WO2021203759A1 - 基于蓝牙分离式架构的脑电采集*** - Google Patents

基于蓝牙分离式架构的脑电采集*** Download PDF

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Publication number
WO2021203759A1
WO2021203759A1 PCT/CN2020/141957 CN2020141957W WO2021203759A1 WO 2021203759 A1 WO2021203759 A1 WO 2021203759A1 CN 2020141957 W CN2020141957 W CN 2020141957W WO 2021203759 A1 WO2021203759 A1 WO 2021203759A1
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receiver
computer
implanted device
bluetooth
data
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PCT/CN2020/141957
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English (en)
French (fr)
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金泽
黄�俊
陈浩
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北京品驰医疗设备有限公司
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Publication of WO2021203759A1 publication Critical patent/WO2021203759A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • A61B5/0006—ECG or EEG signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/002—Monitoring the patient using a local or closed circuit, e.g. in a room or building
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A61N1/37223—Circuits for electromagnetic coupling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37252—Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04W—WIRELESS COMMUNICATION NETWORKS
    • H04W4/00—Services specially adapted for wireless communication networks; Facilities therefor
    • H04W4/80—Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication

Definitions

  • the invention relates to the field of implantable medical devices, in particular to a brain electricity acquisition system based on a Bluetooth separated architecture.
  • Bluetooth is now the most popular low-power, low-cost wireless communication connection method.
  • the inventor hopes to create a unified set of standardized protocols for the communication between devices to solve the interconnection and intercommunication of incompatible mobile electronic devices between users.
  • the traditional wires are omitted between these devices.
  • electronic devices equipped with Bluetooth technology can communicate with each other within a short distance, and the transmission speed can reach 1Mbps per second.
  • the Bluetooth protocol includes two technologies: Basic Rate (abbreviated as BR) and Low Energy (abbreviated as LE).
  • BR Basic Rate
  • LE Low Energy
  • Bluetooth low energy is currently the wireless technology with the lowest power consumption that can be designed and used.
  • the Bluetooth protocol specification has been revised to version 5.1.
  • the specification stipulates two levels of Bluetooth low energy protocols, namely the Bluetooth Core protocol and the Bluetooth Application layer protocol (Bluetooth Application).
  • the Bluetooth core protocol consists of two parts, the host layer (Host) and the control layer (Controller). Communication between the two layers is achieved through the host control interface (HCI).
  • Bluetooth low energy devices based on this specification are emerging in an endless stream.
  • the existing technology does not separate the host layer and control layer of Bluetooth, so that the powerful attributes of the Bluetooth 5.0 specification cannot be exerted to a large extent, and only some basic wireless communication requirements can be achieved. .
  • Bluetooth functions need to be expanded, or Bluetooth services need to be customized, existing products often cannot meet the requirements.
  • the EEG signal based on Bluetooth transmission has the characteristics of large transmission data volume, long data packet length, and fast transmission rate. At the same time, operations such as authentication, pairing, encryption, etc. need to be implemented during the transmission process, and it is difficult to meet the needs of brain electricity collection only relying on the existing Bluetooth protocol stack of mobile phones or computers.
  • the present invention provides an EEG acquisition system based on a Bluetooth separated architecture, including a computer, a receiver, and an implanted device, wherein the computer is used to implement the Bluetooth host layer, and the receiver is used to implement the Bluetooth control layer.
  • the computer sets the implanted device through the receiver, the implanted device collects the deep electrical signals of the human brain and sends brain electricity data, and the receiver is wirelessly connected to the implanted device to receive and
  • the EEG data is analyzed, and the computer displays the analysis result of the EEG data.
  • the computer is used to send a device search instruction to the receiver; after receiving the device search instruction, the receiver receives the device information broadcast by the implanted device; the computer according to the Device information shows the implantable devices that can be connected.
  • the computer is configured to send a connection instruction to the receiver to establish a connection with the implanted device; after the implanted device establishes a connection with the receiver, return connection status information; The computer obtains and displays the connection status information through the receiver.
  • the computer is used to send an authentication pairing instruction to the receiver to enable pairing with the implanted device.
  • the parameters include a pairing method and a pairing password.
  • the receiver can be paired with the implanted device. Encrypted data transmission between the implanted devices.
