WO2021246704A1 - Uv-blocking cosmetic composition having increased uv-blocking efficiency due to heat and uv light - Google Patents

Uv-blocking cosmetic composition having increased uv-blocking efficiency due to heat and uv light Download PDF

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WO2021246704A1
WO2021246704A1 PCT/KR2021/006456 KR2021006456W WO2021246704A1 WO 2021246704 A1 WO2021246704 A1 WO 2021246704A1 KR 2021006456 W KR2021006456 W KR 2021006456W WO 2021246704 A1 WO2021246704 A1 WO 2021246704A1
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composition
polymer
self
heat
acrylate
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PCT/KR2021/006456
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French (fr)
Korean (ko)
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조형진
최민성
송승진
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주식회사 엘지생활건강
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Priority to CN202180037957.1A priority Critical patent/CN115697296B/en
Priority to JP2022574823A priority patent/JP2023528506A/en
Priority to US18/000,821 priority patent/US20230248634A1/en
Priority to CN202311566696.XA priority patent/CN117357434A/en
Publication of WO2021246704A1 publication Critical patent/WO2021246704A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/496—Triazoles or their condensed derivatives, e.g. benzotriazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4966—Triazines or their condensed derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/87—Polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48—Thickener, Thickening system

Definitions

  • the present invention relates to a method, composition, use or application for increasing the sun protection efficiency of a sunscreen agent by heat.
  • UV rays irradiated from sunlight act as a major cause of erythema, edema, freckles, or skin cancer on the skin.
  • UV rays are classified according to their wavelength, with a wavelength of 200-280 nm being UV-C, a wavelength of 280-320 nm being UV-B, or a wavelength of 320-400 nm being UV-A.
  • UV-C passes through the ozone layer and is lost without reaching the earth's surface.
  • UV-A is known to penetrate into the dermis of the skin and cause skin cancer, wrinkles, and melanin formation, thereby causing skin aging and skin irritation. Numerous epidemiological studies have demonstrated a strong relationship between sun exposure and human skin cancer.
  • an inorganic UV blocker such as titanium dioxide or zinc oxide, or ethylhexyl methoxycinnamate, ethylhexyl salicylate, octocrylene, butylmethoxydibenzoylmethane, bis-ethyl
  • organic UV blocking agents such as hexyloxyphenol methoxyphenyltriazine or diethylaminohydroxybenzoylhexylbenzoate.
  • the sunscreen applied to the skin has a problem in that it cannot fulfill its role due to damage to the shielding film by moisture and deterioration of photostability by ultraviolet rays.
  • ethylhexyl methoxycinnamate, isoamyl p-methoxycinnamate, or cinoxate which are sunscreens having a methoxycinnamate structure, have a lower efficiency of absorbing light in the ultraviolet region as the trans structure is changed to a cis structure by ultraviolet rays. Falling problems are known.
  • UV blocking efficiency is lowered by heat, UV rays cannot be effectively blocked, which can lead to skin aging or various skin diseases.
  • the amount of time that the skin is exposed to sunlight increases with the increase in outdoor activities, it may cause inconvenience of having to reapply UV-blocking cosmetics several times.
  • the inventors of the present invention showed that when a combination of a polymer having self-emulsifying ability and a polyalcohol having an IOB value of 5.0 or less is used, the UV blocking efficiency of the UV blocker is improved when heat is applied. Rather, a growing number of surprising discoveries have led to the completion of the present invention.
  • Embodiment 1 A method of increasing the UV blocking efficiency of a UV blocking agent by heat using a combination of (a) a polymer having self-emulsifying ability and (b) a polyhydric alcohol having an IOB value of 5.0 or less.
  • Embodiment 2 The method according to Embodiment 1, wherein the method comprises the steps of: preparing an aqueous phase comprising the self-emulsifying polymer and the polyhydric alcohol; preparing an oil phase containing the sunscreen; mixing the aqueous phase part and the oil phase part to prepare a mixed composition; and applying heat to the mixed composition.
  • Embodiment 3 A composition for increasing the UV blocking efficiency of a UV blocker by heat, comprising as an active ingredient a combination of (a) a polymer having self-emulsifying ability and (b) a polyhydric alcohol having an IOB value of 5.0 or less; Use of a combination of (a) a polymer having self-emulsifying ability and (b) a polyhydric alcohol having an IOB value of 5.0 or less to increase the UV protection efficiency of a UV blocker by heat; Or application of a combination of (a) a polymer having self-emulsifying ability and (b) a polyhydric alcohol having an IOB value of 5.0 or less for the manufacture of cosmetics in which the blocking efficiency is increased by heat.
  • Embodiment 4 The active ingredient according to any one of the preceding embodiments, wherein the active ingredient, which serves to increase the ultraviolet blocking efficiency of the sunscreen by heat, comprises (a) a polymer having self-emulsifying ability and (b) an IOB value of 5.0 A method, composition, use or application, characterized in that it consists of a combination of the following polyhydric alcohols.
  • Embodiment 5 The polymer according to any one of the preceding embodiments, wherein the self-emulsifying polymer is a sodium acrylate/behenes-25 methacrylate crosspolymer, a sodium acrylate/sodium acryloyldimethyltaurate copolymer.
  • Sodium acrylate / acryloyl dimethacrylate / dimethyl acrylamide cross polymer sodium polyacrylate, acrylate / C10-30 alkyl acrylate cross polymer, acrylate / Behenes-25 methacrylate copolymer, acrylic Late copolymer, ammonium acryloyl dimethyl taurate / Behenes-25 methacrylate cross polymer, ammonium acryloyl dimethyl taurate / VPicopolymer, polyacrylate-13, polyacrylate cross polymer-6, polyacrylic A method, characterized in that at least one selected from the group consisting of amide, PEG-240/H diicopolymer bis-decyltetradeceth-20 ether, and hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer , composition, use or application.
  • Embodiment 6 The polyalcohol according to any one of the preceding embodiments, wherein the polyalcohol having an IOB value of 5.0 or less is glycerin, sorbitol, xylitol, glucose, trehalose, diglycerin, propanediol, propylene glycol, polyglycerin-3, from the group consisting of methylpropanediol, butylene glycol, pentylene glycol, PEG-6, PEG-8, glycereth-26, dipropylene glycol, 1,2-hexanediol and caprylyl glycol
  • IOB value of 5.0 or less is glycerin, sorbitol, xylitol, glucose, trehalose, diglycerin, propanediol, propylene glycol, polyglycerin-3, from the group consisting of methylpropanediol, butylene glycol, pentylene glycol, PEG-6, P
  • Embodiment 7 The sunscreen according to any one of the preceding embodiments, wherein the sunscreen is an aminobenzoic acid-based compound, a benzophenone-based compound, a cinnamate-based compound, or a salicylate.
  • the sunscreen is an aminobenzoic acid-based compound, a benzophenone-based compound, a cinnamate-based compound, or a salicylate.
  • Embodiment 8 The method, composition, use or application according to any one of the preceding embodiments, wherein the self-emulsifying polymer is an aqueous phase thickener.
  • Embodiment 9 The composition according to any one of the preceding embodiments, wherein the composition comprises an aqueous phase part and an oil phase part, and (a) a polymer having self-emulsifying ability and (b) a polyalcohol having an IOB value of 5.0 or less is the aqueous phase part It is included in the method, composition, use or application, characterized in that the sunscreen is included in the oil phase.
  • Embodiment 10 The method, composition, use or application according to any one of the preceding embodiments, wherein the composition further increases the synergistic effect of the UV blocking efficiency of the UV blocking agent by heat upon UV irradiation.
  • Embodiment 10 A cosmetic comprising the composition according to any one of the preceding embodiments.
  • One aspect of the present invention is to provide a method for increasing the sunscreen efficiency of a sunscreen by heat using a combination of (a) a self-emulsifying polymer and (b) a polyhydric alcohol having an IOB value of 5.0 or less.
  • the method comprises the steps of preparing an aqueous phase comprising the above-described self-emulsifying polymer and polyhydric alcohol; Preparing an oil phase containing the above-described sunscreen; mixing the aqueous phase part and the oil phase part to prepare a mixed composition; and applying heat to the mixed composition.
  • compositions for increasing the UV protection efficiency of a UV blocker by heat comprising a combination of (a) a polymer having self-emulsifying ability and (b) a polyhydric alcohol having an IOB value of 5.0 or less as an active ingredient will do
  • the self-emulsifying polymer (SEP) of the present invention means a polymer that has both a hydrophilic and a hydrophobic group in the chain and thus has an emulsifying ability and a thickening ability at the same time. It is possible to produce a stable composition without a separate emulsifier, and when heat is applied after application, the sunscreen film can be spread, resulting in a wide and uniform UV-blocking area due to heat, thereby increasing the effect. . On the other hand, in the case of general emulsification, even when heat is applied, the emulsifier located at the interface interferes with the movement of the sunscreen, so there is no change in the blocking effect before and after heating. Compared with this general emulsification, the principle of synergy of the UV protection effect by the polymeric emulsification of the present invention is briefly shown in FIG. 1 .
  • polymer having self-emulsifying ability examples include sodium acrylate/behenes-25 methacrylate crosspolymer, sodium acrylate/sodium acryloyldimethyltaurate copolymer, sodium acrylate/acryloyldimethacrylate/dimethacrylate.
  • Methylacrylamide crosspolymer sodium polyacrylate, acrylate/C10-30 alkyl acrylate crosspolymer, acrylate/behenes-25 methacrylate copolymer, acrylate copolymer, ammonium acryloyldimethyltaurate/behe Ness-25 methacrylate cross polymer, ammonium acryloyl dimethyl taurate/vpicopolymer, polyacrylate-13, polyacrylate crosspolymer-6, polyacrylamide, PG-240/H diicopolymer bis- Decyltetradeceth-20 ether, hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, etc., but are not limited thereto.
  • the self-emulsifying polymer may be included in an amount of 0.01 wt% to 10 wt% in the composition of the present invention.
  • the IOB (inorganic-organic balance) value is a numerical value indicating the hydrophilicity of an organic compound, and the higher the value, the higher the hydrophilicity.
  • the composition according to the present invention has a viscosity of 1,000 cps or less, more preferably 500 cps or less (measurement conditions: Brookfield viscometer, 40°C, LVF spindle#1, 30rpm, 1 min) of the oil phase.
  • the viscosity of the oil component among the components blended in the oil phase is preferably 1,000 cps or less, more preferably 500 cps or less (measurement conditions: Brookfield viscometer, 40° C., LVF spindle#1, 30 rpm, 1 min).
  • Polyhydric alcohols having an IOB value of 5.0 or less used in the present invention include, for example, glycerin, sorbitol, xylitol, glucose, trehalose, diglycerin, propanediol, propylene glycol polyglycerin-3, methylpropanediol, butylene glycol, It may be one or more selected from the group consisting of pentylene glycol PEG-6, PEG-8, glycereth-26, dipropylene glycol, 1,2-hexanediol, and caprylyl glycol, but is not limited thereto. .
  • the polyalcohol having an IOB value of 5.0 or less may be included in an amount of 0.1 wt% to 50 wt% in the composition of the present invention.
  • sunscreens can be used regardless of the type of both organic sunscreens having a UV absorbing effect and inorganic sunscreens having a scattering effect.
  • Examples of the aminobenzoic acid-based compound include PABA, glyceryl PABA, Padimate O, Roxadimate, and the like
  • examples of the benzophenone-based compound include deoxybenzone. (Dioxybenzone), oxybenzone, sulisonbenzone, etc.
  • examples of the cinnamate-based compound include octocrylene, octyl methoxycinnamate (octinoxate), deoxy Ethoxyethyl p-methoxycinnamate (cinoxate), and the like
  • examples of the salicylate-based compound include Homomenthyl salicylate (homosalate), Ethylhexyl salicylate (octyl salicylate/octisalate)), trolamine salicylate, and the like
  • the inorganic metal oxides include, but are not limited to, titanium dioxide or zinc oxide.
  • the sunscreen agent may be included in 0.5 wt% to 30 wt% in the composition of the present invention.
  • the active ingredient which serves to increase the UV blocking efficiency of the UV blocker by heat, includes (a) a polymer having self-emulsifying ability and (b) a polyalcohol having an IOB value of 5.0 or less. It may be made up of a combination of
  • the composition for increasing the ultraviolet blocking efficiency of a sunscreen by heat of the present invention may include an aqueous phase and an oil phase, wherein the self-emulsifying polymer is an aqueous phase thickener, and the IOB value It is included in the aqueous phase together with 5.0 or less polyhydric alcohol, and the sunscreen may be included in the oil phase.
  • the composition for increasing the sunscreen efficiency of a sunscreen by heat of the present invention is dextrin palmitate, disteadimonium hectorite, stearoyl inulin, polyamide-8, glyceryl behenate/eico It may be one that does not substantially contain an oily thickener such as sadioate.
