YU65103A - Peg-konjugati hgf-nk4 - Google Patents
Peg-konjugati hgf-nk4Info
- Publication number
- YU65103A YU65103A YU65103A YUP65103A YU65103A YU 65103 A YU65103 A YU 65103A YU 65103 A YU65103 A YU 65103A YU P65103 A YUP65103 A YU P65103A YU 65103 A YU65103 A YU 65103A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- hgf
- conjugates
- peg
- kda
- conjugate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Konjugat koji se sastoji od N-terminalnog fragmenta faktora rasta hepatocita (HGF/SF) koji sadrži domen ukosnice i α-lanac sa četiri kring regiona i od jedne polietilen glikol grupe sa ukupnom molekulskom težinom od oko 20 do oko 40 kD, pokazuje poboljšana svojstva i može se primeniti kao terapeutski agens u terapiji tumora.[A conjugate comprising an N-terminal fragment of hepatocyte growth factor (HGF/SF) consisting of the hairpin domain and the four kringle regions of the α-chain and a polyethylene glycol group having an overall molecular weight of from about 20 to 40 kDA, has improved properties is a useful therapeutic agent for tumor treatment.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01104640A EP1234583A1 (en) | 2001-02-23 | 2001-02-23 | PEG-conjugates of HGF-NK4 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU65103A true YU65103A (sh) | 2006-03-03 |
Family
ID=8176596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU65103A YU65103A (sh) | 2001-02-23 | 2002-02-21 | Peg-konjugati hgf-nk4 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US20030012775A1 (sh) |
| EP (2) | EP1234583A1 (sh) |
| JP (2) | JP2004521139A (sh) |
| KR (2) | KR20090020713A (sh) |
| CN (1) | CN100339393C (sh) |
| AR (1) | AR032574A1 (sh) |
| AU (1) | AU2002233354B2 (sh) |
| BG (1) | BG108125A (sh) |
| BR (1) | BR0207510A (sh) |
| CA (1) | CA2438308A1 (sh) |
| CZ (1) | CZ20032511A3 (sh) |
| EC (1) | ECSP034741A (sh) |
| GT (1) | GT200200038A (sh) |
| HR (1) | HRP20030659A2 (sh) |
| HU (1) | HUP0400979A2 (sh) |
| IL (1) | IL157426A0 (sh) |
| MA (1) | MA26998A1 (sh) |
| MX (1) | MXPA03007130A (sh) |
| NO (1) | NO20033737L (sh) |
| PA (1) | PA8540501A1 (sh) |
| PE (1) | PE20020992A1 (sh) |
| PL (1) | PL367402A1 (sh) |
| RU (1) | RU2293574C2 (sh) |
| SK (1) | SK11652003A3 (sh) |
| WO (1) | WO2002074344A2 (sh) |
| YU (1) | YU65103A (sh) |
| ZA (1) | ZA200306080B (sh) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004019991A2 (en) * | 2002-08-30 | 2004-03-11 | F. Hoffmann-La Roche Ag | Scatter factor/hepatocyte growth factor antagonist nk4 for the treatment of glioma |
| JP2007525425A (ja) * | 2003-03-24 | 2007-09-06 | ノボ ノルディスク アクティーゼルスカブ | Ｇｌｐ−２誘導体 |
| WO2005095611A1 (en) * | 2004-03-03 | 2005-10-13 | F. Hoffmann-La Roche Ag | Method for the recombinant expression of an n-terminal fragment of hepatocyte growth factor |
| EP1723171B1 (en) | 2004-03-03 | 2007-12-19 | F.Hoffmann-La Roche Ag | Method for the purification of an n-terminal fragment of hepatocyte growth factor |
| US20090202606A1 (en) * | 2008-01-25 | 2009-08-13 | Viromed Co., Ltd. | Treatment and Prevention of Cardiac Conditions Using Two or More Isoforms of Hepatocyte Growth Factor |
| CA2720611C (en) * | 2008-04-09 | 2016-07-12 | Viromed Co., Ltd. | Lyophilized dna formulations for enhanced expression of plasmid dna |
| CN102399293B (zh) * | 2008-06-03 | 2013-12-04 | 中国科学院遗传与发育生物学研究所 | 一种与纤维蛋白特异结合的重组蛋白及其应用 |
| US10532020B2 (en) | 2012-08-22 | 2020-01-14 | Revlon Consumer Products Corporation | Nail coatings having enhanced adhesion |
| JP2016519108A (ja) | 2013-04-18 | 2016-06-30 | アルモ・バイオサイエンシーズ・インコーポレイテッド | インターロイキン−１０を疾病及び疾患の治療に用いる方法 |
| WO2014204816A2 (en) | 2013-06-17 | 2014-12-24 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
