WO2022185434A1 - Non-combustion heating flavor inhaler, and cartridge - Google Patents
Non-combustion heating flavor inhaler, and cartridge Download PDFInfo
- Publication number
- WO2022185434A1 WO2022185434A1 PCT/JP2021/008098 JP2021008098W WO2022185434A1 WO 2022185434 A1 WO2022185434 A1 WO 2022185434A1 JP 2021008098 W JP2021008098 W JP 2021008098W WO 2022185434 A1 WO2022185434 A1 WO 2022185434A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aerosol
- flavor inhaler
- source
- aerosol source
- tobacco
- Prior art date
Links
- 239000000796 flavoring agent Substances 0.000 title claims abstract description 99
- 235000019634 flavors Nutrition 0.000 title claims abstract description 99
- 238000010438 heat treatment Methods 0.000 title claims abstract description 63
- 238000002485 combustion reaction Methods 0.000 title claims abstract description 61
- 239000000443 aerosol Substances 0.000 claims abstract description 162
- 150000001875 compounds Chemical class 0.000 claims abstract description 37
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 10
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 10
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims description 76
- 241000208125 Nicotiana Species 0.000 claims description 71
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 71
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 55
- 229960002715 nicotine Drugs 0.000 claims description 45
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 45
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 36
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 26
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 26
- 229940041616 menthol Drugs 0.000 claims description 26
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 23
- 239000001069 triethyl citrate Substances 0.000 claims description 23
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 23
- 235000013769 triethyl citrate Nutrition 0.000 claims description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 22
- 238000000889 atomisation Methods 0.000 claims description 19
- 235000011187 glycerol Nutrition 0.000 claims description 11
- 239000003205 fragrance Substances 0.000 claims description 3
- 230000037361 pathway Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 21
- 239000002994 raw material Substances 0.000 description 21
- 230000000694 effects Effects 0.000 description 10
- 238000011156 evaluation Methods 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 9
- 239000002304 perfume Substances 0.000 description 9
- 239000002245 particle Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 235000019658 bitter taste Nutrition 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000001953 sensory effect Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000001007 puffing effect Effects 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- GYHFUZHODSMOHU-UHFFFAOYSA-N nonanal Chemical compound CCCCCCCCC=O GYHFUZHODSMOHU-UHFFFAOYSA-N 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 230000000391 smoking effect Effects 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 150000003934 aromatic aldehydes Chemical class 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- -1 furfural Chemical compound 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229940040102 levulinic acid Drugs 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 229910001416 lithium ion Inorganic materials 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
Definitions
- the present invention relates to a non-combustion heating flavor inhaler and cartridge.
- Non-combustion heated flavor inhalers for supplying ingredients to users are known (eg, Patent Documents 1 and 2).
- the non-combustion heating type flavor inhaler comprises, for example, a cartridge including an aerosol source and atomization means for heating and atomizing the aerosol source, a power supply unit for supplying power to the atomization means, and downstream of the cartridge. and a flavoring cartridge containing a tobacco source positioned thereon.
- the aerosol source may also contain perfume ingredients such as menthol.
- non-combustion heated flavor inhalers that do not have a flavoring cartridge, but instead the aerosol source contains tobacco-derived components.
- tobacco-derived components such as nicotine and flavoring components such as menthol contained in the aerosol may deposit and be lost at the mouthpiece.
- the non-combustion heating type flavor inhaler is provided with a flavoring cartridge, the tobacco-derived component and the flavoring component that have migrated to the aerosol are deposited and lost in the flavoring cartridge even in the flavoring cartridge. There is Such loss within the aerosol pathway reduces the delivery of flavoring ingredients to the user.
- An object of the present invention is to provide a non-combustion heating flavor inhaler in which the loss of flavor components in the aerosol path is suppressed, and a cartridge used for the non-combustion heating flavor inhaler.
- the present invention includes the following embodiments.
- R 1 , R 2 and R 3 are each independently an alkyl group having 3 to 6 carbon atoms.
- atomization means for atomizing the aerosol source to produce an aerosol comprising:
- a cartridge for a non-combustion heating flavor inhaler containing an aerosol source containing a compound represented by the following formula (1).
- R 1 , R 2 and R 3 are each independently an alkyl group having 3 to 6 carbon atoms.
- the present invention it is possible to provide a non-combustion heating flavor inhaler in which the loss of flavor components in the aerosol path is suppressed, and a cartridge used for the non-combustion heating flavor inhaler.
- FIG. 2 is a schematic diagram showing a cartridge in which a flavor imparting cartridge is incorporated in FIG. 1.
- FIG. 1 is a graph showing the delivery amount of nicotine in Examples 1-5 and Comparative Example 1.
- FIG. 2 is a graph showing nicotine delivery amounts in Examples 6 to 9 and Comparative Example 2.
- FIG. 2 is a graph showing the delivery amount of menthol in Examples 6-9 and Comparative Example 2.
- FIG. 10 is a graph showing the delivery amount of nicotine in Examples 10-13 and Comparative Example 3.
- FIG. 2 is a graph showing the delivery amount of menthol in Examples 14-17 and Comparative Example 4.
- FIG. 1 is a graph showing the delivery amount of nicotine in Examples 1-5 and Comparative Example 1.
- FIG. 2 is a graph showing nicotine delivery amounts in Examples 6 to 9 and Comparative Example 2.
- FIG. 2 is a graph showing the delivery amount of menthol in Examples 6-9 and Comparative Example 2.
- FIG. 10 is a graph showing the delivery amount of nicotine in Examples 10-13 and Comparative Example 3.
- FIG. 2 is
- the non-combustion-heating flavor inhaler includes an aerosol source containing a compound represented by the following formula (1), and atomization means for atomizing the aerosol source to generate an aerosol.
- R 1 , R 2 and R 3 are each independently an alkyl group having 3 to 6 carbon atoms.
- the non-combustion heating type flavor inhaler when the aerosol source is atomized to generate an aerosol, the compound represented by the formula (1) migrates to the aerosol. Since the compound represented by the formula (1) has a high boiling point, when the compound represented by the formula (1) is contained in the aerosol, the aerosol particles are less likely to evaporate and stabilize. In addition, the compound represented by the formula (1) has a high solubility of tobacco-derived components such as nicotine and flavoring components such as menthol. Therefore, by including the compound represented by the formula (1) in the aerosol particles, the tobacco-derived component and the flavoring component can be contained in a larger amount in the aerosol particles, and the tobacco-derived component and the flavoring component can be included in the aerosol particles. less likely to be released to the outside. It is considered that the non-combustion heating type flavor inhaler according to the present embodiment suppresses the loss of flavor components in the aerosol path.
