WO2021049045A1 - Device for inactivating influenza virus and inactivation method - Google Patents
Device for inactivating influenza virus and inactivation method Download PDFInfo
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- WO2021049045A1 WO2021049045A1 PCT/JP2019/036251 JP2019036251W WO2021049045A1 WO 2021049045 A1 WO2021049045 A1 WO 2021049045A1 JP 2019036251 W JP2019036251 W JP 2019036251W WO 2021049045 A1 WO2021049045 A1 WO 2021049045A1
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- air
- hypochlorous acid
- acid solution
- influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
- A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
- A61L9/12—Apparatus, e.g. holders, therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2209/00—Aspects relating to disinfection, sterilisation or deodorisation of air
- A61L2209/10—Apparatus features
- A61L2209/13—Dispensing or storing means for active compounds
- A61L2209/134—Distributing means, e.g. baffles, valves, manifolds, nozzles
Definitions
- the present invention relates to an inactivation device and an inactivation method for inactivating influenza virus by hypochlorous acid gas.
- the present invention can inactivate influenza virus even at a relative humidity of 30% to 50%, which is considered difficult to inactivate influenza virus with chlorine dioxide gas by using hypochlorous acid gas.
- the deactivating device and deactivating method More specifically, the present invention relates to an influenza virus deactivating device and a deactivating method capable of suppressing an increase in relative humidity even when the deactivating device is continuously operated in order to continuously generate hypochlorous acid gas.
- hypochlorous acid solution is swirled and swung by surface friction with air as a swirling flow to suppress uneven concentration of the hypochlorous acid solution, and droplets and liquid fine particles of the hypochlorous acid solution.
- Hypochlorous acid gas was generated so as not to scatter, enabling continuous operation, suppressing the amount of water released, and dissipating hypochlorous acid gas.
- the floating virus is inactivated by increasing the relative humidity of the target space, or the floating virus is inactivated by dissipating chlorine dioxide gas when the relative humidity of the target space is set to a predetermined value or higher.
- the technology is known. Until now, it has been considered important to maintain a relative humidity above a predetermined value in order to inactivate airborne viruses.
- Non-Patent Document 1 published in 1961 discloses the results of an experiment conducted by Mr. Harper as an experiment for inactivating a floating influenza virus only by temperature and humidity.
- Non-Patent Document 1 discloses that the virus is inactivated in a humidity environment having a relative humidity of 50% or more at room temperature.
- Non-Patent Document 2 In 1976, 15 years after Non-Patent Document 1, Schaffer et al. Published Non-Patent Document 2 regarding the infectivity of airborne viruses. According to the report, the influenza A airborne virus is easily inactivated so as to lose its infectivity at room temperature of 20 ° C. or higher and relative humidity of 45% to 55%, and conversely it is lost when the relative humidity is higher than that. It was found that the activity effect was reduced. Due to the high reliability of the experiment, Non-Patent Document 2 is highly evaluated among influenza experts as a document that elucidates the "relationship between influenza and relative humidity". Further, if the relative humidity is raised to 70 to 80%, for example, not only the deactivation effect is remarkably reduced, but also the growth of fungi widely known in modern times is promoted, and there is a problem that pneumonia is likely to occur. ..
- Non-Patent Document 3 describes a technique for inactivating airborne viruses by dissipating chlorine dioxide gas. Even in that case, it is said that the gas concentration, the exposure time, and the predetermined humidity environment are important, but it is particularly important to keep the relative humidity at 50% or more.
- Patent Document 1 discloses a technique of a space sterilization device that dissipates hypochlorous acid gas and targets Staphylococcus aureus.
- the technique described in Patent Document 1 pre-humidifies so that the relative humidity is 80% or more to generate hypochlorous acid gas, so that the sterilization effect can be obtained in a shorter time than before.
- sufficient sterilization performance can be obtained by constantly continuing humidification to generate hypochlorous acid gas so as not to cause dew condensation.
- the space sterilization device described in Patent Document 1 increases the contact area between the air and the hypochlorous acid solution so that not only the hypochlorous acid gas but also water is dissipated into the air as water vapor. Specifically, since the relative humidity in the room is raised to 80%, there is a problem that excessive humidification is likely to occur and the growth of fungi is likely to be promoted. Therefore, the spatial sterilization device described in Patent Document 1 is not suitable for the purpose of inactivating the influenza virus in a hygienic air environment.
- the sterilization / deodorizing device described in Patent Document 2 moves by directly sending air by a pressurizing device to the liquid surface of the chemical solution tank in which the hypochlorous acid solution supplied from the chemical solution supply tank is stored.
- a technique is disclosed in which an air stream is brought into contact with an untreated hypochlorous acid solution to dissipate hypochlorous acid gas.
- the contact area between the air and the hypochlorous acid solution is large, there is a problem that the humidity tends to be excessive.
- the effective chlorine concentration of the hypochlorous acid solution was almost halved in 7 hours (see FIG. 4 of Patent Document 2), and in order to operate for a long time, the concentration of the hypochlorous acid solution was adjusted. In order to maintain it, it was necessary to supply a highly concentrated hypochlorous acid solution from the chemical solution supply tank.
- Patent Document 3 discloses a technique of a chlorine dioxide gas generator invented by the inventors of the present application.
- a disk with a hanging shaft with a vertical hole is axially moved by an axial means with the axis of the columnar container as the central axis, and stabilized chlorine dioxide water is sucked up and diffused and scattered.
- a device for generating fine droplets and generating chlorine dioxide gas is disclosed.
- it is difficult to raise the relative humidity to 50% or more by this device there is a problem that the influenza virus cannot be inactivated when chlorine dioxide gas is generated.
- the inventor of the present application has made extensive studies and has invented a device and a method for inactivating influenza virus at room temperature without increasing the relative humidity and for easily controlling the concentration of the hypochlorous acid solution. ..
- the problem to be solved by the present invention is to inactivate influenza virus by using hypochlorous acid gas in a humidity atmosphere of 30% to 50% relative humidity, which is considered difficult to inactivate influenza virus by chlorine dioxide gas. Further, it is intended to provide an apparatus and a method for easily controlling the concentration of the hypochlorous acid solution.
- the container is a hypochlorite solution storage portion, an air circulation portion, an air intake, and air.
- the storage unit and the air circulation unit are provided with a discharge port, and each of the storage unit and the air circulation unit has a circular cross-sectional shape and are arranged on the same axis, and the air circulation means is axially moved around the same axis.
- the hypochlorous acid solution causes droplets and liquid fine particles to be generated by surface friction between the air and the hypochlorite solution as the disk moves.
- hypochlorous acid gas is generated in the air from the hypochlorite solution, and the air inlet and the air outlet due to the axial movement of the disk
- a storage unit for a hypochlorous acid solution provided in a container and an air circulation unit for generating hypochlorous acid gas are arranged on the same axis, and each of them is arranged.
- the cross-sectional shape is a circular cross-sectional shape and is in contact with each other.
- swirling swing means not only swirling around the central axis, but also a liquid level in which one around the liquid surface is high and the other is low across the axis, and the liquid is further tilted. It means that the liquid surface sways and swirls so as to orbit around the axis while remaining in the surface state. Since the hypochlorous acid solution swirls and swings in the storage portion, the concentration of the hypochlorous acid solution tends to be uniform, and the range up to the predetermined height of the inner surface around the container becomes the hypochlorous acid solution. It becomes moist and tends to generate hypochlorous acid gas.
- hypochlorous acid gas is released with the amount of water released suppressed, and the indoor space at room temperature is filled with hypochlorous acid gas of 0.007 ppm or more, and the relative humidity is 30% to 50%. It becomes possible to make it.
- hypochlorous acid gas generated by evaporation of the hypochlorous acid solution is unstable, and it is difficult to maintain the property of sterilizing and disinfecting, so it is said that it is important to generate it continuously.
- a humidity environment with a relative humidity of 30% to 50% which was conventionally considered to be ineffective for virus inactivation even when only humidification or chlorine dioxide gas was added, a remarkable influenza virus inactivation effect was obtained. This will be shown in an embodiment (see FIG. 1) described later.
- the inactivation device of the first invention it is possible to inactivate the influenza virus by continuously generating hypochlorous acid gas even in a dry atmosphere, which is an unprecedented advantage. It works.
- the amount of humidification per hour is 16 cc or less per hour (see Type B in Table 2).
- the general-purpose humidifier applied to a room with a size of 25 m 3 has a rated humidifying capacity of 300 cc per hour.
- the deactivating device of the first invention of the present invention is extremely small, about 1/20 as compared with the general-purpose humidifier, it does not over-humidify even in a highly closed space, so that it can be operated continuously. It can have the advantageous effect of being less likely to generate fungi.
- the liquid fine particles of the hypochlorous acid solution are not released into the indoor space, problems such as corrosion of the surface of the metal material existing in the indoor space, poor insulation of electric circuit parts, and decolorization of the colored fiber material do not occur.
- problems such as corrosion of the surface of the metal material existing in the indoor space, poor insulation of electric circuit parts, and decolorization of the colored fiber material do not occur.
- the second invention of the present invention has a shaft body that is vertically provided from the central axis of the disk and penetrates into the hypochlorous acid solution in the influenza virus inactivating device of the first invention.
- the tip of the shaft body is closed, and as the shaft moves, a vortex is generated around the shaft body in the hypochlorous acid solution while maintaining the liquid phase state. It is a feature.
- the lower end of the hanging shaft is closed from the center of the disk.
- the shaft body immersed in the hypochlorous acid solution moves axially, but the hypochlorous acid solution flows from the lower end of the shaft body because the lower end of the shaft body is blocked. It is not sucked up to the disk due to the difference in atmospheric pressure and scattered.
- the hypochlorous acid solution is swirled and swung in a liquid phase state in which droplets and liquid fine particles are not generated.
- the hypochlorous acid gas existing in the space is adsorbed on the inner wall surface of the space and the surface of the object existing in the space to reduce the concentration.
- the concentration of the hypochlorous acid solution is controlled. It is not necessary to supply hypochlorous acid gas constantly and continuously (see Type A in Fig. 7), and the inactivating effect of the influenza virus in the indoor space can be maintained for a long time. It has a favorable effect.
- a third invention is an influenza virus inactivating device including a container and an air circulation means, wherein the container has a hypochlorite solution storage portion, an air circulation portion, an air inlet, and an air outlet.
- the storage portion and the air circulation portion have a circular cross-sectional shape, are arranged on the same shaft core, and the air circulation means is axially moved around the same shaft core. It has a disk with a body, the shaft body has a tubular portion inside, and is vertically hung from the central axis of the disk, and the tubular portion has an inverted conical shape and is scattered around the upper end portion thereof.
- the hypochlorous acid solution has a hole and an open portion in which the lower end portion is penetrated into the hypochlorite solution, and the hypochlorite solution moves from the open portion to the cylinder portion as the disk moves. It is raised along the inner wall and is dissipated from the spray hole to the inner wall of the container to wet the inner surface of the container. Hypochlorite gas is generated in the air from the hypochlorite solution in contact with the air circulation portion, and the pressure difference between the air inlet and the air outlet due to the axial movement of the disk causes the said.
- the air outside the deactivating device was introduced into the air circulation section, and the air containing the hypochlorite gas was released from the air circulation section to suppress the amount of water released to the outside of the container. It is characterized by releasing hypochlorous acid gas in the state.
- the deactivating device of the third invention is provided with a shaft body that is vertically hung from the central axis of the disk and has an inverted conical tubular portion inside that forms a rising portion of the hypochlorous acid solution.
- An open portion is formed at the lower end portion of the tubular portion, and a spray hole is formed around the upper end portion.
- the tubular portion is also axially moved, and the hypochlorous acid solution raised from the open portion is scattered from the dissipating portion, wetting the inner surface of the container and generating hypochlorous acid gas.
- hypochlorous acid solution drips along the inner surface of the container, and it was found that a small amount of liquid fine particles of 1 ⁇ m or more, which are closely related to corrosion and decolorization, were generated (see Type O in Table 1), but lost. No moisture release was observed that caused the humidity of the living room in which the active device was installed to become excessive (see Type O in Table 2 and Fig. 2).
- the generation of small-diameter droplets and liquid fine particles was observed, but there was no moisture release that would cause excessive humidity, and hypochlorous acid gas was continuously maintained while maintaining a dry atmosphere. Has the effect of being able to generate.