  • the receiver is used to read the service data of the implanted device; the computer is used to confirm the data transmission characteristics and description information supported by the implanted device according to the service data.
  • the receiver reads the universally unique identification code of the implanted device, and the computer obtains the service handle according to the universally unique identification code to confirm the data transmission characteristics and description information supported by the implanted device .
  • the computer is configured to set the Bluetooth data packet length of the implanted device through the receiver to match the brain electricity data packet length.
  • the computer is used to set the EEG acquisition parameters of the implanted device through the receiver, so that the implanted device collects the deep brain electrical signals of the human body according to the EEG acquisition parameters.
  • the EEG acquisition parameters include acquisition polarity, acquisition channel, sampling rate, and sampling time.
  • the receiver is used to parse the EEG data into a voltage value; the computer is used to draw an EEG waveform diagram according to the voltage value.
  • the computer and the receiver are connected through an HCI interface.
  • the EEG acquisition system implementeds the host layer and the control layer on the computer and the receiver respectively.
  • the receiver implements the Bluetooth low-level protocol stack and encapsulates the Bluetooth instructions; develops desktop applications on the computer platform, that is, EEG acquisition Software to realize the Bluetooth control layer.
  • the computer and the receiver realize the Bluetooth protocol together, and carry out data communication and command sending and receiving through the serial port.
  • the system can adapt to the Bluetooth protocol specification, separate the Bluetooth host layer and the control layer, and realize the features and functions of the Bluetooth protocol to the greatest extent. , Which can realize the long-term EEG data acquisition under the multi-channel high sampling rate.
  • Figure 1 is a schematic structural diagram of an EEG acquisition system in an embodiment of the present invention
  • Fig. 2 is a timing diagram of EEG acquisition of the EEG acquisition system in an embodiment of the present invention.
  • the embodiment of the present invention provides an EEG acquisition system based on a Bluetooth separated architecture. As shown in FIG. 1, the system includes a computer 1, a receiver 2 and an implanted device 3.
  • the computer 1 is used to implement the Bluetooth host layer
  • the receiver 2 is used to implement the Bluetooth control layer.
  • the computer 1 (host layer) and the receiver 2 (control layer) implement data transmission through the host control interface (HCI, Host Controller Interface).
  • HCI Host Controller Interface
  • the Bluetooth application layer relying on the property protocol and general property protocol abstracted by the Bluetooth upper layer, can operate Bluetooth services (specifically, the collection and transmission of brain electricity and related settings), which is more conducive to the realization of customized upper-level Machine program.
  • corresponding application programs and interactive interfaces can be set in the computer 1.
  • the user can set the collection parameters, control the Bluetooth connection status, view the brain electricity signal and so on through the computer 1.
  • the receiver 2 implements the underlying protocols related to the control layer, including functions such as physical layer data channel distribution, state switching, data packet verification, encryption, etc., and implements link layer related protocols on this basis.
  • the control layer implements the link layer message structure, including broadcast messages and data messages. On the basis of messages, basic operations of the Bluetooth control layer are implemented, such as device discovery, device scanning, device connection and response, and flow control.
  • the implanted device 3 may specifically be a deep brain nerve stimulation device, which is provided with a pulse generator, an EEG acquisition module and a Bluetooth module. As a device implanted in the human body, it performs data transmission with the receiver 2 through a Bluetooth module.
  • the computer 1 can set the implanted device 3 through the receiver 2 so that the implanted device 3 can collect the deep electrical signals of the human brain and send brain electrical data.
  • the receiver 2 is used to receive and parse the EEG data, and the computer 1 is used to display the analysis result of the EEG data.
  • the EEG acquisition system implementeds the host layer and the control layer on the computer and the receiver respectively.
  • the receiver implements the Bluetooth low-level protocol stack and encapsulates the Bluetooth instructions; develops desktop applications on the computer platform, that is, EEG acquisition Software to realize the Bluetooth control layer.
  • the computer and the receiver realize the Bluetooth protocol together, and carry out data communication and command sending and receiving through the serial port.
  • the system can adapt to the Bluetooth protocol specification, separate the Bluetooth host layer and the control layer, and realize the features and functions of the Bluetooth protocol to the greatest extent. , Which can realize the long-term EEG data acquisition under the multi-channel high sampling rate.
