WO2023136347A1 - 人体用害虫忌避剤 - Google Patents
人体用害虫忌避剤 Download PDFInfo
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- WO2023136347A1 WO2023136347A1 PCT/JP2023/001023 JP2023001023W WO2023136347A1 WO 2023136347 A1 WO2023136347 A1 WO 2023136347A1 JP 2023001023 W JP2023001023 W JP 2023001023W WO 2023136347 A1 WO2023136347 A1 WO 2023136347A1
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- Prior art keywords
- repellent
- fatty acid
- humans
- pest repellent
- pest
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- 229910000271 hectorite Inorganic materials 0.000 description 1
- 229940100463 hexyl laurate Drugs 0.000 description 1
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- 235000010494 karaya gum Nutrition 0.000 description 1
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- 229940094522 laponite Drugs 0.000 description 1
- 229940070765 laurate Drugs 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 1
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- VBAYIYXVOOGXEM-UHFFFAOYSA-N methyl 6-pentylcyclohexene-1-carboxylate Chemical compound COC(=O)C1=CCCCC1CCCCC VBAYIYXVOOGXEM-UHFFFAOYSA-N 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
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- 230000003472 neutralizing effect Effects 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- 239000001814 pectin Substances 0.000 description 1
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- 239000002304 perfume Substances 0.000 description 1
- 229960000490 permethrin Drugs 0.000 description 1
- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 description 1
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- SMKRKQBMYOFFMU-UHFFFAOYSA-N prallethrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OC1C(C)=C(CC#C)C(=O)C1 SMKRKQBMYOFFMU-UHFFFAOYSA-N 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
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- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
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- 235000019423 pullulan Nutrition 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
- LKUNXBRZDFMZOK-UHFFFAOYSA-N rac-1-monodecanoylglycerol Chemical compound CCCCCCCCCC(=O)OCC(O)CO LKUNXBRZDFMZOK-UHFFFAOYSA-N 0.000 description 1
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 1
- DCBSHORRWZKAKO-UHFFFAOYSA-N rac-1-monomyristoylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(O)CO DCBSHORRWZKAKO-UHFFFAOYSA-N 0.000 description 1
- GRWFGVWFFZKLTI-UHFFFAOYSA-N rac-alpha-Pinene Natural products CC1=CCC2C(C)(C)C1C2 GRWFGVWFFZKLTI-UHFFFAOYSA-N 0.000 description 1
- 230000001846 repelling effect Effects 0.000 description 1
- 229940108410 resmethrin Drugs 0.000 description 1
- VEMKTZHHVJILDY-FIWHBWSRSA-N resmethrin Chemical compound CC1(C)[C@H](C=C(C)C)C1C(=O)OCC1=COC(CC=2C=CC=CC=2)=C1 VEMKTZHHVJILDY-FIWHBWSRSA-N 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 229920003179 starch-based polymer Polymers 0.000 description 1
- 239000004628 starch-based polymer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960005199 tetramethrin Drugs 0.000 description 1
- CXBMCYHAMVGWJQ-UHFFFAOYSA-N tetramethrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCN1C(=O)C(CCCC2)=C2C1=O CXBMCYHAMVGWJQ-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- DDVNRFNDOPPVQJ-HQJQHLMTSA-N transfluthrin Chemical compound CC1(C)[C@H](C=C(Cl)Cl)[C@H]1C(=O)OCC1=C(F)C(F)=CC(F)=C1F DDVNRFNDOPPVQJ-HQJQHLMTSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P17/00—Pest repellants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Definitions
- the present disclosure relates to a pest repellent for the human body, and more specifically, it does not scatter the repellent active ingredient, can be applied not only to the hands and feet, but also to the face and neck evenly and evenly, and the skin feels tight when used.
- the present invention relates to a pest repellent agent for human body which gives less irritation, excellent retention of repellent active ingredients, and good stability over time.
- Patent Document 1 proposes a method using DEET and hexyl laurate
- Patent Document 2 proposes a method of blending an emulsifier composition and DEET.
- repellents such as aerosols and mists that are used by spraying on the skin in liquid form contain ethanol and polyhydric alcohols at high concentrations in order to improve the solubility and dispersibility of the repellent active ingredients and to stabilize the formulation.