- the container in the inactivating device for the influenza virus of the first to third inventions, is a sphere composed of an upper main body and a lower main body, and the lower main body is a storage portion.
- the upper main body serves as the air circulation portion, and includes the air circulation means, the air intake port, and the air discharge port, and the disk extends radially so as to project from the top surface. It has a projecting piece, and the axial movement of the projecting piece accompanying the axial movement of the disk causes the air pressure around the disk to be higher than the air pressure at the center of the disk, and air from the air intake to the center of the disk. Is introduced, and air containing hypochlorous acid gas is discharged from the peripheral portion of the disk to the air discharge port.
- the deactivating device of the fourth invention is a sphere composed of an upper main body and a lower main body. Since the container is spherical, the hypochlorous acid solution is smooth along the bottom surface so that one side around the liquid level is high and the other side is low with the axis in between. The liquid level is likely to be swung and swung so as to orbit around the axis while the liquid level is still inclined.
- the projecting pieces extending radially on the top surface of the disk are axially moved, so that centrifugal force is likely to act on the air in the vicinity of the projecting pieces, and the peripheral portion of the disk.
- the air pressure is higher than the air pressure in the center of the disk.
- the inner surface of the container is widely moistened with a hypochlorous acid solution, easily generates hypochlorous acid gas, and is added separately from the disk that swirls and swings the hypochlorous acid solution.
- a hypochlorous acid solution easily generates hypochlorous acid gas
- the inner surface of the container is widely moistened with a hypochlorous acid solution, easily generates hypochlorous acid gas, and is added separately from the disk that swirls and swings the hypochlorous acid solution.
- air is introduced using a pressurizing device without the need for a pressure device, it has the effect of being less likely to generate droplets and liquid fine particles.
- the hypochlorous acid solution is swirled and swung with the air by surface friction with the air swirled horizontally, and droplets and liquid fine particles are swirled.
- Relative humidity by suppressing the amount of water released and dissipating hypochlorite gas in a liquid phase state that does not generate influenza virus, and filling the space that inactivates influenza virus with 0.007 ppm or more of hypochlorite gas. It is characterized in that it is possible to inactivate the influenza virus even in a humidity environment of 30% or more and 50% or less.
- the inactivation method of the fifth invention it is possible to inactivate influenza virus by continuously generating hypochlorous acid gas even in a dry atmosphere, which is an unprecedented advantage. It works.
- the surface area of the contact liquid between the air and the hypochlorous acid solution is kept limited, and the amount of water released is suppressed to dissipate the hypochlorous acid gas, so that the space is not over-humidified even in a highly closed space. Therefore, it can be operated continuously, and has an advantageous effect that fungi are less likely to be generated.
- a vortex flow is generated inside the hypochlorous acid solution that is swirling and rocking in the liquid phase state. It is characterized by being generated.
- the sixth invention it is not necessary to control the concentration of the hypochlorous acid solution, it is easy to constantly and continuously replenish the hypochlorous acid gas, and the inactivating effect of the influenza virus in the indoor space is maintained for a long time. It has an unprecedented advantageous effect of being able to do it.
- a seventh aspect of the present invention is the radial direction of the swirling flow due to the pressure difference between the inside and outside of the swirling flow of the horizontally swirled air in the method of inactivating the influenza virus of the fifth or sixth invention. It is characterized in that air is introduced from the inner portion and swirled, and the air containing hypochlorite gas is discharged into the space via the radial outer portion of the swirling flow.
- the seventh invention there is no need for a dedicated pressurizing device for taking in air and releasing air containing hypochlorous acid gas. Compared to the case where air is blown using a pressurizing device equipped with a fan, it has the effect of being less likely to generate droplets and liquid fine particles.
- the influenza virus is inactivated by continuously generating hypochlorous acid gas even in a dry atmosphere. It has an unprecedented advantageous effect that it is possible. In addition, since the amount of water released is suppressed and hypochlorous acid gas is dissipated, it is not over-humidified even in a highly closed space, so it is possible to operate continuously and it is difficult to generate fungi. It has a great effect.
- -According to the deactivating device of the second invention and the deactivating method of the sixth invention it is not necessary to control the concentration of the hypochlorous acid solution, and it is easy to constantly and continuously replenish the hypochlorous acid gas. It has an unprecedented advantageous effect that the inactivating effect of influenza virus in the indoor space can be maintained for a long time.
- a dedicated pressurizing device for taking in air and releasing air containing hypochlorous acid gas is not required. Compared to the case where air is blown using a pressurizing device equipped with a fan, it has the effect of being less likely to generate droplets and liquid fine particles.
- hypochlorous acid solution is swirled and swung to limit the contact area between the air and the hypochlorous acid solution and prevent the generation of droplets and liquid fine particles to suppress the amount of water released to reduce the amount of hypochlorous acid gas. I tried to dissipate it.
- hypochlorous acid solution was applied instead of the stabilized chlorine dioxide water stored in the chlorine dioxide gas generator, and at the Sendai Medical Center of the National Hospital Organization, in a test room with an air volume of 10 m 3 , the O type shown below was used.
- hypochlorous acid gas was dissipated from a hypochlorous acid solution having a pH of 4.14 and a concentration of 97 ppm, and the inactivating effect of influenza virus was verified.
- the O-type device of Example 1 described later was continuously operated for about 10 hours with the door having the ventilation louver closed.
- the change in temperature and humidity as shown in Fig. 2, the temperature is maintained at about 23 ° C, and the humidity is humidified by the O-type device even if the air in the corridor is introduced from the ventilation louver.
- the humidity is humidified by the O-type device even if the air in the corridor is introduced from the ventilation louver.
- Example 1 the hypochlorous acid gas generated while swirling and rocking the hypochlorous acid solution according to the example, the two examples, and one comparative example, which was the starting point of the present invention (hereinafter, the present invention).
- the inactivating effect of the influenza virus will be explained while showing the measurement results of the amount of gas generated, the time of occurrence, and the amount of water released accordingly.
- Example 1, Example 2, Example 3, and Comparative Example 1 will be specifically described, and then their effects will be compared and described.
- the influenza virus inactivating device 1 (hereinafter referred to as an O-type device) will be described with reference to FIG.
- the O-type device has a spherical shape with an overall shape of 17 cm in diameter, and is composed of an upper main body 10 and a lower main body 20 that can be divided.
- the upper main body is provided with a motor 11 as an air circulation means and as a drive means to which electric power is supplied from a power source (not shown).
- a projecting piece 14 extending radially is attached to the top surface of the disk.
- the number of rotations of the disk 12 is set to 300 rotations per minute.
- the lower main body 20 is used as a storage portion for the hypochlorous acid solution.
- As the hypochlorous acid solution a hypochlorous acid solution having a pH of 4.14 and a concentration of 97 ppm prepared by dissolving granules (TMT System Co., Ltd .: trade name “Diawater White Sand”) in distilled water was used.
- the air in the air circulation portion 13 in contact with the disk is swirled (see arrow A).
- the hypochlorous acid solution in contact with the air is swirled due to surface friction with the air.
- the hypochlorous acid solution is swirled, in the case of the deactivating device 1, about 10 seconds after the disk is axially moved, one around the liquid surface is high and the other is sandwiched between the shaft cores. Will be in a low graded liquid level state.
- the liquid level is tilted, the liquid level is swirled so as to orbit around the axis, and the tops of the liquid level are B (dashed line top), C (dashed line top), and D. It is swirled and swung so as to circulate with (the top of the solid line) (see FIG. 3).
- An inverted conical shaft body 15 with an open lower end is attached below the shaft core of the disk.
- the hypochlorous acid solution in contact with the inside of the lower end portion rises along the inclined surface of the shaft body surface, and the connection between the disk and the shaft body is established.
- the hypochlorous acid solution is radially sprayed around the spray holes 16 provided in the portion.
- the sprayed hypochlorous acid solution collides with the inner surface of the container and most of it drips along the inner surface of the container, but some droplets are scattered around the disk and the droplets colliding with the wall of the container are fine. It was measured that a part of the liquid fine particles was also generated from the air outlet (see Type O in Table 1).
- the upper main body 10 is formed with an air intake port 17 and an air emission port 18. Due to the rotation of the projecting piece 14 on the top surface of the disk, the air pressure around the disk is made higher than the air pressure at the center of the disk.
- the path from the air intake and the path to the air dissipation port are separated from each other with respect to the air circulation unit 13.
- the path from the air intake 17 to the center of the disk is the air introduction path (see the white arrow in FIG. 3), and the path from the periphery of the disk in the air circulation section to the air discharge port 18 is the air release path (FIG. 3). (See the black arrow in).
- the influenza virus inactivating device 2 (hereinafter referred to as type A device) of Example 2 will be described with reference to FIG.
- the same configuration as that of the deactivating device 1 is designated by the same reference numerals in the drawings, and the description thereof is omitted.
- the A-type device is common to the O-type device except that there is no open lower end of the shaft body provided below the axis of the disk of the O-type device, but the shaft body has an inverted conical shape. Of course, it does not have to be, and the connection portion between the disk and the shaft body does not have to have a spray hole.
- FIG. 4 shows only one aspect (D) of the top of the liquid surface
- the top is swirled and swung in the same manner as the O-type device.
- the swirling speed of the part of the hypochlorous acid solution in contact with the periphery of the shaft body is faster than the swirling speed of the entire hypochlorous acid solution due to surface friction with air. .. Therefore, as the hypochlorous acid solution swirls and swings, the vortex flow 19 is generated and disappears by changing the position to any position of the hypochlorous acid solution, and the hypochlorous acid solution is uniformly stirred. It is easy to make the whole concentration uniform.
- the influenza virus inactivating device 3 (hereinafter referred to as a B-type device) of Example 3 will be described with reference to FIG.
- the shaft body provided below the shaft core of the disk of the O-type device is removed.
- the swirling fluctuation of the hypochlorous acid solution is generated only by the surface friction with the air.
- the gradient of the inclined surface of the liquid surface which is high on one side around the liquid surface and low on the other side across the axis, due to the swirling of the hypochlorous acid solution, is smaller than that of the O-type device and the A-type device.
- the speed of the swirling swing of the hypochlorous acid solution is also slower than that of the O-type device and the A-type device.
- the influenza virus inactivating device 4 (hereinafter referred to as C-type device) of Comparative Example 1 will be described with reference to FIG.
- C-type device stirring plate bodies 21 are attached to both sides of the lower end portion of the shaft body provided below the shaft core of the disk of the A-type device.
- the hypochlorous acid solution is violently stirred by the axial movement of the stirring plate 21 in addition to the swirling and rocking motion of the hypochlorous acid solution of the A-type device. Therefore, in the vicinity of the wetted portion of the shaft body, air was drawn into the solution from the surface of the hypochlorous acid solution, and the solution was swirled and swung with a state 22 in which the solution was bubbling.
- the top surface of the disk was not wet with the hypochlorous acid solution, and no droplets or liquid fine particles were observed to be emitted to the outside of the container.
- the concentration of the number of liquid fine particles for each particle size scattered to the outside of the deactivating device of the O-type device and the A-type device will be described.
- the concentration of liquid fine particles is 1 liter of 1 liter at a position 30 cm away from the blowout air port by installing either the O-type device or the A-type device in a glove box of 1.2 m 3 and operating it for 60 minutes.
- the concentration of the number of liquid fine particles contained in a liter of gas was measured by particle size with a semiconductor laser particle counter. Measurements were carried out 10 times for each of the two types of devices, the O-type device and the A-type device, and the average value was calculated. The results are shown in Table 1.
- the A-type device in the case of the A-type device, almost no liquid fine particles were observed at all particle sizes as compared with the O-type device.
- the B-type device and the C-type device do not scatter the particles of the hypochlorous acid solution by the disk. Therefore, as with the A-type device, liquid fine particles are placed outside the device for all particle sizes. It can be estimated that it hardly occurs.
- Table 2 shows a comparison table of the water release rate from each deactivating device and the total amount of gas generated
- FIG. 7 shows each deactivating device.
- the graph shows the total amount of gas generated up to the hour. In the B-type device and the C-type device, almost no gas was generated after 4 hours, so the measurement was discontinued in 4 hours.
- the experiment was carried out by driving each deactivating device in a closed space at 20 ° C. where an air flow of 1.25 m 3 was not generated.
