the active ingredient.

Country Status (20)

Country	Link
US (1)	US6956033B2 (xx)
EP (1)	EP1306373B1 (xx)
JP (1)	JP4982937B2 (xx)
KR (1)	KR20030017660A (xx)
CN (1)	CN1466577A (xx)
AT (1)	ATE362470T1 (xx)
AU (1)	AU2001275798A1 (xx)
BR (1)	BR0112883A (xx)
CA (1)	CA2417156A1 (xx)
CZ (1)	CZ2003284A3 (xx)
DE (1)	DE60128476D1 (xx)
HU (1)	HUP0303070A2 (xx)
IL (1)	IL154082A0 (xx)
MX (1)	MXPA03000952A (xx)
NO (1)	NO20030490L (xx)
NZ (1)	NZ523839A (xx)
PL (1)	PL362916A1 (xx)
RU (1)	RU2272030C2 (xx)
WO (1)	WO2002010135A1 (xx)
ZA (1)	ZA200300619B (xx)

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WO2003061699A1 (fr) *	2001-12-27	2003-07-31	Japan Tobacco, Inc.	Remedes pour affections allergiques
WO2003064389A1 (fr) *	2002-01-31	2003-08-07	Ono Pharmaceutical Co., Ltd.	Composes bicycliques contenant de l'azote et medicaments contenant ces composes en tant qu'ingredient actif
EP1661572A1 (en) *	2003-08-18	2006-05-31	Shionogi & Co., Ltd.	Novel use of cannabinoid receptor agonist
TW200533657A (en) *	2004-02-17	2005-10-16	Esteve Labor Dr	Substituted pyrazoline compounds, their preparation and use as medicaments
AR051596A1 (es) *	2004-10-26	2007-01-24	Irm Llc	Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios
TWI360539B (en) *	2004-10-28	2012-03-21	Shionogi & Co	3-carbamoyl-2-pyridone derivatives
MX2007007103A (es) *	2004-12-13	2008-03-10	Lilly Co Eli	Derivados espiro como inhibidores de lipoxigenasa.
WO2006078697A1 (en)	2005-01-18	2006-07-27	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoid receptor modulators
EP1743890A1 (en) *	2005-07-15	2007-01-17	Laboratorios Del Dr. Esteve, S.A.	4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments
EP1743892A1 (en) *	2005-07-15	2007-01-17	Laboratorios del Dr. Esteve S.A.	Substituted pyrazoline compounds, their preparation and use as medicaments
US7897589B2 (en) *	2005-07-15	2011-03-01	Laboratorios Del Dr. Esteve, S.A.	Substituted pyrazoline compounds, their preparation and use as medicaments
EP1757587A1 (en) *	2005-07-15	2007-02-28	Laboratorios Del Dr. Esteve, S.A.	Substituted pyrazoline compounds, their preparation and use as medicaments
AU2007205114B2 (en) *	2006-01-06	2012-11-08	Sunovion Pharmaceuticals Inc.	Cycloalkylamines as monoamine reuptake inhibitors
KR101373087B1 (ko) *	2006-10-30	2014-03-11	산메디카루 가부시키가이샤	치과용 셀프 에칭 프라이머 조성물
EP2124568A1 (en) *	2007-01-17	2009-12-02	Merck & Co., Inc.	Decahydroquinoline analogs as cb2 receptor modulators
WO2008111296A1 (ja)	2007-03-09	2008-09-18	Kyoto University	角化の亢進に起因する皮膚疾患の予防及び治療のための医薬
EP2151234A1 (en) *	2008-07-28	2010-02-10	Laboratorios Del. Dr. Esteve, S.A.	Pharmaceutical formulation comprising a CB1-receptor compound in a solid solution and/or solid dispersion
KR101685718B1 (ko) *	2008-12-19	2016-12-12	제넨테크, 인크.	헤테로시클릭 화합물 및 사용 방법
ES2511065T3 (es)	2009-06-17	2014-10-22	Ono Pharmaceutical Co., Ltd.	Nuevo compuesto imidazopiridina
EP2456428A1 (en)	2009-07-23	2012-05-30	INSERM - Institut National de la Santé et de la Recherche Médicale	Selective cb2 receptor agonists for use in the prevention or treatment of alcoholic liver disease
HUE034911T2 (hu)	2009-07-27	2018-03-28	Gilead Sciences Inc	Fúzionált heterociklusos vegyületek mint ioncsatorna modulátorok
CN103096977B (zh)	2010-07-02	2017-02-15	吉利德科学公司	作为离子通道调节剂的稠杂环化合物
WO2012037349A2 (en) *	2010-09-17	2012-03-22	Glaxosmithkline Llc	Compounds
WO2012037351A1 (en) *	2010-09-17	2012-03-22	Glaxosmithkline Llc	Compounds
US9115096B2 (en)	2011-05-10	2015-08-25	Gilead Sciences, Inc.	Fused heterocyclic compounds as ion channel modulators
NO3175985T3 (xx)	2011-07-01	2018-04-28
UY34171A (es)	2011-07-01	2013-01-31	Gilead Sciences Inc	Compuestos heterocíclicos fusionados como moduladores del canal iónico
CN103987711B (zh)	2011-10-14	2016-08-24	艾伯维公司	作为用于治疗癌症和免疫性和自身免疫性疾病的凋亡诱导剂的8-氨基甲酰基-2-(2,3-二取代吡啶-6-基)-1,2,3,4-四氢异喹啉衍生物
CN103958508B (zh)	2011-10-14	2019-02-12	艾伯维公司	用于治疗癌症以及免疫与自身免疫性疾病的细胞凋亡诱导剂
CN111892576A (zh) *	2015-03-27	2020-11-06	先正达参股股份有限公司	杀微生物的杂二环衍生物

