ES2170918T3 - Inhibidor de proteina quinasa c sustituidos con halo. - Google Patents
Inhibidor de proteina quinasa c sustituidos con halo.Info
- Publication number
- ES2170918T3 ES2170918T3 ES97302996T ES97302996T ES2170918T3 ES 2170918 T3 ES2170918 T3 ES 2170918T3 ES 97302996 T ES97302996 T ES 97302996T ES 97302996 T ES97302996 T ES 97302996T ES 2170918 T3 ES2170918 T3 ES 2170918T3
- Authority
- ES
- Spain
- Prior art keywords
- halo
- quinase
- protein
- inhibitor
- replaced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS DE BIS INDOLMALEIMIDA HALO ON TAMBIEN SE REFIERE A UN METODO PARA LA PREPARACION DE LOS COMPUESTOS PRESENTADOS Y PARA LA PREPARACION DE UNA FORMULACION FARMACEUTICA A UTILIZAR EN LA INHIBICION DE LA CINASA C DE PROTEINAS EN MAMIFEROS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1638296P | 1996-05-01 | 1996-05-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2170918T3 true ES2170918T3 (es) | 2002-08-16 |
Family
ID=21776838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97302996T Expired - Lifetime ES2170918T3 (es) | 1996-05-01 | 1997-05-01 | Inhibidor de proteina quinasa c sustituidos con halo. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5936084A (es) |
EP (1) | EP0805158B1 (es) |
JP (1) | JP3235840B2 (es) |
KR (1) | KR20000065137A (es) |
AT (1) | ATE212026T1 (es) |
AU (1) | AU703395B2 (es) |
BR (1) | BR9709301A (es) |
CA (1) | CA2252701C (es) |
CZ (1) | CZ347098A3 (es) |
DE (1) | DE69709568T2 (es) |
DK (1) | DK0805158T3 (es) |
EA (1) | EA001450B1 (es) |
ES (1) | ES2170918T3 (es) |
IL (1) | IL126762A0 (es) |
NO (1) | NO310416B1 (es) |
NZ (1) | NZ332658A (es) |
PL (1) | PL329681A1 (es) |
PT (1) | PT805158E (es) |
TR (1) | TR199802193T2 (es) |
WO (1) | WO1997041127A1 (es) |
YU (1) | YU48398A (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6127401A (en) | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
US7425537B2 (en) * | 2000-08-22 | 2008-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SH2 domain binding inhibitors |
DE60112611T2 (de) * | 2000-12-08 | 2006-06-14 | Ortho Mcneil Pharm Inc | Makroheterocyclische verbindungen als kinase inhibitoren |
EP1441772A2 (en) * | 2001-10-29 | 2004-08-04 | Nektar Therapeutics Al, Corporation | Polymer conjugates of protein kinase c inhibitors |
WO2003099284A1 (en) | 2002-05-22 | 2003-12-04 | Amgen Inc. | Amino-pyridine, -pyridine and pyridazine derivatives for use as vanilloid receptor ligands for the treatment of pain |
AU2003264047B2 (en) | 2002-08-08 | 2008-06-26 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
DE10244453A1 (de) * | 2002-09-24 | 2004-04-01 | Phenomiques Gmbh | Hemmung der Proteinkinase C-alpha zur Behandlung von Krankheiten |
US7245117B1 (en) * | 2004-11-01 | 2007-07-17 | Cardiomems, Inc. | Communicating with implanted wireless sensor |
MY139645A (en) | 2004-02-11 | 2009-10-30 | Amgen Inc | Vanilloid receptor ligands and their use in treatments |
CA2556239A1 (en) | 2004-02-11 | 2005-08-25 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
RU2433124C2 (ru) | 2004-09-14 | 2011-11-10 | Фармассет, Инк. | Способ получения 2'-фтор-2'-алкилзамещенных или других замещенных рибофуранозилпиримидинов и пуринов и их производных |
WO2006089311A1 (en) * | 2005-02-15 | 2006-08-24 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
EP1877424A4 (en) * | 2005-04-11 | 2010-09-29 | Pharmagap Inc | INHIBITORS OF PROTEIN KINASES AND USES THEREOF |
EP1877400A1 (en) * | 2005-04-15 | 2008-01-16 | Amgen, Inc | Vanilloid receptor ligands and their use in treatments |
WO2010049947A2 (en) * | 2008-10-28 | 2010-05-06 | Accrete Pharmaceutical Private Limited | Preparation of gemcitabine and intermediates thereof |
NZ597477A (en) | 2009-06-10 | 2014-03-28 | Chugai Pharmaceutical Co Ltd | Tetracyclic compounds |
CN103052386B (zh) | 2010-08-20 | 2016-03-02 | 中外制药株式会社 | 含有四环化合物的组合物 |
HUE040055T2 (hu) | 2012-09-25 | 2019-02-28 | Chugai Pharmaceutical Co Ltd | RET inhibitor |
CA2946518C (en) | 2014-04-25 | 2022-07-26 | Chugai Seiyaku Kabushiki Kaisha | Preparation containing tetracyclic compound at high dose |
