ZA200104139B - Cycloalkyl-substituted aminomethylpyrrolidine derivative. - Google Patents
Cycloalkyl-substituted aminomethylpyrrolidine derivative. Download PDFInfo
- Publication number
- ZA200104139B ZA200104139B ZA200104139A ZA200104139A ZA200104139B ZA 200104139 B ZA200104139 B ZA 200104139B ZA 200104139 A ZA200104139 A ZA 200104139A ZA 200104139 A ZA200104139 A ZA 200104139A ZA 200104139 B ZA200104139 B ZA 200104139B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- carbon atoms
- hydrates
- salts
- campound
- Prior art date
Links
- VMPYTOIPVPQDNX-UHFFFAOYSA-N pyrrolidin-1-ylmethanamine Chemical class NCN1CCCC1 VMPYTOIPVPQDNX-UHFFFAOYSA-N 0.000 title description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 26
- 125000000217 alkyl group Chemical group 0.000 claims description 21
- 150000001875 compounds Chemical class 0.000 claims description 20
- 150000004677 hydrates Chemical class 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 19
- 125000001424 substituent group Chemical group 0.000 claims description 19
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 15
- 230000000844 anti-bacterial effect Effects 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 239000001257 hydrogen Substances 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 5
- 150000002367 halogens Chemical class 0.000 claims description 5
- 150000007660 quinolones Chemical class 0.000 claims description 5
- 241000894006 Bacteria Species 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims description 3
- 125000001188 haloalkyl group Chemical group 0.000 claims description 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 2
- -1 acetoxymethyl group Chemical group 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000006165 cyclic alkyl group Chemical group 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000003884 phenylalkyl group Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000003248 quinolines Chemical group 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 description 11
- 229940072132 quinolone antibacterials Drugs 0.000 description 9
- XOQQVKDBGLYPGH-UHFFFAOYSA-N 2-oxo-1h-quinoline-3-carboxylic acid Chemical class C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1 XOQQVKDBGLYPGH-UHFFFAOYSA-N 0.000 description 3
- 241000192125 Firmicutes Species 0.000 description 3
- 150000005130 benzoxazines Chemical group 0.000 description 3
- 102100025142 Beta-microseminoprotein Human genes 0.000 description 2
- 101100185029 Homo sapiens MSMB gene Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 206010041925 Staphylococcal infections Diseases 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 2
- OQCUGPQOZNYIMV-UHFFFAOYSA-N pyrrolidin-3-ylmethanamine Chemical compound NCC1CCNC1 OQCUGPQOZNYIMV-UHFFFAOYSA-N 0.000 description 2
- PMZDQRJGMBOQBF-UHFFFAOYSA-N quinolin-4-ol Chemical group C1=CC=C2C(O)=CC=NC2=C1 PMZDQRJGMBOQBF-UHFFFAOYSA-N 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- GFRNQDVTRYIXFV-CMPLNLGQSA-N 1-[(1r,2s)-2-fluorocyclopropyl]-2h-quinoline Chemical group F[C@H]1C[C@H]1N1C2=CC=CC=C2C=CC1 GFRNQDVTRYIXFV-CMPLNLGQSA-N 0.000 description 1
- XNIVKSPSCYJKBL-UHFFFAOYSA-N 2h-1,2-benzoxazine-6-carboxylic acid Chemical class O1NC=CC2=CC(C(=O)O)=CC=C21 XNIVKSPSCYJKBL-UHFFFAOYSA-N 0.000 description 1