- ethanol and polyhydric alcohols at high concentrations in order to improve the solubility and dispersibility of the repellent active ingredients and to stabilize the formulation.
- Icaridin and Deet are sparingly soluble in water, but soluble in ethanol, so the addition of ethanol improves the stability of the formulation.
- repellents containing ethanol have the problem that when applied to the skin, the repellent active ingredients are less likely to stay on the skin.
- the repellent active ingredients are less likely to stay on the skin.
- due to the ethanol content some users may feel irritation, dryness, and tightness of the skin.
- Patent Document 3 proposes an ethanol-free repellent with a minimal amount of added polyhydric alcohol.
- repellents are in the form of aerosols or mists, and consumers sometimes feel irritation when inhaling the repellent active ingredients that scatter when used.
- it is difficult to use such as dripping during use
- it sometimes gives a poor feeling of use such as a tight feeling on the skin, which is peculiar to repellents.
- formulations containing high-concentration repellent active ingredients that have excellent repellent effects and can be appealed for longevity contain surfactants, higher alcohols and polyhydric alcohols in high concentrations, resulting in stickiness and stickiness during use.
- a slippery feeling and a tight feeling on the skin after application are caused, and as a result, it has been difficult to obtain a repellent that is easy to use and has a high concentration of repellent components.
- the present disclosure has been made in view of this point, and the purpose is to prevent scattering, to be able to apply not only to the hands and feet, but also to the face and neck evenly and uniformly, and to feel sticky and slimy when applied.
- the present invention has the following aspects.
- a repellent active ingredient (a)
- two or more nonionic surfactants selected from the group consisting of glycerin fatty acid esters and polyoxyethylene fatty acid esters, a water-soluble polymer (c), and water It can be a pest repellent for humans containing.
- the repellent active ingredient (a) may be at least one selected from the group consisting of icaridin and DEET.
- the HLB of one or more nonionic surfactants (b) selected from the group consisting of glycerin fatty acid esters and polyoxyethylene fatty acid esters may be 8 to 19, or 9 to 16; Alternatively, the concentration range may be 8-24% by weight, or 9-20% by weight.
- the concentration of the water-soluble polymer (c) may be 0.01 to 2% by mass, or 0.01 to 1% by mass with respect to the total mass of the pest repellent for humans.
- the glycerin fatty acid ester may be an ester of glycerin and a fatty acid, the fatty acid may have 12 or more carbon atoms, and the glycerin fatty acid ester may have an HLB of 8 or less.
- the polyoxyethylene fatty acid ester may be an ester of polyethylene glycol and fatty acid, the fatty acid may have 12 or more carbon atoms, and the POE fatty acid ester may have an HLB of 9 or more.
- the concentration range of the repellent active ingredient (a) may be 5 to 30% by mass, 5 to 25% by mass, or 5 to 20% by mass. Moreover, other components may be included.
- the pest repellent for human body according to the present disclosure does not scatter when used, can be applied not only to the hands and feet, but also to the face and neck evenly and uniformly. It has less tight feeling, excellent retention of repellent active ingredients, does not cause separation even under long-term storage, and has good stability.
- the pest repellent for humans comprises an active repellent ingredient (a) and one or more nonionic surfactants (b) selected from the group consisting of glycerin fatty acid esters and polyoxyethylene fatty acid esters. , a water-soluble polymer (c), and water. Water is, for example, purified water.
- the pest repellent for humans may contain other ingredients as necessary.
- the human pest repellent can be marketed as a pest repellent product, for example, in a container or the like.
- the container may be, for example, a spray container, an aerosol container, or the like. In the case of an aerosol container, a propellant for injecting the pest repellent for humans is also contained together.
- the repellent active ingredient (a) is an ingredient having a repellent effect on pests. Pests are, for example, mosquitoes.
- the repellent active ingredient (a) is not particularly limited as long as it has a repellent effect against insect pests.
