YU46919B - Postupak za dobijanje derivata l-alanil-l-prolina - Google Patents

Postupak za dobijanje derivata l-alanil-l-prolina

Info

Publication number
YU46919B
YU46919B YU135588A YU135588A YU46919B YU 46919 B YU46919 B YU 46919B YU 135588 A YU135588 A YU 135588A YU 135588 A YU135588 A YU 135588A YU 46919 B YU46919 B YU 46919B
Authority
YU
Yugoslavia
Prior art keywords
formula
alanyl
preparation
proline
proline derivatives
Prior art date
Application number
YU135588A
Other languages
English (en)
Serbian (sr)
Other versions
YU135588A (en
Inventor
M. Merslavić
P. Zupet
V. Flego
M. Japelj
B. Stanovnik
J. Cirnski
Original Assignee
Krka Tovarna Zdravil N.Sol.O.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil N.Sol.O. filed Critical Krka Tovarna Zdravil N.Sol.O.
Priority to YU135588A priority Critical patent/YU46919B/sh
Priority to SI8811355A priority patent/SI8811355A/sl
Priority to NO892813A priority patent/NO172894C/no
Priority to ES8902425A priority patent/ES2015723A6/es
Priority to AT168189A priority patent/AT394726B/de
Priority to PL28052689A priority patent/PL154625B1/pl
Priority to DD33068889A priority patent/DD284028B5/de
Priority to SU894614532A priority patent/SU1757471A3/ru
Priority to UA4614532A priority patent/UA18634A1/uk
Priority to JP1179211A priority patent/JP2714447B2/ja
Publication of YU135588A publication Critical patent/YU135588A/xx
Priority to LV930829A priority patent/LV5528A3/xx
Priority to LTRP821A priority patent/LT2188B/xx
Priority to HRP-1355/88A priority patent/HRP931139B1/xx
Publication of YU46919B publication Critical patent/YU46919B/sh

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE DERIVATA L-ALANIL-L-PROLINA, i njihovih farmaceutski prihvatljivih soli, naznačen time, što se N,O-bistrimetil sili-L-prolin formule II kondenzuje sa derivatom N-/1(S)-etoksikarbonil-3-fenilpropil/-L-alanina opšte formule III u kojoj Het označava ostatak imidazola-1 ili 2-tiobenzotiazola, u nepolarnim organskim rastvaračima, kao što su dioksan, tetrahidrofuran i metilenhlorid, prvenstveno tetrahidrofuran, u temperaturnom intervalu od -10 do 20 C i po želji dobijeno jedinjenje formule I, gde je R etil, hidrolizuje u jedinjenje formule I, gde je R vodonik.
YU135588A 1988-07-13 1988-07-13 Postupak za dobijanje derivata l-alanil-l-prolina YU46919B (sh)

Priority Applications (13)

Application Number Priority Date Filing Date Title
YU135588A YU46919B (sh) 1988-07-13 1988-07-13 Postupak za dobijanje derivata l-alanil-l-prolina
SI8811355A SI8811355A (en) 1988-07-13 1988-07-13 Process for preparing of L-alanine-L-proline derivatives
NO892813A NO172894C (no) 1988-07-13 1989-07-07 Fremgangsmaate til fremstilling av l-alanyl-l-prolinderivater
ES8902425A ES2015723A6 (es) 1988-07-13 1989-07-10 Un procedimiento para la preparacion de derivados de l-alanil-l-prolina.
AT168189A AT394726B (de) 1988-07-13 1989-07-11 Verfahren zur herstellung von l-alanyl-l-prolin-derivaten
PL28052689A PL154625B1 (en) 1988-07-13 1989-07-11 Method of obtaining l-alanyl-l-proline
DD33068889A DD284028B5 (de) 1988-07-13 1989-07-11 Verfahren zur Herstellung von L-Alanyl-L-prolin-Derivaten
SU894614532A SU1757471A3 (ru) 1988-07-13 1989-07-12 Способ получени производных L-аланил-L-пролина или их фармацевтически приемлемых солей
UA4614532A UA18634A1 (uk) 1988-07-13 1989-07-12 Спосіб одердаhhя похідhих l-алаhіл-l-пропіліhа або їх фармацевтичhо прийhятhих солей
JP1179211A JP2714447B2 (ja) 1988-07-13 1989-07-13 Ｌ―アラニル―ｌ―プロリン誘導体の製造方法
LV930829A LV5528A3 (lv) 1988-07-13 1993-06-30 L-alanil-l-prolina atvasinajumu vai to farmaceitiski derigu salu iegusanas panemiens
LTRP821A LT2188B (lt) 1988-07-13 1993-07-29 L-analil-l-prolino dariniu arba ju farmaceutiskai priimtinu drusku gavimo budas
HRP-1355/88A HRP931139B1 (en) 1988-07-13 1993-08-19 Proces for the preparation of l-alanyl-proline derivates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU135588A YU46919B (sh) 1988-07-13 1988-07-13 Postupak za dobijanje derivata l-alanil-l-prolina

Publications (2)

Publication Number Publication Date
YU135588A YU135588A (en) 1990-02-28
YU46919B true YU46919B (sh) 1994-06-24

Family

ID=25553829

Family Applications (1)

Application Number Title Priority Date Filing Date
YU135588A YU46919B (sh) 1988-07-13 1988-07-13 Postupak za dobijanje derivata l-alanil-l-prolina

Country Status (10)

Country Link
JP (1) JP2714447B2 (sh)
AT (1) AT394726B (sh)
DD (1) DD284028B5 (sh)
ES (1) ES2015723A6 (sh)
NO (1) NO172894C (sh)
PL (1) PL154625B1 (sh)
SI (1) SI8811355A (sh)
SU (1) SU1757471A3 (sh)
UA (1) UA18634A1 (sh)
YU (1) YU46919B (sh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005010028A1 (en) * 2003-07-31 2005-02-03 Lupin Limited Alpha-amino acid benzothiazolylthio ester as intermediates for manufacture of ace inhibitors and process for preparation thereof
US20100204470A1 (en) * 2006-06-27 2010-08-12 Sandoz Ag method for salt preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4442089A (en) * 1982-07-06 1984-04-10 E. R. Squibb & Sons, Inc. Method for treating glaucoma with topical or systemic ACE inhibitor compositions
JPS6248696A (ja) * 1985-08-27 1987-03-03 Kanegafuchi Chem Ind Co Ltd Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニル−ｌ−プロリンの製造法

Also Published As

Publication number Publication date
JP2714447B2 (ja) 1998-02-16
PL154625B1 (en) 1991-08-30
NO892813L (no) 1990-01-15
SI8811355A (en) 1995-04-30
YU135588A (en) 1990-02-28
NO892813D0 (no) 1989-07-07
AT394726B (de) 1992-06-10
JPH0272195A (ja) 1990-03-12
ES2015723A6 (es) 1990-09-01
PL280526A1 (en) 1990-02-05
DD284028B5 (de) 1996-08-08
NO172894C (no) 1993-09-22
SU1757471A3 (ru) 1992-08-23
NO172894B (no) 1993-06-14
UA18634A1 (uk) 1997-12-25
ATA168189A (de) 1991-11-15

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