  • 'substantially not containing an oil phase thickener' means that the viscosity of the oil phase part is 1,000 cps or less, more preferably 500 cps or less (measurement conditions: Brookfield viscometer, 40 °C, LVF spindle#1, 30 rpm, 1 min) can be included in less than that amount. This is to facilitate the diffusion of the composition components into the pores generated when the aqueous phase volatilizes after the composition according to the present invention is applied to the skin.
  • composition for increasing the UV blocking efficiency of the UV blocker by heat of the present invention may not contain an emulsifier component other than the self-emulsifying polymer of the present invention.
  • composition of the present invention may further include a moisturizing agent, a thickener, a surfactant, an oily agent, a preservative, an antioxidant, alcohol, a fragrance, a pH adjuster or a natural extract, but is not limited thereto.
  • a moisturizing agent preferably 1,000 cps or less, more preferably 500 cps or less (measurement conditions: Brookfield viscometer, 40°C, LVF spindle#1, 30rpm, 1 min) is preferred.
  • sunscreens reduce their sunscreen efficiency due to heat, but when using the active ingredient of the present invention, that is, a combination of (a) a polymer having self-emulsifying ability and (b) a polyhydric alcohol having an IOB value of 5.0 or less, it is rather caused by heat.
  • the UV-blocking efficiency of the sunscreen is increased.
  • the SPF value is significantly increased after applying heat of 40° C. for 15 minutes, specifically, at least 1%, at least 5% compared to before the application of heat , at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 100%, at least 110%, at least 120%, at least 130%, at least 140%, at least 150%, at least 160%, at least 170%, at least 180%, at least 190%, at least 200%, at least 210%, at least 220%, at least 230%, at least 240% , at least 250%, at least 260%, at least 270%, at least 280%, at least 290%, at least 300%, at least 310%, at least 320%, at least 330%, at least 340%, at least 350%, at least 360%, at least It may increase by 370%, at least 380%, or at least 390%,
  • composition of the present invention exhibits a synergistic effect with respect to an increase in UV blocking efficiency when UV irradiation is added in addition to heat.
  • Another aspect of the present invention is to provide a cosmetic comprising a composition for increasing the UV blocking efficiency of the UV blocker by the above-described heat.
  • the cosmetic may be prepared in any formulation conventionally prepared in the art, for example, to be formulated as a solution, suspension, emulsion, paste, gel, cream, lotion, soap, surfactant-containing cleansing, oil, etc.
  • the present invention is not limited thereto.
  • the cosmetics include mist, serum, nourishing lotion, softening lotion, soft water, emulsion, astringent, toner, skin, lotion, cream, foam, makeup base, essence, liquid detergent, bathing agent, sunscreen cream, sunscreen Oil, sunscreen emulsion, sunblock product, makeup product, makeup base, foundation, makeup pact, BB cream, CC cream, makeup powder, etc.
  • the cosmetic, cosmetic, or composition according to the present invention contains the ingredients according to the present invention within the content limit allowed by the relevant laws and regulations of each country.
  • the UV blocking efficiency of a sunscreen is reduced by heat, but the present invention provides a technique for rather increasing the UV blocking efficiency of the sunscreen by heat.
  • 1 is a schematic view showing the principle of increasing the UV blocking effect by the polymeric emulsification of the present invention compared to the general emulsification.
  • the emulsifier located at the interface prevents the movement of the sunscreen, so there is no change in the blocking effect before and after heating. Therefore, it does not interfere with the movement of the sunscreen, and the UV blocking area expands after heating, increasing the blocking effect.
  • FIG. 2 is a schematic diagram showing the action of a polyhydric alcohol having an IOB value of 5.0 or less of the present invention. If there is no polyol in the aqueous phase, the sunscreen does not expand when the aqueous phase is completely dried and heated after drying. However, if there is polyol in the aqueous phase, polyol remains in the aqueous phase even after drying Due to the compatibility between polyol and the sunscreen, it is possible to expand the sunscreen to the water phase during heating, increasing the blocking effect.
  • 3 is a graph showing the results of evaluating the effect of polymeric emulsification and general emulsification on the UV blocking effect.
  • the composition was prepared as shown in Table 2 below and applied to the PMMA plate. After application of each sunscreen composition, the initial in vitro SPF was measured after drying at room temperature for 15 minutes. Thereafter, after heating in a thermostat at 40° C. for 15 minutes, the late in vitro SPF was measured to calculate the rate of change of the initial value and the late value, and the results are shown in FIG. 3 .
  • the experimental sample was applied to a PMMA plate (HelioScreen Labs, HD6) at 1.3 mg/cm 2 , dried at room temperature for 15 minutes, and the initial in vitro SPF was measured using SPF-290AS (Solar light, USA). In vitro SPF was measured in 6 different parts of the PMMA plate and the average value was used. Thereafter, the PMMA plate having the initial in vitro SPF measured was placed on a hot plate set at 40°C in advance, heated for 15 minutes, and then the late in vitro SPF was measured to calculate the rate of change between the initial value and the late value.
  • Example 15 Example 16
  • Example 17 Example 18
  • Example 20 Example 21 Prime Minister Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 glycerin 10 dipropylene glycol 10 PEG-6 10 PEG-8 10 propanediol 10 5 Butylene Glycol 10 5 Polyacrylate-13 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 Hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Ammonium acryloyl dimethyl taurate/vpicopolymer 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 paid part Ethylhexylmethoxycinnamate 6.8 6.8 6.8 6.8 6.8 6.8 6.8 6.8 6.8 Diethylaminohydroxybenzoylhexylbenzoate 4 4 4 4 4 4 4 4 4 4 4 4 Bis-ethy
  • a UV protection composition was prepared as shown in Table 7 below and the SPF change rate was calculated after heating. Specifically, each UV blocking composition was applied to a PMMA plate and dried for 15 minutes, and the initial in vitro SPF was measured. Then, after heating in a 40°C thermostat for 15 minutes, the late in vitro SPF was measured, and the SPF change rate compared to the initial value was calculated, and the results are shown in Tables 7 and 5 below.
  • the self-emulsifying polymer of the present invention is included in the aqueous phase as an aqueous thickener. Accordingly, it was attempted to prepare a sunscreen composition using an oily thickener instead of the self-emulsifying polymer of the present invention, but in this case, it was confirmed that the stability of the formulation was greatly reduced. Thus, the effect of the polymer having self-emulsifying ability of the present invention was compared with that of the case where an oily thickener was additionally included in the aqueous thickener, and the results are shown in Table 8 below.
  • composition 1 composition 2 composition 3 composition 4 composition 5 composition 6 Prime Minister Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 propanediol 5 5 5 5 5 5 5 5 5 Hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 Polyacrylate crosspolymer-6 0.2 0.2 0.2 0.2 0.2 0.2 0.2 paid part Ethylhexylmethoxycinnamate 6.8 6.8 6.8 6.8 6.8 6.8 6.8 6.8 6.8 6.8 6.8 Diethylaminohydroxybenzoylhexylbenzoate 4 4 4 4 4 4 4 4 4 4 4 4 Bis-ethylhexyloxyphenol methoxyphenyltriazine 3 3 3 3 3 3 3 3 3 3 3 3 C12-15 Alkylbenzoate 8 8 8 8 8 8 8 Dextrin Palmitate One Disteadimonium Hectorite One Ste
  • compositions 2 to 6 As a result of the experiment, it was confirmed that the SPF increase rate was significantly reduced when various oil thickeners were added to Composition 1, which was prepared only with a polymer having self-emulsifying ability (Compositions 2 to 6).
  • Table 9 shows the results of confirming the in vitro SPF change according to the temperature when the sunscreen composition (composition 1) of the present invention is exposed to ultraviolet rays.
  • the experimental sample was applied to a PMMA plate (HelioScreen Labs, HD6) at 1.3 mg/cm 2 , dried at room temperature for 15 minutes, and the initial in vitro SPF was measured using SPF-290AS (Solar light, USA). Thereafter, the PMMA plate having the initial in vitro SPF measured was placed on a hot plate at a preset temperature and maintained for 15 minutes, and then the late in vitro SPF was measured to calculate the rate of change between the initial and late values. At this time, using a UV irradiator (16S-300, Solar light), the in vitro SPF change rate according to the presence or absence of 2MED UV irradiation was confirmed.
  • a UV irradiator (16S-300, Solar light

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Abstract

The present invention relates to a composition for increasing the UV-blocking efficiency of a UV-blocking body by means of heat.　Ordinarily, the UV-blocking efficiency of a UV-blocking body decreases with heat, but the present invention has the significant benefit wherein the UV-blocking efficiency of a UV-blocking body is actually increased by heat.

Description

열과 자외선에 의해 자외선 차단 효율이 상승하는 자외선 차단용 화장료 조성물 UV-blocking cosmetic composition that increases UV-blocking efficiency by heat and UV rays
본 출원은 2020년 06월 03일 출원된 대한민국출원 제10-2020-0067122호 및 2020년 12월 02일 출원된 대한민국출원 제 10-2020-0166725호에 기초한 우선권을 주장하며, 해당 출원의 명세서 및 도면에 개시된 모든 내용은 본 출원에 원용된다.This application claims priority based on Korean Application No. 10-2020-0067122, filed on June 03, 2020 and Korean Application No. 10-2020-0166725, filed on December 02, 2020, the specification and All contents disclosed in the drawings are incorporated herein by reference.
본 발명은 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키기 위한 방법, 조성물, 용도 또는 응용에 관한 것이다.　The present invention relates to a method, composition, use or application for increasing the sun protection efficiency of a sunscreen agent by heat.
태양광으로부터 조사되는　자외선은 피부에 홍반이나, 부종, 주근깨, 또는 피부암을 일으키는 주요한 원인으로 작용한다. 최근　자외선에 기인한 여러 가지 피부 질병들에 대한 많은 연구가 활발히 진행되고 있다. 일반적으로　자외선은 그 파장에 따라, 200-280 nm의 파장은 UV-C, 280-320 nm의 파장은 UV-B, 또는 320-400 nm의 파장은 UV-A로 분류된다. UV-C는 오존층을 통과하면서 지표면에 도달하지 못하고 소실되며, UV-B는 피부의 표피까지 침투되어 홍반과 주근깨, 또는 부종 등을 일으킨다. UV-A는 피부의 진피까지 침투하여 피부암과 주름, 멜라닌 형성을 촉진하는 등, 피부 노화, 및 피부 자극을 유발하는 것으로 알려져 있다. 다수의 역학 연구로 일광 노출과 인체 피부암의 강력한 관계가 증명되어 있다.Ultraviolet rays irradiated from sunlight act as a major cause of erythema, edema, freckles, or skin cancer on the skin. Recently, many studies on various skin diseases caused by UV rays are being actively conducted. In general, UV rays are classified according to their wavelength, with a wavelength of 200-280 nm being UV-C, a wavelength of 280-320 nm being UV-B, or a wavelength of 320-400 nm being UV-A. UV-C passes through the ozone layer and is lost without reaching the earth's surface. UV-A is known to penetrate into the dermis of the skin and cause skin cancer, wrinkles, and melanin formation, thereby causing skin aging and skin irritation. Numerous epidemiological studies have demonstrated a strong relationship between sun exposure and human skin cancer.
일광 노출과 관련된 상기 언급된 위험의 결과로,　자외선　차단 제품에 대한 일반 대중의 관심은 증가하여 왔으며, 그 결과 다양한 종류의 SPF(자외선　차단지수)를 가지는　자외선　차단 제품이 출시되고 있다.　자외선　차단 제품은 높은 SPF값을 갖도록 하기 위해 이산화티탄, 또는 산화아연 등의 무기　자외선　차단제, 또는 에칠헥실메톡시신나메이트, 에칠헥실살리실레이트, 옥토크릴렌, 부틸메톡시디벤조일메탄, 비스-에칠헥실옥시페놀메톡시페닐트리아진, 또는 디에칠아미노하이드록시벤조일헥실벤조에이트 등의 유기　자외선　차단제를 포함한다.　As a result of the above-mentioned risks associated with sun exposure, public interest in 　UV protection products has increased, and as a result, various types of UV protection products with SPF (UV protection factor) have been launched. In order to have a high SPF value, an inorganic UV blocker such as titanium dioxide or zinc oxide, or ethylhexyl methoxycinnamate, ethylhexyl salicylate, octocrylene, butylmethoxydibenzoylmethane, bis-ethyl Contains organic UV blocking agents such as hexyloxyphenol methoxyphenyltriazine or diethylaminohydroxybenzoylhexylbenzoate.