- the number of measurements that can draw the gradient of the gas generation rate was measured so that the amount of gas generated for each hour could be grasped, and the functional formula of the gas generation rate was calculated. Then, the amount of gas generated for each hour is calculated by the functional expression of the gas generation rate at each time, and the total amount of gas generated is calculated by adding them up.
- the rate of water release to the outside of the device is determined by dividing the amount of decrease in the hypochlorous acid solution by the measurement time.
- the broken line marked with ⁇ indicates the total amount of gas generated by the B-type device (the gradient of the broken line is the gas generation rate: the same applies to other deactivating devices), and the alternate long and short dash line marked with ⁇ is C.
- the type device, the straight line marked with a circle indicates the type A device, and the broken line marked with a cross indicates the total amount of gas generated by the type O device.
- the points marked with each indicate the measurement points.
- the magnitude of the amount of gas generated in the initial 2 hours of operation is generally B-type device (Type B in FIG. 7), C-type device (Type C in FIG. 7), O-type device (Type O in FIG. 7), and A-type device. It becomes smaller in the order of the device (Type A in FIG. 7).
- the operating time was 2 hours or more, the gradient of the polygonal line of the C-type device and the B-type device was reduced, the gas generation rate was reduced, and almost no gas was generated for 4 hours or more.
- the gas generation rate of the A-type device is higher than that of the O-type device up to an operating time of 8 hours. After 8 hours or more, the gas generation rate of the A-type device is slightly lower than that of the O-type device.
- the O-type device and the A-type device have almost the same performance in terms of the magnitude of the amount of gas generated, the gas generation rate, and the sustainability of gas generation.
- the lower surface of the disk becomes significantly wet with the hypochlorous acid solution, and as shown in Table 1, liquid fine particles having a predetermined particle size are emitted to the outside of the apparatus. Admitted.
- the A-type device, the B-type device, and the C-type device are not in a wet state with the hypochlorous acid solution except for the lower part of the inner surface of the container, and the generation of liquid fine particles that go out to the outside of the device is generated. It is recognized that there is almost no. This is also supported by Table 1.
- the type A device which produces the largest amount of gas and has a long duration of gas generation, has the best inactivating effect on influenza virus. Further, even in the case of the O-type device, as in the case of the A-type device, the amount of water released is small, the amount of gas generated is the second largest after the A-type device, and the duration of gas generation is long, so that a small amount of liquid fine particles are generated. If is allowed, then it can be determined that the influenza virus has an inactivating effect.
- the B-type device is suitable for application to, for example, a clinic where medical treatment is performed in short-time units because the amount of gas generated decreases sharply after 4 hours, but the initial gas generation rate is high. It is judged that there is. Regarding the C-type apparatus of Comparative Example 1, the problem that the amount of gas generated sharply decreased after 2 hours and the total amount of gas generated was also small remained.
- the acidity of the hypochlorous acid solution applied to the present invention is preferably pH 3.5 to 4.2, but is not limited, and may be determined in relation to the solution concentration of the hypochlorous acid solution. For example, when the solution concentration is 100 ppm, when the pH value becomes small, the amount of hypochlorous acid gas generated increases, but the risk of chlorine gas generation increases. On the other hand, when the pH value is increased, the risk of chlorine gas generation is eliminated, but the generation of hypochlorous acid gas is reduced. The concentration of the hypochlorous acid solution may be appropriately determined as long as it does not smell. -Although Examples 1 to 3 have described examples of a small deactivating device, the size thereof is not limited.
- any deactivation device that limits the surface area of contact with air and swirls the hypochlorous acid solution by swirling the air may be used, and the present invention may be applied to a part of the air conditioning means of the building.
- the spherical shape deactivating device is shown, but it goes without saying that the hypochlorous acid solution may be swirled and swung, and the container shape may be cylindrical. ..
- the present invention can be applied to various uses such as clinics, hospitals, cram schools, etc., in addition to elderly housing and general housing.
- a deactivation device that easily generates gas at the initial stage of operation even if the gas generation time is about 4 hours.
- a deactivating device that keeps generating gas for a long time may be applied in preparation for going to bed.
- the number of deactivating devices should be changed and the size of the container should be changed accordingly.
- the embodiments disclosed this time should be considered to be exemplary in all respects and not restrictive.
- the technical scope of the present invention is not limited to the above description, and is intended to include all modifications within the meaning and scope equivalent to the claims.
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Abstract
[Problem] To inactivate an influenza virus even at a relative humidity of 30-50% at which it has been considered that influenza viruses are hardly inactivated with chlorine dioxide gas. [Solution] A device for inactivating an influenza virus that comprises a container and an air circulating means, wherein: a hypochlorous acid solution-pooling part and an air circulating part, said air circulating part generating hypochlorous acid gas, have a circular cross-sectional shape and are individually arranged on the same axis; due to the surface friction between air in the air circulating part and a hypochlorous acid solution, the hypochlorous acid solution is swirled and oscillated in a liquid phase state without generating liquid droplets or fine liquid particles so as to generate hypochlorous acid gas; and, due to the difference in pressure between an air inlet and an air outlet, the air is introduced and, at the same time, hypochlorous acid gas-containing air is released so that the hypochlorous acid gas is released while controlling the amount of moisture release.
Description
本発明は、次亜塩素酸ガスによってインフルエンザウイルスを失活させる失活装置及び失活方法に関する。
The present invention relates to an inactivation device and an inactivation method for inactivating influenza virus by hypochlorous acid gas.
従来、室温において浮遊したインフルエンザウイルスを失活させるには、二酸化塩素ガスにより失活させる場合、相対湿度を50%以上に保つことが重要であるとされていた。本発明は、次亜塩素酸ガスを使うことにより、二酸化塩素ガスではインフルエンザウイルスの失活が困難とされていた相対湿度30%~50%においても、インフルエンザウイルスを失活させることができるインフルエンザウイルスの失活装置及び失活方法に関する。詳細には、次亜塩素酸ガスを継続的に発生させるために、失活装置を連続運転させても相対湿度の上昇を抑えることができるインフルエンザウイルスの失活装置及び失活方法に関する。
Conventionally, in order to inactivate an influenza virus floating at room temperature, it has been considered important to keep the relative humidity at 50% or more when inactivating with chlorine dioxide gas. The present invention can inactivate influenza virus even at a relative humidity of 30% to 50%, which is considered difficult to inactivate influenza virus with chlorine dioxide gas by using hypochlorous acid gas. Regarding the deactivating device and deactivating method. More specifically, the present invention relates to an influenza virus deactivating device and a deactivating method capable of suppressing an increase in relative humidity even when the deactivating device is continuously operated in order to continuously generate hypochlorous acid gas.
具体的には、旋回流とされた空気との面摩擦により次亜塩素酸溶液を旋回揺動させ、次亜塩素酸溶液の濃度むらを抑制し、次亜塩素酸溶液の液滴・液体微粒子を飛散させないように次亜塩素酸ガスを発生させ、連続運転を可能にし、水分放出量を抑えて次亜塩素酸ガスを放散させるようにした。
Specifically, the hypochlorous acid solution is swirled and swung by surface friction with air as a swirling flow to suppress uneven concentration of the hypochlorous acid solution, and droplets and liquid fine particles of the hypochlorous acid solution. Hypochlorous acid gas was generated so as not to scatter, enabling continuous operation, suppressing the amount of water released, and dissipating hypochlorous acid gas.
従来から、対象空間の相対湿度を高くすることにより浮遊ウイルスを失活させる方法や、対象空間の相対湿度を所定値以上とさせた状態において、二酸化塩素ガスを放散させて浮遊ウイルスを失活させる技術が知られている。これまで、浮遊ウイルスを失活させるためには相対湿度を所定値以上の湿度環境に保つことが重要であるとされてきた。
Conventionally, the floating virus is inactivated by increasing the relative humidity of the target space, or the floating virus is inactivated by dissipating chlorine dioxide gas when the relative humidity of the target space is set to a predetermined value or higher. The technology is known. Until now, it has been considered important to maintain a relative humidity above a predetermined value in order to inactivate airborne viruses.
一方、相対湿度が高くなると、真菌類が繁殖しやすくなる。アスペルギルスやクリプトコッカス等の真菌を吸い込むと、高齢者や免疫力が低下している患者は肺炎を発症しやすいという問題があった。また、肺炎にかかると、高齢者ほど死亡割合が高くなるため、高齢者の割合が増大しつつある現代においては、真菌による肺炎の発症を抑えるために、相対湿度を高くしないでも浮遊ウイルスの感染症を予防することができる技術の開発が喫緊の課題となっている。
On the other hand, the higher the relative humidity, the easier it is for fungi to grow. Inhalation of fungi such as Aspergillus and Cryptococcus has the problem that elderly people and patients with weakened immunity are more likely to develop pneumonia. In addition, when pneumonia occurs, the mortality rate increases with the elderly, so in the present age when the rate of elderly people is increasing, in order to suppress the onset of pneumonia caused by fungi, airborne virus infection is performed without increasing the relative humidity. The development of technology that can prevent diseases is an urgent issue.
1961年に発表された非特許文献1には、浮遊インフルエンザウイルスを温湿度のみによって失活させる実験としてHarper氏が行った実験結果が開示されている。非特許文献1には、常温において相対湿度が50%以上の湿度環境でウイルスが失活されることが開示されていた。
Non-Patent Document 1 published in 1961 discloses the results of an experiment conducted by Mr. Harper as an experiment for inactivating a floating influenza virus only by temperature and humidity. Non-Patent Document 1 discloses that the virus is inactivated in a humidity environment having a relative humidity of 50% or more at room temperature.
非特許文献1から15年後の1976年には、Schaffer氏らにより浮遊ウイルスの感染性に関する非特許文献2が発表されている。それによると、A型インフルエンザの浮遊ウイルスが、20℃以上の室温、相対湿度45%~55%の範囲で感染性を失うように失活されやすく、それよりも相対湿度が大きくなると逆に失活効果が低下することが判明した。その実験の信頼性の高さにより、非特許文献2は、インフルエンザ専門家の間で「インフルエンザと相対湿度の関係」を解明した文献として高く評価されている。また、相対湿度を、例えば70~80%にあげすぎると、失活効果が著しく減少するだけでなく、現代において広く知られている真菌類の繁殖を促し、肺炎を発症させやすいという課題がある。
In 1976, 15 years after Non-Patent Document 1, Schaffer et al. Published Non-Patent Document 2 regarding the infectivity of airborne viruses. According to the report, the influenza A airborne virus is easily inactivated so as to lose its infectivity at room temperature of 20 ° C. or higher and relative humidity of 45% to 55%, and conversely it is lost when the relative humidity is higher than that. It was found that the activity effect was reduced. Due to the high reliability of the experiment, Non-Patent Document 2 is highly evaluated among influenza experts as a document that elucidates the "relationship between influenza and relative humidity". Further, if the relative humidity is raised to 70 to 80%, for example, not only the deactivation effect is remarkably reduced, but also the growth of fungi widely known in modern times is promoted, and there is a problem that pneumonia is likely to occur. ..
更に、浮遊ウイルスを失活させる研究が重ねられ、濃度が体積比で10億分の1単位の極めて低い濃度の二酸化塩素ガスを室内に放散することや、同様な濃度の次亜塩素酸ガスを室内に放散することも提案されている。非特許文献3には、二酸化塩素ガスを放散させて浮遊ウイルスを失活させる方法についての技術が記載されている。その場合においても、ガス濃度、暴露した時間、所定の湿度環境が重要であるとされているが、その中でも特に相対湿度を50%以上に保つことが重要であるとされている。
Furthermore, research to inactivate airborne viruses has been repeated, and chlorine dioxide gas with an extremely low concentration of one billionth by volume is released indoors, and hypochlorous acid gas with a similar concentration is released. It is also proposed to dissipate indoors. Non-Patent Document 3 describes a technique for inactivating airborne viruses by dissipating chlorine dioxide gas. Even in that case, it is said that the gas concentration, the exposure time, and the predetermined humidity environment are important, but it is particularly important to keep the relative humidity at 50% or more.