  • the computer 1 sends a device search instruction to the receiver 2;
  • the receiver 2 receives the device information broadcast by the implanted device 3 after receiving the device search instruction.
  • the device information specifically includes basic information such as the address information and the device name of the receiving implanted device 3.
  • the computer 1 displays the connectable implantable device 3 according to the device information, and realizes automatic filtering and display according to the device name and device type.
  • the user can select the implanted device to be connected according to the situation displayed on the interface of the computer 1.
  • steps S1-S3 are an optional way to discover the device implanted in the body, that is, the computer 1 sends a scanning instruction through the receiver 2 and receives the Bluetooth broadcast signal of the device 3 in the body to complete the scanning process.
  • the computer 1 sends a connection instruction to the receiver 2, and the serial port data is converted into Bluetooth data through the receiver 2 and sent to the implanted device 3, so that the receiver 2 and the implanted device 3 can establish a connection.
  • the implanted device 3 establishes a connection with the receiver 2, and returns the connection status information.
  • the computer 1 obtains and displays the connection status information through the receiver 2.
  • the above steps S4-S6 are an optional connection method, that is, the computer 1 sends a connection instruction through the receiver 2 and receives the connection status fed back by the implanted device 3 in the body to complete the connection process.
  • the computer 1 can also control the receiver 2 to disconnect from the implanted device 3 and manage the connection of the implanted device 3.
  • the specific operation is to first send an authentication instruction, set the pairing mode to the artificial participation mode, and set the pairing password.
  • the user can enter the password on the software interface of the computer 1 and send a pairing instruction.
  • the implanted device 3 determines whether the passwords are consistent. If the passwords are consistent, the pairing is successful. After the paired devices are successfully paired, data is transmitted in an encrypted manner to ensure data security.
  • the implanted device 3 takes the role of the slave and the receiver 2 takes the role of the master.
  • the service data of the implanted device 3 that is, the characteristics and description of the data transmission supported by the implanted device 3.
  • the Bluetooth data operation of different services can be realized, which specifically includes the following steps:
  • the receiver 2 reads the universally unique identifier (UUID, Universally Unique Identifier) of the implanted device 3;
  • UUID Universally Unique Identifier
  • the computer 1 obtains the service handle (identification) according to the universal unique identification code to confirm the data transmission characteristics and description information (set Bluetooth service information) supported by the implanted device 3.
  • the computer 1 sets the Bluetooth data packet length of the implanted device 3 through the receiver 2 to match the brain electricity data packet length. Since the default Bluetooth data packet length may not meet the multi-channel high sampling rate acquisition requirement of EEG data, the Bluetooth data packet length can be set through the computer 1. In order to realize the EEG data reception under high sampling rate, the data packet length can be set within 255 as required.
  • the collection parameters can also be set, which specifically includes the following steps:
  • the computer 1 sets the EEG acquisition parameters of the implanted device 3 through the receiver 2, so that the implanted device 3 collects the deep brain electrical signals of the human body according to the EEG acquisition parameters.
  • the EEG acquisition parameters include, for example, acquisition polarity (unipolar or bipolar), acquisition channel, sampling rate, and sampling time.
  • the computer 1 can send a start acquisition instruction to start EEG acquisition, and can send an end acquisition instruction to end the acquisition. Specifically include the following steps:
  • the implanted device 3 collects deep brain electrical signals, converts them into digital data, and encapsulates them into Bluetooth data packets;
  • the receiver 2 receives the Bluetooth data packet sent by the implanted device 3, and parses the digital brain electrical data into a voltage value.
  • One frame of data of EEG data protocol is composed of frame type, frame length and frame data. The frame types are divided into start frame, end frame and data frame.
  • the EEG data is composed of three bytes, and the three bytes represent the signed 23-bit AD sampling value. According to the calculation formula corresponding to the acquisition chip, the actual voltage value corresponding to the EEG data can be calculated.
  • the two Bluetooth devices encapsulate and parse EEG data according to the protocol to complete the communication process.
  • the computer 1 draws an EEG waveform diagram according to the analyzed voltage value, and the real-time drawing is displayed in the application program interface.