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KR19990082330A (ko)	1996-02-06	1999-11-25	미즈노 마사루	신규 화합물 및 이의 의약 용도
WO1998041519A1 (en) *	1997-03-18	1998-09-24	Smithkline Beecham Corporation	Novel cannabinoid receptor agonists
FR2783246B1 (fr)	1998-09-11	2000-11-17	Aventis Pharma Sa	Derives d'azetidine, leur preparation et les medicaments les contenant

2001
- 2001-07-30 RU RU2003102888/04A patent/RU2272030C2/ru not_active IP Right Cessation
- 2001-07-30 US US10/333,591 patent/US6956033B2/en not_active Expired - Fee Related
- 2001-07-30 NZ NZ523839A patent/NZ523839A/en unknown
- 2001-07-30 AU AU2001275798A patent/AU2001275798A1/en not_active Abandoned
- 2001-07-30 HU HU0303070A patent/HUP0303070A2/hu unknown
- 2001-07-30 PL PL01362916A patent/PL362916A1/xx unknown
- 2001-07-30 AT AT01953336T patent/ATE362470T1/de not_active IP Right Cessation
- 2001-07-30 KR KR10-2003-7001424A patent/KR20030017660A/ko not_active Application Discontinuation
- 2001-07-30 IL IL15408201A patent/IL154082A0/xx unknown
- 2001-07-30 DE DE60128476T patent/DE60128476D1/de not_active Expired - Lifetime
- 2001-07-30 JP JP2002516267A patent/JP4982937B2/ja not_active Expired - Fee Related
- 2001-07-30 CA CA002417156A patent/CA2417156A1/en not_active Abandoned
- 2001-07-30 CZ CZ2003284A patent/CZ2003284A3/cs unknown
- 2001-07-30 MX MXPA03000952A patent/MXPA03000952A/es unknown
- 2001-07-30 CN CNA01816496XA patent/CN1466577A/zh active Pending
- 2001-07-30 WO PCT/JP2001/006541 patent/WO2002010135A1/ja active IP Right Grant
- 2001-07-30 BR BR0112883-3A patent/BR0112883A/pt not_active IP Right Cessation
- 2001-07-30 EP EP01953336A patent/EP1306373B1/en not_active Expired - Lifetime
2003
- 2003-01-22 ZA ZA200300619A patent/ZA200300619B/xx unknown
- 2003-01-30 NO NO20030490A patent/NO20030490L/no unknown