- aminopropionic acid ethyl ester IR3535
- p-menthane-3,8-diol 2-ethyl-1,3-hexadiol, butyl 3,4-dihydro-2,2-dimethyl-4-oxo-2H- pyran-6-carboxylate
- n-hexyltriethylene glycol monoether methyl 6-n-pentyl-cyclohexene-1-carboxylate, dimethyl phthalate, eucalyptol, ⁇ -pinene, citronellal, camphor, linalool, terpenol , carvone, dioctyl phthalate, dibutyl phthalate, naphthalene, cinnamon, camphor, lemongrass, clover, thyme, geranium, bergamont, laure
- repellent active ingredient (a) a repellent active ingredient that is sparingly soluble in water and soluble in ethanol can be used in terms of usefulness.
- repellent active ingredients (a) include icaridin, deet (diethyltoluamide), 3-(N-n-butyl-N-acetyl)aminopropionic acid ethyl ester (IR3535), and p-menthane-3,8-diol. etc.
- icaridin or DEET can be used in terms of feeling of use and effects when applied to the skin.
- Nonionic surfactant (b) is one or more selected from the group consisting of glycerin fatty acid esters and polyoxyethylene fatty acid esters.
- One or two or more nonionic surfactants (b) uniformly emulsify and disperse the repellent active ingredient (a), thereby contributing to improving the stability of the pest repellent for humans.
- the glycerin fatty acid ester used in the present embodiment is not particularly limited, but for example, it is an ester of glycerin and fatty acid, and at least one hydroxyl group of glycerin is esterified with a fatty acid.
- Specific examples of glycerin fatty acid esters include glyceryl laurate, glyceryl myristate, glyceryl palmitate, glyceryl stearate, glyceryl oleate, glyceryl behenate, and glyceryl caprate.
- the number of carbon atoms in the fatty acid may be 12 or more, or may be 14-22.
- the HLB of the glycerin fatty acid ester can be 8 or less, or can be 2-7.
- the polyoxyethylene fatty acid ester used in the present embodiment is an ester of polyethylene glycol and fatty acid having an average repetition of polyoxyethylene groups (average number of added moles of ethylene oxide), and at least one hydroxyl group of polyethylene glycol is a fatty acid. is esterified by Hereinafter, “polyoxyethylene” is also described as "POE”.
- POE fatty acid esters used in the present embodiment include polyethylene glycol laurate (120 E.O.), polyethylene glycol myristate (150 E.O.), polyethylene glycol palmitate (150 E.O.), and stearic acid.
- polyethylene glycol (150 E.O.) polyethylene glycol distearate (150 E.O.), polyethylene glycol distearate (250 E.O.) and the like.
- the number of carbon atoms in the fatty acid may be 12 or more, or may be 14-22.
- the number of POEs can be 10-250 and can be 100-200.
- the HLB of the POE fatty acid ester can be 9 or higher, or can be 10-20.
- the HLB of the nonionic surfactant (b), which is one or more selected from the group consisting of glycerin fatty acid esters and polyoxyethylene fatty acid esters used in the present embodiment, can be 8 to 19, and 9 ⁇ 16.
- HLB Hydrophile-Lipophile Balance, that is, the relative strength of hydrophilicity and lipophilicity of surfactant molecules, and quantifies the hydrophilic-lipophilic balance. It is.
- the HLB of a nonionic surfactant is obtained from the following formula (1) from each value of the organic and inorganic properties of the molecular structural formula.
- the mixed HLB of one or more nonionic surfactants is obtained from the following formula (2).
- HLB value of nonionic surfactant ⁇ inorganic / ⁇ organic ⁇ 10 (1)
- Two or more nonionic surfactant HLB values HLB1 ⁇ W1 + HLB2 ⁇ W2 + (2)
- HLB1, HLB2: HLB value of nonionic surfactant W1, W2: Weight fraction of nonionic surfactant (W1 + W2 1)
- Water-soluble polymer (c) used in the present embodiment acts on the adsorption layer of the emulsified/dispersed aggregate and contributes to the stabilization of the aggregate due to steric protection and electrostatic repulsion.
- the aggregate can be stabilized even when the concentration of the surfactant is low, and the viscosity change over time can be reduced even under long-term storage. It is possible to suppress the aggregation and coalescence of and prevent separation.
- Water-soluble polymer in the present specification and claims refers to a polymer that dissolves or disperses in water and is capable of thickening an aqueous solvent.
