WO2022156876A1 - Formulations de protéines - Google Patents

Formulations de protéines Download PDF

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Publication number
WO2022156876A1
WO2022156876A1 PCT/EP2021/050998 EP2021050998W WO2022156876A1 WO 2022156876 A1 WO2022156876 A1 WO 2022156876A1 EP 2021050998 W EP2021050998 W EP 2021050998W WO 2022156876 A1 WO2022156876 A1 WO 2022156876A1
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WO
WIPO (PCT)
Prior art keywords
weight
composition
proteins
use according
total
Prior art date
Application number
PCT/EP2021/050998
Other languages
English (en)
Inventor
Ana Karen ZAVALA RAYA
Osvaldo José Fabián CRUZ CERVANTES
Yanel DE MORAL
Original Assignee
Beiersdorf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf Ag filed Critical Beiersdorf Ag
Priority to PCT/EP2021/050998 priority Critical patent/WO2022156876A1/fr
Publication of WO2022156876A1 publication Critical patent/WO2022156876A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention belongs to the cosmetic field and relates to a cosmetic composition comprising proteins.
  • a beautiful and attractive appearance is a desire for many people.
  • One typical sign of such an appearance is a healthy and smooth looking skin. Therefore, in order to take care on the skin, it is for many people a daily routine to apply cosmetic products such as body lotions, sunscreens or deodorant compositions.
  • Body lotions Cosmetic skin care compositions which are meant to be applied to the whole body apart from the head are commonly called body lotions.
  • Those products are usually characterized in that they comprise an aqueous phase and an oil phase, whereby one of the two phases is suspended in the other.
  • those formulations are stabilized by emulsifiers avoiding a separation of the two phase. Due to the suspension of both phases the formulations usually have a milk like appearance.
  • Formulations which are particular suitable to be used as body lotion are commonly characterized in that they have a viscosity in the range from 1000 to 15000 mPa s at 25°C.
  • the present invention is a cosmetic skin care composition
  • a cosmetic skin care composition comprising, based on the total weight of the composition, a) 0.05 to 8.0% by weight of at least one protein, b) at least one emollient, and c) Water.
  • normal conditions refers to 20°C, 1013 hPa and a relative humidity of 50%.
  • skin refers solely to human skin.
  • a further object of the present invention is the use, based on the total weight of the composition, of 0.05% to 8.0% by weight of at least one protein and at least one emollient to thicken a cosmetic skin care composition further containing water.
  • composition according to the invention is characterized in that it is an oil in water emulsion.
  • the total content of the proteins in the compositions is from 0.05% to 8.0%, more preferably from 2.1% to 6.0% by weight and most preferably from 2.8% to 4.8% by weight, calculated to the total weight of the composition.
  • Fibrous proteins are linear (long fibrous) in shape. Typical examples are a-Keratin, - Keratin and Collagen. Globular proteins are spherical or globular in shape. Typical examples are those found in the group of globulins. Particular examples are a-lactalbumin, p- lactoglobulin, myoglobin and hemoglobin.
  • proteins may also be classified according to their composition:
  • Simple proteins are composed of only amino acids, whereby the proteins may be fibrous or globular. Typical simple proteins are bovine albumin and casein.
  • Conjugate proteins are complex proteins, which contain one or more non-amino acid components. Typical examples are lipoproteins or glycoproteins.
  • the at least one protein contained is characterized in that the protein contained is a globular protein.
  • the total content of the globular protein(s) in the composition is from 0.05% to 8.0%, more preferably from 2.1% to 6.0% by weight and most preferably from 2.8% to 4.8% by weight, calculated to the total weight of the composition.
  • the composition comprises at least one protein selected from the group of proteins that are globulin and/or albumin.
  • Globulins and albumins are globular proteins. Globulins are proteins which, for example are present in peas.
  • the total quantity of those proteins is in the range from 0.05% to 8.0%, more preferably from 2.1% to 6.0% by weight and most preferably from 2.8% to 4.8% by weight, calculated to the total weight of the composition.