  • the embodiments of the present invention can be provided as a method, a system, or a computer 1 program product. Therefore, the present invention may adopt the form of a complete hardware embodiment, a complete software embodiment, or an embodiment combining software and hardware. Moreover, the present invention can be in the form of a computer 1 program product implemented on one or more computer 1 usable storage media (including but not limited to disk storage, CD-ROM, optical storage, etc.) containing computer 1 usable program codes. .
  • These computer 1 program instructions can also be stored in the computer 1 readable memory that can guide the computer 1 or other programmable data processing equipment to work in a specific manner, so that the instructions stored in the computer 1 readable memory generate instructions including the manufacturing of the instruction device.
  • the instruction device realizes the functions specified in one process or multiple processes in the flowchart and/or one block or multiple blocks in the block diagram.
  • These computer 1 program instructions can also be loaded on the computer 1 or other programmable data processing equipment, so that a series of operation steps are executed on the computer 1 or other programmable equipment to produce the processing realized by the computer 1, so that the computer 1 or other programmable data processing equipment
  • the instructions executed on the programming device provide steps for implementing functions specified in one or more processes in the flowchart and/or one block or more in the block diagram.

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Abstract

本发明提供一种基于蓝牙分离式架构的脑电采集***，包括计算机、接收器和植入设备，其中所述计算机用于实现蓝牙主机层、所述接收器用于实现蓝牙控制层；所述计算机通过所述接收器对所述植入设备进行设置，所述植入设备采集人体脑深部电信号并发送脑电数据，所述接收器与所述植入设备无线连接，接收和解析所述脑电数据，所述计算机显示脑电数据的解析结果。

Description

基于蓝牙分离式架构的脑电采集*** 技术领域
本发明涉及植入式医疗器械领域，具体涉及一种基于蓝牙分离式架构的脑电采集***。
背景技术