한편, 피부에 도포된 자외선 차단제는 수분에 의한 차단막 손상 및 자외선에 의한 광안정성 저하로 인해 그 역할을 다하지 못하는 문제점이 있음이 대두되었다. 특히 메톡시신나메이트 구조를 갖는 자외선 차단제인 에칠헥실메톡시신나메이트, 이소아밀p-메톡시신나메이트, 또는 시녹세이트는 자외선에 의해 트렌스 구조가 시스 구조로 바뀌면서 자외선 영역의 빛을 흡수하는 효율이 떨어지는 문제점이 알려져 있다. On the other hand, it has been raised that the sunscreen applied to the skin has a problem in that it cannot fulfill its role due to damage to the shielding film by moisture and deterioration of photostability by ultraviolet rays. In particular, ethylhexyl methoxycinnamate, isoamyl p-methoxycinnamate, or cinoxate, which are sunscreens having a methoxycinnamate structure, have a lower efficiency of absorbing light in the ultraviolet region as the trans structure is changed to a cis structure by ultraviolet rays. Falling problems are known.
최근 이러한 자외선 차단 효율 저하 문제를 해결하기 위한 기술이 개발되었지만, 주로 수분 및/또는 광에 의해 자외선 차단 효율이 저하되는 문제를 해결하는 것에 관한 것이고, 열에 의해 발생하는 자외선 차단 효과 저하를 개선하기 위한 연구는 부족한 실정이다.Recently, technology has been developed to solve the problem of lowering the UV blocking efficiency, but it is mainly related to solving the problem that the UV blocking efficiency is lowered by moisture and / or light, and to improve the degradation of the UV blocking effect caused by heat Research is lacking.
매년 여름철 기온이 증가함에 따라 이에 대응하는 자외선 차단제가 필요하다. 열에 의하여 자외선 차단 효율이 떨어지게 되면 효과적으로 자외선을 차단할 수 없어 피부 노화나 각종 피부 질병을 유발할 수 있다. 또한 야외 활동이 많아짐에 따라 피부가 태양광에 노출되는 시간이 길어지면 자외선 차단용 화장품을 여러 번 덧발라줘야 하는 불편함을 유발할 수 있다. 이러한 문제를 해결하기 위해, 열에 의하여 자외선 차단제 자체의 효과가 감소하는 것을 방지하는 방법 또는 동량을 사용하더라도 효과를 보다 더 증진시키는 방법의 개발이 필요한 실정이다. As the summer temperature increases every year, sunscreens are required to respond accordingly. If the UV blocking efficiency is lowered by heat, UV rays cannot be effectively blocked, which can lead to skin aging or various skin diseases. In addition, as the amount of time that the skin is exposed to sunlight increases with the increase in outdoor activities, it may cause inconvenience of having to reapply UV-blocking cosmetics several times. In order to solve this problem, it is necessary to develop a method for preventing the decrease in the effect of the sunscreen itself by heat or a method for further enhancing the effect even if the same amount is used.
본 명세서 전체에 걸쳐 다수의 문헌이 참조되고 그 인용이 표시되어 있다. 인용된 문헌의 개시 내용은 그 전체로서 본 명세서에 참조로 삽입되어 본 발명이 속하는 기술 분야의 수준 및 본 발명의 내용이 보다 명확하게 설명된다. Numerous references are referenced throughout this specification and citations thereof are indicated. The disclosures of the cited documents are incorporated herein by reference in their entirety to more clearly describe the content of the present invention and the level of the art to which the present invention pertains.
본 발명의 발명자들은 상기 종래기술의 문제점을 해결하기 위해 예의 연구 노력한 결과, 자가유화능을 갖는 폴리머 및 IOB 값 5.0 이하의 다가알코올의 조합을 사용하는 경우 열을 가했을 때 자외선 차단제의 자외선 차단 효율이 오히려 증가하는 놀라운 발견을 하여 본 발명을 완성하게 되었다. As a result of intensive research efforts to solve the problems of the prior art, the inventors of the present invention showed that when a combination of a polymer having self-emulsifying ability and a polyalcohol having an IOB value of 5.0 or less is used, the UV blocking efficiency of the UV blocker is improved when heat is applied. Rather, a growing number of surprising discoveries have led to the completion of the present invention.
따라서 본 발명의 목적은 다음의 구현예들을 제공하는 데 있다. Accordingly, it is an object of the present invention to provide the following embodiments.
구현예 1. (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올의 조합을 사용하여, 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키는 방법.Embodiment 1. A method of increasing the UV blocking efficiency of a UV blocking agent by heat using a combination of (a) a polymer having self-emulsifying ability and (b) a polyhydric alcohol having an IOB value of 5.0 or less.
구현예 2. 구현예 1에 있어서, 상기 방법은 상기 자가유화능을 갖는 폴리머 및 상기 다가알코올을 포함하는 수상부를 준비하는 단계; 상기 자외선 차단제를 포함하는 유상부를 준비하는 단계; 상기 수상부 및 유상부를 혼합하여 혼합 조성물을 제조하는 단계; 및 상기 혼합 조성물에 열을 가하는 단계를 포함하는 것을 특징으로 하는 방법.Embodiment 2. The method according to Embodiment 1, wherein the method comprises the steps of: preparing an aqueous phase comprising the self-emulsifying polymer and the polyhydric alcohol; preparing an oil phase containing the sunscreen; mixing the aqueous phase part and the oil phase part to prepare a mixed composition; and applying heat to the mixed composition.
구현예 3. (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올의 조합을 유효성분으로 포함하는, 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키기 위한 조성물; (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올의 조합의, 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키기 위한 용도; 또는 열에 의해 차단 효율이 상승하는 화장품 제조를 위한 (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올의 조합의 응용.Embodiment 3. A composition for increasing the UV blocking efficiency of a UV blocker by heat, comprising as an active ingredient a combination of (a) a polymer having self-emulsifying ability and (b) a polyhydric alcohol having an IOB value of 5.0 or less; Use of a combination of (a) a polymer having self-emulsifying ability and (b) a polyhydric alcohol having an IOB value of 5.0 or less to increase the UV protection efficiency of a UV blocker by heat; Or application of a combination of (a) a polymer having self-emulsifying ability and (b) a polyhydric alcohol having an IOB value of 5.0 or less for the manufacture of cosmetics in which the blocking efficiency is increased by heat.
구현예 4. 선행하는 구현예들 중 어느 하나에 있어서, 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키기는 역할을 하는 상기 유효성분은 (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올의 조합으로 이루어진 것을 특징으로 하는 방법, 조성물, 용도 또는 응용.Embodiment 4. The active ingredient according to any one of the preceding embodiments, wherein the active ingredient, which serves to increase the ultraviolet blocking efficiency of the sunscreen by heat, comprises (a) a polymer having self-emulsifying ability and (b) an IOB value of 5.0 A method, composition, use or application, characterized in that it consists of a combination of the following polyhydric alcohols.
구현예 5. 선행하는 구현예들 중 어느 하나에 있어서, 상기 자가유화능을 갖는 폴리머는 소듐아크릴레이트/베헤네스-25메타크릴레이트크로스폴리머, 소듐아크릴레이트/소듐아크릴로일디메틸타우레이트코폴리머, 소듐아크릴레이트/아크릴로일다이메타트레이트/디메틸아크릴아마이드크로스폴리머, 소듐폴리아크릴레이트, 아크릴레이트/C10-30알킬아크릴레이트크로스폴리머, 아크릴레이트/베헤네스-25메타크릴레이트코폴리머, 아크릴레이트코폴리머, 암모늄아크릴로일디메틸타우레이트/베헤네스-25메타크릴레이트크로스폴리머, 암모늄아크릴로일디메틸타우레이트/브이피코폴리머, 폴리아크릴레이트-13, 폴리아크릴레이트크로스폴리머-6, 폴리아크릴아마이드, 피이지-240/에이치디아이코폴리머비스-데실테트라데세스-20에터, 및 하이드록시에틸아크릴레이트/소듐아크릴로일디메틸타우레이트코폴리머로 이루어진 군으로부터 선택되는 1 이상인 것을 특징으로 하는 방법, 조성물, 용도 또는 응용.Embodiment 5. The polymer according to any one of the preceding embodiments, wherein the self-emulsifying polymer is a sodium acrylate/behenes-25 methacrylate crosspolymer, a sodium acrylate/sodium acryloyldimethyltaurate copolymer. , Sodium acrylate / acryloyl dimethacrylate / dimethyl acrylamide cross polymer, sodium polyacrylate, acrylate / C10-30 alkyl acrylate cross polymer, acrylate / Behenes-25 methacrylate copolymer, acrylic Late copolymer, ammonium acryloyl dimethyl taurate / Behenes-25 methacrylate cross polymer, ammonium acryloyl dimethyl taurate / VPicopolymer, polyacrylate-13, polyacrylate cross polymer-6, polyacrylic A method, characterized in that at least one selected from the group consisting of amide, PEG-240/H diicopolymer bis-decyltetradeceth-20 ether, and hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer , composition, use or application.
구현예 6. 선행하는 구현예들 중 어느 하나에 있어서, 상기 IOB 값 5.0 이하의 다가알코올은 글리세린, 솔비톨, 자일리톨, 글루코스, 트레할로스, 디글리세린, 프로판디올, 프로필렌글라이콜, 폴리글리세린-3, 메틸프로판디올, 부틸렌글라이콜, 펜틸렌글라이콜, 피이지-6, 피이지-8, 글리세레스-26, 디프로필렌글라이콜, 1,2-헥산디올 및 카프릴릴글라이콜로 이루어진 군으로부터 선택되는 1 이상인 것을 특징으로 하는 방법, 조성물, 용도 또는 응용.Embodiment 6. The polyalcohol according to any one of the preceding embodiments, wherein the polyalcohol having an IOB value of 5.0 or less is glycerin, sorbitol, xylitol, glucose, trehalose, diglycerin, propanediol, propylene glycol, polyglycerin-3, from the group consisting of methylpropanediol, butylene glycol, pentylene glycol, PEG-6, PEG-8, glycereth-26, dipropylene glycol, 1,2-hexanediol and caprylyl glycol A method, composition, use or application, characterized in that at least one selected.
구현예 7. 선행하는 구현예들 중 어느 하나에 있어서, 상기 자외선 차단제는 아미노벤조산(aminobenzoic acid)계 화합물, 벤조페논(benzophenone)계 화합물, 신나메이트(cinnamate)계 화합물, 살리실레이트(salicylate)계 화합물, 무기산화금속(inorganic metal oxides), 부틸메톡시디벤조일메탄(butyl methoxydibenzoylmethane), 테레프탈릴리덴 디캠퍼 설폰산(terephthalylidene dicamphor sulfonic acid) 에캄슐(ecamsule), 페닐벤지미다졸설포닉애씨드(phenylbenzimidazole sulfonic acid), 베모트리지놀(bemotrizinol) 및 비스옥트리졸(bisoctrizole)로 이루어진 군으로부터 선택되는 1 이상인 것을 특징으로 하는 방법, 조성물, 용도 또는 응용.Embodiment 7. The sunscreen according to any one of the preceding embodiments, wherein the sunscreen is an aminobenzoic acid-based compound, a benzophenone-based compound, a cinnamate-based compound, or a salicylate. Compounds, inorganic metal oxides, butyl methoxydibenzoylmethane, terephthalylidene dicamphor sulfonic acid ecamsule, phenylbenzimidazole sulfonic acid acid), a method, composition, use or application, characterized in that at least one selected from the group consisting of bemotrizinol and bisoctrizole.
구현예 8. 선행하는 구현예들 중 어느 하나에 있어서, 상기 자가유화능을 갖는 폴리머는 수상 증점제인 것을 특징으로 하는 방법, 조성물, 용도 또는 응용.Embodiment 8. The method, composition, use or application according to any one of the preceding embodiments, wherein the self-emulsifying polymer is an aqueous phase thickener.
구현예 9. 선행하는 구현예들 중 어느 하나에 있어서, 상기 조성물은 수상부 및 유상부를 포함하고, (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올은 상기 수상부에 포함되며, 상기 자외선 차단제는 유상부에 포함되는 것을 특징으로 하는 방법, 조성물, 용도 또는 응용.Embodiment 9. The composition according to any one of the preceding embodiments, wherein the composition comprises an aqueous phase part and an oil phase part, and (a) a polymer having self-emulsifying ability and (b) a polyalcohol having an IOB value of 5.0 or less is the aqueous phase part It is included in the method, composition, use or application, characterized in that the sunscreen is included in the oil phase.
구현예 10. 선행하는 구현예들 중 어느 하나에 있어서, 상기 조성물은 자외선 조사 시, 열에 의해 자외선 차단제의 자외선 차단 효율의 상승효과가 더 증가하는 것을 특징으로 하는 방법, 조성물, 용도 또는 응용.Embodiment 10. The method, composition, use or application according to any one of the preceding embodiments, wherein the composition further increases the synergistic effect of the UV blocking efficiency of the UV blocking agent by heat upon UV irradiation.