- the non-combustion-heating flavor inhaler includes an aerosol source containing the compound represented by the formula (1), and an atomizing means for atomizing the aerosol source to generate an aerosol.
- an aerosol source containing the compound represented by the formula (1)
- an atomizing means for atomizing the aerosol source to generate an aerosol.
- it may include other configurations than the aerosol source and the atomization means.
- Other configurations include, for example, a tobacco source containing tobacco-derived components located downstream of the aerosol source.
- the aerosol source according to this embodiment contains the compound represented by formula (1) above.
- R 1 , R 2 and R 3 are each independently an alkyl group having 3 to 6 carbon atoms.
- R 1 , R 2 and R 3 are alkyl groups having 3 or more carbon atoms, the boiling point of the compound represented by the formula (1) is increased and the aerosol particles are stabilized.
- R 1 , R 2 and R 3 are alkyl groups having 6 or less carbon atoms, the temperature required to vaporize the compound represented by the formula (1) can be lowered, and the aerosol source can be The temperature during atomization can be lowered.
- R 1 , R 2 and R 3 are each independently preferably an alkyl group having 4 to 6 carbon atoms.
- the compound represented by formula (1) is preferably tributyl citrate (TBC).
- TBC tributyl citrate
- the aerosol source may contain one compound represented by the formula (1), or may contain two or more compounds.
- the content of the compound represented by formula (1) in the aerosol source is preferably 5 to 70% by mass with respect to 100% by mass of the aerosol source.
- the content is 5% by mass or more, the aerosol particles are sufficiently stabilized, and the loss of the flavor component in the aerosol path can be sufficiently suppressed.
- the content is 70% by mass or less, the content of other components such as an aerosol generating agent, which will be described later, can be maintained.
- the content is more preferably 5 to 60% by mass, even more preferably 10 to 50% by mass.
- the aerosol source preferably contains triethyl citrate (TEC) in addition to the compound represented by formula (1).
- TEC triethyl citrate
- the added amount of the compound represented by the formula (1) can be reduced while maintaining the effect of suppressing the loss of flavor components in the aerosol path. Thereby, the characteristic odor derived from the compound represented by the formula (1) can be reduced.
- the compound represented by the formula (1) can express the body feeling and stereoscopic effect of tobacco-derived components such as nicotine at the time of use, and triethyl citrate causes discomfort such as irritation derived from the tobacco-derived components. can be reduced.
- the compound represented by the formula (1) can express the body feeling and three-dimensional effect of perfume ingredients such as menthol when used, and triethyl citrate can express the features such as brightness of the perfume ingredients. Therefore, by using both together, it is possible to further improve the sensation based on the tobacco-derived component and the flavoring component during use.
- the aerosol source does not contain the compound represented by the formula (1) and contains only triethyl citrate, the effect of the present embodiment cannot be obtained.
- the content of triethyl citrate in the aerosol source is 3 to 50% by mass with respect to 100% by mass of the aerosol source, from the viewpoint of sufficiently obtaining the effects described above. preferably 5 to 40% by mass, even more preferably 10 to 30% by mass.
- the content ratio of the compound represented by the formula (1) and triethyl citrate is preferably 50 to 90:10 to 50. , 50-70:30-50, more preferably 50-60:40-50.
- the aerosol source can contain an aerosol-generating agent.
- the aerosol generating agent is atomized by heating to generate an aerosol.
- the aerosol-generating agent is not particularly limited as long as it can be atomized by heating to generate an aerosol, and can be selected from extracts from various natural products and constituents thereof.
- Aerosol-generating agents include, for example, polyhydric alcohols such as glycerin (G), propylene glycol (PG), 1,3-butanediol, sorbitol, xylitol and erythritol, and triacetin. These may be used alone or in combination of two or more. Among these, propylene glycol and At least one of glycerin is preferred.
- the content of the aerosol generating agent in the aerosol source is 30 to 30% with respect to 100% by mass of the aerosol source, from the viewpoint of ensuring a sufficient amount of aerosol generation and sufficiently delivering the tobacco-derived component and the fragrance component. It is preferably 95% by mass, more preferably 40 to 90% by mass, even more preferably 45 to 75% by mass.
- the aerosol source preferably further contains at least one selected from the group consisting of nicotine, nicotine salts, and perfume ingredients.
- the aerosol source includes nicotine, nicotine salts, and/or flavoring ingredients such that these ingredients are included in the aerosol when the aerosol is generated. Since the aerosol contains the compound represented by the formula (1), the aerosol particles are stabilized and the components are less likely to be released outside the aerosol particles. As a result, loss of said components in the aerosol path is reduced.
- the nicotine and nicotine salt may be a liquid containing both nicotine and nicotine salt.
- Nicotine salts include, for example, nicotine salts produced by mixing citric acid, tartaric acid, malic acid, levulinic acid, benzoic acid, etc. with nicotine.
- the content of nicotine and/or nicotine salt in the aerosol source is preferably 1 to 15% by mass with respect to 100% by mass of the aerosol source. , more preferably 2 to 10% by mass, more preferably 3 to 5% by mass.
- perfume components include, but are not limited to, terpenes such as menthol and linalool, aromatic aldehydes such as furfural, and aldehydes such as nonanal. These may be used alone or in combination of two or more.
- the content of the perfume component in the aerosol source is preferably 1 to 15% by mass, more preferably 2 to 10% by mass relative to 100% by mass of the aerosol source. and more preferably 3 to 5% by mass.
- the aerosol source according to this embodiment can contain other components such as water in addition to the components described above.
- the aerosol source can be arranged, for example, in a cartridge as described below.
- the compound represented by the formula (1) must be contained in the aerosol source.
- the tobacco source disposed downstream of the aerosol source contains the compound represented by the formula (1), the compound represented by the formula (1) does not sufficiently migrate into the aerosol. No morphological effect is obtained.
- the non-combustion heating flavor inhaler includes atomization means for atomizing the aerosol source to generate an aerosol.
