WO2022122906A1 - Verfahren zur herstellung eines polyisocyanats, polyisocyanat, dessen verwendung und daraus hergestellte polyadditions¬produkte - Google Patents
Verfahren zur herstellung eines polyisocyanats, polyisocyanat, dessen verwendung und daraus hergestellte polyadditions¬produkte Download PDFInfo
- Publication number
- WO2022122906A1 WO2022122906A1 PCT/EP2021/084975 EP2021084975W WO2022122906A1 WO 2022122906 A1 WO2022122906 A1 WO 2022122906A1 EP 2021084975 W EP2021084975 W EP 2021084975W WO 2022122906 A1 WO2022122906 A1 WO 2022122906A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polyol
- polyisocyanate
- polyamine
- anthranilic acid
- reaction
- Prior art date
Links
- 229920001228 polyisocyanate Polymers 0.000 title claims abstract description 62
- 239000005056 polyisocyanate Substances 0.000 title claims abstract description 62
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 19
- 229920005862 polyol Polymers 0.000 claims abstract description 128
- 150000003077 polyols Chemical class 0.000 claims abstract description 120
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 claims abstract description 69
- 238000000034 method Methods 0.000 claims abstract description 68
- 229920000768 polyamine Polymers 0.000 claims abstract description 51
- 238000006243 chemical reaction Methods 0.000 claims abstract description 43
- 239000000203 mixture Substances 0.000 claims abstract description 40
- -1 anthranilic acid halide Chemical class 0.000 claims abstract description 32
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 claims abstract description 24
- VYFOAVADNIHPTR-UHFFFAOYSA-N isatoic anhydride Chemical compound NC1=CC=CC=C1CO VYFOAVADNIHPTR-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 29
- 229920000570 polyether Polymers 0.000 claims description 29
- 238000004821 distillation Methods 0.000 claims description 27
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 25
- 230000002378 acidificating effect Effects 0.000 claims description 23
- 150000001875 compounds Chemical class 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000003054 catalyst Substances 0.000 claims description 16
- 239000007789 gas Substances 0.000 claims description 15
- 239000000853 adhesive Substances 0.000 claims description 11
- 230000001070 adhesive effect Effects 0.000 claims description 11
- 229920000515 polycarbonate Polymers 0.000 claims description 10
- 239000004417 polycarbonate Substances 0.000 claims description 10
- 239000006260 foam Substances 0.000 claims description 7
- 150000002894 organic compounds Chemical class 0.000 claims description 7
- 239000000565 sealant Substances 0.000 claims description 7
- 229920001169 thermoplastic Polymers 0.000 claims description 6
- 239000004416 thermosoftening plastic Substances 0.000 claims description 6
- 125000003158 alcohol group Chemical group 0.000 claims description 5
- 229920001971 elastomer Polymers 0.000 claims description 5
- 239000000806 elastomer Substances 0.000 claims description 5
- 229920005906 polyester polyol Polymers 0.000 claims description 5
- 125000003277 amino group Chemical group 0.000 claims description 4
- 229920006295 polythiol Polymers 0.000 claims description 4
- 238000002425 crystallisation Methods 0.000 claims description 3
- 230000008025 crystallization Effects 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 238000000859 sublimation Methods 0.000 claims description 3
- 230000008022 sublimation Effects 0.000 claims description 3
- 239000002253 acid Substances 0.000 abstract description 20
- 150000002148 esters Chemical class 0.000 abstract description 16
- 150000001412 amines Chemical class 0.000 abstract description 14
- 239000012948 isocyanate Substances 0.000 abstract description 11
- 150000002513 isocyanates Chemical group 0.000 abstract description 11
- RLCMQWBYWOIEGD-UHFFFAOYSA-N 2-aminobenzoyl chloride Chemical compound NC1=CC=CC=C1C(Cl)=O RLCMQWBYWOIEGD-UHFFFAOYSA-N 0.000 abstract description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 28
- 239000000047 product Substances 0.000 description 28
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 26
- 239000002904 solvent Substances 0.000 description 21
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 19
- 238000010992 reflux Methods 0.000 description 19