- water-soluble polymer (c) examples include natural water-soluble polymers such as gum arabic, tamarind gum, tragacanth gum, galactan, guar gum, xanthan gum, carob gum, locust bean gum, karaya gum, carrageenan, pectin, plant-based polymers such as agar, quince seed, algecolloid and starch; microbial-based polymers such as dextran, dextrin, succinoglucan and pullulan; and animal-based polymers such as collagen, casein, albumin and gelatin.
- natural water-soluble polymers such as gum arabic, tamarind gum, tragacanth gum, galactan, guar gum, xanthan gum, carob gum, locust bean gum, karaya gum, carrageenan, pectin, plant-based polymers such as agar, quince seed, algecolloid and starch
- microbial-based polymers such as dextran, dextrin, suc
- semi-synthetic water-soluble polymers include starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxymethylcellulose, Cellulose-based polymers such as sodium methylcellulose (CMC), crystalline cellulose, and cellulose powder, and alginic acid-based polymers such as sodium alginate and propylene glycol alginate are included.
- starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxymethylcellulose
- Cellulose-based polymers such as sodium methylcellulose (CMC), crystalline cellulose, and cellulose powder
- Examples of synthetic water-soluble polymers include vinyl polymers such as polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, carboxyvinyl polymer (carbomer), and polyoxyethylene polymers such as polyethylene glycol (molecular weight 1500, 4000, 6000, etc.). Examples include polymers, polyoxyethylene-polyoxypropylene copolymer polymers, acrylic polymers such as sodium polyacrylate and polyethyl acrylate, polyethyleneimine, cationic polymers, and the like. Examples of inorganic water-soluble polymers include bentonite, AlMg silicate, laponite, hectorite, and anhydrous silicic acid. Any one of these may be used alone, or two or more of them may be used in combination.
- the carboxyvinyl polymer acts on the adsorption layer of the emulsified/dispersed aggregate, and has a steric protective effect and thixotropic properties to prevent aggregation and coalescence of the aggregate. Therefore, it is particularly preferable.
- Carboxyvinyl polymers are alkyl acrylate methacrylate copolymers.
- the human repellent may contain components (other components) other than the components described above.
- Other ingredients include, for example, surfactants other than glycerin fatty acid ester and polyoxyethylene fatty acid ester surfactants.
- Other additives include moisturizing agents, bactericidal and antiseptic agents, thickeners other than water-soluble polymers, pigments, pH adjusters, perfumes, ultraviolet absorbers, ultraviolet scattering agents, antioxidants and the like. Any one of these may be used alone, or two or more of them may be used in combination.
- surfactants are not particularly limited, and known surfactants can be used as appropriate. Specific examples include polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol tetraoleate, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene glycol, etc. These surfactants are pest repellents for humans. stability is less likely to be impaired, which is preferable. Any one of these surfactants may be used alone, or two or more of them may be used in combination.
- the concentration of the repellent active ingredient (a) can be 5 to 30% by mass with respect to the total mass of the pest repellent for humans. Also, the concentration of the repellent active ingredient (a) may be 5 to 25% by mass, or may be 5 to 20% by mass.
- the concentration of the repellent active ingredient (a) is at least the above lower limit, the pest repellent for human body is likely to exert its pest repellent effect when applied to the skin, and when it is at or below the above upper limit, the pest repellent for human body.
- the stability of the agent is better. In the present specification and claims, for example, when “5 to 30% by mass” is described, it means “5% by mass or more and 30% by mass or less", and includes numerical values on both sides of "-”. I'm in. The same is true for others.
- the concentration of the nonionic surfactant (b) can be 8-24% by mass with respect to the total mass of the pest repellent for humans.
- the concentration of the nonionic surfactant (b) may be 9-20% by mass. If the concentration of the nonionic surfactant (b) is less than the above lower limit, the stability of the pest repellent for humans may decrease. There is a risk of
- the concentration of the water-soluble polymer (c) can be 0.01-2% by mass with respect to the total mass of the pest repellent for humans.
- the concentration of the water-soluble polymer (c) can be 0.01-1 mass %.
- the concentration ratio R of the nonionic surfactant (b) concentration to the repellent active ingredient (a) concentration can be obtained by (b)/(a).
- the method for preparing the pest repellent for humans according to this embodiment is not particularly limited, and the pest repellent for humans can be prepared, for example, by the following method.