- MLJBZCFQFLIEMD-UHFFFAOYSA-N 7-[3-(aminomethyl)pyrrolidin-1-yl]-2-oxo-1h-quinoline-3-carboxylic acid Chemical class C1C(CN)CCN1C1=CC=C(C=C(C(O)=O)C(=O)N2)C2=C1 MLJBZCFQFLIEMD-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 206010034972 Photosensitivity reaction Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 229940126575 aminoglycoside Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000003782 beta lactam antibiotic agent Substances 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 description 1
- 229960001180 norfloxacin Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000007578 phototoxic dermatitis Diseases 0.000 description 1
- 231100000018 phototoxicity Toxicity 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 1
- NGXSWUFDCSEIOO-UHFFFAOYSA-N pyrrolidin-3-amine Chemical class NC1CCNC1 NGXSWUFDCSEIOO-UHFFFAOYSA-N 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33223598 | 1998-11-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200104139B true ZA200104139B (en) | 2003-01-15 |
Family
ID=18252698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200104139A ZA200104139B (en) | 1998-11-24 | 2001-05-21 | Cycloalkyl-substituted aminomethylpyrrolidine derivative. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6573260B1 (pt) |
| EP (1) | EP1134219B1 (pt) |
| KR (1) | KR100652470B1 (pt) |
| CN (1) | CN1173971C (pt) |
| AR (1) | AR028806A1 (pt) |
| AT (1) | ATE297912T1 (pt) |
| AU (1) | AU757805B2 (pt) |
| BR (1) | BR9915599A (pt) |
| CA (1) | CA2351497A1 (pt) |
| DE (1) | DE69925859T2 (pt) |
| DK (1) | DK1134219T3 (pt) |
| ES (1) | ES2244248T3 (pt) |
| HK (1) | HK1037635A1 (pt) |
| ID (1) | ID28795A (pt) |
| IL (2) | IL143210A0 (pt) |
| MY (1) | MY125894A (pt) |
| NO (1) | NO321528B1 (pt) |
| PT (1) | PT1134219E (pt) |
| RU (1) | RU2248970C2 (pt) |
| TW (1) | TW542832B (pt) |
| WO (1) | WO2000031062A1 (pt) |
| ZA (1) | ZA200104139B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2292642T3 (es) | 2000-11-20 | 2008-03-16 | Daiichi Sankyo Company, Limited | Compuestos deshalogenados. |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| WO2005111030A1 (en) * | 2004-05-12 | 2005-11-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| US20090156577A1 (en) * | 2004-09-09 | 2009-06-18 | Benjamin Davis | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
| CA2695072A1 (en) * | 2006-08-16 | 2008-02-21 | Achillion Pharmaceuticals, Inc. | Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones |
| NZ577214A (en) * | 2007-01-05 | 2011-11-25 | Daiichi Sankyo Co Ltd | Fused substituted aminopyrrolidine derivatives useful as antibacterial reagents |
| US7902227B2 (en) * | 2007-07-27 | 2011-03-08 | Janssen Pharmaceutica Nv. | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents |
| RU2636751C1 (ru) | 2016-11-02 | 2017-12-01 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Антибактериальные средства на основе производных ципрофлоксацина |
| CN114180594B (zh) * | 2020-09-14 | 2023-05-02 | 中国石油化工股份有限公司 | 一种ith分子筛的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4920120A (en) * | 1988-01-25 | 1990-04-24 | Warner-Lambert Company | Antibacterial agents |
| MY105136A (en) * | 1988-04-27 | 1994-08-30 | Daiichi Seiyaku Co | Optically active pyridonecarboxylic acid derivatives. |