- the atomization means is not particularly limited as long as it can atomize the aerosol source to generate an aerosol, but it can be, for example, a heating atomization means. Specifically, it can be a heating resistor such as a heating wire that generates heat by electric power supplied from a power source as described later.
- the atomizing means can be arranged, for example, in a cartridge as described below.
- the non-combustion-heated flavor inhaler according to this embodiment can further include a tobacco source containing a tobacco-derived component located downstream of the aerosol source.
- tobacco-derived components contained in the tobacco source are transferred to the aerosol and supplied to the user. Examples of tobacco-derived components include nicotine and the like. Since the tobacco-derived component contained in the tobacco source is delivered by the aerosol, it is not necessary to heat the tobacco source itself during use.
- the non-combustion heating flavor inhaler according to this embodiment may not contain a tobacco source, in which case the aerosol source may contain a tobacco-derived component.
- the tobacco source is immersed in the aerosol source, the liquid tobacco-derived component extracted from the tobacco source is mixed with the aerosol source, the tobacco-derived component obtained by chemical synthesis is mixed with the aerosol source, and the like.
- Tobacco-derived ingredients can be included.
- the tobacco source can be composed of raw material pieces that impart tobacco-derived components to the aerosol generated by atomization of the aerosol source.
- the size of the raw material pieces is preferably 0.2 to 1.2 mm, more preferably 0.2 to 0.7 mm. Since the smaller the size of the raw material pieces, the greater the specific surface area, the tobacco-derived components are more likely to be released from the raw material pieces. Therefore, the amount of raw material pieces can be reduced in applying the desired amount of tobacco-derived component to the aerosol.
- shredded tobacco a molded product obtained by molding tobacco raw material into granules, a molded product obtained by molding tobacco raw material into a sheet shape, and the like can be used.
- the raw material pieces are obtained by sieving according to JIS Z 8815 using a stainless steel sieve according to JIS Z 8801, for example.
- a stainless steel sieve with an opening of 0.71 mm the raw material pieces are sieved for 20 minutes by a dry and mechanical shaking method to pass through a stainless steel sieve with an opening of 0.71 mm.
- using a stainless sieve with an opening of 0.212 mm the raw material pieces are sieved for 20 minutes by a dry and mechanical shaking method to pass through a stainless sieve with an opening of 0.212 mm. remove the raw material pieces.
- the tobacco source may contain flavor components in addition to tobacco-derived components.
- the raw material piece may contain a flavor component in addition to the tobacco-derived component.
- the perfume component include the perfume components described above, and it is preferable that menthol is included.
- the raw material pieces may also contain plants other than tobacco, such as mint and herbs.
- the tobacco source can be placed in a flavoring cartridge, for example provided downstream of the cartridge as described below.
- the cartridge according to this embodiment includes an aerosol source containing the compound represented by Formula (1) above.
- the cartridge is detachably attached to a non-combustion heated flavor inhaler.
- the cartridge may comprise atomization means for atomizing the aerosol source to produce an aerosol, as described below.
- FIG. 1 An example of the non-combustion heating type flavor inhaler according to this embodiment is shown in FIG.
- the non-combustion-heating flavor inhaler 100 shown in FIG. 1 is a device for inhaling flavor components without combustion, and has a shape extending along a predetermined direction A, which is the direction from the non-suction end to the suction end.
- FIG. 2 is a diagram showing the cartridge 111 in which the flavor imparting cartridge 130 is incorporated in FIG. Note that the non-combustion heating type flavor inhaler 100 may be simply referred to as the flavor inhaler 100 hereinafter.
- the flavor inhaler 100 has an inhaler body 110 and a flavoring cartridge 130 with a tobacco source.
- the inhaler main body 110 constitutes the main body of the flavor inhaler 100 and has a shape to which the flavor imparting cartridge 130 can be connected.
- the aspirator body 110 has an aspirator housing 110X, and the flavoring cartridge 130 is connected to the mouthpiece end of the aspirator housing 110X.
- the inhaler body 110 comprises a cartridge 111 comprising an aerosol source and atomization means according to the present embodiment, configured to atomize the aerosol source without combustion, and a power supply unit 112 .
- the cartridge 111 has a first cylindrical body 111X that forms part of the aspirator housing 110X.
- the cartridge 111 as shown in FIG. 2, has a reservoir 111P, a wick 111Q and an atomizing means 111R.
- the reservoir 111P, the wick 111Q and the atomizing means 111R are accommodated in the first cylindrical body 111X.
- the first tubular body 111X has a tubular shape (for example, a cylindrical shape) extending along the predetermined direction A.
- Reservoir 111P holds an aerosol source according to this embodiment.
- the reservoir 111P is a porous body made of a material such as a resin web.
- the wick 111Q is an example of a liquid retaining member that retains the aerosol source supplied from the reservoir 111P.
- the wick 111Q is made of glass fiber.
- the atomizing means 111R atomizes the aerosol source held by the wick 111Q.
- the atomization means 111R can be composed of, for example, a heating resistor (for example, a heating wire) wound around the wick 111Q at a predetermined pitch.
- An absorption member 111S that absorbs condensed aerosol is provided on the wall surface exposed to the flow path of the aerosol generated by the atomization means 111R.
- the wall surfaces exposed to the aerosol flow path are, for example, the inner surface of the first cylindrical body 111X exposed to the aerosol flow path, the outer surface of the reservoir 111P exposed to the aerosol flow path, and the like.
- the absorbing member 111S is not in contact with the reservoir 111P, the aerosol (condensed aerosol) absorbed by the absorbing member 111S is led from the absorbing member 111S to the atomizing means 111R using capillary action. is preferred.
- the absorbing member 111S when the absorbing member 111S is in contact with the reservoir 111P, the aerosol (condensed aerosol) absorbed by the absorbing member 111S is preferably guided from the absorbing member 111S to the reservoir 111P.
- the absorbing member 111S may be a member having a function of absorbing condensed aerosol, and may be made of the same material (resin web) as the reservoir 111P, or the same material (glass fiber) as the wick 111Q. may be configured by
- the power supply unit 112 has a second cylindrical body 112X that forms part of the aspirator housing 110X.
- the power supply unit 112 has an inlet 112A. Air flowing in from the inlet 112A is guided to the cartridge 111 (atomization means 111R) as shown in FIG.