- Repellent active ingredient (a), surfactant (nonionic surfactant (b), other surfactants if necessary), oil agent, etc. are stirred in a hot bath of about 80 ° C., and the mixture is purified.
- antiseptics include methylparaben and propylparaben, but other antiseptics may be used.
- the pest repellent for humans according to the present embodiment does not scatter, can be applied evenly and evenly not only on the hands and feet, but also on the face and neck, and has little sticky or slimy feeling when used, and the skin after application. It also has less tight feeling, and is excellent in stability and retention of repellent active ingredients.
- a sparingly water-soluble repellent active ingredient such as Icaridin can be uniformly emulsified and dispersed with a small amount of surfactant. can stabilize pest repellents for humans.
- the nonionic surfactant (b) with the water-soluble polymer (c)
- a stable dispersion state can be maintained even if the amount of surfactant is reduced.
- the water-soluble polymer (c) acts on the adsorption layer of the emulsified/dispersed aggregate and contributes to the stabilization of the aggregate due to steric protection and electrostatic repulsion. Since it has the effect of preventing the aggregation and coalescence of aggregates, it is considered possible to prepare a pest repellent for humans with excellent stability even with a small amount of surfactant by using this together.
- the repellent active ingredient (a) with low volatility such as Icaridin loses its repellent effect mainly due to perspiration and percutaneous absorption, retention can be improved by suppressing percutaneous absorption. . Therefore, the present invention is effective for various repellent active ingredients, and is particularly useful when using a repellent active ingredient with low volatility such as Icaridin.
- the form of the pest repellent for humans according to the present embodiment is not particularly limited, and it can be used in dosage forms such as emulsion, cream, gel, and spray, for example.
- the pest repellent for human body can be accommodated in a container according to the dosage form.
- the pest repellent for humans according to the present embodiment exerts a sufficient repelling effect against pests, for example, when applied to the skin.
- Pests to be repelled by the pest repellent for humans according to the present embodiment include, for example, mosquitoes, gnats, stable flies, house dust mites, bed bugs (bedbugs), ticks, chiggers, and fire ants. Effective.
- Repellent active ingredient (a) of the type and amount (values indicate mass%) shown in Tables 1 to 3 surfactant (nonionic surfactant (b), other surfactants as necessary) ) and a higher alcohol or polyhydric alcohol are stirred in a hot bath of about 80° C., heated purified water is added to the mixture, and the mixture is allowed to cool to 50° C. while stirring. After that, a water-soluble polymer and an antiseptic are added, a neutralizing agent such as sodium hydroxide is added, and the mixture is stirred and cooled to room temperature.
- higher alcohols examples include isostearyl alcohol and octyldodecanol, but higher alcohols other than these may be used.
- polyhydric alcohols examples include glycerin, 1,3-butylene glycol and propylene glycol, but polyhydric alcohols other than these may also be used.
- the "balance" of purified water in Tables 1 to 3 indicates the amount at which the total amount of pest repellent for humans becomes 100% by mass.
- Example 3 The pest repellent for humans was uniformly applied to the inside of the forearms of 5 subjects, and fluttering was evaluated according to the following criteria based on the evaluation results of the subjects. The results are as shown in Table 4. In Example 3, scattering was not felt, but commercially available products A and B felt scattering. Commercial product A is an aerosol product, commercial product B is a pump mist product, and commercial product C is a gel product.
- Example 3 did not irritate the skin, but commercial products A to C irritated the skin.
- ⁇ Skin tightness evaluation> The pest repellent for humans was uniformly applied to the inside of the forearms of five test subjects, and the tightness of the skin after application was evaluated according to the evaluation results of the test subjects according to the following criteria. The results are as shown in Table 4. In Example 3, the skin did not feel tight, but with the commercial products A to C, the skin felt tight.
- ⁇ Blood-sucking inhibition sustained effect test (pest repellent test)> A pest repellent for humans was uniformly applied to the inside of the forearms of 5 subjects, and a syringe containing 10 female Aedes albopictus was applied to the skin after each time (10 hours, 5 hours, and 5 hours before). After pressing for 1 minute, the number of sucked blood was counted, and the repellent effect was measured and evaluated. The results are shown in Table 4. In Example 3, a 90% blood absorption inhibition rate was confirmed even after 10 hours from application. The blood-sucking inhibition rate was below 90%.