CN106458967A (zh) | 2014-04-25 | 2017-02-22 | 中外制药株式会社 | 四环化合物的新结晶 |
TWI803187B (zh) | 2014-08-08 | 2023-05-21 | 日商中外製藥股份有限公司 | 包含4環性化合物的非晶質體之固體分散體及製劑 |
EP3246047A4 (en) | 2015-01-16 | 2018-08-22 | Chugai Seiyaku Kabushiki Kaisha | Combination drug |
WO2019000224A1 (zh) * | 2017-06-27 | 2019-01-03 | 中国海洋大学 | 双吲哚马来酰亚胺衍生物及其制备方法和用途 |
SG11202100983XA (en) | 2018-09-04 | 2021-03-30 | Chugai Pharmaceutical Co Ltd | Method of producing tetracyclic compound |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5438050A (en) * | 1988-02-06 | 1995-08-01 | Godecke Aktiengesellschaft | Indolocarbazole derivatives, processes for their preparation and compositions containing them |
US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
US5589472A (en) * | 1992-09-25 | 1996-12-31 | Vice; Susan F. | Diindolo compounds and pharmaceutical compositions containing them |
PL182124B1 (pl) * | 1993-12-07 | 2001-11-30 | Lilly Co Eli | Nowe zwiazki oraz srodek farmaceutyczny przeznaczony do leczenia powiklan cukrzycowych lub do leczenia nowotworów PL PL PL PL PL PL PL PL |
US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
US5472183A (en) * | 1994-03-17 | 1995-12-05 | Nisca Corporation | Sheet feeding device with multiple sheet stackers |
US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
US5696949A (en) * | 1995-06-15 | 1997-12-09 | Intel Corporation | System for PCI slots expansion using asynchronous PCI-to-PCI bridge with clock generator for providing clock signal to the expansion mother board and expansion side of bridge |
-
1997
- 1997-04-30 BR BR9709301A patent/BR9709301A/pt unknown
- 1997-04-30 JP JP52234397A patent/JP3235840B2/ja not_active Expired - Fee Related
- 1997-04-30 AU AU29292/97A patent/AU703395B2/en not_active Ceased
- 1997-04-30 YU YU48398A patent/YU48398A/sh unknown
- 1997-04-30 CZ CZ983470A patent/CZ347098A3/cs unknown
- 1997-04-30 US US08/846,272 patent/US5936084A/en not_active Expired - Fee Related
- 1997-04-30 KR KR1019980708737A patent/KR20000065137A/ko active IP Right Grant
- 1997-04-30 NZ NZ332658A patent/NZ332658A/xx unknown
- 1997-04-30 CA CA002252701A patent/CA2252701C/en not_active Expired - Fee Related
- 1997-04-30 EA EA199800966A patent/EA001450B1/ru not_active IP Right Cessation
- 1997-04-30 WO PCT/US1997/007302 patent/WO1997041127A1/en not_active Application Discontinuation
- 1997-04-30 TR TR1998/02193T patent/TR199802193T2/xx unknown
- 1997-04-30 PL PL97329681A patent/PL329681A1/xx unknown
- 1997-04-30 IL IL12676297A patent/IL126762A0/xx unknown
- 1997-05-01 DK DK97302996T patent/DK0805158T3/da active
- 1997-05-01 DE DE69709568T patent/DE69709568T2/de not_active Expired - Fee Related
- 1997-05-01 EP EP97302996A patent/EP0805158B1/en not_active Expired - Lifetime
- 1997-05-01 AT AT97302996T patent/ATE212026T1/de not_active IP Right Cessation
- 1997-05-01 ES ES97302996T patent/ES2170918T3/es not_active Expired - Lifetime
- 1997-05-01 PT PT97302996T patent/PT805158E/pt unknown
-
1998
- 1998-10-30 NO NO19985080A patent/NO310416B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO310416B1 (no) | 2001-07-02 |
AU703395B2 (en) | 1999-03-25 |
US5936084A (en) | 1999-08-10 |
ATE212026T1 (de) | 2002-02-15 |
TR199802193T2 (xx) | 1999-02-22 |
EA001450B1 (ru) | 2001-04-23 |
PT805158E (pt) | 2002-06-28 |
DE69709568T2 (de) | 2002-09-05 |
BR9709301A (pt) | 1999-08-10 |
WO1997041127A1 (en) | 1997-11-06 |
DE69709568D1 (de) | 2002-02-21 |
JPH11509233A (ja) | 1999-08-17 |
CZ347098A3 (cs) | 1999-06-16 |
IL126762A0 (en) | 1999-08-17 |
AU2929297A (en) | 1997-11-19 |
JP3235840B2 (ja) | 2001-12-04 |
EP0805158B1 (en) | 2002-01-16 |
NZ332658A (en) | 2000-05-26 |
CA2252701C (en) | 2003-10-28 |
EP0805158A2 (en) | 1997-11-05 |
PL329681A1 (en) | 1999-04-12 |
CA2252701A1 (en) | 1997-11-06 |
EA199800966A1 (ru) | 1999-04-29 |
NO985080D0 (no) | 1998-10-30 |
DK0805158T3 (da) | 2002-03-18 |
YU48398A (sh) | 2000-12-28 |
NO985080L (no) | 1998-12-08 |
EP0805158A3 (en) | 1998-04-01 |
KR20000065137A (ko) | 2000-11-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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