- power supply unit 112 includes power supply 10 , suction sensor 20 , push button 30 , light emitting element 40 , and control circuit 50 .
- the power source 10, the suction sensor 20, the push button 30 and the control circuit 50 are housed in the second cylindrical body 112X.
- the second tubular body 112X has a tubular shape (for example, a cylindrical shape) extending along the predetermined direction A. As shown in FIG.
- the power supply 10 is, for example, a lithium ion battery.
- Power source 10 stores the power required to operate flavor inhaler 100 .
- the power supply 10 stores power to supply the suction sensor 20 and the control circuit 50 .
- the power source 10 accumulates electric power to be supplied to the cartridge 111 (atomizing means 111R).
- the suction sensor 20 detects fluid flow in a continuous suction path from the inlet 112A to the outlet 130A.
- the suction sensor 20 detects suction (suction state) when the fluid flow from the inlet 112A to the outlet 130A side is equal to or greater than a predetermined threshold.
- the suction sensor 20 detects non-suction (non-suction state) when the fluid flow from the inlet 112A to the outlet 130A side is less than a predetermined threshold.
- the push button 30 is configured to be pushed inward from the outside of the flavor inhaler 100 .
- the push button 30 is provided at the non-mouth end of the flavor inhaler 100 and is configured to be pushed in the direction from the non-mouth end toward the mouth end (that is, the predetermined direction A).
- the power of the flavor inhaler 100 may be turned on when the push button 30 is continuously pushed a predetermined number of times while the power of the flavor inhaler 100 is not turned on.
- the power of the flavor inhaler 100 may be turned off when the push button 30 is continuously pushed a predetermined number of times while the power of the flavor inhaler 100 is on.
- the power source of the flavor inhaler 100 may be turned off when a predetermined time has passed since the puffing operation was performed without performing the puffing operation.
- the light emitting element 40 is, for example, a light source such as an LED or electric light.
- the light emitting element 40 is provided on a side wall extending along a predetermined direction.
- the light emitting element 40 is preferably provided on the side wall near the non-mouth end.
- the light emission pattern of the light emitting element 40 is a pattern for notifying the user of the state of the flavor inhaler 100 .
- the light emitting element 40 may constitute a notification unit that notifies that a desired amount of aerosol can be supplied.
- the light emitting element 40 may continuously notify that the desired amount of aerosol can be supplied from the start to the end of the period in which the desired amount of aerosol can be supplied.
- the light emitting element 40 may constitute a notification unit that notifies that the desired amount of aerosol cannot be supplied.
- the light emitting element 40 may continuously notify that the desired amount of aerosol cannot be supplied from the start to the end of the period in which the desired amount of aerosol cannot be supplied.
- the control circuit 50 controls the operation of the flavor inhaler 100. Specifically, the control circuit 50 controls power output to the cartridge 111 (atomization means 111R). Also, the control circuit 50 controls the light emitting element 40 .
- the flavor imparting cartridge 130 is configured to be connectable to the aspirator main body 110 that constitutes the flavor aspirator 100 .
- the flavor imparting cartridge 130 is provided downstream of the cartridge 111 on the flow path of gas (hereinafter referred to as air) sucked from the mouthpiece.
- air gas
- the flavor imparting cartridge 130 does not necessarily need to be physically spaced closer to the mouthpiece side than the cartridge 111, but is located downstream of the cartridge 111 on the aerosol flow path that guides the aerosol generated from the cartridge 111 toward the mouthpiece side. It is sufficient if it is provided.
- the flavoring cartridge 130 has a flavoring cartridge housing 131, a tobacco source 132, a mesh 133A, and a filter 133B.
- the flavoring cartridge 130 also has an outlet 130A provided in the mouthpiece.
- the flavor imparting cartridge housing 131 has a cylindrical shape (for example, a cylindrical shape) extending along the predetermined direction A. Flavoring cartridge housing 131 houses tobacco source 132 . Here, flavoring cartridge housing 131 is configured to be inserted along predetermined direction A into aspirator housing 110X.
- the tobacco source 132 is provided closer to the outlet 130A (mouthpiece) than the cartridge 111 on the continuous suction path from the inlet 112A to the outlet 130A.
- Tobacco source 132 imparts a tobacco-derived component to the aerosol generated from the aerosol source.
- the tobacco-derived component imparted to the aerosol by tobacco source 132 is conveyed to outlet 130A (mouthpiece).
- the tobacco source 132 the tobacco source according to this embodiment described above can be used.
- the mesh 133A is provided upstream of the tobacco source 132 so as to block the opening of the flavor imparting cartridge housing 131 .
- Filter 133B is provided downstream of tobacco source 132 to block the opening of flavoring cartridge housing 131 .
- the mesh 133A has such roughness that the raw material pieces forming the tobacco source 132 cannot pass through.
- the mesh 133A has a mesh size of, for example, 0.077 to 0.198 mm.
- the filter 133B is made of a breathable material. Filter 133B is preferably an acetate filter, for example.
- the filter 133B has a roughness to the extent that the raw material pieces forming the tobacco source 132 do not pass through.
- Example 1 A non-combustion heating flavor inhaler having the configuration shown in FIG. 1 was produced.
- a solution containing 45.0% by weight propylene glycol (PG), 45.0% by weight glycerin (G), and 10.0% by weight tributyl citrate (TBC) was used as an aerosol source.
- PG propylene glycol
- G glycerin
- THC tributyl citrate
- M tobacco-derived components
- the amount of nicotine delivered during use of the non-combustion heated flavor inhaler was measured according to the method described above. The results are shown in FIG.
- Examples 2 to 5, Comparative Example 1 A non-combustion heating flavor inhaler was produced in the same manner as in Example 1, except that an aerosol source having the composition shown in Table 1 was used as the aerosol source, and the delivery amount of nicotine during use was measured. The results are shown in FIG. In Table 1, "PG” is propylene glycol, “G” is glycerin, “TEC” is triethyl citrate, “TBC” is tributyl citrate, and “M” is menthol.
- Examples 1 and 2 in which tributyl citrate was added to the aerosol source showed an increase in the amount of nicotine delivered.
- the amount delivered increased with increasing amounts of added tributyl citrate.
- the combined use of triethyl citrate showed that even if the content of tributyl citrate was reduced, the delivery amount of nicotine was maintained. It was confirmed to be equal to or higher than Example 2.