| US10010588B2 (en) | 2013-08-30 | 2018-07-03 | Armo Biosciences, Inc. | Methods of using pegylated interleukin-10 for treating hyperlipidemia |
| KR20160079114A (ko) | 2013-11-11 | 2016-07-05 | 아르모 바이오사이언시스 인코포레이티드 | 질환 및 장애를 치료하기 위한 인터류킨-10을 사용하는 방법 |
| WO2015187295A2 (en) | 2014-06-02 | 2015-12-10 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
| JP2017536098A (ja) | 2014-10-14 | 2017-12-07 | アルモ・バイオサイエンシーズ・インコーポレイテッド | インターロイキン−１５組成物及びその使用 |
| WO2016064817A1 (en) | 2014-10-22 | 2016-04-28 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| US10618970B2 (en) | 2015-02-03 | 2020-04-14 | Armo Biosciences, Inc. | Method of treating cancer with IL-10 and antibodies that induce ADCC |
| AU2016268403A1 (en) | 2015-05-28 | 2017-12-07 | Armo Biosciences, Inc. | Pegylated interleukin-10 for use in treating cancer |
| JP7053453B2 (ja) | 2015-08-25 | 2022-04-12 | アルモ・バイオサイエンシーズ・インコーポレイテッド | 疾患及び障害を治療するためのインターロイキン１０の使用方法 |
| WO2020158690A1 (ja) * | 2019-01-28 | 2020-08-06 | 東レ株式会社 | 肝細胞増殖因子又はその活性断片のポリエチレングリコール修飾体 |
| WO2020158691A1 (ja) * | 2019-01-28 | 2020-08-06 | 東レ株式会社 | 肝細胞増殖因子又はその活性断片のポリエチレングリコール修飾体 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2118012A1 (en) | 1992-05-18 | 1993-11-25 | Paul J. Godowski | Hepatocyte growth factor variants |
| US6472178B1 (en) | 1998-02-27 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding a modified ciliary neurotrophic factor and method of making thereof |
| GB9225448D0 (en) * | 1992-12-04 | 1993-01-27 | Erba Carlo Spa | Improved synthesis of polymer bioactive conjugates |
| SK166695A3 (en) * | 1994-03-31 | 1997-02-05 | Amgen Inc | Mgdf polypeptide for stimulating growth and megakaryocyte differentiation |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| DE69631329T2 (de) * | 1995-03-10 | 2004-11-18 | Sumitomo Pharmaceuticals Co., Ltd. | Menschlicher wachstumsfaktor (hgf), verändert durch polyethylenglykol |
| EP0741187A2 (en) * | 1995-05-05 | 1996-11-06 | F. Hoffmann-La Roche Ag | Recombinant obese (Ob) proteins |
| US6025324A (en) * | 1996-05-15 | 2000-02-15 | Hoffmann-La Roche Inc. | Pegylated obese (ob) protein compositions |
| EP1007082B1 (en) * | 1997-01-15 | 2006-10-18 | Phoenix Pharmacologics, Inc. | Modified tumor necrosis factor |
| US6133426A (en) * | 1997-02-21 | 2000-10-17 | Genentech, Inc. | Humanized anti-IL-8 monoclonal antibodies |
| EP0922446A1 (en) * | 1997-12-03 | 1999-06-16 | Applied Research Systems Ars Holding N.V. | Solution-phase site-specific preparation of GRF-PEG conjugates |
| JP4574007B2 (ja) * | 1998-04-28 | 2010-11-04 | メルク・セローノ・ソシエテ・アノニム | ポリオール−ｉｆｎ−ベータ複体 |
| US6420339B1 (en) * | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
| PE20010288A1 (es) * | 1999-07-02 | 2001-03-07 | Hoffmann La Roche | Derivados de eritropoyetina |
| CZ299516B6 (cs) * | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
| US6586398B1 (en) * | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| MXPA03005406A (es) * | 2000-12-20 | 2003-09-25 | Hoffmann La Roche | Conjugados de eritropoyetina. |
-
2001
- 2001-02-23 EP EP01104640A patent/EP1234583A1/en not_active Withdrawn
-
2002
- 2002-02-20 PE PE2002000144A patent/PE20020992A1/es not_active Application Discontinuation
- 2002-02-20 PA PA20028540501A patent/PA8540501A1/es unknown
- 2002-02-21 EP EP02700263A patent/EP1389132A2/en not_active Withdrawn
- 2002-02-21 YU YU65103A patent/YU65103A/sh unknown
- 2002-02-21 CZ CZ20032511A patent/CZ20032511A3/cs unknown
- 2002-02-21 AU AU2002233354A patent/AU2002233354B2/en not_active Ceased
- 2002-02-21 WO PCT/EP2002/001837 patent/WO2002074344A2/en not_active Application Discontinuation