- TXJUTRJFNRYTHH-UHFFFAOYSA-N 1h-3,1-benzoxazine-2,4-dione Chemical compound C1=CC=C2C(=O)OC(=O)NC2=C1 TXJUTRJFNRYTHH-UHFFFAOYSA-N 0.000 description 15
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 13
- 229920002396 Polyurea Polymers 0.000 description 12
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
- 239000007787 solid Substances 0.000 description 11
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 10
- 238000010438 heat treatment Methods 0.000 description 9
- 229920002635 polyurethane Polymers 0.000 description 9
- 239000004814 polyurethane Substances 0.000 description 9
- 239000007858 starting material Substances 0.000 description 9
- 238000003756 stirring Methods 0.000 description 9
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 6
- 238000000855 fermentation Methods 0.000 description 6
- 230000004151 fermentation Effects 0.000 description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 5
- 238000002844 melting Methods 0.000 description 5
- OCJBOOLMMGQPQU-UHFFFAOYSA-N 1,4-dichlorobenzene Chemical compound ClC1=CC=C(Cl)C=C1 OCJBOOLMMGQPQU-UHFFFAOYSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 4
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 4
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 4
- 229940117389 dichlorobenzene Drugs 0.000 description 4
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 4
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 4
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 229920001730 Moisture cure polyurethane Polymers 0.000 description 3
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 230000000035 biogenic effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000006555 catalytic reaction Methods 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 229910052801 chlorine Inorganic materials 0.000 description 3
- 150000004292 cyclic ethers Chemical class 0.000 description 3
- 239000000543 intermediate Substances 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 229920003225 polyurethane elastomer Polymers 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 2
- 239000004970 Chain extender Substances 0.000 description 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- CYTYCFOTNPOANT-UHFFFAOYSA-N Perchloroethylene Chemical group ClC(Cl)=C(Cl)Cl CYTYCFOTNPOANT-UHFFFAOYSA-N 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 229920005830 Polyurethane Foam Polymers 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 240000000111 Saccharum officinarum Species 0.000 description 2
- 235000007201 Saccharum officinarum Nutrition 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 235000021536 Sugar beet Nutrition 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 2
- 150000008041 alkali metal carbonates Chemical class 0.000 description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 2
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 2
- 239000003849 aromatic solvent Substances 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 238000013452 biotechnological production Methods 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 229910002091 carbon monoxide Inorganic materials 0.000 description 2
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 2
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 150000004985 diamines Chemical class 0.000 description 2
- JQVDAXLFBXTEQA-UHFFFAOYSA-N dibutylamine Chemical compound CCCCNCCCC JQVDAXLFBXTEQA-UHFFFAOYSA-N 0.000 description 2
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 2
- HCUYBXPSSCRKRF-UHFFFAOYSA-N diphosgene Chemical compound ClC(=O)OC(Cl)(Cl)Cl HCUYBXPSSCRKRF-UHFFFAOYSA-N 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000010528 free radical solution polymerization reaction Methods 0.000 description 2
- 239000012433 hydrogen halide Substances 0.000 description 2
- 229910000039 hydrogen halide Inorganic materials 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 229940073584 methylene chloride Drugs 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 229910052763 palladium Inorganic materials 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 239000011496 polyurethane foam Substances 0.000 description 2
- 239000004588 polyurethane sealant Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 238000010557 suspension polymerization reaction Methods 0.000 description 2