- Example 5 From the results of Example 5, it was confirmed that the delivery amount of nicotine was slightly increased as compared with Comparative Example 1 even when only tributyl citrate was used as an aerosol source. However, since the amount of nicotine delivered is smaller than in Examples 2 to 4, in the presence of an aerosol-generating agent such as propylene glycol or glycerin, the compound represented by the formula (1) such as tributyl citrate, or It was found that the addition of both the compound represented by formula (1) and triethyl citrate further increased the nicotine delivery.
- an aerosol-generating agent such as propylene glycol or glycerin
- the non-combustion heating type flavor inhalers of Comparative Example 1 and Examples 2 to 4 were sensory evaluated by five expert evaluation panels.
- the sensory evaluation was carried out by five professional evaluation panelists using the non-combustion-heating flavor inhaler in the same manner as in normal use, and making free comments.
- the above-mentioned five expert evaluation panels have been sufficiently trained in the sensory evaluation of the non-combustion heating type flavor inhaler, and that the evaluation thresholds are the same and the panelists are unified. .
- the non-combustion-heating flavor inhaler of Example 2 exhibited reduced stimulation of nicotine as compared with Comparative Example 1, expressed a better feeling of nicotine as it passed through the throat, and had a body feeling of nicotine and It was confirmed that the three-dimensional effect was expressed more.
- the peculiar smell and bitterness of tributyl citrate were felt a little.
- the non-combustion heating type flavor inhaler of Example 3 was less stimulating to nicotine than Comparative Example 1, but was more stimulating to nicotine than those of Examples 2 and 4.
- the peculiar smell and bitterness of tributyl citrate were reduced more than in Example 2.
- Example 4 It was confirmed that the non-combustion-heating flavor inhaler of Example 4 exhibited the same reduction in nicotine stimulation as in Example 2, body feeling, and three-dimensional effect. Furthermore, the peculiar odor and bitterness of tributyl citrate were reduced more than in Example 2.
- Examples 6 to 9, Comparative Example 2 A non-combustion heating flavor inhaler was produced in the same manner as in Example 1, except that an aerosol source having the composition shown in Table 1 was used as the aerosol source, and a tobacco source to which menthol (M) was added was used as the tobacco source. and measured the amount of nicotine and menthol delivered during use. The results are shown in FIGS. 4 and 5.
- FIG. 4 An aerosol source having the composition shown in Table 1 was used as the aerosol source, and a tobacco source to which menthol (M) was added was used as the tobacco source.
- the non-combustion heating type flavor inhalers of Comparative Example 2 and Examples 7 to 9 were sensory evaluated by the same five professional evaluation panel as described above. In the sensory evaluation, it was confirmed that the non-combustion heating type flavor inhaler of Example 7 expressed more menthol feeling than Comparative Example 2, and expressed more body feeling and three-dimensional effect of menthol and nicotine. rice field. On the other hand, the peculiar smell and bitterness of tributyl citrate were felt a little. In the non-combustion heating type flavor inhaler of Example 8, the feeling of menthol was expressed more than in Comparative Example 2, but to a lesser extent than in Example 9. Moreover, the body feeling and three-dimensional effect of menthol and nicotine were lower than those of Examples 7 and 9.
- Example 7 On the other hand, the peculiar odor and bitterness of tributyl citrate were reduced more than in Example 7.
- the non-combustion heating type flavor inhaler of Example 9 expressed more menthol feeling than Examples 7 and 8, and the body feeling and three-dimensional effect of menthol and nicotine were comparable to those of Example 7. . Furthermore, the peculiar odor and bitterness of tributyl citrate were reduced more than in Example 7.
- Example 10 In FIG. 1, a non-combustion heating type flavor inhaler similar to that in FIG.
- the aerosol source contains 43.0% by weight propylene glycol (PG), 43.0% by weight glycerin (G), 9.6% by weight tributyl citrate (TBC), and 4.5% by weight nicotine (NIC). solution was used.
- the amount of nicotine delivered during use of the non-combustion heated flavor inhaler was measured according to the method described above. The results are shown in FIG.
- Example 11 to 13 Comparative Example 3
- a non-combustion heating flavor inhaler was produced in the same manner as in Example 10, except that the aerosol source having the composition shown in Table 2 was used as the aerosol source, and the delivery amount of nicotine during use was measured. The results are shown in FIG.
- Examples 10 and 11 in which tributyl citrate was added to the aerosol source showed an increase in the amount of nicotine delivered.
- the amount delivered increased with increasing amounts of added tributyl citrate.
- Examples 12 and 13 in which glycerin was replaced with triethyl citrate and tributyl citrate the combined use of triethyl citrate showed that even if the content of tributyl citrate was reduced, the delivery amount of nicotine was maintained.
- Example 11 or more was confirmed. Therefore, it is preferable to add both the compound represented by the formula (1) and triethyl citrate even in a non-combustion heating type flavor inhaler that does not have a tobacco source and instead the aerosol source contains tobacco-derived components. I found out.
- Examples 14 to 17, Comparative Example 4 A non-combustion heating flavor inhaler was produced in the same manner as in Example 10, except that an aerosol source having the composition shown in Table 2 was used as the aerosol source, and the delivery amount of menthol during use was measured. The results are shown in FIG.
Abstract
Description
[1]下記式(1)で示される化合物を含むエアロゾル源と、 The present invention includes the following embodiments.
