ZA200203358B - Method and compositions for administering taxanes orally to human patients. - Google Patents

Method and compositions for administering taxanes orally to human patients. Download PDF

Info

Publication number: ZA200203358B
Authority: ZA; South Africa
Prior art keywords: taxane; paclitaxel; formulation; combination; orally
Prior art date: 1999-10-27

Application number

ZA200203358A

Other languages

English (en)

Inventor

Samuel Broder

Kenneth Duchin

Sami Selim

Original Assignee

Baker Norton Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-27

Filing date

2002-04-26

Publication date

2003-04-29

2002-04-26 Application filed by Baker Norton Pharma filed Critical Baker Norton Pharma

2003-04-29 Publication of ZA200203358B publication Critical patent/ZA200203358B/en

Links

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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Immunology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA200203358A 1999-10-27 2002-04-26 Method and compositions for administering taxanes orally to human patients. ZA200203358B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US16231099P	1999-10-27	1999-10-27

Publications (1)

Publication Number	Publication Date
ZA200203358B true ZA200203358B (en)	2003-04-29

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ID=22585092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200203358A ZA200203358B (en)	1999-10-27	2002-04-26	Method and compositions for administering taxanes orally to human patients.

Country Status (18)

Country	Link
EP (1)	EP1225956A1 (de)
JP (1)	JP2003512443A (de)
KR (1)	KR20030019296A (de)
CN (1)	CN1450923A (de)
AU (1)	AU1104201A (de)
BR (1)	BR0015149A (de)
CA (1)	CA2389583A1 (de)
CO (1)	CO5251425A1 (de)
CZ (1)	CZ20021484A3 (de)
HU (1)	HUP0203303A3 (de)
IL (1)	IL149360A0 (de)
MX (1)	MXPA02004164A (de)
NO (1)	NO20022008L (de)
PL (1)	PL354777A1 (de)
RU (1)	RU2002113659A (de)
SK (1)	SK5822002A3 (de)
WO (1)	WO2001030448A1 (de)
ZA (1)	ZA200203358B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6750246B1 (en)	2000-02-03	2004-06-15	Bristol-Myers Squibb Company	C-4 carbonate taxanes
JP2004536026A (ja)	2000-11-28	2004-12-02	トランスフォームファーマシューティカルズ，インコーポレーティッド．	パクリタキセル、その誘導体、および薬剤として許容される塩を含む医薬品製剤
US20040092428A1 (en) *	2001-11-27	2004-05-13	Hongming Chen	Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof
WO2004098570A1 (en) *	2002-10-30	2004-11-18	Spherics, Inc.	Nanoparticulate bioactive agents
US7659310B2 (en)	2004-04-27	2010-02-09	Formatech, Inc.	Methods of enhancing solubility of agents
US7345093B2 (en)	2004-04-27	2008-03-18	Formatech, Inc.	Methods of enhancing solubility of compounds
PE20060416A1 (es) *	2004-08-03	2006-06-09	Novartis Ag	Composicion de inhibidores de renina e inhibidores de proteinas de efusion
CN101513395B (zh) *	2008-02-20	2011-01-12	单宝华	紫杉醇类双层软胶囊口服制剂药物
US10143652B2 (en)	2009-09-23	2018-12-04	Curirx Inc.	Methods for the preparation of liposomes
CA2781529C (en)	2009-09-23	2017-10-24	Indu Javeri	Methods for the preparation of liposomes comprising docetaxel
BR112012028037A2 (pt)	2010-05-03	2016-08-02	Teikoku Pharma Usa Inc	formulação de pró-emulsão líquida de taxano não aquosa, métodos para administrar um taxano a um paciente e para fabricar uma formulação de pró-emulsão de taxano, composição de emulsão de taxano, e, kit
JO3685B1 (ar)	2012-10-01	2020-08-27	Teikoku Pharma Usa Inc	صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
JO3737B1 (ar) *	2015-07-21	2021-01-31	Athenex Therapeutics Ltd	تركيبات علاجية من باكليتاكسيل تعطى عن طريق الفم ومثبط P-gp لعلاج السرطان
EP4059497A1 (de) *	2021-03-17	2022-09-21	Dompé farmaceutici S.p.a.	C5ar1 inhibitoren zur behandlung von hypersensitivitätsreaktionen auf taxane
BR112023018826A2 (pt) *	2021-03-17	2024-03-12	Dompe Farm Spa	Inibidores de c5ar1 para tratamento de reações de hipersensibilidade a taxanos

Family Cites Families (8)