- 229950011008 tetrachloroethylene Drugs 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 2
- 229940029284 trichlorofluoromethane Drugs 0.000 description 2
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- KUNJDXHUQFVRCQ-UHFFFAOYSA-N 1,3-bis(2-aminophenyl)-2-hydroxy-2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxymethyl]propane-1,3-dione Chemical compound NC1=CC=CC=C1C(=O)C(O)(COCCOCCOCCO)C(=O)C1=CC=CC=C1N KUNJDXHUQFVRCQ-UHFFFAOYSA-N 0.000 description 1
- JIABEENURMZTTI-UHFFFAOYSA-N 1-isocyanato-2-[(2-isocyanatophenyl)methyl]benzene Chemical compound O=C=NC1=CC=CC=C1CC1=CC=CC=C1N=C=O JIABEENURMZTTI-UHFFFAOYSA-N 0.000 description 1
- SKDHHIUENRGTHK-UHFFFAOYSA-N 4-nitrobenzoyl chloride Chemical compound [O-][N+](=O)C1=CC=C(C(Cl)=O)C=C1 SKDHHIUENRGTHK-UHFFFAOYSA-N 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 241000186226 Corynebacterium glutamicum Species 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 241001465328 Eremothecium gossypii Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000235058 Komagataella pastoris Species 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 241000320412 Ogataea angusta Species 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 description 1
- 229920000265 Polyparaphenylene Polymers 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000589776 Pseudomonas putida Species 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 241000235015 Yarrowia lipolytica Species 0.000 description 1
- 241000235029 Zygosaccharomyces bailii Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000007630 basic procedure Methods 0.000 description 1
- 238000012662 bulk polymerization Methods 0.000 description 1
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 description 1
- 238000012824 chemical production Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000012320 chlorinating reagent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000012262 fermentative production Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 230000002140 halogenating effect Effects 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- VXWPONVCMVLXBW-UHFFFAOYSA-M magnesium;carbanide;iodide Chemical compound [CH3-].[Mg+2].[I-] VXWPONVCMVLXBW-UHFFFAOYSA-M 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920005903 polyol mixture Polymers 0.000 description 1
- 238000004313 potentiometry Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- JXOHGGNKMLTUBP-HSUXUTPPSA-N shikimic acid Chemical compound O[C@@H]1CC(C(O)=O)=C[C@@H](O)[C@H]1O JXOHGGNKMLTUBP-HSUXUTPPSA-N 0.000 description 1
- JXOHGGNKMLTUBP-JKUQZMGJSA-N shikimic acid Natural products O[C@@H]1CC(C(O)=O)=C[C@H](O)[C@@H]1O JXOHGGNKMLTUBP-JKUQZMGJSA-N 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000003106 tissue adhesive Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000004876 x-ray fluorescence Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/72—Polyisocyanates or polyisothiocyanates
- C08G18/74—Polyisocyanates or polyisothiocyanates cyclic
- C08G18/76—Polyisocyanates or polyisothiocyanates cyclic aromatic
- C08G18/7657—Polyisocyanates or polyisothiocyanates cyclic aromatic containing two or more aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C263/00—Preparation of derivatives of isocyanic acid
- C07C263/10—Preparation of derivatives of isocyanic acid by reaction of amines with carbonyl halides, e.g. with phosgene
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C265/00—Derivatives of isocyanic acid
- C07C265/12—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/72—Polyisocyanates or polyisothiocyanates
- C08G18/77—Polyisocyanates or polyisothiocyanates having heteroatoms in addition to the isocyanate or isothiocyanate nitrogen and oxygen or sulfur
- C08G18/771—Polyisocyanates or polyisothiocyanates having heteroatoms in addition to the isocyanate or isothiocyanate nitrogen and oxygen or sulfur oxygen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2527/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- C07C2527/06—Halogens; Compounds thereof
- C07C2527/08—Halides
- C07C2527/10—Chlorides
Definitions
- the present invention relates to a process for preparing a polyisocyanate, namely an isocyanate group-terminated polyol polyanthranilic acid ester.