蓝牙(Bluetooth)作为一种短距离的无线通讯技术，是现在最流行的低功耗、低成本无线通信连接的方法。发明者希望为设备间的通讯创造一组统一的标准化协议，以解决用户间互不兼容的移动电子设备的互连互通，这些设备之间省去了传统的电线。透过芯片上的无线接收器，配有蓝牙技术的电子设备能够在短距离内彼此相通，传输速度可以达到每秒钟1Mbps。
蓝牙协议包括两种技术：Basic Rate(简称BR)和Low Energy(简称LE)。低功耗蓝牙是当前可以用来设计和使用的功耗最低的无线技术。蓝牙协议规范已经修订到5.1版本。该规范中规定低功耗蓝牙两个层次的协议，分别为蓝牙核心协议(Bluetooth Core)和蓝牙应用层协议(Bluetooth Application)。蓝牙核心协议由两部分组成，主机层(Host)和控制层(Controller)。这两层之间通过主机控制接口(HCI)实现通信。
基于该规范的低功耗蓝牙设备层出不穷，现有技术由于没有分离开蓝牙的主机层及控制层，不能够很大程度的发挥出蓝牙5.0规范的强大属性，只能实现一些基本的无线通信需求。当对蓝牙通信性能要求提高，需要拓展蓝牙功能，或者需要定制化蓝牙服务时，现有产品往往无法满足要求。
基于蓝牙传输的脑电信号，具有传输数据量大、数据包长度长、传输速率快等特点。同时传输过程中需要实现鉴权配对、加密等操作，仅仅依托现有的手机或电脑的蓝牙协议栈很难满足脑电采集的需求。
发明内容
有鉴于此，本发明提供一种基于蓝牙分离式架构的脑电采集***，包括计算机、接收器和植入设备，其中所述计算机用于实现蓝牙主机层、所述接收器用于实现蓝牙控制层；所述计算机通过所述接收器对所述植入设备进行设置，所述植入设备采集人体脑深部电信号并发送脑电数据，所述接收器与所述植入设备无线连接，接收和解析所述脑电数据，所述计算机显示脑电数据的解析结果。
可选地，所述计算机用于向所述接收器发送设备搜索指令；所述接收器在接收到所 述设备搜索指令后，接收所述植入设备广播的设备信息；所述计算机根据所述设备信息显示可连接的植入设备。
可选地，所述计算机用于向所述接收器发送连接指令，以使其与所述植入设备建立连接；所述植入设备在与所述接收器建立连接后，返回连接状态信息；所述计算机通过所述接收器获取并显示所述连接状态信息。
可选地，所述计算机用于向所述接收器发送鉴权配对指令，以使其与所述植入设备实现配对，参数包括配对方式及配对密码，配对成功后可以实现所述接收器与所述植入设备之间加密的数据传输。
可选地，所述接收器用于读取所述植入设备的服务数据；所述计算机用于根据所述服务数据确认所述植入设备支持的数据传输特性及描述信息。
可选地，所述接收器读取所述植入设备的通用唯一识别码，所述计算机根据所述通用唯一识别码获取服务句柄，以确认所述植入设备支持的数据传输特性及描述信息。
可选地，所述计算机用于通过所述接收器设置所述植入设备的蓝牙数据包长度，以匹配所述脑电数据包长度。
可选地，所述计算机用于通过所述接收器设置所述植入设备的脑电采集参数，以使所述植入设备按照所述脑电采集参数采集人体脑深部电信号。
可选地，所述脑电采集参数包括采集极性、采集通道、采样率、采样时间。
可选地，所述接收器用于将所述脑电数据解析为电压值；所述计算机用于根据所述电压值绘制脑电波形图。
可选地，所述计算机与所述接收器通过HCI接口连接。
本发明实施例提供的脑电采集***分别在计算机和接收器上实现主机层及控制层，由接收器实现蓝牙底层协议栈，并封装蓝牙指令；在计算机平台开发桌面应用程序，即脑电采集软件，实现蓝牙控制层。计算机及接收器共同实现蓝牙协议，通过串口进行数据通信与指令收发，本***可适配蓝牙协议规范，分离开蓝牙的主机层及控制层，最大程度的实现蓝牙协议中的各项特性及功能，由此可实现多通道高采样率下长时间的脑电数据采集。
附图说明
为了更清楚地说明本发明具体实施方式或现有技术中的技术方案，下面将对具体实施方式或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图是本发明的一些实施方式，对于本领域普通技术人员来讲，在不付出创造性 劳动的前提下，还可以根据这些附图获得其他的附图。
图1为本发明实施例中的脑电采集***的结构示意图；
图2为本发明实施例中的脑电采集***的脑电采集时序图。
具体实施方式
下面将结合附图对本发明的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
此外，下面所描述的本发明不同实施方式中所涉及的技术特征只要彼此之间未构成冲突就可以相互结合。
本发明实施例提供一种基于蓝牙分离式架构的脑电采集***，如图1所示，该***包括计算机1、接收器2和植入设备3。