  • the total content of the globulins in the composition is from 0.05% to 8.0%, more preferably from 2.1% to 6.0% by weight and most preferably from 2.8% to 4.8% by weight, calculated to the total weight of the composition.
  • the total content of the albumins in the composition is from 0.05% to 8.0%, more preferably from 2.1% to 6.0% by weight and most preferably from 2.8% to 4.8% by weight, calculated to the total weight of the composition.
  • the composition comprises one or more proteins of the group consisting of plant based proteins. Plant based proteins are considered as proteins which are soured from plants in any form.
  • the total quantity of plant based proteins is in the range from 0.05% to 8.0%, more preferably from 2.1% to 6.0% by weight and most preferably from 2.8% to 4.8% by weight, calculated to the total weight of the composition.
  • the composition comprises one or more proteins of the group consisting of sunflower proteins, chickpea proteins, pea proteins, lentil proteins, lupin proteins, rice protein, fava bean protein, collagen, keratin, algae derived proteins and yeast derived proteins.
  • sunflower proteins More preferred are sunflower proteins, chickpea proteins, pea proteins, lentil proteins, lupin proteins, rice protein, fava bean protein, algae derived proteins and/or yeast derived proteins.
  • sunflower proteins Most preferred are sunflower proteins, chickpea proteins, pea proteins, lentil proteins, lupin proteins, rice protein and/or fava bean protein.
  • the total quantity of the proteins selected from the group consisting of sunflower proteins, chickpea proteins, pea proteins, lentil proteins, lupin proteins, rice protein, fava bean protein, collagen, keratin, algae derived proteins and yeast derived proteins is in the range from 0.05% to 8.0%, more preferably from 2.1% to 6.0% by weight and most preferably from 2.8% to 4.8% by weight, calculated to the total weight of the composition.
  • the total quantity of the proteins selected from the group consisting of sunflower proteins, chickpea proteins, pea proteins, lentil proteins, lupin proteins, rice protein, fava bean protein, algae derived proteins and yeast derived proteins is in the range from 0.05% to 8.0%, more preferably from 2.1% to 6.0% by weight and most preferably from 2.8% to 4.8% by weight, calculated to the total weight of the composition.
  • the total quantity of the proteins selected from the group consisting of sunflower proteins, chickpea proteins, pea proteins, lentil proteins, lupin proteins, rice protein and fava bean protein is in the range from 0.05% to 8.0%, more preferably from 2.1% to 6.0% by weight and most preferably from 2.8% to 4.8% by weight, calculated to the total weight of the composition.
  • composition is characterized in that it comprises at least one emollient.
  • Emollients are understood to be all substances which are listed in the International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition 2010, (ISBN 1-882621-47-6) under the name "emollient”.
  • the total quantity of the emollients is in the range from 0.5 to 20% by weight, more preferably 5% to 18% by weight and most preferred 8% to 15% by weight, calculated to the total weight of the composition.
  • Preferred emollients to be contained in the composition are selected from the group of cosmetic butters. It is particular preferred if cupuacu butter, murumuru butter and/or butyrospermum parkii (shea) butter are contained. It is most preferred if the emollient system comprises at least butyrospermum parkii (shea) butter.
  • the total quantity of the cosmetic butters is in the range from 0.5 to 20% by weight, more preferably 5% to 18% by weight and most preferred 8% to 15% by weight, calculated to the total weight of the composition.
  • cupuacu butter, murumuru butter and/or butyrospermum parkii (shea) butter are contained in the composition it is preferred if the total quantity of cupuacu butter, murumuru butter and/or butyrospermum parkii (shea) butter is in the range from 0.5 to 20% by weight, more preferably 5% to 18% by weight and most preferred 8% to 15% by weight, calculated to the total weight of the composition.
  • butyrospermum parkii (shea) butter is contained in the composition it is preferred if the total quantity of butyrospermum parkii (shea) butter is in the range from 0.5 to 20% by weight, more preferably 5% to 18% by weight and most preferred 8% to 15% by weight, calculated to the total weight of the composition.
  • the composition comprises further an oil and/or wax component that is liquid under normal conditions it is preferred if at least one natural oil is contained.