- the process comprises reacting an anthranilic acid derivative selected from anthranilic acid halide (particularly anthranilic acid chloride), isatoic anhydride or a mixture thereof with a first polyol having a number average molecular weight of at least 200 g/mol and a functionality ranging from 2 to 8 to give a polyamine (namely a polyol -polyanthranilic acid ester with amine end groups) and reaction of the polyamine with phosgene to obtain a polyisocyanate (namely an isocyanate group-terminated polyol polyanthranilic acid ester).
- the invention also relates to the polyisocyanates obtainable in this way, their use in polyaddition reactions and polyaddition products obtainable in this way.
- Polyurethane prepolymers containing isocyanate groups have long been known in the prior art. They are obtained by reacting a stoichiometric excess of a polyisocyanate component (e.g. methylenediphenylene diisocyanate, optionally in a mixture with its higher homologues, the polyphenylene polymethylene polyisocyanates) with a polyol component (e.g. a polyester polyol, a polyester ether polyol or a mixture of different types of polyols) and are used, for example, during production elastomers, coatings, adhesives and the like.
- a polyisocyanate component e.g. methylenediphenylene diisocyanate, optionally in a mixture with its higher homologues, the polyphenylene polymethylene polyisocyanates
- a polyol component e.g. a polyester polyol, a polyester ether polyol or a mixture of different types of polyols
- EP-A 0 590 398 describes the use of low-monomer isocyanate-terminated polyurethane prepolymers which have been obtained by removing the monomeric polyisocyanates by distillation.
- the basic procedure for preparing prepolymers with NCO end groups was retained.
- the present invention takes an alternative route which also leads to NCO-terminated prepolymers, but not this via the usual route of urethanization of low molecular weight polyisocyanates with a deficit of polyols, but starting from reactive derivatives of anthranilic acid.
- anthranilic acid can be converted into polyanthranilic acid esters and that such polyanthranilic acid esters can be used in polyaddition reactions, for example as a crosslinking agent, as a chain extender or as a starting material in the production of polyureas.
- polyanthranilic acid esters can be used in polyaddition reactions, for example as a crosslinking agent, as a chain extender or as a starting material in the production of polyureas.
- the article “Polyamines containing ester groups as structural components for polyurethane chemistry” in Angew. macromole. Chem. 1972, 26, 29-45 the use of such esters as structural components for polyurethane elastomers US patent application US 2003/0212291 A1 their use as crosslinkers, German patent DE 20 40 644 their use as chain extenders and the US patent US Pat. No. 3,808,250 their use as an amine component in the production of polyureas by reaction with isocyanates.
- WO 89/00589 A1 (also published as US Pat. No. 4,829,099 and DE 38 51 428 T2) relates to adhesives which are made from metabolically compatible polyisocyanate or polyisothiocyanate monomers.
- this reference relates to surgical adhesive polymers derived from these polyisocyanate monomers which are not metabolized to toxic products.
- a possible route to such products for example, the reaction of a polyhydric alcohol with an aromatic nitro acid chloride (such as 2- and especially 4-nitrobenzoyl chloride), followed by catalytic hydrogenation of the nitro group to an amine group and phosgenation of this to an isocyanate group is described.
- NCO-terminated prepolymers with as few portions of the polyisocyanate component used as possible is not resolved by the prior art mentioned. It would also be desirable for a production process for NCO-terminated prepolymers to be as uncomplicated as possible and for the desired products (and the primary amines obtained as intermediates) to be produced in the best possible yields and in a form that is easy to process industrially (liquid with not too high viscosity), provides.
- a first subject matter of the present invention is therefore a process for preparing a polyisocyanate, namely an isocyanate-group-terminated polyol polyanthranilic acid ester.