구현예 10. 선행하는 구현예들 중 어느 하나에 따른 조성물을 포함하는 화장품.Embodiment 10. A cosmetic comprising the composition according to any one of the preceding embodiments.
본 발명의 다른 목적 및 이점은 하기의 발명의 상세한 설명, 청구범위 및 도면에 의해 보다 명확하게 된다. Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims and drawings.
본 발명의 하나의 관점은 (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올의 조합을 사용하여, 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키는 방법을 제공하는 것이다. One aspect of the present invention is to provide a method for increasing the sunscreen efficiency of a sunscreen by heat using a combination of (a) a self-emulsifying polymer and (b) a polyhydric alcohol having an IOB value of 5.0 or less.
상기 방법은, 상술한 자가유화능을 갖는 폴리머 및 다가알코올을 포함하는 수상부를 준비하는 단계; 상술한 자외선 차단제를 포함하는 유상부를 준비하는 단계; 상기 수상부 및 유상부를 혼합하여 혼합 조성물을 제조하는 단계; 및 상기 혼합 조성물에 열을 가하는 단계를 포함할 수 있다.The method comprises the steps of preparing an aqueous phase comprising the above-described self-emulsifying polymer and polyhydric alcohol; Preparing an oil phase containing the above-described sunscreen; mixing the aqueous phase part and the oil phase part to prepare a mixed composition; and applying heat to the mixed composition.
본 발명의 다른 관점은 (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올의 조합을 유효성분으로 포함하는, 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키기 위한 조성물을 제공하는 것이다.Another aspect of the present invention provides a composition for increasing the UV protection efficiency of a UV blocker by heat, comprising a combination of (a) a polymer having self-emulsifying ability and (b) a polyhydric alcohol having an IOB value of 5.0 or less as an active ingredient will do
자가유화능을 갖는 폴리머self-emulsifying polymer
본 발명의 자가유화능을 갖는 폴리머(Self-emulsifying polymer, SEP)란 체인 내에 친수 및 소수성기를 동시에 갖고 있어 점증능력과 동시에 유화능력을 갖는 폴리머를 의미하며 자가유화능을 갖는 폴리머를 이용하여 유화 조성물을 제조할 경우 별도의 유화제 없이도 안정한 조성물 제조가 가능하며 도포 후 열을 가했을 때 자외선 차단제 피막의 확산이 가능해져 결과적으로 열에 의해 자외선 차단 영역이 넓게 균일해져서 그 효과가 상승하는 효과의 구현이 가능하다. 반면에, 일반 유화의 경우 열을 가하여도 계면에 위치한 유화제가 자외선 차단제의 이동을 방해하여 가온 전후 차단 효과에 변화가 없다. 이러한 일반 유화와 비교하여 본 발명의 폴리머릭 유화에 의한 자외선 차단 효과의 상승 원리를 도 1에 간략히 나타내었다.The self-emulsifying polymer (SEP) of the present invention means a polymer that has both a hydrophilic and a hydrophobic group in the chain and thus has an emulsifying ability and a thickening ability at the same time. It is possible to produce a stable composition without a separate emulsifier, and when heat is applied after application, the sunscreen film can be spread, resulting in a wide and uniform UV-blocking area due to heat, thereby increasing the effect. . On the other hand, in the case of general emulsification, even when heat is applied, the emulsifier located at the interface interferes with the movement of the sunscreen, so there is no change in the blocking effect before and after heating. Compared with this general emulsification, the principle of synergy of the UV protection effect by the polymeric emulsification of the present invention is briefly shown in FIG. 1 .
자가유화능을 갖는 폴리머의 예로는 소듐아크릴레이트/베헤네스-25메타크릴레이트크로스폴리머, 소듐아크릴레이트/소듐아크릴로일디메칠타우레이트코폴리머, 소듐아크릴레이트/아크릴로일다이메타트레이트/다이메틸아크릴아마이드크로스폴리머, 소듐폴리아크릴레이트, 아크릴레이트/C10-30알킬아크릴레이트크로스폴리머, 아크릴레이트/베헤네스-25메타크릴레이트코폴리머, 아크릴레이트코폴리머, 암모늄아크릴로일디메칠타우레이트/베헤네스-25메타크릴레이트크로스폴리머, 암모늄아크릴로일디메칠타우레이트/브이피코폴리머, 폴리아크릴레이트-13, 폴리아크릴레이트크로스폴리머-6, 폴리아크릴아마이드, 피이지-240/에이치디아이코폴리머비스-데실테트라데세스-20에터, 하이드록시에칠아크릴레이트/소듐아크릴로일디메칠타우레이트코폴리머 등이 있으나 이에 한정되는 것은 아니다.Examples of the polymer having self-emulsifying ability include sodium acrylate/behenes-25 methacrylate crosspolymer, sodium acrylate/sodium acryloyldimethyltaurate copolymer, sodium acrylate/acryloyldimethacrylate/dimethacrylate. Methylacrylamide crosspolymer, sodium polyacrylate, acrylate/C10-30 alkyl acrylate crosspolymer, acrylate/behenes-25 methacrylate copolymer, acrylate copolymer, ammonium acryloyldimethyltaurate/behe Ness-25 methacrylate cross polymer, ammonium acryloyl dimethyl taurate/vpicopolymer, polyacrylate-13, polyacrylate crosspolymer-6, polyacrylamide, PG-240/H diicopolymer bis- Decyltetradeceth-20 ether, hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, etc., but are not limited thereto.
상기 자가유화능을 갖는 폴리머는 본 발명의 조성물 중에 0.01 중량% 내지 10 중량% 포함될 수 있다.The self-emulsifying polymer may be included in an amount of 0.01 wt% to 10 wt% in the composition of the present invention.
IOB 값 5.0 이하의 다가알코올Polyalcohols with an IOB value of 5.0 or less
IOB(무기성-유기성 균형; inorganic-organic balance) 값은 유기 화합물의 친수성을 나타내는 수치로서, 수치가 클수록 친수성이 높아진다. IOB 값은 「유기 개념도-기초와 응용」(고다요시오 저 (1984) 산쿄 출판) 등에 기재된 유기성, 무기성 표에 기초하여, 유기성 값(OV), 무기성 값(IV)을 계산하여, IOB 값=(무기성 값/유기성 값)으로 계산이 가능하다. The IOB (inorganic-organic balance) value is a numerical value indicating the hydrophilicity of an organic compound, and the higher the value, the higher the hydrophilicity. IOB values are calculated by calculating organic values (OV) and inorganic values (IV) based on the organic and inorganic tables described in "Organic Conceptual Diagram-Basics and Applications" (Kodayoshio (1984) Sankyo Publishing) etc. It can be calculated as = (inorganic value/organic value).
다가 알코올의 경우 도포 후 수분이 증발한 뒤에도 수상부가 위치해 있던 공극에 남아있게 되고 여기에 열이 가해지면 다가 알코올과 자외선 차단제가 포함된 유상의 상용성에 의해 자외선 차단제가 공극으로 확산이 가능해져서 결과적으로 자외선 차단영역이 넓게 균일해지는 효과로 자외선 차단효율이 상승하는 효과가 일어나게 된다. 이러한 확산을 용이하게 하기 위해서, 본 발명에 다른 조성물은 유상부의 점도가 1,000 cps 이하, 더욱 바람직하게는 500 cps 이하 (측정조건 : Brookfield viscometer, 40℃, LVF spindle#1, 30rpm, 1 min)인 것이 바람직하다. 또한, 유상부에 배합되는 성분들 중 오일 성분의 점도는 1,000 cps 이하, 더욱 바람직하게는 500 cps 이하 (측정조건 : Brookfield viscometer, 40℃, LVF spindle#1, 30rpm, 1 min)인 것이 바람직하다.In the case of polyhydric alcohol, even after moisture evaporates after application, it remains in the pores where the water phase is located. With the effect of making the UV blocking area wider and uniform, the UV blocking efficiency is increased. In order to facilitate this diffusion, the composition according to the present invention has a viscosity of 1,000 cps or less, more preferably 500 cps or less (measurement conditions: Brookfield viscometer, 40°C, LVF spindle#1, 30rpm, 1 min) of the oil phase. it is preferable In addition, the viscosity of the oil component among the components blended in the oil phase is preferably 1,000 cps or less, more preferably 500 cps or less (measurement conditions: Brookfield viscometer, 40° C., LVF spindle#1, 30 rpm, 1 min).
에탄올의 IOB값과, 일반적으로 많이 사용하는 다가 알코올의 IOB값을 아래 표 1에 정리하였다.The IOB values of ethanol and the IOB values of polyhydric alcohols commonly used are summarized in Table 1 below.
　원료명Raw material name OVOV IVIV IOBIOB
글리세린glycerin 6060 300300 5.005.00
솔비톨sorbitol 120120 600600 5.005.00
자일리톨 xylitol 100100 500500 5.005.00
글루코스glucose 120120 530530 4.424.42
트레할로스Trehalose 240240 880880 3.673.67
디글리세린diglycerin 120120 420420 3.503.50
프로판디올propanediol 6060 200200 3.333.33
폴리글리세린-3Polyglycerin-3 180180 540540 3.003.00
메칠프로판디올Methylpropanediol 7070 200200 2.862.86
에탄올ethanol 4040 100100 2.502.50
부틸렌글라이콜Butylene Glycol 8080 200200 2.502.50
피이지-6PEG-6 240240 575575 2.402.40
피이지-8PEG-8 320320 725725 2.272.27
글리세레스-26Glyceres-26 180180 360360 2.002.00
디프로필렌글라이콜dipropylene glycol 120120 220220 1.831.83
1,2-헥산디올1,2-Hexanediol 120120 200200 1.671.67
본 발명에서 사용되는 IOB 값 5.0 이하의 다가알코올은 예를 들어 글리세린, 솔비톨, 자일리톨, 글루코스, 트레할로스, 디글리세린, 프로판디올, 프로필렌글라이콜폴리글리세린-3, 메틸프로판디올, 부틸렌글라이콜, 펜틸렌글라이콜피이지-6, 피이지-8, 글리세레스-26, 디프로필렌글라이콜, 1,2-헥산디올 및 카프릴릴글라이콜로 이루어진 군으로부터 선택되는 1 이상일 수 있으나 이에 한정되는 것은 아니다.상기 IOB 값 5.0 이하의 다가알코올은 본 발명의 조성물 중에 0.1 중량% 내지 50 중량% 포함될 수 있다.Polyhydric alcohols having an IOB value of 5.0 or less used in the present invention include, for example, glycerin, sorbitol, xylitol, glucose, trehalose, diglycerin, propanediol, propylene glycol polyglycerin-3, methylpropanediol, butylene glycol, It may be one or more selected from the group consisting of pentylene glycol PEG-6, PEG-8, glycereth-26, dipropylene glycol, 1,2-hexanediol, and caprylyl glycol, but is not limited thereto. . The polyalcohol having an IOB value of 5.0 or less may be included in an amount of 0.1 wt% to 50 wt% in the composition of the present invention.
자외선 차단제sunscreen
자외선 차단제는 일반적으로 자외선 흡수효과를 갖는 유기 자외선 차단제와 산란효과를 갖는 무기 자외선 차단제 모두 종류에 관계 없이 사용 가능하다.In general, sunscreens can be used regardless of the type of both organic sunscreens having a UV absorbing effect and inorganic sunscreens having a scattering effect.
상기 자외선 차단제는 아미노벤조산(aminobenzoic acid)계 화합물, 벤조페논(benzophenone)계 화합물, 신나메이트(cinnamate)계 화합물, 살리실레이트(salicylate)계 화합물, 무기산화금속(inorganic metal oxides), 부틸메톡시디벤조일메탄(butyl methoxydibenzoylmethane), 테레프탈릴리덴 디캠퍼 설폰산(terephthalylidene dicamphor sulfonic acid) 에캄슐(ecamsule), 페닐벤지미다졸설포닉애씨드(phenylbenzimidazole sulfonic acid), 베모트리지놀(bemotrizinol) 및 비스옥트리졸(bisoctrizole)로 이루어진 군으로부터 선택되는 1 이상일 수 있으나 이에 한정되는 것은 아니다.The sunscreen is an aminobenzoic acid-based compound, a benzophenone-based compound, a cinnamate-based compound, a salicylate-based compound, inorganic metal oxides, butylmethoxydi Benzoylmethane (butyl methoxydibenzoylmethane), terephthalylidene dicamphor sulfonic acid (ecamsule), phenylbenzimidazole sulfonic acid (phenylbenzimidazole sulfonic acid), bemotrizinol (bisoctrizole) and bisoctrizole ) may be one or more selected from the group consisting of, but is not limited thereto.