- the nonionic surfactant (b) is a glycerin fatty acid ester alone system and a polyoxyethylene fatty acid ester alone system, but the repellent active ingredient can be uniformly emulsified and dispersed.
- the pest repellent for humans in Example 6 contains DEET as an active repellent ingredient, and DEET was uniformly emulsified and dispersed in the same manner as Icaridin, and the stability test after one month was also good.
- Examples 10 to 16 in which the mixed HLB of the nonionic surfactant (b) is within the range of 9 to 16, uniformly emulsify and disperse the repellent active ingredient, and maintain stability after one month.
- the test results were also good.
- Comparative Examples 4 and 5 in which the mixed HLB value was 8 or less, the appearance was uniform emulsification/dispersion immediately after blending, but the stability after one month was not good.
- the human pest repellents of Examples 17 to 20 contain CMC (hydroxymethyl cellulose), HEC (hydroxyethyl cellulose), xanthan gum, and cationized guar gum as water-soluble polymers. An emulsion could be produced, and the stability test after one month was also good.
- human pest repellents of Examples 24 to 28 contained higher alcohols and polyhydric alcohols as additives. there were.
- the pest repellent for human body of Example 3 does not scatter the active ingredient of the repellent as compared with the commercial product A and the commercial product B. Not only that, it was easy to apply evenly around the face and neck.
- the pest repellent for human body of Example 3 causes less dripping during application, is easy to apply evenly to the entire body including the face and neck, and gives a sticky or slimy feeling during use. There was little sensation, and the skin did not feel tight after application.
- the pest repellent for human body of Example 3 is easier to apply evenly to the entire body including the face and nape than commercial products A to C, and has less sticky or slimy feeling when used. It can be seen that there is no tight feeling on the skin after application, and that the anti-blood absorption effect test shows high persistence. In the same way, the other examples were also easier to apply evenly to the entire body including the face and neck compared to the commercial products A to C, and had less stickiness and sliminess during use, and the skin after application. There was no tight feeling, and the anti-sucking effect test showed high persistence.