- the procedure includes the steps:
- anthranilic acid derivative (which can be produced from anthranilic acid obtained by fermentation) selected from anthranilic acid halide (in particular anthranilic acid chloride), isatoic acid anhydride or a mixture thereof with a first polyol having a functionality b and the general formula X-(OH)b, where b im is in the range from 2 to 8 and X is a residue which is derived from the first polyol by removing all alcohol groups, and where the first polyol has a hydroxyl number (determined from the hydroxyl number according to DIN 53240-2 (2007-11) and the functionality b calculated) number-average molar mass of at least 200 g/mol, to obtain a polyamine (namely a polyol-polyanthranilic acid ester with amine end groups) of the formula
- a second object of the present invention is a polyisocyanate (namely, an isocyanate group-terminated polyol polyanthranilic acid ester) of the formula OCN-(o/t/7O-C6H 4 )-(CO)-OX-[-O-(CO)-(o/t/7O-C6H 4 )-NCO]a wherein
- the polyisocyanate can be obtained in particular by the process according to the invention and therefore has a considerable mass fraction of biogenic carbon, in particular up to 46%, when using the above-mentioned possible embodiment using an anthranilic acid derivative produced from anthranilic acid obtained by fermentation.
- a third subject matter of the present invention relates to the use of the polyisocyanate according to the invention for the production of a polyaddition product by reaction with a compound comprising 2 or more acidic hydrogen atoms.
- a fourth subject matter of the present invention relates to the polyaddition products from the polyisocyanate according to the invention and a compound comprising 2 or more acidic hydrogen atoms.
- the polymeric properties of the isocyanate-terminated polyol polyanthranilic acid esters produced using the process according to the invention do not originate from a polyurethane structure, but are based on the polymeric structure of the first polyol X-(OH)b used. Therefore, one can produce according to the invention Isocyanate-terminated polyol polyanthranilic acid esters also refer to as isocyanate-terminated Po/yo/-prepolymers.
- b is in the range from 2 to 4.
- the first polyol has polyether groups based on ethylene oxide and/or propylene oxide.
- the first polyol has polyether groups which are selected from water, a polyamine, a second polyol with a number-average molar mass by polyaddition of a cyclic ether to a starter compound less than 200 g/mol or a mixture of two or more of the aforementioned starter compounds.
- the polyaddition is mediated by a double metal cyanide catalyst.
- the polyaddition is mediated by a base catalyst.
- the polyaddition is mediated by a double metal cyanide catalyst and by a base catalyst.
- reaction of the anthranilic acid derivative with the first polyol is carried out in the presence of a basic catalyst.
- step (A) resulting polyamine isolated by a method selected from filtration, distillation, sublimation, crystallization, precipitation or a combination of two or more of the above methods.
- the isatoic anhydride is converted by reacting anthranilic acid with
- a phosgenation medium selected from phosgene, diphosgene, triphosgene, oxalyl chloride or a mixture of two or more of the aforementioned phosgenation media or
- the fermentable carbon-containing compound comprises starch hydrolyzate, sugar cane juice, sugar beet juice and/or hydrolysates from lignocellulose-containing raw materials, the nitrogen-containing compound being ammonia gas, ammonia water, ammonium salts and/or urea.
- the organic compound comprising 2 or more acidic hydrogen atoms comprises a third polyol (and is in particular a third polyol), with a polyurethane elastomer, a polyurethane Thermoplastic, a polyurethane foam, a polyurethane adhesive or a polyurethane sealant is obtained.
- the first polyol has a number-average molar mass in the range from 200 g/mol to 25000 g/mol, preferably in the range from 200 g/mol to 4000 g/mol , particularly preferably in the range from 200 g/mol to 1200 g/mol.
- the first polyol is selected from a polyether polyol, a polyether ester polyol, a Polyetherpolycarbonatepolyol or a mixture of two or more of the aforementioned polyols.
- the content of unsaturated end groups in the first polyol is in the range from 0 meq/g to 0.02 meq/g, preferably in the range from 0 meq/g to 0.015 meq/g, more preferably in the range 0 meq/g to 0.01 meq/g.
- the first polyol has polyether groups selected by polyaddition to starter compounds from water, a polyamine, a second polyol having a number-average molecular weight of less than 200 g/mol or a mixture of two or more of the aforementioned starter compounds are available.