| US5157128A (en) * | 1990-11-30 | 1992-10-20 | Warner-Lambert Company | Certain optically active substituted α,α-dialkyl-pyrrolidine-3-methamines useful as intermediates |
| EP0871628A1 (en) * | 1995-06-06 | 1998-10-21 | Abbott Laboratories | Quinolizinone type compounds |
| JPH10198204A (ja) * | 1997-01-09 | 1998-07-31 | Fuji Xerox Co Ltd | 画像定着装置 |
| JPH10287669A (ja) * | 1997-04-10 | 1998-10-27 | Dai Ichi Seiyaku Co Ltd | 置換アミノメチルピロリジン誘導体 |
| PL339408A1 (en) * | 1997-09-15 | 2000-12-18 | Procter & Gamble | Antimicrobial quinolones, agents containing them and their applications |
-
1999
- 1999-11-22 US US09/856,631 patent/US6573260B1/en not_active Expired - Fee Related
- 1999-11-22 AT AT99972631T patent/ATE297912T1/de not_active IP Right Cessation
- 1999-11-22 ID IDW00200101127A patent/ID28795A/id unknown
- 1999-11-22 BR BR9915599-0A patent/BR9915599A/pt not_active Application Discontinuation
- 1999-11-22 KR KR1020017006537A patent/KR100652470B1/ko not_active IP Right Cessation
- 1999-11-22 RU RU2001114213/04A patent/RU2248970C2/ru not_active IP Right Cessation
- 1999-11-22 WO PCT/JP1999/006521 patent/WO2000031062A1/ja active IP Right Grant
- 1999-11-22 DE DE69925859T patent/DE69925859T2/de not_active Expired - Fee Related
- 1999-11-22 AU AU11862/00A patent/AU757805B2/en not_active Ceased
- 1999-11-22 ES ES99972631T patent/ES2244248T3/es not_active Expired - Lifetime
- 1999-11-22 MY MYPI99005083A patent/MY125894A/en unknown
- 1999-11-22 CN CNB998158380A patent/CN1173971C/zh not_active Expired - Fee Related
- 1999-11-22 PT PT99972631T patent/PT1134219E/pt unknown
- 1999-11-22 CA CA002351497A patent/CA2351497A1/en not_active Abandoned
- 1999-11-22 DK DK99972631T patent/DK1134219T3/da active
- 1999-11-22 EP EP99972631A patent/EP1134219B1/en not_active Expired - Lifetime
- 1999-11-22 IL IL14321099A patent/IL143210A0/xx active IP Right Grant
- 1999-11-24 AR ARP990105976A patent/AR028806A1/es active IP Right Grant
- 1999-11-24 TW TW088120516A patent/TW542832B/zh not_active IP Right Cessation
-
2001
- 2001-05-17 IL IL143210A patent/IL143210A/en not_active IP Right Cessation
- 2001-05-21 ZA ZA200104139A patent/ZA200104139B/en unknown
- 2001-05-22 NO NO20012522A patent/NO321528B1/no unknown
- 2001-12-11 HK HK01108680A patent/HK1037635A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69925859T2 (de) | 2006-05-11 |
| CN1333765A (zh) | 2002-01-30 |
| HK1037635A1 (en) | 2002-02-15 |
| EP1134219B1 (en) | 2005-06-15 |
| DE69925859D1 (en) | 2005-07-21 |
| EP1134219A4 (en) | 2002-11-06 |
| MY125894A (en) | 2006-08-30 |
| CA2351497A1 (en) | 2000-06-02 |
| AR028806A1 (es) | 2003-05-28 |
| RU2248970C2 (ru) | 2005-03-27 |
| KR20010080564A (ko) | 2001-08-22 |
| PT1134219E (pt) | 2005-09-30 |
| ES2244248T3 (es) | 2005-12-01 |
| ID28795A (id) | 2001-07-05 |
| DK1134219T3 (da) | 2005-10-17 |
| WO2000031062A1 (fr) | 2000-06-02 |
| IL143210A (en) | 2006-04-10 |
| EP1134219A1 (en) | 2001-09-19 |
| IL143210A0 (en) | 2002-04-21 |
| ATE297912T1 (de) | 2005-07-15 |
| US6573260B1 (en) | 2003-06-03 |
| TW542832B (en) | 2003-07-21 |
| BR9915599A (pt) | 2001-11-20 |
| KR100652470B1 (ko) | 2006-12-01 |
| NO20012522L (no) | 2001-07-24 |
| AU1186200A (en) | 2000-06-13 |
| AU757805B2 (en) | 2003-03-06 |
| CN1173971C (zh) | 2004-11-03 |
| NO321528B1 (no) | 2006-05-15 |
| NO20012522D0 (no) | 2001-05-22 |
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