- the pest repellent for humans according to the present invention can be used to repel pests such as mosquitoes, gnats, stable flies, house dust mites, bedbugs (bed bugs), ticks, chiggers, and fire ants.
- pests such as mosquitoes, gnats, stable flies, house dust mites, bedbugs (bed bugs), ticks, chiggers, and fire ants.
- it can be used as an insect repellent applied to human skin, an insect repellent applied to the epidermis of pets and livestock, and the like.
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Abstract
Description
忌避有効成分(a)は、害虫に対する忌避効果を有する成分である。害虫とは、例えば蚊などである。
ノニオン界面活性剤(b)は、グリセリン脂肪酸エステルおよびポリオキシエチレン脂肪酸エステルからなる群から選ばれる1種または2種以上である。1種または2種以上のノニオン界面活性剤(b)は、忌避有効成分(a)を均一乳化・分散させて人体用害虫忌避剤の安定性の向上に寄与する。
2種以上のノニオン界面活性剤HLB値=HLB1・W1+HLB2・W2+・・・ (2)
HLB1、HLB2:ノニオン界面活性剤のHLB値
W1、W2:ノニオン界面活性剤の重量分率(W1+W2=1)
本実施形態に用いられる水溶性高分子(c)は、乳化・分散させた会合体の吸着層に作用し、立体保護作用や静電反発力に起因し、会合体の安定化に寄与する。人体用害虫忌避剤が水溶性高分子(c)を含むことで、界面活性剤の濃度が少なくても会合体を安定化することができ、長期保存下でも経日粘度変化の低減や会合体の凝集や合一を抑制し、分離を防ぐことができる。
人体用忌避剤には、上述した成分以外の成分(他の成分)が含まれていてもよい。他の成分としては、例えばグリセリン脂肪酸エステルおよびポリオキシエチレン脂肪酸エステルの界面活性剤以外の他の界面活性剤が挙げられる。その他、保湿剤、殺菌・防腐剤、水溶性高分子以外の増粘剤、色素、pH調整剤、香料、紫外線吸収剤、紫外線散乱剤、酸化防止剤等の添加剤等が挙げられる。これらのいずれか1種を単独で用いてもよいし、任意の2種以上を組み合わせて用いてもよい。
本実施形態に係る人体用害虫忌避剤中、忌避有効成分(a)の濃度は、人体用害虫忌避剤の全質量に対して5~30質量%とすることができる。また、忌避有効成分(a)の濃度は、5~25質量%としてもよいし、5~20質量%としてもよい。忌避有効成分(a)の濃度が上記下限値以上であれば、人体用害虫忌避剤を肌に使用したときに害虫に対する忌避効果が発揮されやすく、上記上限値以下であれば、人体用害虫忌避剤の安定性がより優れる。尚、本明細書および特許請求の範囲で例えば「5~30質量%」と記載している場合、「5質量%以上30質量%以下」のことであり、「~」の両側の数値を含んでいる。他も同様である。
本実施形態に係る人体用害虫忌避剤の調製方法は特に限定されず、例えば以下の方法により人体用害虫忌避剤を調製可能である。
本実施形態に係る人体用害虫忌避剤は、舞い散りがなく、手足のみならず、顔や首筋にもムラなく均一に塗布でき、使用時のべたつき感やぬるつき感が少なく、塗布後の肌のツッパリ感も少なく、安定性および忌避有効成分の滞留性に優れる。
表1~3に記載の種類および配合量(数値は質量%を示す)の忌避有効成分(a)と、界面活性剤(ノニオン性界面活性剤(b)、必要に応じて他の界面活性剤)と、高級アルコールや多価アルコールを80℃程度の温浴で撹拌し、この混合物に加温した精製水を添加し、撹拌しながら50℃まで放冷する。その後、水溶性高分子と防腐剤を投入し、水酸化ナトリウム等の中和剤を添加し、室温まで撹拌、冷却する。高級アルコールとしては、例えばイソステアリルアルコール、オクチルドデカノール等を挙げることができるが、これら以外の高級アルコールを使用してもよい。また、多価アルコールとしては、例えばグリセリン、1,3-ブチレングリコール、プロピレングリコール等を挙げることができるが、これら以外の多価アルコールを使用してもよい。
上記作成方法によって作成された人体用害虫忌避剤(実施例1~28、比較例1~8)を室温(RT)、-5℃、50℃でそれぞれ1ヵ月保存した。保存後の人体用害虫忌避剤の状態(外観)をそれぞれ目視評価し、以下の基準で安定性を評価した。結果は表1~3に示したとおりであり、実施例1~28では幅広い温度範囲で分離がなく、均一に乳化・分散しているのに対し、比較例1~8では、液中に油滴が存在していたり、2相に分離しているものが見られた。
〇:分離がなく、均一に乳化・分散している。
△:一部乳化・分散しているが、油滴がある。
×:2相に分離している。
人体用害虫忌避剤を被験者5名の前腕内側に均一塗布し、被験者の評価結果より以下の基準で舞い散りを評価した。結果は表4に示したとおりであり、実施例3では舞い散りが感じられなかったが、市販品A、Bでは舞い散りが感じられた。市販品Aはエアゾール製品であり、市販品Bはポンプミスト製品であり、市販品Cはジェル製品である。