  • Preferred natural oils are selected from the list soya oil, cotton seed oil, sunflower oil, palm oil, palm kernel oil, linseed oil, almond oil, castor oil, vegetable oil, corn oil, olive oil, rapeseed oil, sesame oil, thistle oil, wheat germ oil, avocado oil, peach kernel oil and/or the liquid fractions of coconut oil. Most preferred is vegetable oil.
  • the composition comprises further oil and/or wax components that are liquid under normal conditions, it is preferred if the total quantity of those ingredients is in the range from 0.1% to 20% by weight, more preferably 0.5 to 4% by weight and most preferably 1.0 to 3.0% by weight, calculated to the total weight of the composition.
  • the total quantity of natural oils if present, is in the range from 0.1% to 20% by weight, more preferably 0.5 to 4% by weight and most preferably 1.0 to 3.0% by weight, calculated to the total weight of the composition.
  • the total quantity of natural oils selected from the list of soya oil, cotton seed oil, sunflower oil, palm oil, palm kernel oil, linseed oil, almond oil, castor oil, vegetable oil, corn oil, olive oil, rapeseed oil, sesame oil, thistle oil, wheat germ oil, avocado oil, peach kernel oil and/or the liquid fractions of coconut oil, if present, is in the range from 0.1% to 20% by weight, more preferably 0.5 to 4% by weight and most preferably 1.0 to 3.0% by weight, calculated to the total weight of the composition.
  • the total quantity of vegetable oil is in the range from 0.1% to 5% by weight, more preferably 0.5 to 4% by weight and most preferably 1.0 to 3.0% by weight, calculated to the total weight of the composition.
  • Preferred embodiments of the invention are characterized in that at least one further oil or wax component is contained, which has a natural origin index of at least 0.5, whereby the natural origin index of the components is determined as outlined in the ISO 16128-2:2017; First Edition 2017-09. For example C18-38 Alkyl Beeswax has a Natural origin index of 0.55.
  • the composition comprises further at least one fatty alcohol selected from the group of cetyl alcohol, stearyl alcohol and/or cetearyl alcohol.
  • the total quantity of those fatty alcohols is in the range from 0.5 to 6% by weight, more preferably 1.5 to 5.5% by weight and most preferably from 2.2 to 4.2% by weight calculated to the total weight of the composition.
  • preferred compositions according to the invention are characterized in that the composition comprises an outer aqueous phase and an inner oil phase.
  • the composition comprises one or more polysaccharide, preferably at least one gum.
  • Preferred polysaccharides are selected from the group of xanthan gum, succinoglycan, sclerotium gum and hydroxypropyl starch phosphate. Most preferred is xanthan gum.
  • the total quantity of the polysaccharides is in the range from 0.01 to 1.0% by weight, more preferably 0.04 to 0.8% by weight, calculated to the total weight of the composition.
  • the total quantity of the gums is in the range from 0.01 to 1.0% by weight, more preferably 0.04 to 0.8% by weight, calculated to the total weight of the composition.
  • xanthan gum is contained in the composition, it is preferred if the total quantity of xanthan gum is in the range from 0.05 to 0.5% by weight, more preferably 0.1 to 0.4% by weight, calculated to the total weight of the composition.
  • the composition does not comprise a polymer formed by homo- or copolymerization with acrylic acid and/or methacrylic acid.
  • the quantities of those polymers is 0% by weight of the composition.
  • the composition comprises ethanol in small quantities, ranging from 0.1 to 2% by weight, based on the total weight of the composition.
  • compositions according to the invention are preferably further characterized in that they contain at least one fatty acid having 12 to 20 carbon atoms. If those fatty acids are contained, it is preferred if the total quantity of those is in the range from 0.1 to 2% by weight, calculated to the total weight of the composition. Further it is preferred if the composition comprises glycerol, whereby it is preferred if the total quantity of glycerol is in the range from 1.0 to 15% by weight, more preferably 1.5 to 10.0% and most preferably 3.0 to 8.0% by weight, calculated to the total weight of the composition.