상기 아미노벤조산(aminobenzoic acid)계 화합물의 예로는 PABA, 글리세릴 PABA, 파디메이트 O (Padimate O), 록사디메이트(Roxadimate) 등이 있고, 상기 벤조페논(benzophenone)계 화합물의 예로는 디옥시벤존(Dioxybenzone), 옥시벤존, 술리손벤존(Sulisonbenzone) 등이 있고, 상기 신나메이트(cinnamate)계 화합물의 예로는 옥토크릴렌(Octocrylene), 옥틸 메톡시신나메이트(Octyl methoxycinnamate (octinoxate)), 데톡시에틸 p-메톡시신나메이트(Ethoxyethyl p-methoxycinnamate (cinoxate)) 등이 있고, 상기 살리실레이트(salicylate)계 화합물의 예로는 호모살레이트(Homomenthyl salicylate (homosalate)), 에틸헥실 살리실레이트(Ethylhexyl salicylate (octyl salicylate/octisalate)), 트롤라민 살리실레이트(Trolamine salicylate) 등이 있으며, 상기 무기산화금속(inorganic metal oxides)으로는 이산화티탄, 또는 산화아연 등이 있으나 이에 한정되는 것은 아니다.Examples of the aminobenzoic acid-based compound include PABA, glyceryl PABA, Padimate O, Roxadimate, and the like, and examples of the benzophenone-based compound include deoxybenzone. (Dioxybenzone), oxybenzone, sulisonbenzone, etc., and examples of the cinnamate-based compound include octocrylene, octyl methoxycinnamate (octinoxate), deoxy Ethoxyethyl p-methoxycinnamate (cinoxate), and the like, and examples of the salicylate-based compound include Homomenthyl salicylate (homosalate), Ethylhexyl salicylate (octyl salicylate/octisalate)), trolamine salicylate, and the like, and the inorganic metal oxides include, but are not limited to, titanium dioxide or zinc oxide.
상기 자외선 차단제는 본 발명의 조성물 중에 0.5 중량% 내지 30 중량% 포함될 수 있다.The sunscreen agent may be included in 0.5 wt% to 30 wt% in the composition of the present invention.
한편, 본 발명의 일 구현예에 따르면, 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키기는 역할을 하는 상기 유효성분은 (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올의 조합으로 이루어진 것일 수 있다.Meanwhile, according to one embodiment of the present invention, the active ingredient, which serves to increase the UV blocking efficiency of the UV blocker by heat, includes (a) a polymer having self-emulsifying ability and (b) a polyalcohol having an IOB value of 5.0 or less. It may be made up of a combination of
본 발명의 다른 구현예에서, 본 발명의 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키기 위한 조성물은 수상부 및 유상부를 포함할 수 있는데, 여기서 상기 자가유화능을 갖는 폴리머는 수상 증점제로서, IOB 값 5.0 이하의 다가알코올과 함께 상기 수상부에 포함되며, 상기 자외선 차단제는 유상부에 포함될 수 있다.In another embodiment of the present invention, the composition for increasing the ultraviolet blocking efficiency of a sunscreen by heat of the present invention may include an aqueous phase and an oil phase, wherein the self-emulsifying polymer is an aqueous phase thickener, and the IOB value It is included in the aqueous phase together with 5.0 or less polyhydric alcohol, and the sunscreen may be included in the oil phase.
또 다른 구현예에서, 본 발명의 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키기 위한 조성물은 덱스트린 팔미테이트, 디스테아디모늄헥토라이트, 스테아로일 이눌린, 폴리아마이드-8, 글리세릴베헤네이트/에이코사디오에이트 등과 같은 유상 증점제를 실질적으로 포함하지 않는 것일 수 있다. 여기에서 '유상 점증제를 실질적으로 포함하지 않는다는 의미'는, 유상 점증제를 포함하지 않거나 포함되더라도 유상부의 점도가 1,000 cps 이하, 더욱 바람직하게는 500 cps 이하 (측정조건: Brookfield viscometer, 40℃, LVF spindle#1, 30rpm, 1 min)가 되도록 하는 양 이하로 포함될 수 있다는 것을 의미한다. 이는 본 발명에 따른 조성물을 피부에 도포한 후 수상부가 휘발되었을 때 발생하는 공극으로의 조성물 구성성분들의 확산을 용이하게 하기 위함이다.In another embodiment, the composition for increasing the sunscreen efficiency of a sunscreen by heat of the present invention is dextrin palmitate, disteadimonium hectorite, stearoyl inulin, polyamide-8, glyceryl behenate/eico It may be one that does not substantially contain an oily thickener such as sadioate. Herein, 'substantially not containing an oil phase thickener' means that the viscosity of the oil phase part is 1,000 cps or less, more preferably 500 cps or less (measurement conditions: Brookfield viscometer, 40 ℃, LVF spindle#1, 30 rpm, 1 min) can be included in less than that amount. This is to facilitate the diffusion of the composition components into the pores generated when the aqueous phase volatilizes after the composition according to the present invention is applied to the skin.
또 다른 구현예에서, 본 발명의 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키기 위한 조성물은, 본 발명의 자가유화능을 갖는 폴리머 이외의 다른 유화제 성분을 포함하지 않는 것일 수 있다.In another embodiment, the composition for increasing the UV blocking efficiency of the UV blocker by heat of the present invention may not contain an emulsifier component other than the self-emulsifying polymer of the present invention.
또한, 본 발명의 조성물은 보습제, 증점제, 계면활성제, 유상기제, 방부제, 산화방지제, 알코올, 향료, pH 조절제 또는 천연추출물 등을 추가로 포함할 수 있으나, 이에 제한되지 않는다. 본 발명에 따르면, 이러한 추가의 성분을 포함할 경우, 바람직하게는 유상부의 점도가 1,000 cps 이하, 더욱 바람직하게는 500 cps 이하 (측정조건: Brookfield viscometer, 40℃, LVF spindle#1, 30rpm, 1 min)인 것이 바람직하다.In addition, the composition of the present invention may further include a moisturizing agent, a thickener, a surfactant, an oily agent, a preservative, an antioxidant, alcohol, a fragrance, a pH adjuster or a natural extract, but is not limited thereto. According to the present invention, when these additional components are included, the viscosity of the oil phase is preferably 1,000 cps or less, more preferably 500 cps or less (measurement conditions: Brookfield viscometer, 40°C, LVF spindle#1, 30rpm, 1 min) is preferred.
일반적으로 자외선 차단제는 열에 의해 자외선 차단 효율이 감소하지만, 본 발명의 유효성분, 즉 (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올의 조합을 사용하는 경우 오히려 열에 의해 자외선 차단제의 자외선 차단 효율이 증가하게 된다.In general, sunscreens reduce their sunscreen efficiency due to heat, but when using the active ingredient of the present invention, that is, a combination of (a) a polymer having self-emulsifying ability and (b) a polyhydric alcohol having an IOB value of 5.0 or less, it is rather caused by heat. The UV-blocking efficiency of the sunscreen is increased.
본 발명의 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키기 위한 조성물은 40℃의 열을 15분 동안 가한 후 SPF 값이 현저하게 증가되며, 구체적으로 열을 가하기 전과 비교하여 적어도 1%, 적어도 5%, 적어도 10%, 적어도 15%, 적어도 20%, 적어도 30%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 적어도 90%, 적어도 100%, 적어도 110%, 적어도 120%, 적어도 130%, 적어도 140%, 적어도 150%, 적어도 160%, 적어도 170%, 적어도 180%, 적어도 190%, 적어도 200%, 적어도 210%, 적어도 220%, 적어도 230%, 적어도 240%, 적어도 250%, 적어도 260%, 적어도 270%, 적어도 280%, 적어도 290%, 적어도 300%, 적어도 310%, 적어도 320%, 적어도 330%, 적어도 340%, 적어도 350%, 적어도 360%, 적어도 370%, 적어도 380%, 또는 적어도 390% 증가할 수 있으며, 400%까지도 증가될 수 있다.In the composition for increasing the sunscreen efficiency of the sunscreen by the heat of the present invention, the SPF value is significantly increased after applying heat of 40° C. for 15 minutes, specifically, at least 1%, at least 5% compared to before the application of heat , at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 100%, at least 110%, at least 120%, at least 130%, at least 140%, at least 150%, at least 160%, at least 170%, at least 180%, at least 190%, at least 200%, at least 210%, at least 220%, at least 230%, at least 240% , at least 250%, at least 260%, at least 270%, at least 280%, at least 290%, at least 300%, at least 310%, at least 320%, at least 330%, at least 340%, at least 350%, at least 360%, at least It may increase by 370%, at least 380%, or at least 390%, and may increase by even 400%.
또한, 본 발명의 조성물은 열 외에 자외선 조사를 추가하는 경우 자외선 차단 효율의 상승과 관련하여 시너지 효과를 나타낸다.In addition, the composition of the present invention exhibits a synergistic effect with respect to an increase in UV blocking efficiency when UV irradiation is added in addition to heat.
본 발명의 또 다른 관점은 전술한 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키기 위한 조성물을 포함하는 화장품을 제공하는 것이다.Another aspect of the present invention is to provide a cosmetic comprising a composition for increasing the UV blocking efficiency of the UV blocker by the above-described heat.
상기 화장품은 당업계에서 통상적으로 제조되는 어떠한　제형으로도 제조될 수 있으며, 예컨대, 용액, 현탁액, 유탁액, 페이스트, 겔, 크림, 로션, 비누, 계면활성제-함유 클린싱, 오일 등으로　제형화될 수 있으나, 이에 한정되는 것은 아니다. The cosmetic may be prepared in any formulation conventionally prepared in the art, for example, to be formulated as a solution, suspension, emulsion, paste, gel, cream, lotion, soap, surfactant-containing cleansing, oil, etc. However, the present invention is not limited thereto.
보다 구체적으로, 상기 화장품은 미스트, 세럼, 영양화장수, 유연화장수, 유연수, 유액, 아스트리젠트, 토너, 스킨, 로션, 크림, 폼, 메이크업베이스, 에센스, 액체 세정료, 입욕제, 선 스크린크림, 선오일, 선스크린 유액, 선블록 제품, 메이크업 제품, 메이크업 베이스, 파운데이션, 메이크업 팩트, 비비크림, 씨씨크림, 메이크업 파우더 등의　제형으로 제조될 수 있으며, 이에 한정되는 것은 아니다.More specifically, the cosmetics include mist, serum, nourishing lotion, softening lotion, soft water, emulsion, astringent, toner, skin, lotion, cream, foam, makeup base, essence, liquid detergent, bathing agent, sunscreen cream, sunscreen Oil, sunscreen emulsion, sunblock product, makeup product, makeup base, foundation, makeup pact, BB cream, CC cream, makeup powder, etc.
본 발명에 기재된 모든 성분은, 바람직하게는, 한국, 중국, 미국, 유럽, 일본 등의 관련 법규, 규범(예를 들어, 화장품 안전 기준 등에 관한 규정(한국), 화장품 안전 기술 규범(중국), 등에서 규정한 최대사용치를 초과하지 않는다. 즉, 바람직하게, 본 발명에 따른 화장료, 화장품, 또는 조성물은 각국의 관련 법규, 규범에서 허용되는 함량 한도로 본 발명에 따른 성분들을 포함한다.All ingredients described in the present invention, preferably, the relevant laws and regulations of Korea, China, the United States, Europe, Japan, etc. (eg, regulations on cosmetic safety standards (Korea), cosmetic safety technical standards (China), It does not exceed the maximum use value stipulated in etc. That is, preferably, the cosmetic, cosmetic, or composition according to the present invention contains the ingredients according to the present invention within the content limit allowed by the relevant laws and regulations of each country.
일반적으로 자외선 차단제는 열에 의해 자외선 차단 효율이 감소하지만, 본 발명은 열에 의해 자외선 차단제의 자외선 차단 효율을 오히려 증가시키는 기술을 제공한다. In general, the UV blocking efficiency of a sunscreen is reduced by heat, but the present invention provides a technique for rather increasing the UV blocking efficiency of the sunscreen by heat.
도 1은 일반 유화와 비교하여 본 발명의 폴리머릭 유화에 의한 자외선 차단 효과의 상승 원리를 나타낸 모식도이다. 일반 유화의 경우 열을 가하여도 계면에 위치한 유화제가 자외선 차단제의 이동을 방해하여 가온 전후 차단 효과에 변화가 없지만, 폴리머릭 유화의 경우 온도상승으로 인한 자외선 차단제의 mobility 증가 시, 계면의 유동성이 크기 때문에 자외선 차단제의 이동을 방해하지 않아 가온 후 자외선 차단 면적이 확장하여 차단효과가 상승한다.1 is a schematic view showing the principle of increasing the UV blocking effect by the polymeric emulsification of the present invention compared to the general emulsification. In the case of general emulsification, even when heat is applied, the emulsifier located at the interface prevents the movement of the sunscreen, so there is no change in the blocking effect before and after heating. Therefore, it does not interfere with the movement of the sunscreen, and the UV blocking area expands after heating, increasing the blocking effect.