- 2002-02-21 AR ARP020100593A patent/AR032574A1/es not_active Application Discontinuation
- 2002-02-21 US US10/081,309 patent/US20030012775A1/en not_active Abandoned
- 2002-02-21 JP JP2002573051A patent/JP2004521139A/ja not_active Withdrawn
- 2002-02-21 CN CNB028052951A patent/CN100339393C/zh not_active Expired - Fee Related
- 2002-02-21 IL IL15742602A patent/IL157426A0/xx unknown
- 2002-02-21 MX MXPA03007130A patent/MXPA03007130A/es not_active Application Discontinuation
- 2002-02-21 KR KR1020097002234A patent/KR20090020713A/ko not_active Application Discontinuation
- 2002-02-21 PL PL02367402A patent/PL367402A1/xx not_active Application Discontinuation
- 2002-02-21 HU HU0400979A patent/HUP0400979A2/hu unknown
- 2002-02-21 RU RU2003127395/15A patent/RU2293574C2/ru not_active IP Right Cessation
- 2002-02-21 CA CA002438308A patent/CA2438308A1/en not_active Abandoned
- 2002-02-21 BR BR0207510-5A patent/BR0207510A/pt not_active IP Right Cessation
- 2002-02-21 KR KR10-2003-7010748A patent/KR20030072629A/ko active Search and Examination
- 2002-02-21 SK SK1165-2003A patent/SK11652003A3/sk unknown
- 2002-02-22 GT GT200200038A patent/GT200200038A/es unknown
-
2003
- 2003-08-06 ZA ZA200306080A patent/ZA200306080B/en unknown
- 2003-08-19 MA MA27285A patent/MA26998A1/fr unknown
- 2003-08-19 HR HR20030659A patent/HRP20030659A2/hr not_active Application Discontinuation
- 2003-08-21 EC EC2003004741A patent/ECSP034741A/es unknown
- 2003-08-22 NO NO20033737A patent/NO20033737L/no not_active Application Discontinuation
- 2003-08-22 BG BG108125A patent/BG108125A/bg unknown
-
2007
- 2007-10-10 US US11/869,797 patent/US7846896B2/en not_active Expired - Lifetime
-
2010
- 2010-04-22 JP JP2010099120A patent/JP2010174034A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU65103A (sh) | Peg-konjugati hgf-nk4 | |
| MXPA03006771A (es) | Anticuerpos modificados y metodos de uso. | |
| DE69635026D1 (de) | Varianten des menschlichen wachstumshormons | |
| MX9606386A (es) | Agentes que afectan la hemostasis trombotica. | |
| BR0210056A (pt) | composições e métodos para tratamento de hiperplasia | |
| BR9910251A (pt) | Estimulação hematopoiética | |
| DE60006100D1 (de) | Lang wirkende insulinotrope peptide | |
| DK1028753T4 (da) | Indgivelse af poly(ethylenglycol)-konjugerede molekyler fra nedbrydelige hydrogeler | |
| FR13C0021I2 (fr) | Conjugates d'exendin-4 et leur utilisation medicale | |
| CY1107351T1 (el) | Καινοφανης μεταλλαγμενη μορφη απιμινασης αργινινης | |
| AU2001235006A1 (en) | Prophylactic and therapeutic monoclonal antibodies | |
| HK1040983A1 (en) | Quinones for treatment of diseases. | |
| CA2234263A1 (fr) | Composition pharmaceutique contre les tumeurs et infections a papillomavirus | |
| ATE368455T1 (de) | Verwendung von (+)-tramadol, o-demethyltramadol, o-desmethyl-n-mono-desmethyl-tramadol zur therapie der harninkontinenz | |
| BG106008A (en) | Novel lhrh antagonists with improved solubility characteristics | |
| ATE359798T1 (de) | Verwendungvon dextransulfat zur behandlung von ibmir | |
| NO984052D0 (no) | Rekombinante, adenovirale vektorer for human tumorgenterapi | |
| GB9811465D0 (en) | Glycoproteins having lipid mobilising properties and therapeutic applications thereof | |
| DE60229867D1 (de) | Zielgerichtete ligande gegen peyer's flecke- und/oder m-zellen | |
| SI1699468T1 (sl) | Farmacevtski sestavek, ki obsega kompleks cink-hialuronan, za zdravljenje multiple skleroze | |
| NZ514027A (en) | Cloning and expression of haemophilus somnus transferrin-binding proteins | |
| UY27182A1 (es) | Conjugados peg de hgf-nk4 | |
| UA32281A (uk) | Засіб "регенерин" для зовнішнього лікування гнійних ран і трофічних виразок |