特許文献1には、次亜塩素酸ガスを放散させ、黄色ブドウ球菌を対象とする空間除菌装置の技術が開示されている。特許文献1に記載の技術は、相対湿度を80%以上とさせるように事前加湿して次亜塩素酸ガスを発生させ、従来よりも短時間で除菌効果が得られるようにしている。また事前加湿後の殺菌工程においても、結露させないように常に加湿を続けて次亜塩素酸ガスを発生させることにより、殺菌性能が十分に得られるとしている。
Patent Document 1 discloses a technique of a space sterilization device that dissipates hypochlorous acid gas and targets Staphylococcus aureus. The technique described in Patent Document 1 pre-humidifies so that the relative humidity is 80% or more to generate hypochlorous acid gas, so that the sterilization effect can be obtained in a shorter time than before. In addition, even in the sterilization process after pre-humidification, sufficient sterilization performance can be obtained by constantly continuing humidification to generate hypochlorous acid gas so as not to cause dew condensation.
しかし、特許文献1に記載の空間除菌装置は、空気と次亜塩素酸溶液との接触面積を大きくし次亜塩素酸ガスのみならず水も水蒸気として空気中に放散させるようにしている。具体的には、室内の相対湿度を80%にあげるため、加湿過多となりやすく、真菌類の繁殖を促しやすいという問題があった。そのため、特許文献1に記載の空間除菌装置は、衛生的空気環境下でインフルエンザウイルスを失活させるという目的には適していなかった。
However, the space sterilization device described in Patent Document 1 increases the contact area between the air and the hypochlorous acid solution so that not only the hypochlorous acid gas but also water is dissipated into the air as water vapor. Specifically, since the relative humidity in the room is raised to 80%, there is a problem that excessive humidification is likely to occur and the growth of fungi is likely to be promoted. Therefore, the spatial sterilization device described in Patent Document 1 is not suitable for the purpose of inactivating the influenza virus in a hygienic air environment.
また特許文献2に記載の除菌・消臭装置には、薬液供給槽から供給された次亜塩素酸液を貯留させた薬液槽の液面に、加圧装置により空気を直接送り込んで、動いていない次亜塩素酸液に空気流を接触させて次亜塩素酸ガスを放散させる技術が開示されている。しかしこの技術による場合においても、空気と次亜塩素酸溶液との接触面積を大きくしているため、湿度過多になりやすいという課題があった。また、次亜塩素酸液の有効塩素濃度が7時間でほぼ半減する(特許文献2の図4参照)ことが示され、長時間の運転をさせるためには、次亜塩素酸液の濃度を維持させるために、薬液供給槽から濃度の高い次亜塩素酸液を供給させることが必要であった。
Further, the sterilization / deodorizing device described in Patent Document 2 moves by directly sending air by a pressurizing device to the liquid surface of the chemical solution tank in which the hypochlorous acid solution supplied from the chemical solution supply tank is stored. A technique is disclosed in which an air stream is brought into contact with an untreated hypochlorous acid solution to dissipate hypochlorous acid gas. However, even in the case of this technique, since the contact area between the air and the hypochlorous acid solution is large, there is a problem that the humidity tends to be excessive. Further, it was shown that the effective chlorine concentration of the hypochlorous acid solution was almost halved in 7 hours (see FIG. 4 of Patent Document 2), and in order to operate for a long time, the concentration of the hypochlorous acid solution was adjusted. In order to maintain it, it was necessary to supply a highly concentrated hypochlorous acid solution from the chemical solution supply tank.
また特許文献3には、本願の発明者等が発明した二酸化塩素ガス発生装置の技術が開示されている。この文献には、円柱状容器の軸芯を中心軸として、垂下された垂直孔付き軸体を付設させた円盤を軸動手段により軸動させて、安定化二酸化塩素水を吸い上げて拡散飛散させて微細な液滴とさせ、二酸化塩素ガスを発生させる装置が開示されている。しかし、この装置により、相対湿度を50%以上に高めることは困難であることから、二酸化塩素ガスを発生させた場合にはインフルエンザウイルスを失活させることができないという問題があった。
Further, Patent Document 3 discloses a technique of a chlorine dioxide gas generator invented by the inventors of the present application. In this document, a disk with a hanging shaft with a vertical hole is axially moved by an axial means with the axis of the columnar container as the central axis, and stabilized chlorine dioxide water is sucked up and diffused and scattered. A device for generating fine droplets and generating chlorine dioxide gas is disclosed. However, since it is difficult to raise the relative humidity to 50% or more by this device, there is a problem that the influenza virus cannot be inactivated when chlorine dioxide gas is generated.
そこで、本願の発明者は、鋭意研究を重ね、室温において、相対湿度を高くさせないでインフルエンザウイルスを失活させ、また、次亜塩素酸溶液の濃度管理が容易な装置及び方法の発明に至った。
Therefore, the inventor of the present application has made extensive studies and has invented a device and a method for inactivating influenza virus at room temperature without increasing the relative humidity and for easily controlling the concentration of the hypochlorous acid solution. ..
本発明が解決しようとする課題は、二酸化塩素ガスでインフルエンザウイルスの失活が困難とされていた相対湿度30%~50%の湿度雰囲気において、次亜塩素酸ガスを使ってインフルエンザウイルスを失活させ、また、次亜塩素酸溶液の濃度管理が容易な装置及び方法を提供することである。
The problem to be solved by the present invention is to inactivate influenza virus by using hypochlorous acid gas in a humidity atmosphere of 30% to 50% relative humidity, which is considered difficult to inactivate influenza virus by chlorine dioxide gas. Further, it is intended to provide an apparatus and a method for easily controlling the concentration of the hypochlorous acid solution.
本発明の第1の発明は、容器と空気循環手段とからなるインフルエンザウイルスの失活装置において、前記容器が、次亜塩素酸溶液の貯留部と、空気循環部と、空気取入口と、空気放出口とを備え、前記貯留部と前記空気循環部とは、断面形状が円断面形状をなし、夫々が同一軸芯に配され、前記空気循環手段が、前記同一軸芯の周りに軸動される円盤を有し、前記貯留部において、前記次亜塩素酸溶液が、前記円盤の軸動に連れて、前記空気と前記次亜塩素酸溶液との面摩擦により、液滴・液体微粒子を発生させない液相状態のまま旋回揺動され、前記次亜塩素酸溶液から前記空気の中に次亜塩素酸ガスが発生され、前記円盤の軸動による前記空気取入口と前記空気放出口との気圧差により、空気が前記空気循環部の中に導入されると共に前記次亜塩素酸ガスを含んだ空気が前記空気循環部から放出され、前記容器の外部に、水分放出量を抑制させた状態で次亜塩素酸ガスが放出されることを特徴としている。
According to the first invention of the present invention, in an influenza virus inactivating device including a container and an air circulation means, the container is a hypochlorite solution storage portion, an air circulation portion, an air intake, and air. The storage unit and the air circulation unit are provided with a discharge port, and each of the storage unit and the air circulation unit has a circular cross-sectional shape and are arranged on the same axis, and the air circulation means is axially moved around the same axis. In the storage portion, the hypochlorous acid solution causes droplets and liquid fine particles to be generated by surface friction between the air and the hypochlorite solution as the disk moves. It swirls and swings in a liquid phase state in which it is not generated, hypochlorous acid gas is generated in the air from the hypochlorite solution, and the air inlet and the air outlet due to the axial movement of the disk A state in which air is introduced into the air circulation section due to the pressure difference and air containing the hypochlorite gas is released from the air circulation section to suppress the amount of water released to the outside of the container. It is characterized by the release of hypochlorous acid gas.
第1の発明のインフルエンザウイルスの失活装置は、容器に備えられた次亜塩素酸溶液の貯留部と、次亜塩素酸ガスを発生させる空気循環部とが同一軸芯に配され、夫々の断面形状が円断面形状をなし接しあっている。空気循環部において配された円盤が軸動すると、空気循環部の空気が円盤の軸動に連れて水平方向に旋回される。そうすると旋回される空気と次亜塩素酸溶液との面摩擦のみにより、次亜塩素酸溶液が液滴・液体微粒子を発生させない液相状態のまま旋回揺動される。
In the influenza virus inactivating device of the first invention, a storage unit for a hypochlorous acid solution provided in a container and an air circulation unit for generating hypochlorous acid gas are arranged on the same axis, and each of them is arranged. The cross-sectional shape is a circular cross-sectional shape and is in contact with each other. When the disk arranged in the air circulation section moves axially, the air in the air circulation section is swirled in the horizontal direction along with the axial movement of the disk. Then, the hypochlorous acid solution is swirled and swung in a liquid phase state in which droplets and liquid fine particles are not generated due to only the surface friction between the swirled air and the hypochlorous acid solution.
ここで旋回揺動とは、中心軸の周りに旋回するだけではなく、液面の周囲の一方が高く、軸芯を挟んで他方が低い傾斜された液面状態とされ、更に傾斜された液面状態のままで、軸芯の周りを周回するように、液面が揺れ動きながら旋回されることをいう。貯留部の中で次亜塩素酸溶液が旋回揺動されるため、次亜塩素酸溶液の濃度が均一になりやすいと共に、容器の周囲内面の所定の高さまでの範囲が次亜塩素酸溶液に湿潤された状態となり、次亜塩素酸ガスが発生されやすい。
Here, swirling swing means not only swirling around the central axis, but also a liquid level in which one around the liquid surface is high and the other is low across the axis, and the liquid is further tilted. It means that the liquid surface sways and swirls so as to orbit around the axis while remaining in the surface state. Since the hypochlorous acid solution swirls and swings in the storage portion, the concentration of the hypochlorous acid solution tends to be uniform, and the range up to the predetermined height of the inner surface around the container becomes the hypochlorous acid solution. It becomes moist and tends to generate hypochlorous acid gas.
また、円盤の軸動により発生された、空気取入口と空気放出口との気圧差により、空気循環部の中に空気が導入されると共に、次亜塩素酸ガスを含んだ空気が前記空気循環部から放出されるため、次亜塩素酸ガスを含んだ空気の放出量が極めて緩やかとなる。これにより、水分放出量を抑制させた状態で次亜塩素酸ガスが放出され、常温の室内空間を0.007ppm以上の次亜塩素酸ガスで充満させると共に相対湿度30%~50%の湿度環境とさせることが可能となる。
In addition, air is introduced into the air circulation section due to the pressure difference between the air inlet and the air outlet generated by the axial movement of the disk, and the air containing hypochlorite gas circulates in the air. Since it is released from the part, the amount of air containing hypochlorite gas is released extremely slowly. As a result, hypochlorous acid gas is released with the amount of water released suppressed, and the indoor space at room temperature is filled with hypochlorous acid gas of 0.007 ppm or more, and the relative humidity is 30% to 50%. It becomes possible to make it.
また、次亜塩素酸溶液が蒸発して発生する次亜塩素酸ガスは不安定であり、殺菌・消毒させる性質が維持されにくいため、連続して発生させることが重要であるとされている。なお、従来、加湿のみまたは二酸化塩素ガスを加えたとしてもウイルス失活が有効でないとされていた相対湿度30%~50%の湿度環境において、著しいインフルエンザウイルスの失活効果が得られた。このことは、後述の実施例(図1参照)において示す。
In addition, the hypochlorous acid gas generated by evaporation of the hypochlorous acid solution is unstable, and it is difficult to maintain the property of sterilizing and disinfecting, so it is said that it is important to generate it continuously. In addition, in a humidity environment with a relative humidity of 30% to 50%, which was conventionally considered to be ineffective for virus inactivation even when only humidification or chlorine dioxide gas was added, a remarkable influenza virus inactivation effect was obtained. This will be shown in an embodiment (see FIG. 1) described later.
第1の発明の失活装置によれば、乾燥雰囲気中であっても、連続して次亜塩素酸ガスを発生させることによりインフルエンザウイルスを失活させることが可能であるという従来にない有利な効果を奏する。本発明の第1の発明の失活装置によれば、時間あたりの加湿量が毎時16cc以下である(表2のType B参照)。一方、25m3の大きさの部屋に適用される汎用加湿器は、定格加湿能力が毎時300ccとされている。
According to the inactivation device of the first invention, it is possible to inactivate the influenza virus by continuously generating hypochlorous acid gas even in a dry atmosphere, which is an unprecedented advantage. It works. According to the deactivating device of the first invention of the present invention, the amount of humidification per hour is 16 cc or less per hour (see Type B in Table 2). On the other hand, the general-purpose humidifier applied to a room with a size of 25 m 3 has a rated humidifying capacity of 300 cc per hour.