- the first polyol to be used in step (A) of the process according to the invention has a functionality in the range from 2 to 8, preferably 2 to 4, and has a number-average molar mass of at least 200 g/mol, preferably in the range from 200 g/mol to 25000 g/mol. mol, particularly preferably in the range from 200 g/mol to 4000 g/mol and very particularly preferably in the range from 200 g/mol to 1200 g/mol.
- the first polyol can also be a mixture of several polyols; in this case, the previously mentioned values of functionality and number average molar mass refer to the corresponding mean values of the mixture.
- Anthranilic acid halides can be obtained by reacting anthranilic acid with a suitable halogenating reagent, as is known in the art and therefore need not be detailed here.
- anthranilic acid chloride is preferred. This is obtained in particular by reacting anthranilic acid with thionyl chloride.
- isatoic anhydride is preferred and is particularly prepared by reacting anthranilic acid with
- a phosgenation medium selected from phosgene, diphosgene, triphosgene, oxalyl chloride or a mixture of two or more of the aforementioned phosgenation media or
- anthranilic acid The chemical production of anthranilic acid is described in the literature.
- a suitable synthesis route is, for example, the reaction of phthalimide with sodium hypochlorite. Phthalimide, in turn, can be obtained from phthalic anhydride and ammonia.
- a suitable process for producing anthranilic acid is described, for example, in EP 0 004635 A2.
- the fermentative production of anthranilic acid which is preferred in the context of the present invention, makes use of the fact that anthranilic acid is formed in the metabolism of bacteria and yeasts in the shikimic acid pathway as a natural intermediate in the synthesis of tryptophan.
- the anthranilic acid is therefore preferably obtained by fermenting a raw material containing a fermentable carbon-containing compound and a nitrogen-containing compound in the presence of microorganisms.
- the fermentable carbon-containing compound preferably includes starch hydrolyzate, sugar cane juice, sugar beet juice and/or hydrolyzates from lignocellulose-containing raw materials, and the nitrogen-containing compound preferably includes ammonia gas, ammonia water, ammonium salts and/or urea.
- the microorganisms preferably include those described in the aforementioned references, ie Escherichia coli, Pseudomonas putida, Corynebacterium glutamicum, Ashbya gossypii, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Zygosaccharomyces bailii or Saccharomyces cerevisiae.
- the reaction of the anthranilic acid derivative with the first polyol is preferably carried out in the presence of a catalyst, particularly when isatoic anhydride is used as the anthranilic acid derivative.
- a catalyst particularly when isatoic anhydride is used as the anthranilic acid derivative.
- the temperature for the reaction of the anthranilic acid derivative with the first polyol is preferably in the range from 0°C to 120°C, particularly preferably from 20°C to 115°C and very particularly preferably from 35°C to 110°C.
- step (A) gas is evolved (CO2 in the case of isatoic anhydride and hydrogen halide in the case of anthranilic acid halides). This gas can be discharged in gaseous form, chemically bound or physically bound.
- the reaction of the anthranilic acid derivative with the first polyol can be carried out in the presence or absence (bulk or bulk) of a solvent. If the reaction takes place in the presence of a solvent, this is preferably selected from acetone, tetrahydrofuran, diethyl ether, dimethylformamide, dimethylacetamide, an aliphatic hydrocarbon (such as in particular hexane, heptane, getane or a mixture of two or more of the aforementioned aliphatic hydrocarbons), an aromatic Hydrocarbon (such as in particular benzene, toluene or a mixture of both), a chlorinated aliphatic solvent (especially dichloromethane, chloroform, carbon tetrachloride or a mixture of two or more of the aforementioned chlorinated aliphatic solvents) or a chlorinated aromatic solvent (such as in particular chlorobenzene, dichlorobenzene or a mixture of both).