  • composition comprises p-anisic acid, levulinic acid and/or sodium levulinate.
  • the total quantity of p-anisic acid, levulinic acid and/or sodium levulinate is in the range from 0.05 to 1% by weight, more preferably 0.1 to 0.8% by weight and most preferably 0.15 to 0.4% by weight, calculated to the total weight of the composition.
  • composition comprises phenoxyethanol, ethylhexylglycerin and/or hydroxyacetophenone.
  • phenoxyethanol is contained it is preferred if the total quantity of phenoxyethanol is in the range from 0.1 to 1% by weight, calculated to the total weight of the composition.
  • ethylhexylglycerin is contained it is preferred if the total quantity of ethylhexylglycerin is in the range from 0.1 to 1% by weight, calculated to the total weight of the composition.
  • hydroxyacetophenone is contained it is preferred if the total quantity of hydroxyacetophenone is in the range from 0.1 to 0.5% by weight, calculated to the total weight of the composition.
  • the composition is characterized in that at least one UV- filter is contained.
  • UV filter is understood as a substance which is listed in the IIV-A and IIV-B filter list in the Annex VI of the Regulation (EC) No 1223/2009 of the European Parliament and of the Council.
  • composition comprises at least one organic UV-filter, which is selected from the group consisting of camphor benzalkonium methosulfate, homosalate, benzophenone-3, butyl methoxydibenzoylmethane, benzylidene camphor sulfonic acid, octocrylene, polyacrylamidomethyl benzylidene camphor, ethylhexyl methoxycinnamate, peg-25 paba, isoamyl p-methoxycinnamate, ethylhexyl triazone, drometrizole trisiloxane, diethylhexyl butamido triazone, 4-methylbenzylidene camphor, ethylhexyl salicylate, ethylhexyl dimethyl paba, methylene bis-benzotriazolyl tetramethylbutylphenol, methylene bis-benzotriazolyl
  • the composition comprises bis-ethylhexyloxyphenol methoxyphenyl triazine, whereby the total quantity of bis-ethylhexyloxyphenol methoxyphenyl triazine is preferably in the range from 0.5 to 12% by weight, preferably 0.6 to 6% by weight, particularly preferably 0.7 to 3.5% by weight based on the total weight of composition.
  • the composition comprises ethylhexyl salicylate, whereby the total quantity of ethylhexyl salicylate is preferably in the range from 0.5 to 12% by weight, preferably 2 to 9% by weight, particularly preferably 3 to 7.5% by weight based on the total weight of composition.
  • the composition comprises ethylhexyl triazone, whereby the total quantity of ethylhexyl triazone is preferably in the range from 0.1 to 5% by weight, preferably 0.2 to 3% by weight, particularly preferably 0.3 to 1.5% by weight based on the total weight of composition.
  • the composition comprises butyl methoxydibenzoylmethane, whereby the total quantity of butyl methoxydibenzoylmethane is preferably in the range from 0.5 to 12% by weight, preferably 0.6 to 6% by weight, particularly preferably 0.7 to 2.5% by weight based on the total weight of composition.
  • the total quantity of all organic UV filters is in the range from 5 to 18% by weight, more preferably 7 to 15% by weight and most preferably 8.5 to 12.5% by weight, calculated to the total weight of the composition.
  • the composition of the invention is free from octocrylene. That means the content of octocrylene is preferably 0% by weight based on the total weight of the composition. Further, it is preferred if the composition comprises titanium dioxide and/or zinc oxide in order to improve the light protection factor.
  • the total content of water is in the range from 65% to 90% by weight, more preferably from 68 to 75% by weight, calculated to the total weight of the composition
  • compositions were actually stable for a prolonged amount of time, even though no further emulsifier needed to be present. Accordingly it is further preferred if the composition comprises further emulsifier in a total quantity of less than 1.0% by weight, more preferably less than 0.5% by weight, more preferably less than 0.3% by weight, still more preferably less than 0.1% by weight and most preferably 0% by weight. Accordingly it is most preferred if the composition does not comprise further emulsifier.