本発明の第1の発明の失活装置は、汎用加湿器と比較して約1/20と極めて少ないため、閉鎖性の高い空間でも加湿しすぎることがないため、連続して運転することができ、真菌を発生させにくいという有利な効果を奏する。また、次亜塩素酸溶液の液体微粒子を室内空間に放出しないため、室内空間に存在する金属材料表面の腐食や電気回路部品の絶縁不良、着色繊維素材の脱色などの障害を発生させない。また、次亜塩素酸溶液の液体微粒子を室内空間に放出しないため、室内空間に存在する金属材料表面の腐食や電気回路部品の絶縁不良、着色繊維素材の脱色などの障害を発生させない。
Since the deactivating device of the first invention of the present invention is extremely small, about 1/20 as compared with the general-purpose humidifier, it does not over-humidify even in a highly closed space, so that it can be operated continuously. It can have the advantageous effect of being less likely to generate fungi. In addition, since the liquid fine particles of the hypochlorous acid solution are not released into the indoor space, problems such as corrosion of the surface of the metal material existing in the indoor space, poor insulation of electric circuit parts, and decolorization of the colored fiber material do not occur. In addition, since the liquid fine particles of the hypochlorous acid solution are not released into the indoor space, problems such as corrosion of the surface of the metal material existing in the indoor space, poor insulation of electric circuit parts, and decolorization of the colored fiber material do not occur.
本発明の第2の発明は、第1の発明のインフルエンザウイルスの失活装置において、前記円盤の中心軸から垂設され、前記次亜塩素酸溶液の中に浸入する軸体を有し、前記軸体の先端が閉塞されており、前記軸体の軸動に連れて、前記液相状態のまま、前記次亜塩素酸溶液の中において、前記軸体の周囲に渦流が発生されることを特徴としている。
The second invention of the present invention has a shaft body that is vertically provided from the central axis of the disk and penetrates into the hypochlorous acid solution in the influenza virus inactivating device of the first invention. The tip of the shaft body is closed, and as the shaft moves, a vortex is generated around the shaft body in the hypochlorous acid solution while maintaining the liquid phase state. It is a feature.
第2の発明の失活装置は、円盤の中心から、垂下されている軸体の下端部が閉塞されている。円盤が旋回すると、次亜塩素酸溶液の中に浸入されている軸体が軸動するが、軸体の下端部が閉塞されていることにより、次亜塩素酸溶液が軸体の下端部から円盤まで、気圧差等により吸い上げられて飛散されることがない。これにより次亜塩素酸溶液が、液滴・液体微粒子を発生させない液相状態で旋回揺動される。
In the deactivating device of the second invention, the lower end of the hanging shaft is closed from the center of the disk. When the disk turns, the shaft body immersed in the hypochlorous acid solution moves axially, but the hypochlorous acid solution flows from the lower end of the shaft body because the lower end of the shaft body is blocked. It is not sucked up to the disk due to the difference in atmospheric pressure and scattered. As a result, the hypochlorous acid solution is swirled and swung in a liquid phase state in which droplets and liquid fine particles are not generated.
また、軸体が次亜塩素酸溶液の中に浸入された状態で軸動されるため、次亜塩素酸溶液の中において、次亜塩素酸溶液を攪拌させるように、軸体の周囲に渦流が発生される。渦流は、次亜塩素酸溶液の中において、軸体の周囲のいずれかの位置に順に発生と消滅が繰り返される。これにより、次亜塩素酸溶液が均一に攪拌されやすい。
In addition, since the shaft body is axially moved while being immersed in the hypochlorous acid solution, a vortex flows around the shaft body so as to stir the hypochlorous acid solution in the hypochlorous acid solution. Is generated. The vortex is repeatedly generated and extinguished at any position around the shaft in the hypochlorous acid solution. This makes it easy for the hypochlorous acid solution to be uniformly agitated.
空間内に存在する次亜塩素酸ガスは、空間内壁面や空間内に存在する物体表面に吸着されて濃度を減じていくが、第2の発明によれば、次亜塩素酸溶液の濃度管理も不要で、次亜塩素酸ガスを定常的、持続的に補給させやすく(図7のType A参照)、室内空間のインフルエンザウイルスの失活効果を長時間維持させることができるという従来にはない有利な効果を奏する。
The hypochlorous acid gas existing in the space is adsorbed on the inner wall surface of the space and the surface of the object existing in the space to reduce the concentration. According to the second invention, the concentration of the hypochlorous acid solution is controlled. It is not necessary to supply hypochlorous acid gas constantly and continuously (see Type A in Fig. 7), and the inactivating effect of the influenza virus in the indoor space can be maintained for a long time. It has a favorable effect.
第3の発明は、容器と空気循環手段とからなるインフルエンザウイルスの失活装置において、前記容器が、次亜塩素酸溶液の貯留部と、空気循環部と、空気取入口と、空気放出口とを備え、前記貯留部と前記空気循環部とは、断面形状が円断面形状をなし、夫々が同一軸芯に配され、前記空気循環手段が、前記同一軸芯の周りに軸動される軸体を備えた円盤を有し、前記軸体が、その内部に筒部を有すると共に前記円盤の中心軸から垂設され、前記筒部が、逆円錐形状をなし、その上端部の周囲に散布孔を有すると共に下端部が前記次亜塩素酸溶液の中に浸入される開放部を有し、前記円盤の軸動に連れて、前記次亜塩素酸溶液が、前記開放部から前記筒部の内壁を伝わって上昇され、前記散布孔から前記容器の内壁に放散されて容器の内面を濡らし、前記貯留部においては、前記空気と前記次亜塩素酸溶液との面摩擦により旋回揺動され、前記空気循環部に接している次亜塩素酸溶液から前記空気の中に次亜塩素酸ガスが発生され、前記円盤の軸動による前記空気取入口と前記空気放出口との気圧差により、前記失活装置外の空気が前記空気循環部の中に導入されると共に前記次亜塩素酸ガスを含んだ空気が前記空気循環部から放出され、前記容器の外部に、水分放出量を抑制させた状態で次亜塩素酸ガスを放出させることを特徴としている。
A third invention is an influenza virus inactivating device including a container and an air circulation means, wherein the container has a hypochlorite solution storage portion, an air circulation portion, an air inlet, and an air outlet. The storage portion and the air circulation portion have a circular cross-sectional shape, are arranged on the same shaft core, and the air circulation means is axially moved around the same shaft core. It has a disk with a body, the shaft body has a tubular portion inside, and is vertically hung from the central axis of the disk, and the tubular portion has an inverted conical shape and is scattered around the upper end portion thereof. The hypochlorous acid solution has a hole and an open portion in which the lower end portion is penetrated into the hypochlorite solution, and the hypochlorite solution moves from the open portion to the cylinder portion as the disk moves. It is raised along the inner wall and is dissipated from the spray hole to the inner wall of the container to wet the inner surface of the container. Hypochlorite gas is generated in the air from the hypochlorite solution in contact with the air circulation portion, and the pressure difference between the air inlet and the air outlet due to the axial movement of the disk causes the said. The air outside the deactivating device was introduced into the air circulation section, and the air containing the hypochlorite gas was released from the air circulation section to suppress the amount of water released to the outside of the container. It is characterized by releasing hypochlorous acid gas in the state.
第3の発明の失活装置は、円盤の中心軸から垂設され、内部に次亜塩素酸溶液の上昇部をなす逆円錐形状の筒部を内部に有する軸体を備えている。筒部には、下端部に開放部が形成され、上端部の周囲に散布孔が形成されている。円盤の軸動に連れて、筒部も軸動され、開放部から上昇された次亜塩素酸溶液が放散部から飛散され、容器の内面を濡らし次亜塩素酸ガスが発生される。
The deactivating device of the third invention is provided with a shaft body that is vertically hung from the central axis of the disk and has an inverted conical tubular portion inside that forms a rising portion of the hypochlorous acid solution. An open portion is formed at the lower end portion of the tubular portion, and a spray hole is formed around the upper end portion. Along with the axial movement of the disk, the tubular portion is also axially moved, and the hypochlorous acid solution raised from the open portion is scattered from the dissipating portion, wetting the inner surface of the container and generating hypochlorous acid gas.
円盤の軸動による空気取入口と空気放出口と間の小さな気圧差により次亜塩素酸ガスを含む空気を放出させているため、放出される空気の速度が小さく、放散部から飛散された次亜塩素酸溶液は容器の内面に沿って滴ることになり、腐食や脱色と密接に関与する1μm以上の液体微粒子が僅かに発生したことが認められたが(表1のType O参照)、失活装置を設置した居室の湿度を、湿度過多とさせるような水分放出は認められなかった(表2のType O、図2参照)。
Since the air containing hypochlorous acid gas is released due to the small pressure difference between the air intake and the air discharge port due to the axial movement of the disk, the speed of the released air is low and the air is scattered from the emission part. The hypochlorous acid solution drips along the inner surface of the container, and it was found that a small amount of liquid fine particles of 1 μm or more, which are closely related to corrosion and decolorization, were generated (see Type O in Table 1), but lost. No moisture release was observed that caused the humidity of the living room in which the active device was installed to become excessive (see Type O in Table 2 and Fig. 2).
第3の発明によれば、小径の液滴・液体微粒子の発生は、認められたが、湿度過多とさせるような水分放出はなく、乾燥雰囲気を維持したまま、連続して次亜塩素酸ガスを発生させることができるという効果を奏する。
According to the third invention, the generation of small-diameter droplets and liquid fine particles was observed, but there was no moisture release that would cause excessive humidity, and hypochlorous acid gas was continuously maintained while maintaining a dry atmosphere. Has the effect of being able to generate.
本発明の第4の発明は、第1から第3の発明のインフルエンザウイルスの失活装置において、前記容器が、上部本体と下部本体とからなる球体とされ、前記下部本体が、前記貯留部とされ、前記上部本体が、前記空気循環部とされると共に、前記空気循環手段と、前記空気取入口と、前記空気放出口とを備え、前記円盤が、天面に突設された放射状に伸びる突設片を有し、前記円盤の軸動に伴った前記突設片の軸動により、円盤周辺部の気圧が円盤中央部の気圧より高くされ、前記円盤中央部に前記空気取入口から空気が導入され、前記空気放出口に前記円盤周辺部から次亜塩素酸ガスを含んだ空気が放出されることを特徴としている。
In the fourth invention of the present invention, in the inactivating device for the influenza virus of the first to third inventions, the container is a sphere composed of an upper main body and a lower main body, and the lower main body is a storage portion. The upper main body serves as the air circulation portion, and includes the air circulation means, the air intake port, and the air discharge port, and the disk extends radially so as to project from the top surface. It has a projecting piece, and the axial movement of the projecting piece accompanying the axial movement of the disk causes the air pressure around the disk to be higher than the air pressure at the center of the disk, and air from the air intake to the center of the disk. Is introduced, and air containing hypochlorous acid gas is discharged from the peripheral portion of the disk to the air discharge port.
第4の発明の失活装置は、上部本体と下部本体とからなる球体とされている。容器が球体とされていることにより、液面の周囲の一方が高く、軸芯を挟んで他方が低い傾斜された液面状態とされるように、底面に沿って次亜塩素酸溶液が滑らかに揺動されやすく、更に傾斜された液面状態のままで、軸芯の周りを周回するように、液面が旋回揺動されやすい。
The deactivating device of the fourth invention is a sphere composed of an upper main body and a lower main body. Since the container is spherical, the hypochlorous acid solution is smooth along the bottom surface so that one side around the liquid level is high and the other side is low with the axis in between. The liquid level is likely to be swung and swung so as to orbit around the axis while the liquid level is still inclined.