计算机1用于实现蓝牙主机层、接收器2用于实现蓝牙控制层。计算机1(主机层)与接收器2(控制层)通过主机控制接口(HCI,Host Controller Interface)实现数据传输。主机层面对蓝牙应用层，依托蓝牙上层抽象出的属性协议及通用属性协议，可以对蓝牙的服务(具体是指脑电的采集和传输及其相关设置)进行操作，更利于实现定制化的上位机程序。比如可根据脑电采集的各种需要，在计算机1中设置相应的应用程序和交互界面，用户可以通过计算机1设定采集参数、控制蓝牙连接状态、查看脑电信号等等。
接收器2实现控制层相关的底层协议，包括物理层数据通道的分发、状态切换、数据包校验、加密等功能，并在此基础上实现链路层相关协议。控制层实现链路层报文结构，包括广播报文及数据报文。在报文的基础上，实现蓝牙控制层的基本操作，比如设备发现、设备扫描、设备连接及应答与流控等。
植入设备3具体可以是脑深部神经刺激设备，设有脉冲发生器、脑电采集模块和蓝牙模块。作为植入人体内部的设备，通过蓝牙模块与接收器2进行数据传输。计算机1可通过接收器2对植入设备3进行设置，以使植入设备3采集人体脑深部电信号并发送脑电数据。接收器2用于接收和解析脑电数据，计算机1用于显示脑电数据的解析结果。
本发明实施例提供的脑电采集***分别在计算机和接收器上实现主机层及控制层，由接收器实现蓝牙底层协议栈，并封装蓝牙指令；在计算机平台开发桌面应用程序，即脑电采集软件，实现蓝牙控制层。计算机及接收器共同实现蓝牙协议，通过串口进行数 据通信与指令收发，本***可适配蓝牙协议规范，分离开蓝牙的主机层及控制层，最大程度的实现蓝牙协议中的各项特性及功能，由此可实现多通道高采样率下长时间的脑电数据采集。
下面结合图2介绍上述***采集脑电信号的一个具体过程。首先需要搜索植入设备3，具体包括如下步骤：
S1,计算机1向接收器2发送设备搜索指令；
S2,接收器2在接收到设备搜索指令后，接收植入设备3广播的设备信息。设备信息具体包括接收植入设备3的地址信息、设备名称等基本信息。
S3,计算机1根据设备信息显示可连接的植入设备3，实现根据设备名称及设备类型自动过滤显示。用户可以根据计算机1的界面上显示的情况，选择需建立连接的植入设备。
上述步骤S1-S3是一种可选的发现体内植入设备的方式，即计算机1通过接收器2发送扫描指令，并接收体内植入设备3的蓝牙广播信号，完成扫描过程。
进一步地，在发现可连接的植入设备3后，需要建立体内、体外设备间的蓝牙连接，具体包括如下步骤：
S4，计算机1向接收器2发送连接指令，经过接收器2将串口数据转换为蓝牙数据发送至植入设备3，以使接收器2与植入设备3建立连接。
S5，植入设备3与接收器2建立连接，返回连接状态信息。
S6，计算机1通过接收器2获取并显示连接状态信息。
上述步骤S4-S6是一种可选的连接方式，即计算机1通过接收器2发送连接指令，并接收体内植入设备3反馈的连接状态，完成连接过程。计算机1还可以控制接收器2与植入设备3断开连接，对植入设备3的连接进行管理。
连接成功后，为保证数据传输安全性，可选择配置接收器2与植入设备3之间的配对。具体操作是首先发送鉴权指令，设置配对方式为人为参与方式，并设置配对密码。用户可以在计算机1的软件界面输入密码，发送配对指令，植入设备3判断密码是否一致，密码一致即配对成功。配对成功后的设备之间，数据以加密的方式进行传输，保证数据安全。
连接建立后，植入设备3作为从机角色，接收器2作为主机角色。为实现蓝牙数据传输，需要读取植入设备3的服务数据，即植入设备3所支持的数据传输的特性及描述。得到服务对应的句柄后，方可实现对不同服务的蓝牙数据操作，具体包括如下步骤：
S7,接收器2读取植入设备3的通用唯一识别码(UUID,Universally Unique  Identifier)；
S8，计算机1根据通用唯一识别码获取服务句柄(标识)，以确认植入设备3支持的数据传输特性及描述信息(设置蓝牙服务信息)。
服务读取后，可选择设置蓝牙数据包长度。在可选的实施例中，可以执行如下操作：
S9，计算机1通过接收器2设置植入设备3的蓝牙数据包长度，以匹配脑电数据包长度。由于默认的蓝牙数据包长度可能不满足脑电数据多通道高采样率的采集需求，因此可以通过计算机1设置蓝牙数据包长度。为实现高采样率下的脑电数据接收，数据包长度可在255以内根据需要进行设置。
在植入设备3采集脑深部电信号之前，还可以设置采集参数，具体包括如下步骤：
S10，计算机1通过接收器2设置植入设备3的脑电采集参数，以使植入设备3按照脑电采集参数采集人体脑深部电信号。脑电采集参数例如包括采集极性(单极或双极)、采集通道、采样率、采样时间。
确定采集参数后，计算机1可发送开始采集指令开启脑电采集，并可以发送结束采集指令以结束采集。具体包括如下步骤：
S11，植入设备3采集脑深部电信号，并转换为数字型数据，封装为蓝牙数据包；