  • Emulsifiers are understood to be all substances which are listed in the International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition 2010, (ISBN 1-882621-47-6) under the name "emulsifying agent”.
  • Surfactants are understood to be all substances which are listed in the International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition 2010, (ISBN 1-882621-47-6) under the name "surfactant”.
  • compositions of the invention may further comprise active ingredients which can have a beneficial aspect for the human skin.
  • active ingredients are glycyrrhetinic acid, arctiin, folic acid, coenzyme Q10 (ubiquinone), alpha-glucosylrutin, carnitine, carnosine, caffeine, natural and I or synthetic isoflavonoids, glycerylglucose, creatine, creatinine, taurine, tocopherol, tocopherol acetate, vitamin C, vitamin C phosphate, vitamin C palmitate, niacinamides, vitamin A palmitate, retinol, panthenol, glycyrrhiza inflata root extract, licochalcon A, 4-butylresorcinol, N - [(2,4-dihydroxyphenyl) thiazol-2-yl] isobutyramide, honociol and magnolol (also as a component of Magnolia- Extracts
  • the pH of the composition is in the range from 3.5 to 7.5.
  • viscosity values are disclosed in this document, all values relate unless otherwise described to a measurement at 25 ° C in a 150 ml wide neck bottle (VWR no .: 807-001) using Rheomat R 123 from proRheo.
  • the Rheomat R 123 from proRheo GmbH is a rotation viscometer. The force is measured that is required to make the measuring body rotate in the sample at a specified speed. The viscosity is calculated from this torque, the speed of the measuring body and the geometric dimensions of the measuring system used.
  • the measuring body used is measuring body No. 1 (item no. 200 0191), suitable for a viscosity range up to 10,000 [mPa s], speed range 62.5 min' 1 .
  • Globulins legumin, vicilin and convicilin
  • Minor parts of Albumin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition cosmétique.
PCT/EP2021/050998 2021-01-19 2021-01-19 Formulations de protéines WO2022156876A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2021/050998 WO2022156876A1 (fr) 2021-01-19 2021-01-19 Formulations de protéines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2021/050998 WO2022156876A1 (fr) 2021-01-19 2021-01-19 Formulations de protéines

Publications (1)

Publication Number Publication Date
WO2022156876A1 true WO2022156876A1 (fr) 2022-07-28

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006103123A1 (fr) 2005-03-29 2006-10-05 Beiersdorf Ag Preparation cosmetique donnant une sensation de legerete lorsqu'elle est appliquee sur la peau
WO2008070368A2 (fr) * 2006-11-01 2008-06-12 Living Proof, Inc. Procédés et compositions pour le soin de la peau
US20100093599A1 (en) * 2008-10-10 2010-04-15 Jeffrey Wu Shine control cleanser
WO2012120290A2 (fr) * 2011-03-04 2012-09-13 Sana Pharma As Formulations cosmétiques
CN104523553A (zh) * 2015-01-22 2015-04-22 *** 一种具有表皮保湿和皮肤抗皱作用的护肤化妆品及其制备和应用
WO2019204793A1 (fr) * 2018-04-19 2019-10-24 Phytoption Llc Émulsifiants et leurs utilisations

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006103123A1 (fr) 2005-03-29 2006-10-05 Beiersdorf Ag Preparation cosmetique donnant une sensation de legerete lorsqu'elle est appliquee sur la peau
WO2008070368A2 (fr) * 2006-11-01 2008-06-12 Living Proof, Inc. Procédés et compositions pour le soin de la peau
US20100093599A1 (en) * 2008-10-10 2010-04-15 Jeffrey Wu Shine control cleanser
WO2012120290A2 (fr) * 2011-03-04 2012-09-13 Sana Pharma As Formulations cosmétiques
CN104523553A (zh) * 2015-01-22 2015-04-22 *** 一种具有表皮保湿和皮肤抗皱作用的护肤化妆品及其制备和应用
WO2019204793A1 (fr) * 2018-04-19 2019-10-24 Phytoption Llc Émulsifiants et leurs utilisations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"International Cosmetic Ingredient Dictionary and Handbook", 2010

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