また、円盤が軸動されるに連れて、円盤の天面に放射状に伸びている突設片が軸動されることにより、突設片近傍の空気に遠心力が作用しやすく、円盤周辺部の気圧が円盤中心部の気圧より高くされる。空気取入口から円盤中央部に外部空気を取入れさせ、空気放出口に円盤周辺部から内部空気を放出させることにより、気体を直接加圧する加圧装置を使わないで、空気を取入れ、水分放出量を抑制させた状態で次亜塩素酸ガスを放出させやすい。
In addition, as the disk is axially moved, the projecting pieces extending radially on the top surface of the disk are axially moved, so that centrifugal force is likely to act on the air in the vicinity of the projecting pieces, and the peripheral portion of the disk. The air pressure is higher than the air pressure in the center of the disk. By taking in external air from the air intake to the center of the disk and releasing internal air from the periphery of the disk to the air outlet, air is taken in and the amount of water released without using a pressurizing device that directly pressurizes the gas. It is easy to release hypochlorous acid gas in a state where
第4の失活装置によれば、容器内面を広く次亜塩素酸溶液で湿潤させやすく、次亜塩素酸ガスを発生させやすく、次亜塩素酸溶液を旋回揺動させる円盤とは別の加圧装置を必要とせず、加圧装置を使って空気を流入させる場合に比べて、液滴・液体微粒子を発生させにくいという効果を奏する。
According to the fourth deactivating device, the inner surface of the container is widely moistened with a hypochlorous acid solution, easily generates hypochlorous acid gas, and is added separately from the disk that swirls and swings the hypochlorous acid solution. Compared to the case where air is introduced using a pressurizing device without the need for a pressure device, it has the effect of being less likely to generate droplets and liquid fine particles.
本発明の第5の発明は、インフルエンザウイルスの失活方法において、水平に旋回させた空気との面摩擦により、次亜塩素酸溶液を前記空気に連れて旋回揺動させ、液滴・液体微粒子を発生させない液相状態のまま、水分放出量を抑えて次亜塩素酸ガスを放散させ、インフルエンザウイルスを失活させる空間に0.007ppm以上の次亜塩素酸ガスを充満させることにより、相対湿度が30%以上50%以下の湿度環境においてもインフルエンザウイルスを失活させることが可能とされていることを特徴としている。
In the fifth aspect of the present invention, in the method of inactivating influenza virus, the hypochlorous acid solution is swirled and swung with the air by surface friction with the air swirled horizontally, and droplets and liquid fine particles are swirled. Relative humidity by suppressing the amount of water released and dissipating hypochlorite gas in a liquid phase state that does not generate influenza virus, and filling the space that inactivates influenza virus with 0.007 ppm or more of hypochlorite gas. It is characterized in that it is possible to inactivate the influenza virus even in a humidity environment of 30% or more and 50% or less.
第5の発明の失活方法によれば、乾燥雰囲気中であっても、連続して次亜塩素酸ガスを発生させることによりインフルエンザウイルスを失活させることが可能であるという従来にない有利な効果を奏する。また、空気と次亜塩素酸溶液との接液表面積を限定したままとし、水分放出量を抑えて次亜塩素酸ガスを放散させているため、閉鎖性の高い空間でも加湿しすぎることがないため、連続して運転することができ、真菌を発生させにくいという有利な効果を奏する。
According to the inactivation method of the fifth invention, it is possible to inactivate influenza virus by continuously generating hypochlorous acid gas even in a dry atmosphere, which is an unprecedented advantage. It works. In addition, the surface area of the contact liquid between the air and the hypochlorous acid solution is kept limited, and the amount of water released is suppressed to dissipate the hypochlorous acid gas, so that the space is not over-humidified even in a highly closed space. Therefore, it can be operated continuously, and has an advantageous effect that fungi are less likely to be generated.
本発明の第6の発明は、第5の発明のインフルエンザウイルスを失活させる失活方法において、旋回揺動されている前記次亜塩素酸溶液の内部において、前記液相状態のまま、渦流が発生されていることを特徴としている。
According to a sixth aspect of the present invention, in the inactivation method for inactivating the influenza virus of the fifth invention, a vortex flow is generated inside the hypochlorous acid solution that is swirling and rocking in the liquid phase state. It is characterized by being generated.
第6の発明によれば、次亜塩素酸溶液の濃度管理も不要で、次亜塩素酸ガスを定常的、持続的に補給させやすく、室内空間のインフルエンザウイルスの失活効果を長時間維持させることができるという従来にはない有利な効果を奏する。
According to the sixth invention, it is not necessary to control the concentration of the hypochlorous acid solution, it is easy to constantly and continuously replenish the hypochlorous acid gas, and the inactivating effect of the influenza virus in the indoor space is maintained for a long time. It has an unprecedented advantageous effect of being able to do it.
本発明の第7の発明は、第5又は第6の発明のインフルエンザウイルスの失活方法において、前記水平に旋回された空気の旋回流の径方向内外の気圧差により、前記旋回流の径方向内方部から空気を導入し旋回させ、前記空気に次亜塩素酸ガスを含んだ空気を、前記旋回流の径方向外方部を経由して前記空間に放出させることを特徴としている。
A seventh aspect of the present invention is the radial direction of the swirling flow due to the pressure difference between the inside and outside of the swirling flow of the horizontally swirled air in the method of inactivating the influenza virus of the fifth or sixth invention. It is characterized in that air is introduced from the inner portion and swirled, and the air containing hypochlorite gas is discharged into the space via the radial outer portion of the swirling flow.
第7の発明によれば、空気を取入れ、次亜塩素酸ガスを含んだ空気を放出させるための専用の加圧装置が不要である。ファンを備えた加圧装置を使って空気を吹き込む場合に比べて、液滴・液体微粒子を発生させにくいという効果を奏する。
According to the seventh invention, there is no need for a dedicated pressurizing device for taking in air and releasing air containing hypochlorous acid gas. Compared to the case where air is blown using a pressurizing device equipped with a fan, it has the effect of being less likely to generate droplets and liquid fine particles.
・第1の発明の失活装置および第5の発明の失活方法によれば、乾燥雰囲気中であっても、連続して次亜塩素酸ガスを発生させることによりインフルエンザウイルスを失活させることが可能であるという従来にない有利な効果を奏する。また、水分放出量を抑えて次亜塩素酸ガスを放散させているため、閉鎖性の高い空間でも加湿しすぎることがないため、連続して運転することができ、真菌を発生させにくいという有利な効果を奏する。
・第2の発明の失活装置および第6の発明の失活方法によれば、次亜塩素酸溶液の濃度管理も不要で、次亜塩素酸ガスを定常的、持続的に補給させやすく、室内空間のインフルエンザウイルスの失活効果を長時間維持させることができるという従来にはない有利な効果を奏する。 -According to the deactivating device of the first invention and the deactivating method of the fifth invention, the influenza virus is inactivated by continuously generating hypochlorous acid gas even in a dry atmosphere. It has an unprecedented advantageous effect that it is possible. In addition, since the amount of water released is suppressed and hypochlorous acid gas is dissipated, it is not over-humidified even in a highly closed space, so it is possible to operate continuously and it is difficult to generate fungi. It has a great effect.
-According to the deactivating device of the second invention and the deactivating method of the sixth invention, it is not necessary to control the concentration of the hypochlorous acid solution, and it is easy to constantly and continuously replenish the hypochlorous acid gas. It has an unprecedented advantageous effect that the inactivating effect of influenza virus in the indoor space can be maintained for a long time.
・第2の発明の失活装置および第6の発明の失活方法によれば、次亜塩素酸溶液の濃度管理も不要で、次亜塩素酸ガスを定常的、持続的に補給させやすく、室内空間のインフルエンザウイルスの失活効果を長時間維持させることができるという従来にはない有利な効果を奏する。 -According to the deactivating device of the first invention and the deactivating method of the fifth invention, the influenza virus is inactivated by continuously generating hypochlorous acid gas even in a dry atmosphere. It has an unprecedented advantageous effect that it is possible. In addition, since the amount of water released is suppressed and hypochlorous acid gas is dissipated, it is not over-humidified even in a highly closed space, so it is possible to operate continuously and it is difficult to generate fungi. It has a great effect.
-According to the deactivating device of the second invention and the deactivating method of the sixth invention, it is not necessary to control the concentration of the hypochlorous acid solution, and it is easy to constantly and continuously replenish the hypochlorous acid gas. It has an unprecedented advantageous effect that the inactivating effect of influenza virus in the indoor space can be maintained for a long time.
・第3の発明の失活装置によれば、小径の液滴・液体微粒子の発生は、認められたが、湿度過多とさせるような水分放出はなく、乾燥雰囲気中であっても、連続して次亜塩素酸ガスを発生させることができるという効果を奏する。
・第4の発明の失活装置によれば、容器内面を広く次亜塩素酸溶液で湿潤させやすく、次亜塩素酸ガスを発生させやすく、次亜塩素酸溶液を旋回揺動させる円盤とは別の加圧装置を必要とせず、加圧装置を使って空気を流入させる場合に比べて、液滴・液体微粒子を発生させにくいという効果を奏する。
・第7の発明の失活方法によれば、空気を取入れ、次亜塩素酸ガスを含んだ空気を放出させるための専用の加圧装置が不要である。ファンを備えた加圧装置を使って空気を吹き込む場合に比べて、液滴・液体微粒子を発生させにくいという効果を奏する。 -According to the deactivating device of the third invention, the generation of small-diameter droplets and liquid fine particles was observed, but there was no water release that would cause excessive humidity, and it was continuous even in a dry atmosphere. It has the effect of being able to generate hypochlorous acid gas.
-According to the deactivating device of the fourth invention, what is a disk that makes it easy to wet the inner surface of the container with a hypochlorous acid solution widely, easily generates hypochlorous acid gas, and swirls the hypochlorous acid solution? It does not require a separate pressurizing device, and has the effect of making it difficult to generate droplets and liquid fine particles as compared with the case where air is flowed in using the pressurizing device.
-According to the deactivation method of the seventh invention, a dedicated pressurizing device for taking in air and releasing air containing hypochlorous acid gas is not required. Compared to the case where air is blown using a pressurizing device equipped with a fan, it has the effect of being less likely to generate droplets and liquid fine particles.
・第4の発明の失活装置によれば、容器内面を広く次亜塩素酸溶液で湿潤させやすく、次亜塩素酸ガスを発生させやすく、次亜塩素酸溶液を旋回揺動させる円盤とは別の加圧装置を必要とせず、加圧装置を使って空気を流入させる場合に比べて、液滴・液体微粒子を発生させにくいという効果を奏する。
・第7の発明の失活方法によれば、空気を取入れ、次亜塩素酸ガスを含んだ空気を放出させるための専用の加圧装置が不要である。ファンを備えた加圧装置を使って空気を吹き込む場合に比べて、液滴・液体微粒子を発生させにくいという効果を奏する。 -According to the deactivating device of the third invention, the generation of small-diameter droplets and liquid fine particles was observed, but there was no water release that would cause excessive humidity, and it was continuous even in a dry atmosphere. It has the effect of being able to generate hypochlorous acid gas.
-According to the deactivating device of the fourth invention, what is a disk that makes it easy to wet the inner surface of the container with a hypochlorous acid solution widely, easily generates hypochlorous acid gas, and swirls the hypochlorous acid solution? It does not require a separate pressurizing device, and has the effect of making it difficult to generate droplets and liquid fine particles as compared with the case where air is flowed in using the pressurizing device.
-According to the deactivation method of the seventh invention, a dedicated pressurizing device for taking in air and releasing air containing hypochlorous acid gas is not required. Compared to the case where air is blown using a pressurizing device equipped with a fan, it has the effect of being less likely to generate droplets and liquid fine particles.
「乾燥雰囲気中においても、次亜塩素酸ガスを連続して発生させることによりインフルエンザウイルスを失活させるようにする」という目的を、水平に旋回された空気との面摩擦により、空気に連れて次亜塩素酸溶液を旋回揺動させ、空気と次亜塩素酸溶液との接触面積を限定させると共に液滴・液体微粒子を発生させないようにして、水分放出量を抑えて次亜塩素酸ガスを放散させるようにした。
The purpose of "to inactivate the influenza virus by continuously generating hypochlorous acid gas even in a dry atmosphere" is taken to the air by surface friction with the horizontally swirled air. The hypochlorous acid solution is swirled and swung to limit the contact area between the air and the hypochlorous acid solution and prevent the generation of droplets and liquid fine particles to suppress the amount of water released to reduce the amount of hypochlorous acid gas. I tried to dissipate it.