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Publication number	Priority date	Publication date	Assignee	Title
US6964946B1 (en) *	1995-10-26	2005-11-15	Baker Norton Pharmaceuticals, Inc.	Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same
US6245805B1 (en) *	1995-10-26	2001-06-12	Baker Norton Pharmaceuticals, Inc.	Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
EP0822815A4 (de) *	1996-01-31	1998-04-01	Bristol Myers Squibb Co	Verfahren zur oralen bioverfügbarkeitmachung pharmazeutisch aktiver taxane
US6025359A (en) *	1996-06-17	2000-02-15	Eli Lilly And Company	Drug resistance and multidrug resistance modulators
BR9809694A (pt) *	1997-05-27	2000-10-03	Baker Norton Pharma	Processo e composição para administração de taxanos oralmente a pacientes humanos
GB9718903D0 (en) *	1997-09-05	1997-11-12	Glaxo Group Ltd	Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents
CA2326485C (en) *	1998-04-01	2008-12-09	Rtp Pharma Inc.	Anticancer compositions
CA2684454A1 (en) *	1999-05-21	2000-11-18	American Bioscience, Llc.	Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof

2000
- 2000-10-27 IL IL14936000A patent/IL149360A0/xx unknown
- 2000-10-27 CN CN00815924A patent/CN1450923A/zh active Pending
- 2000-10-27 AU AU11042/01A patent/AU1104201A/en not_active Abandoned
- 2000-10-27 SK SK582-2002A patent/SK5822002A3/sk unknown
- 2000-10-27 KR KR1020027005396A patent/KR20030019296A/ko not_active Application Discontinuation
- 2000-10-27 CO CO00082131A patent/CO5251425A1/es not_active Application Discontinuation
- 2000-10-27 PL PL00354777A patent/PL354777A1/xx not_active Application Discontinuation
- 2000-10-27 JP JP2001532859A patent/JP2003512443A/ja active Pending
- 2000-10-27 MX MXPA02004164A patent/MXPA02004164A/es unknown
- 2000-10-27 WO PCT/US2000/029633 patent/WO2001030448A1/en not_active Application Discontinuation
- 2000-10-27 BR BR0015149-1A patent/BR0015149A/pt not_active IP Right Cessation
- 2000-10-27 EP EP00972373A patent/EP1225956A1/de not_active Withdrawn
- 2000-10-27 CA CA002389583A patent/CA2389583A1/en not_active Abandoned
- 2000-10-27 RU RU2002113659/15A patent/RU2002113659A/ru not_active Application Discontinuation
- 2000-10-27 CZ CZ20021484A patent/CZ20021484A3/cs unknown
- 2000-10-27 HU HU0203303A patent/HUP0203303A3/hu unknown
2002
- 2002-04-26 ZA ZA200203358A patent/ZA200203358B/en unknown
- 2002-04-26 NO NO20022008A patent/NO20022008L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
MXPA02004164A (es)	2002-10-17
CO5251425A1 (es)	2003-02-28
CZ20021484A3 (cs)	2003-12-17
NO20022008D0 (no)	2002-04-26
CN1450923A (zh)	2003-10-22
KR20030019296A (ko)	2003-03-06
IL149360A0 (en)	2002-11-10
NO20022008L (no)	2002-06-19
WO2001030448A1 (en)	2001-05-03
EP1225956A1 (de)	2002-07-31
AU1104201A (en)	2001-05-08
RU2002113659A (ru)	2004-01-27
HUP0203303A3 (en)	2005-01-28
SK5822002A3 (en)	2003-01-09
CA2389583A1 (en)	2001-05-03
BR0015149A (pt)	2002-10-29
HUP0203303A2 (hu)	2003-02-28
PL354777A1 (en)	2004-02-23
JP2003512443A (ja)	2003-04-02

Publication	Publication Date	Title
US6730698B2 (en)	2004-05-04	Method and compositions for administering taxanes orally to human patients
EP0794794B1 (de)	2005-12-07	Verfahren, zusammensetzungen und kits zur erhöhung der oralen bioverfügbarkeit von pharmazeutika
US5968972A (en)	1999-10-19	Method for increasing the oral bioactivity of pharmaceutical agents
AU774060B2 (en)	2004-06-17	Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same
ZA200203358B (en)	2003-04-29	Method and compositions for administering taxanes orally to human patients.
EP0994706B1 (de)	2005-11-02	Zusammensetzungen zur oralen verabreichung von taxanen und deren verwendung
AU784159B2 (en)	2006-02-16	Method and compositions for administering taxanes orally to human patients
EP1634607A2 (de)	2006-03-15	Verfahren, Zusammensetzungen und Kits zur Erhöhung der oralen Bioverfügbarkeit von Pharmazeutika