도 2는 본 발명의 IOB 값 5.0 이하의 다가알코올의 작용을 나타낸 모식도이다. 수상에 다가알코올(polyol)이 없을 경우, 건조 후 수상부가 완전히 건조되어 가온 했을 때 자외선 차단제의 확장이 발생하지 않지만, 수상에 다가알코올(polyol)이 있을 경우, 건조 후에도 수상부에 polyol이 남아있고 polyol과 자외선 차단제 간의 상용성으로 인해 가온 시 수상부로 자외선 차단제의 확장이 가능하여 차단 효과의 상승이 일어난다.2 is a schematic diagram showing the action of a polyhydric alcohol having an IOB value of 5.0 or less of the present invention. If there is no polyol in the aqueous phase, the sunscreen does not expand when the aqueous phase is completely dried and heated after drying. However, if there is polyol in the aqueous phase, polyol remains in the aqueous phase even after drying Due to the compatibility between polyol and the sunscreen, it is possible to expand the sunscreen to the water phase during heating, increasing the blocking effect.
도 3은 폴리머릭 유화 및 일반유화의 자외선 차단 효과에 대한 영향을 평가한 결과를 나타난 그래프이다.3 is a graph showing the results of evaluating the effect of polymeric emulsification and general emulsification on the UV blocking effect.
도 4는 다가 알코올 종류에 따른 상용성을 평가한 결과를 나타낸 것이다.4 shows the results of evaluating the compatibility according to the type of polyhydric alcohol.
도 5는 유화제 포함여부의 영향 확인하기 위해 자외선 차단 조성물을 제조하고 가온 뒤 SPF 변화율을 계산한 결과를 나타낸 것이다.5 shows the results of calculating the SPF change rate after preparing and heating the sunscreen composition in order to check the effect of including the emulsifier.
이하, 실시예를 통하여 본 발명을 더욱 상세히 설명 하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로서, 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다는 것은 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자에게 있어서 자명할 것이다. Hereinafter, the present invention will be described in more detail through examples. These examples are only for illustrating the present invention in more detail, and it will be apparent to those of ordinary skill in the art to which the present invention pertains that the scope of the present invention is not limited by these examples.
실시예Example
1. 폴리머릭 유화 및 일반유화의 비교1. Comparison of polymeric emulsification and general emulsification
체인 내에 친수 및 소수성기를 동시에 갖고 있어 점증능력과 동시에 유화능력을 갖는 폴리머를 사용한 폴리머릭 유화 및 일반유화의 자외선 차단 효과에 대한 영향을 평가하기 위하여, 하기 표 2와 같이 조성물을 준비하고 PMMA plate에 각각의 자외선 차단 조성물 도포 후 15분 상온 건조 한 뒤 초기 in vitro SPF를 측정하였다. 그 후 40℃ 항온조에서 15분 가온 뒤 후기 in vitro SPF 측정하여 초기 수치와 후기 수치의 변화율을 계산하고 그 결과를 도 3에 나타내었다.In order to evaluate the effect of polymeric emulsification and general emulsification using a polymer having both hydrophilic and hydrophobic groups in the chain, which has thickening ability and emulsification ability at the same time, on the UV blocking effect, the composition was prepared as shown in Table 2 below and applied to the PMMA plate. After application of each sunscreen composition, the initial in vitro SPF was measured after drying at room temperature for 15 minutes. Thereafter, after heating in a thermostat at 40° C. for 15 minutes, the late in vitro SPF was measured to calculate the rate of change of the initial value and the late value, and the results are shown in FIG. 3 .
　 성분명Ingredient name 폴리머릭 유화polymeric emulsification 일반유화general oil painting
수상부Prime Minister 정제수Purified water To 100To 100 To 100To 100
부틸렌글라이콜Butylene Glycol 66 66
프로판디올propanediol 55 55
1,2-헥산디올1,2-Hexanediol 1.51.5 1.51.5
폴리아크릴레이트-13Polyacrylate-13 0.40.4 --
하이드록시에틸아크릴레이트/소듐아크릴로일디메틸타우레이트코폴리머Hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer 0.20.2 --
암모늄아크릴로일디메틸타우레이트/브이피코폴리머Ammonium acryloyl dimethyl taurate/vpicopolymer 0.20.2 --
폴리소르베이트20(tween 20)/유화제Polysorbate 20 (tween 20) / Emulsifier -- 1One
카보머Carbomer -- 0.30.3
유상부paid part 에틸헥실메톡시신나메이트Ethylhexylmethoxycinnamate 6.86.8 6.86.8
디에틸아미노하이드록시벤조일헥실벤조에이트Diethylaminohydroxybenzoylhexylbenzoate 44 44
비스-에틸헥실옥시페놀메톡시페닐트리아진Bis-ethylhexyloxyphenol methoxyphenyltriazine 44 44
C12-15 알킬벤조에이트C12-15 Alkylbenzoate 88 88
티타늄디옥사이드titanium dioxide 2.452.45 2.452.45
알루미늄스테아레이트aluminum stearate 0.420.42 0.420.42
폴리하이드록시스테아릭애씨드polyhydroxystearic acid 0.350.35 0.350.35
알루미나alumina 0.140.14 0.140.14
사이클로펜타실록산Cyclopentasiloxane 1.51.5 1.51.5
실리카silica 1One 1One
디메치콘dimethicone 22 22
트리실록산Trisiloxane 1.51.5 1.51.5
총합total 100100 100100
In vitro SPF 변화율 (%)In vitro SPF change (%) 269.58269.58 2.762.76
실험결과, 일반적인 유화 대비 자기유화능을 갖는 폴리머를 이용한 폴리머릭 유화 조성물의 경우, 가온 후 in vitro SPF 상승률이 현저하게 높은 것으로 확인되었다.As a result of the experiment, in the case of a polymeric emulsion composition using a polymer having self-emulsifying ability compared to general emulsification, it was confirmed that the in vitro SPF increase rate after heating was significantly higher.
2. 자가유화 폴리머(self-emulsifying polymer, SEP) 영향 확인2. Confirmation of effect of self-emulsifying polymer (SEP)
체인 내에 친수 및 소수성기를 동시에 갖고 있어 점증능력과 동시에 유화능력을 갖는 다양한 자가유화 폴리머를 사용하여, 이들의 자외선 차단 효과에 대한 영향을 확인하였다. Various self-emulsifying polymers that have both hydrophilic and hydrophobic groups in the chain and have emulsification ability and thickening ability at the same time were used, and their influence on the UV blocking effect was confirmed.
구체적으로 실험 샘플을 PMMA plate(HelioScreen Labs, HD6)에 1.3mg/cm2으로 도포하고 15분 상온 건조 한 뒤 초기 in vitro SPF를 SPF-290AS (Solar light, USA)을 통해 측정하였다. In vitro SPF는 PMMA plate의 6개의 다른 부분에서 측정하고 그 평균값을 사용하였다. 그 후 초기 in vitro SPF를 측정한 PMMA 플레이트를 미리 40℃로 설정된 핫플레이트 위에 올려놓아 15분 동안 가온한 뒤 후기 in vitro SPF를 측정하여 초기 수치와 후기 수치의 변화율을 계산하였다.Specifically, the experimental sample was applied to a PMMA plate (HelioScreen Labs, HD6) at 1.3 mg/cm 2 , dried at room temperature for 15 minutes, and the initial in vitro SPF was measured using SPF-290AS (Solar light, USA). In vitro SPF was measured in 6 different parts of the PMMA plate and the average value was used. Thereafter, the PMMA plate having the initial in vitro SPF measured was placed on a hot plate set at 40°C in advance, heated for 15 minutes, and then the late in vitro SPF was measured to calculate the rate of change between the initial value and the late value.
SEP 폴리머의 영향을 확인하기 위해 유화능이 없는 폴리머와 유화제를 이용하여 제조한 조성물과 자가유화 폴리머를 이용하여 제조한 14종의 조성물의 열에 의한 in vitro SPF 수치 변화율을 확인하여 그 결과를 하기 표 3 및 표 4에 나타내었다.In order to confirm the effect of the SEP polymer, the in vitro SPF value change rate by heat of the composition prepared using a polymer without emulsification ability and an emulsifier and the composition prepared using the self-emulsifying polymer was confirmed in Table 3 below. and Table 4.
원료명Raw material name 비교예1Comparative Example 1 실시예1Example 1 실시예2Example 2 실시예3Example 3 실시예4Example 4 실시예5Example 5 실시예6Example 6 실시예7Example 7
수상부Prime Minister 정제수Purified water to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100
부틸렌글라이콜Butylene Glycol 55 55 55 55 55 55 55 55
프로판디올propanediol 55 55 55 55 55 55 55 55
1,2-헥산디올1,2-Hexanediol 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5
카보머Carbomer 0.30.3
폴리소르베이트 20Polysorbate 20 1One
아크릴레이트／C1O-30알킬아크릴레이트크로스폴리머Acrylate/C1O-30 alkyl acrylate crosspolymer 1One
피이지-240/에이치디아이코폴리머비스-데실테트라데세스-20에터PEG-240/HDI Copolymer bis-decyltetradeceth-20 ether 1One
소듐폴리아크릴레이트Sodium Polyacrylate 1One
암모늄아크릴로일디메틸타우레이트/브이피코폴리머Ammonium acryloyl dimethyl taurate/vpicopolymer 1One
암모늄아크릴로일디메틸타우레이트/베헤네스-25메타크릴레이트크로스폴리머Ammonium acryloyl dimethyl taurate / Behenes-25 methacrylate crosspolymer 1One
폴리아크릴레이트크로스폴리머-6Polyacrylate crosspolymer-6 1One
하이드록시에틸아크릴레이트/소듐아크릴로일디메틸타우레이트코폴리머Hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer 1One
유상부paid part 에틸헥실메톡시신나메이트Ethylhexylmethoxycinnamate 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8
디에틸아미노하이드록시벤조일헥실벤조에이트Diethylaminohydroxybenzoylhexylbenzoate 44 44 44 44 44 44 44 44
비스-에틸헥실옥시페놀메톡시페닐트리아진Bis-ethylhexyloxyphenol methoxyphenyltriazine 33 33 33 33 33 33 33 33
C12-15 알킬벤조에이트C12-15 Alkylbenzoate 88 88 88 88 88 88 88 88
티타늄디옥사이드titanium dioxide 33 33 33 33 33 33 33 33
사이클로펜타실록산Cyclopentasiloxane 22 22 22 22 22 22 22 22
디메치콘dimethicone 33 33 33 33 33 33 33 33
실리카silica 1One 1One 1One 1One 1One 1One 1One 1One
총합 total 100100 100100 100100 100100 100100 100100 100100 100100
in vitro SPF 변화율(%)In vitro SPF change (%) -0.13-0.13 7.147.14 9.879.87 22.8422.84 30.3730.37 28.1828.18 46.8946.89 16.316.3
원료명Raw material name 실시예8Example 8 실시예9Example 9 실시예10Example 10 실시예11Example 11 실시예12Example 12 실시예13Example 13 실시예14Example 14
수상부Prime Minister 정제수Purified water to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100
부틸렌글라이콜Butylene Glycol 55 55 55 55 55 55 55
프로판디올propanediol 55 55 55 55 55 55 55
1,2-헥산디올1,2-Hexanediol 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5
폴리아크릴레이트-13Polyacrylate-13 1One
폴리아크릴아마이드polyacrylamide 1One
아크릴레이트코폴리머acrylate copolymer 1One
아크릴레이트/베헤네스-25메타크릴레이트코폴리머Acrylate/Behenes-25 Methacrylate Copolymer 1One
소듐아크릴레이트/아크릴로일다이메타트레이트/디메틸아크릴아마이드크로스폴리머Sodium acrylate / acryloyl dimethacrylate / dimethyl acrylamide cross polymer 1One
소듐아크릴레이트/소듐아크릴로일디메틸타우레이트코폴리머Sodium acrylate/sodium acryloyl dimethyl taurate copolymer 1One
소듐아크릴레이트/베헤네스-25메타크릴레이트크로스폴리머Sodium acrylate/Behenes-25 methacrylate crosspolymer 1One
유상부paid part 에틸헥실메톡시신나메이트Ethylhexylmethoxycinnamate 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8
디에틸아미노하이드록시벤조일헥실벤조에이트Diethylaminohydroxybenzoylhexylbenzoate 44 44 44 44 44 44 44
비스-에틸헥실옥시페놀메톡시페닐트리아진Bis-ethylhexyloxyphenol methoxyphenyltriazine 33 33 33 33 33 33 33
C12-15 알킬벤조에이트C12-15 Alkylbenzoate 88 88 88 88 88 88 88
티타늄디옥사이드titanium dioxide 33 33 33 33 33 33 33
사이클로펜타실록산Cyclopentasiloxane 22 22 22 22 22 22 22
디메치콘dimethicone 33 33 33 33 33 33 33
실리카silica 1One 1One 1One 1One 1One 1One 1One
총합 total 100100 100100 100100 100100 100100 100100 100100
in vitro SPF 변화율(%)In vitro SPF change (%) 10.4910.49 11.2311.23 15.3215.32 8.688.68 16.716.7 20.2320.23 17.6817.68
실험 결과 일반적인 유화(비교예 1)의 경우 가온 전후 in vitro SPF 수치에 변화가 없었으나 SEP을 이용한 조성물의 경우 열에 의해 in vitro SPF 수치가 상승함을 확인하였다. As a result of the experiment, it was confirmed that in the case of general emulsification (Comparative Example 1), there was no change in the in vitro SPF level before and after heating, but in the case of the composition using SEP, it was confirmed that the in vitro SPF level was increased by heat.