まず、二酸化塩素ガス発生装置に貯留させる安定化二酸化塩素水に替えて次亜塩素酸溶液を適用し、国立病院機構仙台医療センターにおいて、気積が10m3の試験室に、下記に示すO型装置を使用して、pH4.14、濃度97ppmとさせた次亜塩素酸溶液から次亜塩素酸ガスを放散させ、インフルエンザウイルスの失活効果を検証した。
First, a hypochlorous acid solution was applied instead of the stabilized chlorine dioxide water stored in the chlorine dioxide gas generator, and at the Sendai Medical Center of the National Hospital Organization, in a test room with an air volume of 10 m 3 , the O type shown below was used. Using an apparatus, hypochlorous acid gas was dissipated from a hypochlorous acid solution having a pH of 4.14 and a concentration of 97 ppm, and the inactivating effect of influenza virus was verified.
予め前記試験室に次亜塩素酸ガスを1時間放散させガス濃度を0.007ppmとさせておき、インフルエンザウイルスの試験液を噴霧し失活装置を運転継続させ、その1時間後のインフルエンザウイルスの浮遊量の感染価の減少率を検証した。その結果、図1に示したように、60分後には、20℃の温度環境において、相対湿度が30%~35%の場合には約1700分の1(図1(A)参照)、相対湿度が50%~51%の場合には約9000分の1(図1(B)参照)に感染価の減少を確認することができた。1時間の実験終了後のガス濃度は0.012ppmであった。
Hypochlorous acid gas was dissipated in the test room in advance for 1 hour to make the gas concentration 0.007 ppm, and the test solution for influenza virus was sprayed to continue the operation of the inactivation device. One hour later, the influenza virus The rate of decrease in the infectious titer of the floating amount was examined. As a result, as shown in FIG. 1, after 60 minutes, in a temperature environment of 20 ° C., when the relative humidity is 30% to 35%, the relative humidity is about 1/1700 (see FIG. 1 (A)). When the humidity was 50% to 51%, a decrease in the infectious titer could be confirmed at about 1/9000 (see FIG. 1 (B)). The gas concentration after the 1-hour experiment was 0.012 ppm.
また、30m3の空調されている居室において、換気ルーバのある扉を閉じた状態で、後述する実施例1のO型装置を、約10時間連続運転させた。その温度・湿度の変化は、図2に示したように、温度は約23℃が維持され、湿度は、換気ルーバから廊下の空気が導入されているだけでも、O型装置による加湿は認められず、一般的な用途の居室においては湿度過多となる可能性がないことを確認した。
Further, in an air-conditioned living room of 30 m 3 , the O-type device of Example 1 described later was continuously operated for about 10 hours with the door having the ventilation louver closed. As for the change in temperature and humidity, as shown in Fig. 2, the temperature is maintained at about 23 ° C, and the humidity is humidified by the O-type device even if the air in the corridor is introduced from the ventilation louver. However, it was confirmed that there is no possibility of excessive humidity in a living room for general use.
以下、本発明の出発点となった実施例と、2つの実施例と、1つの比較例とによる、次亜塩素酸溶液を旋回・揺動させながら発生させた次亜塩素酸ガス(以下、ガスという。)の発生量、発生時間、それに伴う水分放出量の測定結果を示しつつ、インフルエンザウイルスの失活効果を説明する。理解を容易にするために、実施例1、実施例2、実施例3、比較例1の形態・作用を具体的に説明してから、それらの効果を比較して説明する。
Hereinafter, the hypochlorous acid gas generated while swirling and rocking the hypochlorous acid solution according to the example, the two examples, and one comparative example, which was the starting point of the present invention (hereinafter, the present invention). The inactivating effect of the influenza virus will be explained while showing the measurement results of the amount of gas generated, the time of occurrence, and the amount of water released accordingly. In order to facilitate understanding, the forms and actions of Example 1, Example 2, Example 3, and Comparative Example 1 will be specifically described, and then their effects will be compared and described.
実施例1の装置として、図3を参照して、インフルエンザウイルスの失活装置1(以下、O型装置という)を説明する。O型装置は、全体形状が直径17cmの球体形状をなし、分割可能な上部本体10と下部本体20とからなっている。上部本体には、空気循環手段として、図示していない電源から電力を供給された駆動手段としてモータ11が備えられている。モータの下方部には、モータの駆動軸の周りに軸動される直径9cmの円盤12が装着され、円盤の下方が空気循環部13とされている。円盤の天面には、放射状に伸びる突設片14が付設されている。円盤12の回転数は、1分間300回転とされている。下部本体20は、次亜塩素酸溶液の貯留部とされている。次亜塩素酸溶液は、顆粒剤(株式会社TMTシステム:商品名「ジアウォータ・ホワイトサンド」)を蒸留水に溶解して作成したpH4.14、濃度97ppmの次亜塩素酸溶液を使用した。
As the device of the first embodiment, the influenza virus inactivating device 1 (hereinafter referred to as an O-type device) will be described with reference to FIG. The O-type device has a spherical shape with an overall shape of 17 cm in diameter, and is composed of an upper main body 10 and a lower main body 20 that can be divided. The upper main body is provided with a motor 11 as an air circulation means and as a drive means to which electric power is supplied from a power source (not shown). A disk 12 having a diameter of 9 cm, which is axially moved around the drive shaft of the motor, is mounted on the lower portion of the motor, and the lower portion of the disk is the air circulation portion 13. A projecting piece 14 extending radially is attached to the top surface of the disk. The number of rotations of the disk 12 is set to 300 rotations per minute. The lower main body 20 is used as a storage portion for the hypochlorous acid solution. As the hypochlorous acid solution, a hypochlorous acid solution having a pH of 4.14 and a concentration of 97 ppm prepared by dissolving granules (TMT System Co., Ltd .: trade name “Diawater White Sand”) in distilled water was used.
円盤12が軸動されると、円盤に接した空気循環部13の空気が旋回される(矢印A参照)。空気が旋回されると空気に接している次亜塩素酸溶液が空気との面摩擦により旋回されるようになる。次亜塩素酸溶液は旋回されるに連れて、失活装置1の場合には、円盤を軸動させてから約10秒経過すると、液面の周囲の一方が高く、軸芯を挟んで他方が低い傾斜された液面状態とされるようになる。そして、傾斜された液面状態のままで、軸芯の周りを周回するように、液面が揺れ動くように旋回され、液面の頂部がB(一点鎖線頂部)、C(鎖線頂部)、D(実線頂部)(図3参照)と巡回するように旋回揺動される。
When the disk 12 is axially moved, the air in the air circulation portion 13 in contact with the disk is swirled (see arrow A). When the air is swirled, the hypochlorous acid solution in contact with the air is swirled due to surface friction with the air. As the hypochlorous acid solution is swirled, in the case of the deactivating device 1, about 10 seconds after the disk is axially moved, one around the liquid surface is high and the other is sandwiched between the shaft cores. Will be in a low graded liquid level state. Then, while the liquid level is tilted, the liquid level is swirled so as to orbit around the axis, and the tops of the liquid level are B (dashed line top), C (dashed line top), and D. It is swirled and swung so as to circulate with (the top of the solid line) (see FIG. 3).
円盤の軸芯の下方には下方端部が開放された逆円錐形状の軸体15が付設されている。円盤12の軸動に伴い軸体15が軸動されると、下方端部の内部に接している次亜塩素酸溶液が軸体内面の傾斜面に沿って上昇し、円盤と軸体の接続部に設けられた散布孔16から、周囲に次亜塩素酸溶液が放射状に散布される。散布された次亜塩素酸溶液は、容器内面に衝突し、大部分は容器内面に沿って滴り落ちるが、一部の液滴が円盤の周囲に飛散し容器の壁に衝突した液滴が微細化し、円盤の上方にも微細な液滴を放散させ、空気放出口からも液体微粒子の一部が発生されていることが計測された(表1のType O参照)。
An inverted conical shaft body 15 with an open lower end is attached below the shaft core of the disk. When the shaft body 15 is axially moved along with the axial movement of the disk 12, the hypochlorous acid solution in contact with the inside of the lower end portion rises along the inclined surface of the shaft body surface, and the connection between the disk and the shaft body is established. The hypochlorous acid solution is radially sprayed around the spray holes 16 provided in the portion. The sprayed hypochlorous acid solution collides with the inner surface of the container and most of it drips along the inner surface of the container, but some droplets are scattered around the disk and the droplets colliding with the wall of the container are fine. It was measured that a part of the liquid fine particles was also generated from the air outlet (see Type O in Table 1).
上部本体10には、空気取入口17と空気放散口18が形成されている。円盤天面の突設片14の旋回により、円盤周辺部の気圧は円盤中央部の気圧より高くされる。O型装置においては、空気循環部13に対して、空気取入口からの経路と空気放散口への経路とは分離されている。空気取入口17からの円盤中央部への経路が空気導入経路(図3の白塗り矢印参照)とされ、空気循環部の円盤周辺部から空気放出口18への経路が空気放出経路(図3の黒塗り矢印参照)とされている。円盤12の軸動だけで、容器外部から導入した空気にガスを含ませ、容器外部に放散させるため、専用の加圧装置が備えられていない。専用の加圧装置により、空気を次亜塩素酸溶液の液面に噴きつけていないため、液滴・液体微粒子が発生しにくい。
The upper main body 10 is formed with an air intake port 17 and an air emission port 18. Due to the rotation of the projecting piece 14 on the top surface of the disk, the air pressure around the disk is made higher than the air pressure at the center of the disk. In the O-type device, the path from the air intake and the path to the air dissipation port are separated from each other with respect to the air circulation unit 13. The path from the air intake 17 to the center of the disk is the air introduction path (see the white arrow in FIG. 3), and the path from the periphery of the disk in the air circulation section to the air discharge port 18 is the air release path (FIG. 3). (See the black arrow in). Since the air introduced from the outside of the container is impregnated with gas and dissipated to the outside of the container only by the axial movement of the disk 12, a dedicated pressurizing device is not provided. Since air is not blown onto the surface of the hypochlorous acid solution by the dedicated pressurizing device, droplets and liquid fine particles are unlikely to be generated.
実施例2のインフルエンザウイルスの失活装置2(以下、A型装置という)を、図4を参照して説明する。失活装置1と同じ構成については、図面に同一の符号を付して説明を省略している。A型装置は、O型装置の円盤の軸芯の下方に設けられた軸体の開放された下方端部がない点を除き、O型装置と共通であるが、軸体が逆円錐形状でなくてもよく、円盤と軸体の接続部に散布孔がなくてもよいのは勿論のことである。
The influenza virus inactivating device 2 (hereinafter referred to as type A device) of Example 2 will be described with reference to FIG. The same configuration as that of the deactivating device 1 is designated by the same reference numerals in the drawings, and the description thereof is omitted. The A-type device is common to the O-type device except that there is no open lower end of the shaft body provided below the axis of the disk of the O-type device, but the shaft body has an inverted conical shape. Of course, it does not have to be, and the connection portion between the disk and the shaft body does not have to have a spray hole.
図4においては液面の頂部の一つの態様(D)しか示していないが、頂部が旋回揺動されるのはO型装置と同様である。A型装置においては、空気との面摩擦による次亜塩素酸溶液の全体の旋回揺動の速さよりも、軸体の周囲に接している次亜塩素酸溶液の部分の旋回の速さが速い。そのため次亜塩素酸溶液の旋回揺動に連れて、次亜塩素酸溶液のいずれかの位置に、位置を変えて渦流19が発生・消滅するようになり、次亜塩素酸溶液が均一に攪拌されやすく全体の濃度が均一とされやすい。
Although FIG. 4 shows only one aspect (D) of the top of the liquid surface, the top is swirled and swung in the same manner as the O-type device. In the A-type device, the swirling speed of the part of the hypochlorous acid solution in contact with the periphery of the shaft body is faster than the swirling speed of the entire hypochlorous acid solution due to surface friction with air. .. Therefore, as the hypochlorous acid solution swirls and swings, the vortex flow 19 is generated and disappears by changing the position to any position of the hypochlorous acid solution, and the hypochlorous acid solution is uniformly stirred. It is easy to make the whole concentration uniform.
実施例3のインフルエンザウイルスの失活装置3(以下、B型装置という)を、図5を参照して説明する。B型装置は、O型装置の円盤の軸芯の下方に設けられた軸体を撤去させている。B型装置においては、次亜塩素酸溶液の旋回揺動は、空気との面摩擦のみにより発生されている。
The influenza virus inactivating device 3 (hereinafter referred to as a B-type device) of Example 3 will be described with reference to FIG. In the B-type device, the shaft body provided below the shaft core of the disk of the O-type device is removed. In the B-type apparatus, the swirling fluctuation of the hypochlorous acid solution is generated only by the surface friction with the air.