- a solvent especially selected from
- the polyamine formed in the reaction of step (A) can be isolated by methods customary and known in the art, in particular filtration, distillation, sublimation, crystallization, precipitation or a combination of two or more of these methods may be mentioned. Which of these is best suited in the individual case is evident to the person skilled in the art from the reaction conditions used and can, if necessary, be determined by simple preliminary tests.
- the polyamine obtained in step (A) is phosgenated. This preferably takes place at a temperature in the range from 0.degree. C. to 200.degree. C., particularly preferably 5.degree. C. to 180.degree. C., very particularly preferably 5.degree. C. to 150.degree.
- the reaction with phosgene is preferably carried out using a stoichiometric excess of phosgene, based on the amino groups of the polyamine.
- Toluene, xylene, chlorobenzene, dichlorobenzene (in particular the ortho isomer), dioxane, methylene chloride, perchlorethylene, trichlorofluoromethane or a mixture of two or more of the aforementioned solvents is preferably used as the solvent for the phosgenation.
- step (B) can be reacted in a step (C)(i) with an organic compound comprising 2 or more acidic hydrogen atoms to give a polyaddition product (so-called 2-component polyurethane products).
- acidic hydrogen atoms are hydrogen atoms bonded to N, O or S if these yield methane by reaction with methylmagnesium iodide. This method was developed by Zerewitinoff, which is why acidic hydrogen atoms are also referred to as Zerewitinoff-active hydrogen atoms in this sense.
- polyurethane elastomers examples of possible compounds with 2 or more acidic hydrogen atoms are polyols (third polyol).
- polyurethane elastomers examples of possible compounds with 2 or more acidic hydrogen atoms are polyols (third polyol).
- polyurethane elastomers examples of possible compounds with 2 or more acidic hydrogen atoms are polyols (third polyol).
- polyurethane elastomers polyurethane thermoplastics, polyurethane foams, polyurethane adhesives (see also DE 10 2009 008 867) and polyurethane sealants can be obtained.
- polyamines including the amines obtained according to step (A) of the process according to the invention
- polyamines are also suitable as compounds having 2 or more acidic hydrogen atoms.
- polyurea elastomers, polyurea thermoplastics, polyurea foams, polyurea adhesives and polyurea sealants can be obtained.
- mixtures of polyols and polyamines as compounds having 2 or more acidic hydrogen atoms, polyaddition products having mixed urethane and urea structures being formed.
- step (B) It is also possible to react the polyisocyanates obtained in step (B) with water (a substoichiometric amount, based on the isocyanate groups present) (step (C)(ii), which follows step (B)).
- water a substoichiometric amount, based on the isocyanate groups present
- foams, adhesives or sealants in particular as so-called 1-component products (DE 10 2009 005 017), can be obtained.
- the water comes from a gaseous atmosphere surrounding the polyisocyanate (usually air) or from a substrate (an aqueous surface) on which the polyisocyanate is (or is applied).
- one-component or two-component formulations according to step (C) can also be used in particular in the medical field (see WO 2009/100853 for application examples).
- 2-component Systems advantageous to use the polyamines from step (A) as a compound having 2 or more acidic hydrogen atoms or water.
- the statements made above regarding the process according to the invention apply accordingly, so that repetitions can be dispensed with.
- the polyisocyanate has a mass fraction of biogenic carbon, based on its total mass, which is in the range from 0.60% to 46%, preferably from 1.5% to 43%, particularly preferably from 7.0% to 41 % lies.
- the relevant measurement method is ASTM D 6866-21 (DOI: 10.1520/D6866-21).
- the polyisocyanates according to the invention can be used to produce a polyaddition product by reaction with a compound comprising 2 or more acidic hydrogen atoms, the statements made above in connection with the process also applying accordingly.
- the compound comprising 2 or more acidic hydrogen atoms can comprise a third polyol and/or water. The same applies, of course, to the polyaddition products according to the invention from the polyisocyanate according to the invention and a compound comprising 2 or more acidic hydrogen atoms.