〇:5名全員が舞い散りを感じなかった。
×:1名以上が舞い散りを感じた。
人体用害虫忌避剤を被験者5名の前腕内側に塗布し、被験者の評価結果より以下の基準で、均一塗布のしやすさを評価した。結果は表4に示したとおりであり、実施例3では均一塗布し易かった。
〇:5名全員が均一塗布しやすいと感じた。
×:1名以上が均一塗布しにくいと感じた。
人体用害虫忌避剤を被験者5名の前腕内側に均一塗布し、被験者の評価結果より以下の基準で、刺激感を評価した。結果は表4に示したとおりであり、実施例3では肌への刺激を感じなかったが、市販品A~Cでは肌への刺激感を感じた。
〇:5名全員が刺激を感じなかった。
×:1名以上が刺激を感じた。
人体用害虫忌避剤を被験者5名の前腕内側に均一塗布し、被験者の評価結果より以下の基準で、塗布後の肌のツッパリ感を評価した。結果は表4に示したとおりであり、実施例3では肌のツッパリ感を感じなかったが、市販品A~Cでは肌のツッパリ感を感じた。
〇:5名全員が肌にツッパリ感を感じなかった。
×:1名以上が肌にツッパリ感を感じた。
人体用害虫忌避剤を被験者5名の前腕内側に均一塗布し、メスのヒトスジシマカ10匹を入れたシリンジを各時間経過後(10時間経過後、5時間経過後、5時間経過前)に肌に1分間押し当て、吸血した数をカウントし、忌避効果を測定し評価した。結果は表4に示したとおりであり、実施例3では塗布後、10時間経過しても90%の吸血阻止率を確認できたが、市販品A~Cでは塗布後、5時間経過すると、吸血阻止率が90%を下回った。
〇:10h後に90%吸血阻止効果を確認
△:5h後に90%吸血阻止効果を確認
×:5h未満で90%吸血阻止効果を確認
Claims (8)
- 忌避有効成分(a)と、グリセリン脂肪酸エステルおよびポリオキシエチレン脂肪酸エステルからなる群から選ばれる少なくとも1種または2種以上のノニオン界面活性剤(b)と、水溶性高分子(c)と、水とを含む人体用害虫忌避剤。
- 前記忌避有効成分(a)が、イカリジンおよびディートからなる群から選ばれる少なくとも1種である、請求項1に記載の人体用害虫忌避剤。
- 前記グリセリン脂肪酸エステルおよびポリオキシエチレン脂肪酸エステルからなる群から選ばれる1種または2種以上のノニオン界面活性剤(b)のHLBが8~19であり、ノニオン界面活性剤(b)の濃度範囲が8~24質量%である、請求項1に記載の人体用害虫忌避剤。
- 前記水溶性高分子(c)の濃度は、人体用害虫忌避剤の全質量に対して0.01~2質量%である、請求項1に記載の人体用害虫忌避剤。
- 前記グリセリン脂肪酸エステルおよびポリオキシエチレン脂肪酸エステルからある群から選ばれる1種または2種以上のノニオン界面活性剤(b)の濃度と、前記忌避有効成分(a)の濃度との濃度比(R=b/a)が、R=0.5~2.0である、請求項1に記載の人体用害虫忌避剤。
- 前記グリセリン脂肪酸エステルは、グリセリンと脂肪酸のエステルであり、前記脂肪酸の炭素数は12以上で、前記グリセリン脂肪酸エステルのHLBが8以下である、請求項1に記載の人体用害虫忌避剤。
- 前記ポリオキシエチレン脂肪酸エステルは、ポリエチレングリコールと脂肪酸のエステルであり、前記脂肪酸の炭素数は12以上で、前記ポリオキシエチレン脂肪酸エステルのHLBが9以上である、請求項1に記載の人体用害虫忌避剤。
- 前記忌避有効成分(a)の濃度範囲が5~30質量%である、請求項1に記載の人体用害虫忌避剤。
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JPH111404A (ja) | 1997-06-11 | 1999-01-06 | Dainippon Jochugiku Co Ltd | 新規害虫忌避剤 |
JP2000225360A (ja) * | 1998-12-01 | 2000-08-15 | Koike Kagaku Kk | 塗布用アクチュエーター付エアゾール製品 |
JP2003012414A (ja) | 2001-06-29 | 2003-01-15 | Earth Chem Corp Ltd | 人体用害虫忌避組成物 |
JP2003192503A (ja) * | 2001-12-26 | 2003-07-09 | Johnson Co Ltd | 人体用害虫忌避組成物及び人体用害虫忌避エアゾール組成物 |
JP2005132780A (ja) * | 2003-10-31 | 2005-05-26 | Dainippon Jochugiku Co Ltd | 人体用害虫忌避組成物 |
JP2007039342A (ja) * | 2005-08-01 | 2007-02-15 | Dainippon Jochugiku Co Ltd | 人体用ゲル状害虫忌避組成物 |
JP2007051097A (ja) * | 2005-08-18 | 2007-03-01 | Fumakilla Ltd | 人体用害虫忌避剤 |
JP2013203663A (ja) * | 2012-03-27 | 2013-10-07 | Toyo Aerosol Ind Co Ltd | 害虫忌避クラッキングエアゾール組成物 |
JP2019026603A (ja) | 2017-08-01 | 2019-02-21 | ライオン株式会社 | 忌避剤組成物 |
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