[1] an aerosol source containing a compound represented by the following formula (1);
前記エアロゾル源を霧化してエアロゾルを生成する霧化手段と、
を含む、非燃焼加熱型香味吸引器。 (In formula (1) above, R 1 , R 2 and R 3 are each independently an alkyl group having 3 to 6 carbon atoms.)
atomization means for atomizing the aerosol source to produce an aerosol;
A non-combustion heated flavor inhaler comprising:
本実施形態に係るエアロゾル源は、前記式(1)で示される化合物を含む。前記式(1)において、R1、R2及びR3は、それぞれ独立して炭素数3~6のアルキル基である。R1、R2及びR3が炭素数3以上のアルキル基であることにより、前記式(1)で示される化合物の沸点が高くなり、エアロゾル粒子が安定化する。また、R1、R2及びR3が炭素数6以下のアルキル基であることにより、前記式(1)で示される化合物を気化させるのに必要な温度を低くすることができ、エアロゾル源を霧化する際の温度を下げることができる。前記式(1)において、R1、R2及びR3はそれぞれ独立して炭素数4~6のアルキル基であることが好ましい。特に、前記式(1)で示される化合物はクエン酸トリブチル(TBC)であることが好ましい。前記エアロゾル源は、前記式(1)で示される化合物を一種含んでもよく、二種以上含んでもよい。 (aerosol source)
The aerosol source according to this embodiment contains the compound represented by formula (1) above. In formula (1), R 1 , R 2 and R 3 are each independently an alkyl group having 3 to 6 carbon atoms. When R 1 , R 2 and R 3 are alkyl groups having 3 or more carbon atoms, the boiling point of the compound represented by the formula (1) is increased and the aerosol particles are stabilized. In addition, since R 1 , R 2 and R 3 are alkyl groups having 6 or less carbon atoms, the temperature required to vaporize the compound represented by the formula (1) can be lowered, and the aerosol source can be The temperature during atomization can be lowered. In formula (1), R 1 , R 2 and R 3 are each independently preferably an alkyl group having 4 to 6 carbon atoms. In particular, the compound represented by formula (1) is preferably tributyl citrate (TBC). The aerosol source may contain one compound represented by the formula (1), or may contain two or more compounds.
本実施形態に係る非燃焼加熱型香味吸引器は、前記エアロゾル源を霧化してエアロゾルを生成する霧化手段を含む。霧化手段としては、前記エアロゾル源を霧化してエアロゾルを生成することができれば特に限定されないが、例えば加熱霧化手段であることができる。具体的には、後述するような電源から供給される電力により発熱する、電熱線などの発熱抵抗体であることができる。霧化手段は、後述するように例えばカートリッジ内に配置されることができる。 (Atomizing means)
The non-combustion heating flavor inhaler according to this embodiment includes atomization means for atomizing the aerosol source to generate an aerosol. The atomization means is not particularly limited as long as it can atomize the aerosol source to generate an aerosol, but it can be, for example, a heating atomization means. Specifically, it can be a heating resistor such as a heating wire that generates heat by electric power supplied from a power source as described later. The atomizing means can be arranged, for example, in a cartridge as described below.
本実施形態に係る非燃焼加熱型香味吸引器は、前記エアロゾル源よりも下流側に配置された、たばこ由来成分を含むたばこ源をさらに含むことができる。エアロゾル源の霧化により生成したエアロゾルがたばこ源を通過することで、たばこ源に含まれるたばこ由来成分がエアロゾルへ移行し、使用者へ供給される。たばこ由来成分としては、例えばニコチン等が挙げられる。なお、たばこ源に含まれるたばこ由来成分はエアロゾルによって搬送されるため、使用時にたばこ源自体を加熱する必要はない。また、本実施形態に係る非燃焼加熱型香味吸引器はたばこ源を含まなくてもよく、この場合エアロゾル源がたばこ由来成分を含むことができる。例えば、エアロゾル源中にたばこ源を浸漬させる、たばこ源から抽出した液体のたばこ由来成分をエアロゾル源に混合する、化学合成により得られたたばこ由来成分をエアロゾル源に混合する、等によりエアロゾル源にたばこ由来成分を含ませることができる。 (tobacco source)
The non-combustion-heated flavor inhaler according to this embodiment can further include a tobacco source containing a tobacco-derived component located downstream of the aerosol source. When the aerosol generated by atomization of the aerosol source passes through the tobacco source, tobacco-derived components contained in the tobacco source are transferred to the aerosol and supplied to the user. Examples of tobacco-derived components include nicotine and the like. Since the tobacco-derived component contained in the tobacco source is delivered by the aerosol, it is not necessary to heat the tobacco source itself during use. Also, the non-combustion heating flavor inhaler according to this embodiment may not contain a tobacco source, in which case the aerosol source may contain a tobacco-derived component. For example, the tobacco source is immersed in the aerosol source, the liquid tobacco-derived component extracted from the tobacco source is mixed with the aerosol source, the tobacco-derived component obtained by chemical synthesis is mixed with the aerosol source, and the like. Tobacco-derived ingredients can be included.
本実施形態に係るカートリッジは、前記式(1)で示される化合物を含むエアロゾル源を含む。該カートリッジは、非燃焼加熱型香味吸引器に着脱可能に取り付けられる。該カートリッジは、後述するように該エアロゾル源を霧化してエアロゾルを生成する霧化手段を備えてもよい。 (cartridge)
The cartridge according to this embodiment includes an aerosol source containing the compound represented by Formula (1) above. The cartridge is detachably attached to a non-combustion heated flavor inhaler. The cartridge may comprise atomization means for atomizing the aerosol source to produce an aerosol, as described below.
本実施形態に係る非燃焼加熱型香味吸引器の一例を図1に示す。図1に示される非燃焼加熱型香味吸引器100は、燃焼を伴わずに香味成分を吸引するための器具であり、非吸口端から吸口端に向かう方向である所定方向Aに沿って延びる形状を有する。図2は、図1において、香味付与カートリッジ130が組み込まれたカートリッジ111を示す図である。なお、以下においては、非燃焼加熱型香味吸引器100を単に香味吸引器100と称することがある。 (Configuration of non-combustion heating type flavor inhaler)
An example of the non-combustion heating type flavor inhaler according to this embodiment is shown in FIG. The non-combustion-
非燃焼加熱型香味吸引器の吸口端を、成分捕集用フィルタをセットしたフィルタホルダーに差し込み、フィルタホルダー下流部を喫煙器に接続した。該喫煙器で吸引することで、非燃焼加熱型香味吸引器から放出されるエアロゾルをフィルタホルダー内に捕集した。吸引条件は、55cc/puffで3秒吸引し、30秒間隔で5回繰り返すことで、フィルタホルダー内に5puff分のエアロゾルを捕集した。捕集後、フィルタホルダーからフィルタを取り出し、メタノールで成分を振とう抽出した後、GCでニコチン及び/又はメンソール量を定量した。 [Method for measuring delivery amount of nicotine and menthol]
The mouthpiece end of the non-combustion heating type flavor inhaler was inserted into a filter holder in which a component collection filter was set, and the downstream part of the filter holder was connected to the smoking device. By inhaling with the smoking device, the aerosol emitted from the non-combustion heating flavor inhaler was collected in the filter holder. The aspiration conditions were 55 cc/puff for 3 seconds, and repeated 5 times at 30-second intervals to collect 5 puff of aerosol in the filter holder. After the collection, the filter was taken out from the filter holder, and the components were shaken and extracted with methanol, and the amount of nicotine and/or menthol was quantified by GC.