S12，接收器2接收植入设备3发出的蓝牙数据包，将数字型的脑电数据解析为电压值。脑电数据协议的一帧数据由帧类型、帧长度及帧数据构成。其中帧类型分为开始帧、结束帧及数据帧。脑电数据由三个字节组成，三个字节代表有符号的23位AD采样值。根据采集芯片对应的计算公式，可以计算出脑电数据对应的实际电压值。两蓝牙设备依据协议来封装及解析脑电数据，完成通信过程。
S13，计算机1根据解析出的电压值绘制脑电波形图，实时绘图显示在应用程序界面中。
本领域内的技术人员应明白，本发明的实施例可提供为方法、***、或计算机1程序产品。因此，本发明可采用完全硬件实施例、完全软件实施例、或结合软件和硬件方面的实施例的形式。而且，本发明可采用在一个或多个其中包含有计算机1可用程序代码的计算机1可用存储介质(包括但不限于磁盘存储器、CD-ROM、光学存储器等)上实施的计算机1程序产品的形式。
本发明是参照根据本发明实施例的方法、设备(***)、和计算机1程序产品的流程图和/或方框图来描述的。应理解可由计算机1程序指令实现流程图和/或方框图中的每一流程和/或方框、以及流程图和/或方框图中的流程和/或方框的结合。可提供这些计算机1程序指令到通用计算机1、专用计算机1、嵌入式处理机或其他可编程数 据处理设备的处理器以产生一个机器，使得通过计算机1或其他可编程数据处理设备的处理器执行的指令产生用于实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能的装置。
这些计算机1程序指令也可存储在能引导计算机1或其他可编程数据处理设备以特定方式工作的计算机1可读存储器中，使得存储在该计算机1可读存储器中的指令产生包括指令装置的制造品，该指令装置实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能。
这些计算机1程序指令也可装载到计算机1或其他可编程数据处理设备上，使得在计算机1或其他可编程设备上执行一系列操作步骤以产生计算机1实现的处理，从而在计算机1或其他可编程设备上执行的指令提供用于实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能的步骤。
显然，上述实施例仅仅是为清楚地说明所作的举例，而并非对实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。而由此所引伸出的显而易见的变化或变动仍处于本发明创造的保护范围之中。

Claims (10)

  1. 一种基于蓝牙分离式架构的脑电采集***，其特征在于，包括计算机、接收器和植入设备，其中所述计算机用于实现蓝牙主机层、所述接收器用于实现蓝牙控制层；所述计算机通过所述接收器对所述植入设备进行设置，所述植入设备采集人体脑深部电信号并发送脑电数据，所述接收器与所述植入设备无线连接，接收和解析所述脑电数据，所述计算机显示脑电数据的解析结果。
  2. 根据权利要求1所述的***，其特征在于，所述计算机用于向所述接收器发送设备搜索指令；所述接收器在接收到所述设备搜索指令后，接收所述植入设备广播的设备信息；所述计算机根据所述设备信息显示可连接的植入设备。
  3. 根据权利要求1所述的***，其特征在于，所述计算机用于向所述接收器发送连接指令，以使其与所述植入设备建立连接；所述植入设备在与所述接收器建立连接后，返回连接状态信息；所述计算机通过所述接收器获取并显示所述连接状态信息。
  4. 根据权利要求1所述的***，其特征在于，所述接收器用于读取所述植入设备的服务数据；所述计算机用于根据所述服务数据确认所述植入设备支持的数据传输特性及描述信息。
  5. 根据权利要求4所述的***，其特征在于，所述接收器读取所述植入设备的通用唯一识别码，所述计算机根据所述通用唯一识别码获取服务句柄，以确认所述植入设备支持的数据传输特性及描述信息。
  6. 根据权利要求1所述的***，其特征在于，所述计算机用于通过所述接收器设置所述植入设备的蓝牙数据包长度，以匹配所述脑电数据包长度。
  7. 根据权利要求1所述的***，其特征在于，所述计算机用于通过所述接收器设置所述植入设备的脑电采集参数，以使所述植入设备按照所述脑电采集参数采集人体脑深部电信号。
  8. 根据权利要求7所述的***，其特征在于，所述脑电采集参数包括采集极性、 采集通道、采样率、采样时间。
  9. 根据权利要求1所述的***，其特征在于，所述接收器用于将所述脑电数据解析为电压值；所述计算机用于根据所述电压值绘制脑电波形图。
  10. 根据权利要求1所述的***，其特征在于，所述计算机与所述接收器通过HCI接口连接。
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