이는 SEP을 이용한 폴리머릭 유화의 경우 온도상승으로 인한 자외선 차단제의 유동성 증가 시, 자외선 차단제의 이동을 방해하지 않아 자외선 차단제의 이동으로 인한 자외선 차단 면적이 확장하여 차단 효과가 상승한 것으로 평가된다.It is evaluated that, in the case of polymeric emulsification using SEP, when the fluidity of the sunscreen agent increases due to a temperature increase, the movement of the sunscreen agent is not hindered, and the UV blocking area due to the movement of the sunscreen agent expands, thereby increasing the blocking effect.
3. IOB 값 5.0 이하의 다가 알코올 영향 확인3. Confirm the effect of polyhydric alcohols with an IOB value of 5.0 or less
다가 알코올의 영향을 확인하기 위하여 수상부에 다가 알코올을 포함하지 않는 조성물과 많이 사용되는 IOB 5.0이하의 다가 알코올 6종을 이용하여 제조한 조성물의 가온 전후 in vitro SPF 변화율을 측정하고, 그 결과를 하기 표 5에 나타내었다. In order to confirm the effect of polyhydric alcohol, the in vitro SPF change rate before and after heating of the composition prepared using a composition that does not contain polyhydric alcohol in the aqueous phase and 6 polyhydric alcohols of IOB 5.0 or less commonly used is measured, and the results are analyzed. It is shown in Table 5 below.
원료명Raw material name 비교예2Comparative Example 2 실시예15Example 15 실시예16Example 16 실시예17Example 17 실시예18Example 18 실시예19Example 19 실시예20Example 20 실시예21Example 21
수상부Prime Minister 정제수Purified water to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100
글리세린glycerin 1010
디프로필렌글라이콜dipropylene glycol 1010
피이지-6PEG-6 1010
피이지-8PEG-8 1010
프로판디올propanediol 1010 55
부틸렌글라이콜Butylene Glycol 1010 55
폴리아크릴레이트-13Polyacrylate-13 0.350.35 0.350.35 0.350.35 0.350.35 0.350.35 0.350.35 0.350.35 0.350.35
하이드록시에틸아크릴레이트/소듐아크릴로일디메틸타우레이트코폴리머Hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2
암모늄아크릴로일디메틸타우레이트/브이피코폴리머Ammonium acryloyl dimethyl taurate/vpicopolymer 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2
유상부paid part 에틸헥실메톡시신나메이트Ethylhexylmethoxycinnamate 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8
디에틸아미노하이드록시벤조일헥실벤조에이트Diethylaminohydroxybenzoylhexylbenzoate 44 44 44 44 44 44 44 44
비스-에틸헥실옥시페놀메톡시페닐트리아진Bis-ethylhexyloxyphenol methoxyphenyltriazine 33 33 33 33 33 33 33 33
C12-15 알킬벤조에이트C12-15 Alkylbenzoate 88 88 88 88 88 88 88 88
티타늄디옥사이드titanium dioxide 33 33 33 33 33 33 33 33
사이클로펜타실록산Cyclopentasiloxane 22 22 22 22 22 22 22 22
디메치콘dimethicone 33 33 33 33 33 33 33 33
실리카silica 1One 1One 1One 1One 1One 1One 1One 1One
종합 Synthesis 100100 100100 100100 100100 100100 100100 100100 100100
in vitro SPF 변화율(%)In vitro SPF change (%) -12.74-12.74 1.671.67 16.6316.63 17.6117.61 34.4934.49 62.5562.55 137.3137.3 269.58269.58
실험 결과 다가 알코올을 포함하지 않는 조성물(비교예2)의 경우 열을 가할 경우 in vitro SPF 수치가 크게 감소하였으나 IOB 값 5.0 이하의 다가알코올을 포함하는 경우 가온 후 수치가 상승함을 확인하였다.다가 알코올 종류에 따른 수치 상승 차이의 원인을 확인하기 위하여 분체를 제외한 유상부와 실시예 15~21에 사용된 다가 알코올을 1:1 질량비로 혼합한 뒤 익일 분리 정도를 육안으로 확인하여 5점 척도로 상용성을 평가한 결과를 아래 표 6와 도 4에 나타내었다. As a result of the experiment, it was confirmed that in the case of the composition not containing polyhydric alcohol (Comparative Example 2), when heat was applied, the in vitro SPF value was greatly decreased, but when the polyhydric alcohol with an IOB value of 5.0 or less was included, the value increased after heating. In order to confirm the cause of the difference in the numerical value increase according to the type of alcohol, the oil phase excluding the powder and the polyhydric alcohol used in Examples 15 to 21 were mixed in a 1:1 mass ratio, and then the degree of separation was visually checked the next day and commercialized on a 5-point scale. The results of evaluating the sex are shown in Table 6 and FIG. 4 below.
글리세린glycerin 디프로필렌글라이콜dipropylene glycol 피이지-8PEG-8 피이지-6PEG-6 프로판디올propanediol 부틸렌글라이콜Butylene Glycol 프로판디올+
부틸렌글라이콜propanediol+
Butylene Glycol
상용성compatibility 1One 1.51.5 22 22 33 33 44
실험 결과 유상부와 다가 알코올의 상용성이 좋을수록 in vitro SPF 변화율이 높은 경향을 확인하였다.이를 토대로 IOB 값 5.0이하의 다가 알코올을 포함할 경우 제형 도포 후 수상부에 남아있는 다가 알코올과 자외선 차단제 간의 상용성으로 인해 가온 시 수상부로 자외선 차단제의 확장이 가능하여 차단효과의 상승이 발생한 것을 확인할 수 있었다.As a result of the experiment, it was confirmed that the better the compatibility between the oil phase part and the polyhydric alcohol, the higher the in vitro SPF change rate. Due to the compatibility, it was confirmed that the sunscreen effect was increased because it was possible to extend the sunscreen to the water phase during heating.
4. 유화제 포함여부의 영향 확인4. Check the effect of including emulsifier
자기유화능을 갖는 폴리머를 이용한 폴리머릭 유화 조성물의 경우, 다른 유화제 첨가에 효과를 비교하기 위하여, 하기 표 7과 같이 자외선 차단 조성물을 제조하고 가온 뒤 SPF 변화율을 계산하였다. 구체적으로, PMMA plate에 각각의 자외선 차단 조성물을 도포하고 15분 건조시킨 후 초기 in vitro SPF를 측정하였다. 그 다음, 40℃ 항온조에서 15분 가온 뒤 후기 in vitro SPF를 측정하고, 상기 초기 수치 대비 SPF 변화율 계산하여 그 결과를 하기 표 7 및 도 5에 나타내었다.In the case of a polymeric emulsion composition using a polymer having self-emulsifying ability, in order to compare the effects of adding other emulsifiers, a UV protection composition was prepared as shown in Table 7 below and the SPF change rate was calculated after heating. Specifically, each UV blocking composition was applied to a PMMA plate and dried for 15 minutes, and the initial in vitro SPF was measured. Then, after heating in a 40°C thermostat for 15 minutes, the late in vitro SPF was measured, and the SPF change rate compared to the initial value was calculated, and the results are shown in Tables 7 and 5 below.
　 성분명Ingredient name 실시예 22Example 22 실시예 23Example 23 실시예 24Example 24 실시예 25Example 25 실시예 26Example 26 실시예 27Example 27 실시예 28Example 28
수상부Prime Minister 정제수Purified water To 100To 100 To 100To 100 To 100To 100 To 100To 100 To 100To 100 To 100To 100 To 100To 100
부틸렌글라이콜Butylene Glycol 66 66 66 66 66 66 66
프로판디올propanediol 55 55 55 55 55 55 55
1,2-헥산디올1,2-Hexanediol 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5
폴리소르베이트20 (Tween 20)Polysorbate 20 (Tween 20) 1One 22
글리세릴스테아레이트, 피이지-100스테아레이트 (Lipomulse 165)Glyceryl Stearate, PEG-100 Stearate (Lipomulse 165) 1One 22
폴리글리세릴-3메틸글루코오스디스테아레이트 (Tego care 450)Polyglyceryl-3 methylglucose distearate (Tego care 450) 1One 22
폴리아크릴레이트-13Polyacrylate-13 0.40.4 0.40.4 0.40.4 0.40.4 0.40.4 0.40.4 0.40.4
하이드록시에틸아크릴레이트/소듐아크릴로일디메틸타우레이트코폴리머Hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2
암모늄아크릴로일디메틸타우레이트/브이피코폴리머Ammonium acryloyl dimethyl taurate/vpicopolymer 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2
유상부paid part 에틸헥실메톡시신나메이트Ethylhexylmethoxycinnamate 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8
디에틸아미노하이드록시벤조일헥실벤조에이트Diethylaminohydroxybenzoylhexylbenzoate 44 44 44 44 44 44 44
비스-에틸헥실옥시페놀메톡시페닐트리아진Bis-ethylhexyloxyphenol methoxyphenyltriazine 44 44 44 44 44 44 44
C12-15 알킬벤조에이트C12-15 Alkylbenzoate 88 88 88 88 88 88 88
티타늄디옥사이드titanium dioxide 2.452.45 2.452.45 2.452.45 2.452.45 2.452.45 2.452.45 2.452.45
알루미늄스테아레이트aluminum stearate 0.420.42 0.420.42 0.420.42 0.420.42 0.420.42 0.420.42 0.420.42
폴리하이드록시스테아릭애씨드polyhydroxystearic acid 0.350.35 0.350.35 0.350.35 0.350.35 0.350.35 0.350.35 0.350.35
알루미나alumina 0.140.14 0.140.14 0.140.14 0.140.14 0.140.14 0.140.14 0.140.14
사이클로펜타실록산Cyclopentasiloxane 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5
실리카silica 1One 1One 1One 1One 1One 1One 1One
디메치콘dimethicone 22 22 22 22 22 22 22
트리실록산Trisiloxane 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5 1.51.5
총합total 100100 100100 100100 100100 100100 100100 100100
In vitro SPF 변화율 (%)In vitro SPF change (%) 322322 134134 100100 172172 127127 4444 1212
자기유화능을 갖는 폴리머를 이용한 폴리머릭 유화 조성물의 경우, 유화제가 첨가될수록 상승률이 감소하지만 전부 일반유화(비교예1)와 대비해서는 가온 후 in vitro SPF 상승률이 현저히 높은 것으로 확인되었다.In the case of a polymeric emulsion composition using a polymer having self-emulsifying ability, the increase rate decreased as the emulsifier was added, but it was confirmed that the in vitro SPF increase rate after heating was significantly higher compared to the general emulsification (Comparative Example 1).
5. 유상 증점제 포함여부의 영향 확인5. Confirmation of influence of oil thickener included
본 발명의 자기유화능을 갖는 폴리머는 수성 증점제로서 수상부에 포함된다. 이에 본 발명의 자기유화능을 갖는 폴리머 대신 유상 증점제를 사용하여 자외선 차단 조성물을 제조하고자 하였으나 이 경우 제형의 안정성이 크게 떨어지는 것으로 확인되었다. 그리하여, 본 발명의 자기유화능을 갖는 폴리머는 수성 증점제에 유상 증점제를 추가로 포함하는 경우와의 효과를 비교하고, 그 결과를 하기 표 8에 나타내었다. The self-emulsifying polymer of the present invention is included in the aqueous phase as an aqueous thickener. Accordingly, it was attempted to prepare a sunscreen composition using an oily thickener instead of the self-emulsifying polymer of the present invention, but in this case, it was confirmed that the stability of the formulation was greatly reduced. Thus, the effect of the polymer having self-emulsifying ability of the present invention was compared with that of the case where an oily thickener was additionally included in the aqueous thickener, and the results are shown in Table 8 below.