図1に示される構成を有する非燃焼加熱型香味吸引器を作製した。エアロゾル源としては、プロピレングリコール(PG)45.0質量%、グリセリン(G)45.0質量%、及びクエン酸トリブチル(TBC)10.0質量%を含む溶液を用いた。たばこ源としては、メンソール(M)が含まれない、ニコチン等のたばこ由来成分を含むたばこ源を使用した。前記非燃焼加熱型香味吸引器について、前記方法により使用時におけるニコチンの送達量を測定した。結果を図3に示す。 [Example 1]
A non-combustion heating flavor inhaler having the configuration shown in FIG. 1 was produced. A solution containing 45.0% by weight propylene glycol (PG), 45.0% by weight glycerin (G), and 10.0% by weight tributyl citrate (TBC) was used as an aerosol source. As the tobacco source, a tobacco source containing tobacco-derived components such as nicotine and not containing menthol (M) was used. The amount of nicotine delivered during use of the non-combustion heated flavor inhaler was measured according to the method described above. The results are shown in FIG.
エアロゾル源として、表1に示される組成を有するエアロゾル源を使用した以外は、実施例1と同様に非燃焼加熱型香味吸引器を作製し、使用時におけるニコチンの送達量を測定した。結果を図3に示す。なお、表1において、「PG」はプロピレングリコール、「G」はグリセリン、「TEC」はクエン酸トリエチル、「TBC」はクエン酸トリブチル、「M」はメンソールをそれぞれ示す。 [Examples 2 to 5, Comparative Example 1]
A non-combustion heating flavor inhaler was produced in the same manner as in Example 1, except that an aerosol source having the composition shown in Table 1 was used as the aerosol source, and the delivery amount of nicotine during use was measured. The results are shown in FIG. In Table 1, "PG" is propylene glycol, "G" is glycerin, "TEC" is triethyl citrate, "TBC" is tributyl citrate, and "M" is menthol.
エアロゾル源として表1に示される組成を有するエアロゾル源を使用し、たばこ源としてメンソール(M)を添加したたばこ源を使用した以外は、実施例1と同様に非燃焼加熱型香味吸引器を作製し、使用時におけるニコチン及びメンソールの送達量を測定した。結果を図4及び図5に示す。 [Examples 6 to 9, Comparative Example 2]
A non-combustion heating flavor inhaler was produced in the same manner as in Example 1, except that an aerosol source having the composition shown in Table 1 was used as the aerosol source, and a tobacco source to which menthol (M) was added was used as the tobacco source. and measured the amount of nicotine and menthol delivered during use. The results are shown in FIGS. 4 and 5. FIG.
図1において、香味付与カートリッジ130を有さない以外は図1と同様の非燃焼加熱型香味吸引器を作製した。エアロゾル源としては、プロピレングリコール(PG)43.0質量%、グリセリン(G)43.0質量%、クエン酸トリブチル(TBC)9.6質量%、及びニコチン(NIC)4.5質量%を含む溶液を用いた。前記非燃焼加熱型香味吸引器について、前記方法により使用時におけるニコチンの送達量を測定した。結果を図6に示す。 [Example 10]
In FIG. 1, a non-combustion heating type flavor inhaler similar to that in FIG. The aerosol source contains 43.0% by weight propylene glycol (PG), 43.0% by weight glycerin (G), 9.6% by weight tributyl citrate (TBC), and 4.5% by weight nicotine (NIC). solution was used. The amount of nicotine delivered during use of the non-combustion heated flavor inhaler was measured according to the method described above. The results are shown in FIG.
エアロゾル源として、表2に示される組成を有するエアロゾル源を使用した以外は、実施例10と同様に非燃焼加熱型香味吸引器を作製し、使用時におけるニコチンの送達量を測定した。結果を図6に示す。 [Examples 11 to 13, Comparative Example 3]
A non-combustion heating flavor inhaler was produced in the same manner as in Example 10, except that the aerosol source having the composition shown in Table 2 was used as the aerosol source, and the delivery amount of nicotine during use was measured. The results are shown in FIG.
エアロゾル源として、表2に示される組成を有するエアロゾル源を使用した以外は、実施例10と同様に非燃焼加熱型香味吸引器を作製し、使用時におけるメンソールの送達量を測定した。結果を図7に示す。 [Examples 14 to 17, Comparative Example 4]
A non-combustion heating flavor inhaler was produced in the same manner as in Example 10, except that an aerosol source having the composition shown in Table 2 was used as the aerosol source, and the delivery amount of menthol during use was measured. The results are shown in FIG.
111 カートリッジ
112 電源ユニット
130 香味付与カートリッジ
132 たばこ源
111P リザーバ
111R 霧化手段 100 non-combustion
Claims (8)
- 下記式(1)で示される化合物を含むエアロゾル源と、
前記エアロゾル源を霧化してエアロゾルを生成する霧化手段と、
を含む、非燃焼加熱型香味吸引器。 an aerosol source containing a compound represented by the following formula (1);
atomization means for atomizing the aerosol source to produce an aerosol;
A non-combustion heated flavor inhaler comprising: - 前記式(1)で示される化合物がクエン酸トリブチルである、請求項1に記載の非燃焼加熱型香味吸引器。 The non-combustion heating flavor inhaler according to claim 1, wherein the compound represented by formula (1) is tributyl citrate.
- 前記エアロゾル源がクエン酸トリエチルをさらに含む、請求項1又は2に記載の非燃焼加熱型香味吸引器。 The non-combustion heating flavor inhaler according to claim 1 or 2, wherein the aerosol source further contains triethyl citrate.
- 前記エアロゾル源が、プロピレングリコール及びグリセリンの少なくとも一方をさらに含む、請求項1から3のいずれか一項に記載の非燃焼加熱型香味吸引器。 The non-combustion heated flavor inhaler according to any one of claims 1 to 3, wherein the aerosol source further contains at least one of propylene glycol and glycerin.