- Dynamic viscosity determined using a MCR 51 rheometer from Anton Paar in accordance with DIN 53019 (09-2008).
- NCO content determined according to DIN 53185 (05-1997).
- OH number (hydroxyl number): determined on the basis of DIN 53240-2 (2007-11), with pyridine being used as the solvent instead of THF/dichloromethane, in deviation from this specification. It was titrated with 0.5 molar ethanolic KOH (endpoint recognition by potentiometry).
- mg/g refers to mg[KOH]/g[polyol]
- Amine number determined according to DIN EN ISO 2114 (June 2002).
- Acid number determined according to DIN EN ISO 2114 (June 2002).
- Polyamine D 55.3 g of polyol 4, 163 g of isatoic anhydride, 2.8 g of KOH and 280 g of dioxane were initially taken at room temperature in a 2 L multi-necked flask equipped with a stirrer, heating mantle and reflux condenser. The reaction solution was heated to 75° C. within approx. 1 h, with CO2 escaping as a gas. Then 280 g of methanol were added. The product was then precipitated by adding 560 ml of distilled water, filtered off and washed with methanol. The solid was dried overnight at 80° C. in a drying cabinet. 154 g (89.5% of theory) of a brownish solid were obtained. Once again, the amount of CO2 that escaped corresponded to the value that could theoretically be expected if the conversion was complete, within the limits of measurement accuracy. The polyamine D obtained was solid at room temperature and had the following properties:
- the dynamic viscosity was measured using a falling ball viscometer at 25°C.
- the resulting suspension was gradually heated to 100°C over 1 hour with stirring. The mixture was then heated to reflux temperature within 10 min while stirring. The reaction mixture was refluxed for about another 15 min. During the heating and reflux phases, gaseous phosgene was continuously introduced into the reaction mixture in a stream of 10 standard liters/h.
- the phosgenation of 124 g of polyamine B was carried out analogously to Example 1 (ie the same excess of phosgene).
- the bottom product obtained had an NCO value of 11.4%, a viscosity of 3241 mPa.s and a total chlorine content of 1.29%.
- the distillation bottoms that remained were transferred to a distillation apparatus. At a pressure in the top of the distillation apparatus of about 1-2 mbar (abs) and at a temperature of the heating medium for the distillation pot of 150° C., the remaining chlorobenzene was removed in the course of about 20 minutes. The bottom product was then quickly cooled to room temperature and characterized. The bottom product obtained had an NCO value of 21.35% and was solid at room temperature. The melting point was found to be 90.7°C.
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- Chemical Kinetics & Catalysis (AREA)
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- Medicinal Chemistry (AREA)
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- Emergency Medicine (AREA)
- Polyurethanes Or Polyureas (AREA)
Abstract
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EP21823919.2A EP4259685A1 (de) | 2020-12-10 | 2021-12-09 | Verfahren zur herstellung eines polyisocyanats, polyisocyanat, dessen verwendung und daraus hergestellte polyadditions¬produkte |
CN202180082467.3A CN116568723A (zh) | 2020-12-10 | 2021-12-09 | 制备多异氰酸酯的方法、多异氰酸酯、其用途和由其制成的加聚产物 |
US18/256,219 US20240018097A1 (en) | 2020-12-10 | 2021-12-09 | Process for preparing a polyisocyanate, polyisocyanate, its use and polyaddition products prepared therefrom |
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WO2015124686A1 (en) | 2014-02-20 | 2015-08-27 | Bayer Materialscience Ag | Production of aniline via anthranilate |
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-
2021
- 2021-12-09 WO PCT/EP2021/084975 patent/WO2022122906A1/de active Application Filing
- 2021-12-09 US US18/256,219 patent/US20240018097A1/en active Pending
- 2021-12-09 EP EP21823919.2A patent/EP4259685A1/de active Pending
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DE2040644A1 (de) | 1970-08-17 | 1972-02-24 | Bayer Ag | Neue aromatische Diamine,ein Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Polyurethanen |
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