　 성분명Ingredient name 조성물1composition 1 조성물2composition 2 조성물3composition 3 조성물4composition 4 조성물5composition 5 조성물6composition 6
수상부Prime Minister 정제수Purified water To 100To 100 To 100To 100 To 100To 100 To 100To 100 To 100To 100 To 100To 100
프로판디올propanediol 55 55 55 55 55 55
부틸렌글라이콜Butylene Glycol 55 55 55 55 55 55
하이드록시에틸아크릴레이트/소듐아크릴로일디메틸타우레이트코폴리머Hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer 0.350.35 0.350.35 0.350.35 0.350.35 0.350.35 0.350.35
폴리아크릴레이트크로스폴리머-6Polyacrylate crosspolymer-6 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2 0.20.2
유상부paid part 에틸헥실메톡시신나메이트Ethylhexylmethoxycinnamate 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8 6.86.8
디에틸아미노하이드록시벤조일헥실벤조에이트Diethylaminohydroxybenzoylhexylbenzoate 44 44 44 44 44 44
비스-에틸헥실옥시페놀메톡시페닐트리아진Bis-ethylhexyloxyphenol methoxyphenyltriazine 33 33 33 33 33 33
C12-15 알킬벤조에이트C12-15 Alkylbenzoate 88 88 88 88 88 88
덱스트린 팔미테이트Dextrin Palmitate 1One
디스테아디모늄헥토라이트Disteadimonium Hectorite 1One
스테아로일 이눌린Stearoyl Inulin 1One
폴리아마이드-8Polyamide-8 1One
글리세릴베헤네이트/에이코사디오에이트Glyceryl behenate/eicosadioate 1One
티타늄디옥사이드titanium dioxide 33 33 33 33 33 33
사이클로펜타실록산Cyclopentasiloxane 22 22 22 22 22 22
디메치콘dimethicone 33 33 33 33 33 33
실리카silica 1One 1One 1One 1One 1One 1One
총합 total 100100 100100 100100 100100 100100 100100
In vitro SPF 변화율 (%)In vitro SPF change (%) 82.2082.20 32.7832.78 20.8920.89 48.1648.16 14.6614.66 40.2140.21
실험결과, 자기유화능을 갖는 폴리머만으로 제형을 제조한 조성물 1에 다양한 유상 점증제를 추가할 경우(조성물 2 내지 6) SPF 상승률이 현저하게 감소함이 확인되었다.As a result of the experiment, it was confirmed that the SPF increase rate was significantly reduced when various oil thickeners were added to Composition 1, which was prepared only with a polymer having self-emulsifying ability (Compositions 2 to 6).
6. 자외선 조사의 영향 확인6. Confirmation of Effects of UV Irradiation
본 발명의 자외선 차단 조성물(조성물1)에 대하여 자외선에 노출 되었을 때 온도에 따른 in vitro SPF 변화를 확인한 결과를 아래 표 9에 나타내었다.Table 9 below shows the results of confirming the in vitro SPF change according to the temperature when the sunscreen composition (composition 1) of the present invention is exposed to ultraviolet rays.
구체적으로 실험 샘플을 PMMA plate(HelioScreen Labs, HD6)에 1.3mg/cm2으로 도포하고 15분 상온 건조 한 뒤 초기 in vitro SPF를 SPF-290AS(Solar light, USA)을 통해 측정하였다. 그 후 초기 in vitro SPF를 측정한 PMMA 플레이트를 미리 설정된 온도의 핫플레이트 위에 올려놓아 15분 동안 유지한 뒤 후기 in vitro SPF를 측정하여 초기 수치와 후기 수치의 변화율을 계산하였다. 이때 자외선 조사기(16S-300, Solar light)를 이용하여 2MED 자외선 조사 유무에 따른 in vitro SPF 변화율을 확인하였다.Specifically, the experimental sample was applied to a PMMA plate (HelioScreen Labs, HD6) at 1.3 mg/cm 2 , dried at room temperature for 15 minutes, and the initial in vitro SPF was measured using SPF-290AS (Solar light, USA). Thereafter, the PMMA plate having the initial in vitro SPF measured was placed on a hot plate at a preset temperature and maintained for 15 minutes, and then the late in vitro SPF was measured to calculate the rate of change between the initial and late values. At this time, using a UV irradiator (16S-300, Solar light), the in vitro SPF change rate according to the presence or absence of 2MED UV irradiation was confirmed.
In vitro SPF 변화율In vitro SPF rate of change 온도Temperature
25℃25℃ 30℃30℃ 40℃40℃
자외선 조사 없음No UV irradiation 2.132.13 18.6518.65 82.2082.20
2MED 조사2MED investigation 5.005.00 25.225.2 115.71115.71
실험결과, 온도가 높아질수록 in vitro SPF 변화율이 상승하였고 자외선 조사 시 상승 효과가 더욱 두드러짐이 확인되었다.As a result of the experiment, it was confirmed that the in vitro SPF change rate increased as the temperature increased, and the synergistic effect was more pronounced during UV irradiation.

Claims (11)

  1. (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올의 조합을 사용하여, 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키는 방법.A method of increasing the UV protection efficiency of a UV blocker by heat using a combination of (a) a polymer having self-emulsifying ability and (b) a polyhydric alcohol having an IOB value of 5.0 or less.
  2. 제1항에 있어서, 상기 방법은 The method of claim 1, wherein the method
    상기 자가유화능을 갖는 폴리머 및 상기 다가알코올을 포함하는 수상부를 준비하는 단계;preparing an aqueous phase comprising the polymer having the self-emulsifying ability and the polyhydric alcohol;
    상기 자외선 차단제를 포함하는 유상부를 준비하는 단계;preparing an oil phase containing the sunscreen;
    상기 수상부 및 유상부를 혼합하여 혼합 조성물을 제조하는 단계; 및mixing the aqueous phase part and the oil phase part to prepare a mixed composition; and
    상기 혼합 조성물에 열을 가하는 단계applying heat to the mixture composition
    를 포함하는 것을 특징으로 하는 방법.A method comprising a.
  3. (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올의 조합을 유효성분으로 포함하는, 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키기 위한 조성물.(a) a polymer having self-emulsifying ability and (b) an IOB value of 5.0 or less polyalcohol as an active ingredient, comprising as an active ingredient, a composition for increasing the UV protection efficiency of a UV blocker by heat.
  4. 제3항에 있어서, 열에 의해 자외선 차단제의 자외선 차단 효율을 상승시키기는 역할을 하는 상기 유효성분은 (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올의 조합으로 이루어진 것을 특징으로 하는 조성물.The method according to claim 3, wherein the active ingredient, which serves to increase the UV blocking efficiency of the UV blocker by heat, is composed of a combination of (a) a self-emulsifying polymer and (b) a polyhydric alcohol having an IOB value of 5.0 or less. Characterized composition.
  5. 제3항에 있어서, 상기 자가유화능을 갖는 폴리머는 소듐아크릴레이트/베헤네스-25메타크릴레이트크로스폴리머, 소듐아크릴레이트/소듐아크릴로일디메틸타우레이트코폴리머, 소듐아크릴레이트/아크릴로일다이메타트레이트/디메틸아크릴아마이드크로스폴리머, 소듐폴리아크릴레이트, 아크릴레이트/C10-30알킬아크릴레이트크로스폴리머, 아크릴레이트/베헤네스-25메타크릴레이트코폴리머, 아크릴레이트코폴리머, 암모늄아크릴로일디메틸타우레이트/베헤네스-25메타크릴레이트크로스폴리머, 암모늄아크릴로일디메틸타우레이트/브이피코폴리머, 폴리아크릴레이트-13, 폴리아크릴레이트크로스폴리머-6, 폴리아크릴아마이드, 피이지-240/에이치디아이코폴리머비스-데실테트라데세스-20에터, 및 하이드록시에틸아크릴레이트/소듐아크릴로일디메틸타우레이트코폴리머로 이루어진 군으로부터 선택되는 1 이상인 것을 특징으로 하는 조성물.According to claim 3, wherein the self-emulsifying polymer is sodium acrylate / Behenes-25 methacrylate cross polymer, sodium acrylate / sodium acryloyl dimethyl taurate copolymer, sodium acrylate / acryloyl die Methrate/dimethylacrylamide crosspolymer, sodium polyacrylate, acrylate/C10-30 alkyl acrylate crosspolymer, acrylate/behenes-25 methacrylate copolymer, acrylate copolymer, ammonium acryloyldimethyl Taurate/Behenes-25methacrylate crosspolymer, ammonium acryloyldimethyltaurate/vpicopolymer, polyacrylate-13, polyacrylate crosspolymer-6, polyacrylamide, PG-240/HDI A composition, characterized in that at least one selected from the group consisting of copolymer bis-decyltetradeceth-20 ether, and hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer.
  6. 제3항에 있어서, 상기 IOB 값 5.0 이하의 다가알코올은 글리세린, 솔비톨, 자일리톨, 글루코스, 트레할로스, 디글리세린, 프로판디올, 프로필렌글라이콜, 폴리글리세린-3, 메틸프로판디올, 부틸렌글라이콜, 펜틸렌글라이콜, 피이지-6, 피이지-8, 글리세레스-26, 디프로필렌글라이콜, 1,2-헥산디올 및 카프릴릴글라이콜로 이루어진 군으로부터 선택되는 1 이상인 것을 특징으로 하는 조성물.The method of claim 3, wherein the polyhydric alcohol having an IOB value of 5.0 or less is glycerin, sorbitol, xylitol, glucose, trehalose, diglycerin, propanediol, propylene glycol, polyglycerin-3, methylpropanediol, butylene glycol, Composition, characterized in that at least one selected from the group consisting of pentylene glycol, PEG-6, PEG-8, glycereth-26, dipropylene glycol, 1,2-hexanediol and caprylyl glycol .
  7. 제3항에 있어서, 상기 자외선 차단제는 아미노벤조산(aminobenzoic acid)계 화합물, 벤조페논(benzophenone)계 화합물, 신나메이트(cinnamate)계 화합물, 살리실레이트(salicylate)계 화합물, 무기산화금속(inorganic metal oxides), 부틸메톡시디벤조일메탄(butyl methoxydibenzoylmethane), 테레프탈릴리덴 디캠퍼 설폰산(terephthalylidene dicamphor sulfonic acid) 에캄슐(ecamsule), 페닐벤지미다졸설포닉애씨드(phenylbenzimidazole sulfonic acid), 베모트리지놀(bemotrizinol) 및 비스옥트리졸(bisoctrizole)로 이루어진 군으로부터 선택되는 1 이상인 것을 특징으로 하는 조성물.The method of claim 3, wherein the sunscreen is an aminobenzoic acid-based compound, a benzophenone-based compound, a cinnamate-based compound, a salicylate-based compound, or an inorganic metal oxide. oxides), butyl methoxydibenzoylmethane, terephthalylidene dicamphor sulfonic acid, ecamsule, phenylbenzimidazole sulfonic acid, bemotrizinol and at least one selected from the group consisting of bisoctrizole.
  8. 제3항에 있어서, 상기 자가유화능을 갖는 폴리머는 수상 증점제인 것을 특징으로 하는 조성물.The composition according to claim 3, wherein the self-emulsifying polymer is an aqueous phase thickener.
  9. 제3항에 있어서, 상기 조성물은 수상부 및 유상부를 포함하고, (a) 자가유화능을 갖는 폴리머 및 (b) IOB 값 5.0 이하의 다가알코올은 상기 수상부에 포함되며, 상기 자외선 차단제는 유상부에 포함되는 것을 특징으로 하는 조성물.The method according to claim 3, wherein the composition includes an aqueous phase and an oil phase, (a) a polymer having self-emulsifying ability and (b) a polyalcohol having an IOB value of 5.0 or less is included in the aqueous phase, and the sunscreen is an oil phase Composition characterized in that it is included in the.
  10. 제 3항에 있어서, 상기 조성물은 자외선 조사 시, 열에 의해 자외선 차단제의 자외선 차단 효율의 상승효과가 더 증가하는 것을 특징으로 하는 조성물. The composition according to claim 3, wherein the composition further increases the synergistic effect of the UV blocking efficiency of the UV blocker by heat when irradiated with UV rays.
  11. 제3항 내지 제10항 중 어느 하나의 항에 따른 조성물을 포함하는 화장품.A cosmetic comprising the composition according to any one of claims 3 to 10.
PCT/KR2021/006456 2020-06-03 2021-05-24 Uv-blocking cosmetic composition having increased uv-blocking efficiency due to heat and uv light WO2021246704A1 (en)

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