- 前記エアロゾル源が、ニコチン、ニコチン塩、及び香料成分からなる群から選択される少なくとも一種をさらに含む、請求項1から4のいずれか一項に記載の非燃焼加熱型香味吸引器。 The non-combustion heating flavor inhaler according to any one of claims 1 to 4, wherein the aerosol source further contains at least one selected from the group consisting of nicotine, nicotine salts, and flavor components.
- 前記香料成分がメンソールを含む、請求項5に記載の非燃焼加熱型香味吸引器。 The non-combustion heating type flavor inhaler according to claim 5, wherein the fragrance component contains menthol.
- 前記エアロゾル源よりも下流側に配置されたたばこ源をさらに含む、請求項1から6のいずれか一項に記載の非燃焼加熱型香味吸引器。 The non-combustion heating flavor inhaler according to any one of claims 1 to 6, further comprising a tobacco source located downstream of the aerosol source.
- 下記式(1)で示される化合物を含むエアロゾル源を含む、非燃焼加熱型香味吸引器用のカートリッジ。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2021/008098 WO2022185434A1 (en) | 2021-03-03 | 2021-03-03 | Non-combustion heating flavor inhaler, and cartridge |
JP2023503588A JPWO2022185434A1 (en) | 2021-03-03 | 2021-03-03 | |
EP21929010.3A EP4302620A1 (en) | 2021-03-03 | 2021-03-03 | Non-combustion heating flavor inhaler, and cartridge |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2021/008098 WO2022185434A1 (en) | 2021-03-03 | 2021-03-03 | Non-combustion heating flavor inhaler, and cartridge |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2022185434A1 true WO2022185434A1 (en) | 2022-09-09 |
Family
ID=83153999
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2021/008098 WO2022185434A1 (en) | 2021-03-03 | 2021-03-03 | Non-combustion heating flavor inhaler, and cartridge |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP4302620A1 (en) |
JP (1) | JPWO2022185434A1 (en) |
WO (1) | WO2022185434A1 (en) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012133289A1 (en) * | 2011-03-29 | 2012-10-04 | 日本たばこ産業株式会社 | Non-combustion suction type tobacco product |
WO2015046420A1 (en) * | 2013-09-30 | 2015-04-02 | 日本たばこ産業株式会社 | Non-combusting flavor inhaler |
WO2016178377A1 (en) * | 2015-05-01 | 2016-11-10 | 日本たばこ産業株式会社 | Non-combustion type flavor inhaler, flavor inhalation component source unit, and atomizing unit |
JP2017518042A (en) * | 2014-04-28 | 2017-07-06 | バットマーク・リミテッド | Aerosol forming components |
US20190124982A1 (en) * | 2016-04-22 | 2019-05-02 | Juul Labs, Inc. | Aerosol Devices Having Compartmentalized Materials |
JP2020519276A (en) | 2017-05-15 | 2020-07-02 | ブリティッシュ アメリカン タバコ (インヴェストメンツ) リミテッドBritish American Tobacco (Investments) Limited | Liquid tobacco extract |
-
2021
- 2021-03-03 EP EP21929010.3A patent/EP4302620A1/en active Pending
- 2021-03-03 WO PCT/JP2021/008098 patent/WO2022185434A1/en active Application Filing
- 2021-03-03 JP JP2023503588A patent/JPWO2022185434A1/ja active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012133289A1 (en) * | 2011-03-29 | 2012-10-04 | 日本たばこ産業株式会社 | Non-combustion suction type tobacco product |
WO2015046420A1 (en) * | 2013-09-30 | 2015-04-02 | 日本たばこ産業株式会社 | Non-combusting flavor inhaler |
JP2017518042A (en) * | 2014-04-28 | 2017-07-06 | バットマーク・リミテッド | Aerosol forming components |
WO2016178377A1 (en) * | 2015-05-01 | 2016-11-10 | 日本たばこ産業株式会社 | Non-combustion type flavor inhaler, flavor inhalation component source unit, and atomizing unit |
US20190124982A1 (en) * | 2016-04-22 | 2019-05-02 | Juul Labs, Inc. | Aerosol Devices Having Compartmentalized Materials |
JP2020519276A (en) | 2017-05-15 | 2020-07-02 | ブリティッシュ アメリカン タバコ (インヴェストメンツ) リミテッドBritish American Tobacco (Investments) Limited | Liquid tobacco extract |
Also Published As
Publication number | Publication date |
---|---|
JPWO2022185434A1 (en) | 2022-09-09 |
EP4302620A1 (en) | 2024-01-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6710802B2 (en) | Electric aerosol delivery system | |
RU2729529C1 (en) | Aerosol generation device and aerosol generation article | |
CN109952035B (en) | Aerosol delivery article | |
RU2729654C1 (en) | Aerosol generation device and aerosol generation article | |
RU2631623C2 (en) | Electronic cigarette with improved flavour properties | |
JP6698876B2 (en) | Heating type flavor suction device | |
CN106455710B (en) | Aerosol-forming component | |
CN116076801A (en) | Aerosol delivery device | |
RU2770456C2 (en) | Aerosol-providing article | |
JP2019501667A (en) | Electric aerosol delivery system | |
JP7291777B2 (en) | generation of aspirable media | |
JP7074396B2 (en) | Aerosol-producing articles | |
TW202019299A (en) | Tobacco blend | |
JP2023134677A (en) | Aerosol generation | |
JP7273167B2 (en) | Container for aerosolizable material | |
JP2022507066A (en) | Generation of suctionable medium | |
WO2022185434A1 (en) | Non-combustion heating flavor inhaler, and cartridge | |
JP2023085486A (en) | Aerosol generation | |
TWI689261B (en) | Heating-type fragrance inhaler | |
RU2800012C2 (en) | Aerosol generation | |
RU2806657C2 (en) | Product for producing aerosol, containing its device assembly for producing inhaled medium (options) and set for use in producing inhaled medium | |
RU2771772C2 (en) | Aerosol delivery device | |
RU2772329C1 (en) | Aerosol production | |
WO2023052085A1 (en) | Vaporisable liquid for a smoking substitute apparatus | |
JP2022543741A (en) | Hybrid aerosol delivery system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 21929010 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 2023503588 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2021929010 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2021929010 Country of ref document: EP Effective date: 20231004 |