Also Published As

Publication number	Publication date
HUP0303070A2 (hu)	2003-12-29
CA2417156A1 (en)	2003-01-23
EP1306373A1 (en)	2003-05-02
WO2002010135A1 (fr)	2002-02-07
ATE362470T1 (de)	2007-06-15
AU2001275798A1 (en)	2002-02-13
BR0112883A (pt)	2003-06-24
EP1306373B1 (en)	2007-05-16
EP1306373A4 (en)	2004-09-01
MXPA03000952A (es)	2003-09-05
DE60128476D1 (de)	2007-06-28
RU2272030C2 (ru)	2006-03-20
PL362916A1 (en)	2004-11-02
JP4982937B2 (ja)	2012-07-25
KR20030017660A (ko)	2003-03-03
IL154082A0 (en)	2003-07-31
NZ523839A (en)	2005-07-29
NO20030490D0 (no)	2003-01-30
US20040077643A1 (en)	2004-04-22
NO20030490L (no)	2003-03-27
CN1466577A (zh)	2004-01-07
US6956033B2 (en)	2005-10-18
CZ2003284A3 (cs)	2003-09-17

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JO2311B1 (en)	2005-09-12	Alkyl inhibitors Ariel phosphodiesterase-4
NO306464B1 (no)	1999-11-08	Benzimidazolforbindelser, farmasöytiske preparater som omfatter slike forbindelser, samt anvendelse av forbindelsene for fremstilling av medikamenter
MXPA02005465A (es)	2003-10-15	Derivados de triazaspiro(5.5)undecano y composiciones farmaceuticas que los comprenden, como un ingrediente activo.
HUP0401086A3 (en)	2011-07-28	4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for preparation of pharmaceutical compositions for the treatment of pain, anxiety or gastrointestinal disorders and process for preparation the compounds
GEP20033025B (en)	2003-07-25	4,4-Biarylpiperidine Derivatives with Opioid Receptor Activity
HUP0301167A3 (en)	2009-12-28	Sulfonyl-pyrrolidine derivatives useful for the treatment of neurological disorders, process for their preparation, pharmaceutical compositions containing them and their use
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PL374325A1 (en)	2005-10-17	Succinic acid salts of 5,8,14-triazatetracyclo[10.3.1.0 2,11 .0 4,9 ]-hexadeca-2(11),3,5,7,9,-pentaene and pharmaceutical compositions thereof
WO2002024697A1 (fr)	2002-03-28	Composes spiro et inhibiteurs de molecules d'adhesion contenant ces composes comme ingredient actif
EP1084711A4 (en)	2003-05-14	REMEDIES, CONTAINING PGD 2 ANTAGONISTS
WO2003015780A3 (en)	2003-11-13	Isoxazolopyridinones and use thereof in the treatment of parkinson's disease
EP1254898A4 (en)	2003-03-12	BENZO-CONDENSED HETEROCYCLIC DERIVATIVES AND THESE MEDICINES CONTAINING ACTIVE SUBSTANCES
WO2003024941A1 (fr)	2003-03-27	Composes de naphtalene et leur utilisation comme medicament
WO1998031704A3 (en)	1998-09-11	Tachykinin antagonists
BR9916220A (pt)	2001-09-11	Derivados de arilpiperidina e aril-1,2,5,6-tetraidropiridina uréia tendo atividade de receptor 5ht1a
HK1083839A1 (en)	2006-07-14	Indoline compound and medicinal use thereof
HRP20030696A2 (en)	2005-04-30	GlyT-1 INHIBITORS
IL154625A0 (en)	2003-09-17	Novel crystals of n-hydroxy-2 (s)-methyl-5-ethoxymethoxy-4-(s)-[n-(4-phenoxyphenylcarbonyl) amino] pentanamide, process for their production and medicines containing the crystals as the active ingredient
TH39271A (th)	2000-07-10	อนุพันธ์สไปโร-ไพเพอริดีน และการใช้งานของสิ่งเหล่านั้นเป็นสารอายุรเวช
WO2000078751A3 (en)	2001-03-08	Compounds for use in treatment of neurological disorders
TH66556A (th)	2005-01-21	สารยับยั้งเมททัลโลโพรทีเนส สไพโร-ไพริมิดีน-2,4,6-ไตรโอน