そのため次亜塩素酸溶液が旋回されることによる、液面の周囲の一方が高く、軸芯を挟んで他方が低い液面の傾斜面の勾配は、O型装置、A型装置と比べて小さくなっており、次亜塩素酸溶液の旋回揺動の速さも、O型装置、A型装置と比べて緩やかである。これにより、空気循環部に液滴・液体微粒子が発生されず、容器の外部への水分放散量は、極めて小さくなるという特徴がある。
Therefore, the gradient of the inclined surface of the liquid surface, which is high on one side around the liquid surface and low on the other side across the axis, due to the swirling of the hypochlorous acid solution, is smaller than that of the O-type device and the A-type device. The speed of the swirling swing of the hypochlorous acid solution is also slower than that of the O-type device and the A-type device. As a result, droplets and liquid fine particles are not generated in the air circulation portion, and the amount of water released to the outside of the container is extremely small.
比較例1のインフルエンザウイルスの失活装置4(以下、C型装置という)を、図6を参照して説明する。C型装置は、A型装置の円盤の軸芯の下方に設けられた軸体の下端部の両側方に攪拌板体21を付設させている。C型装置においては、A型装置の次亜塩素酸溶液の旋回揺動の動きに加えて、攪拌板体21の軸動により次亜塩素酸溶液が激しく攪拌される。そのため、軸体の接液部の近傍において、次亜塩素酸溶液の表面から溶液の中に空気が引き込まれ、溶液を泡立たせるような状態22を伴いながら旋回揺動された。ただし円盤の天面は次亜塩素酸溶液に濡れた状態とはされておらず、容器外への液滴・液体微粒子の放散は認められなかった。
The influenza virus inactivating device 4 (hereinafter referred to as C-type device) of Comparative Example 1 will be described with reference to FIG. In the C-type device, stirring plate bodies 21 are attached to both sides of the lower end portion of the shaft body provided below the shaft core of the disk of the A-type device. In the C-type device, the hypochlorous acid solution is violently stirred by the axial movement of the stirring plate 21 in addition to the swirling and rocking motion of the hypochlorous acid solution of the A-type device. Therefore, in the vicinity of the wetted portion of the shaft body, air was drawn into the solution from the surface of the hypochlorous acid solution, and the solution was swirled and swung with a state 22 in which the solution was bubbling. However, the top surface of the disk was not wet with the hypochlorous acid solution, and no droplets or liquid fine particles were observed to be emitted to the outside of the container.
ここで、O型装置とA型装置の失活装置の外部に飛散させる粒子径別の液体微粒子数の濃度について説明する。液体微粒子数濃度は、1.2m3のグローブボックス内に、O型装置とA型装置のいずれか一方を設置し、60分間運転させて、吹き出し空気口から30cm離れた位置の1リットルの1リットルの気体中に含まれていた液体微粒子数の濃度を半導体レーザ式パーティクルカウンタにより、粒子径別に測定した。O型装置とA型装置の2種の装置について、夫々10回測定を実施し、その平均値を求めた。その結果は、表1に示している。
Here, the concentration of the number of liquid fine particles for each particle size scattered to the outside of the deactivating device of the O-type device and the A-type device will be described. The concentration of liquid fine particles is 1 liter of 1 liter at a position 30 cm away from the blowout air port by installing either the O-type device or the A-type device in a glove box of 1.2 m 3 and operating it for 60 minutes. The concentration of the number of liquid fine particles contained in a liter of gas was measured by particle size with a semiconductor laser particle counter. Measurements were carried out 10 times for each of the two types of devices, the O-type device and the A-type device, and the average value was calculated. The results are shown in Table 1.
表1によればO型装置の場合には比較的粒子径の小さな直径0.3μm~0.5μmについては1730の液体微粒子数濃度が認められた。また、腐食や脱色をさせやすいとされている直径1μm以上についても僅かな量の液体微粒子数濃度が認められた。これは円盤から容器の内面に飛散した次亜塩素酸溶液の粒子が細粒化することが原因によると認められる。一方、粒子径の大きな直径5μmを超える液体微粒子の発生は認められなかった。図2に示したように一般居室であれば、居室内の湿度の増加をさせるほどの量の液体微粒子数濃度はO型装置によっても発生されていない。
According to Table 1, in the case of the O-type apparatus, a concentration of 1730 liquid fine particles was observed for a diameter of 0.3 μm to 0.5 μm having a relatively small particle diameter. In addition, a small amount of liquid fine particle number concentration was observed even for diameters of 1 μm or more, which are said to be easily corroded or decolorized. It is considered that this is due to the fine particles of the hypochlorous acid solution scattered from the disk to the inner surface of the container. On the other hand, no generation of liquid fine particles having a large particle diameter exceeding 5 μm was observed. As shown in FIG. 2, in the case of a general living room, the concentration of the number of liquid fine particles in an amount sufficient to increase the humidity in the living room is not generated even by the O-type device.
一方、A型装置の場合には、O型装置に比較して、すべての粒子径において、ほとんど液体微粒子の発生は認められなかった。B型装置及びC型装置は、A型装置と同様に、円盤により次亜塩素酸溶液の粒子を飛散させないため、すべての粒子径についてA型装置と同様に、装置外には、液体微粒子をほとんど発生させないと推定できる。
On the other hand, in the case of the A-type device, almost no liquid fine particles were observed at all particle sizes as compared with the O-type device. Like the A-type device, the B-type device and the C-type device do not scatter the particles of the hypochlorous acid solution by the disk. Therefore, as with the A-type device, liquid fine particles are placed outside the device for all particle sizes. It can be estimated that it hardly occurs.
また、運転開始から約12時間を目途として、表2には、各失活装置からの水分放出速度とガスの総発生量の比較表を示し、図7には、各失活装置からの各時間までのガスの総発生量をグラフで示している。なおB型装置とC型装置は、4時間経過後にはガスの発生がほとんど認められなくなったため、4時間で計測を打ち切っている。実験は1.25m3の気流が発生しない20℃の密閉空間内において、それぞれの失活装置を駆動させて行った。
In addition, about 12 hours from the start of operation, Table 2 shows a comparison table of the water release rate from each deactivating device and the total amount of gas generated, and FIG. 7 shows each deactivating device. The graph shows the total amount of gas generated up to the hour. In the B-type device and the C-type device, almost no gas was generated after 4 hours, so the measurement was discontinued in 4 hours. The experiment was carried out by driving each deactivating device in a closed space at 20 ° C. where an air flow of 1.25 m 3 was not generated.
具体的には、12時間の1時間毎について、時間毎のガス発生量を把握できるように、ガス発生速度の勾配が描ける測定数の測定を行い、ガス発生速度の関数式を演算した。そして各時間のガス発生速度の関数式により時間毎のガス発生量を演算し、それらを合算してガスの総発生量を求めている。装置外への水分放出速度は次亜塩素酸溶液の減少量を計測時間で除して求めている。
Specifically, for every hour of 12 hours, the number of measurements that can draw the gradient of the gas generation rate was measured so that the amount of gas generated for each hour could be grasped, and the functional formula of the gas generation rate was calculated. Then, the amount of gas generated for each hour is calculated by the functional expression of the gas generation rate at each time, and the total amount of gas generated is calculated by adding them up. The rate of water release to the outside of the device is determined by dividing the amount of decrease in the hypochlorous acid solution by the measurement time.
まず、図7を参照して、各実施例に示した失活装置からの次亜塩素酸ガス発生速度について説明する。図7において△印を付した破線はB型装置のガスの総発生量(その破線の勾配はガス発生速度:他の失活装置についても同じ)を示し、□印を付した一点鎖線はC型装置、○印を付した直線はA型装置、×印を付した破線はO型装置のガスの総発生量を示している。図7において、夫々の印を付した点が測定点を示している。
First, with reference to FIG. 7, the hypochlorous acid gas generation rate from the deactivating device shown in each embodiment will be described. In FIG. 7, the broken line marked with Δ indicates the total amount of gas generated by the B-type device (the gradient of the broken line is the gas generation rate: the same applies to other deactivating devices), and the alternate long and short dash line marked with □ is C. The type device, the straight line marked with a circle indicates the type A device, and the broken line marked with a cross indicates the total amount of gas generated by the type O device. In FIG. 7, the points marked with each indicate the measurement points.
運転初期2時間におけるガス発生量の大きさは、概ね、B型装置(図7のType B)、C型装置(図7のType C)、O型装置(図7のType O)、A型装置(図7のType A)の順に小さくなっている。しかし、運転時間が2時間以上になると、C型装置とB型装置は、折れ線の勾配が小さくなりガス発生速度が減少すると共に、4時間以上はガスの発生がほとんど認められなかった。運転時間が8時間までA型装置がO型装置よりもガス発生速度が大きい。8時間以上になるとA型装置はO型装置よりもガス発生速度がやや小さくなる。
The magnitude of the amount of gas generated in the initial 2 hours of operation is generally B-type device (Type B in FIG. 7), C-type device (Type C in FIG. 7), O-type device (Type O in FIG. 7), and A-type device. It becomes smaller in the order of the device (Type A in FIG. 7). However, when the operating time was 2 hours or more, the gradient of the polygonal line of the C-type device and the B-type device was reduced, the gas generation rate was reduced, and almost no gas was generated for 4 hours or more. The gas generation rate of the A-type device is higher than that of the O-type device up to an operating time of 8 hours. After 8 hours or more, the gas generation rate of the A-type device is slightly lower than that of the O-type device.
表2、図7に示したようにガス発生量の大きさ、ガス発生速度、ガス発生の持続性の点では、O型装置とA型装置は、ほぼ同等の性能と判定できる。しかし、O型装置は、表2に示したように円盤の下面が著しく次亜塩素酸溶液に濡れた状態となり、表1に示したように装置外部に所定の粒子径の液体微粒子の放散が認められた。一方、A型装置、B型装置、C型装置は、容器内面下方部を除いては、次亜塩素酸溶液に濡れた状態となっておらず、装置外部へ出るような液体微粒子の発生はほとんどないと認められる。これは表1によっても裏付けられている。
As shown in Table 2 and FIG. 7, it can be judged that the O-type device and the A-type device have almost the same performance in terms of the magnitude of the amount of gas generated, the gas generation rate, and the sustainability of gas generation. However, in the O-type apparatus, as shown in Table 2, the lower surface of the disk becomes significantly wet with the hypochlorous acid solution, and as shown in Table 1, liquid fine particles having a predetermined particle size are emitted to the outside of the apparatus. Admitted. On the other hand, the A-type device, the B-type device, and the C-type device are not in a wet state with the hypochlorous acid solution except for the lower part of the inner surface of the container, and the generation of liquid fine particles that go out to the outside of the device is generated. It is recognized that there is almost no. This is also supported by Table 1.
総合的には、ガス発生量が最も大きく、ガス発生の持続時間も長いA型装置が最も良いインフルエンザウイルスの不活化効果を有すると判定できる。また、O型装置の場合でも、A型装置と同様に、水分放出量が少なく、A型装置に次いでガス発生量が最も大きく、ガス発生の持続時間も長い点から、僅かな液体微粒子の発生を許容すれば、次にインフルエンザウイルスの不活化効果を有すると判定できる。なお、B型装置は、4時間を経過すると急激にガス発生量が減少する反面、初期のガス発生速度が速いことから、例えば、短時間単位で診療される診療所などへの適用は好適であると判断される。比較例1のC型装置については、2時間を過ぎた時点から急激にガス発生量が減少し、ガスの総発生量も少ないという課題を残した。
Overall, it can be determined that the type A device, which produces the largest amount of gas and has a long duration of gas generation, has the best inactivating effect on influenza virus. Further, even in the case of the O-type device, as in the case of the A-type device, the amount of water released is small, the amount of gas generated is the second largest after the A-type device, and the duration of gas generation is long, so that a small amount of liquid fine particles are generated. If is allowed, then it can be determined that the influenza virus has an inactivating effect. It should be noted that the B-type device is suitable for application to, for example, a clinic where medical treatment is performed in short-time units because the amount of gas generated decreases sharply after 4 hours, but the initial gas generation rate is high. It is judged that there is. Regarding the C-type apparatus of Comparative Example 1, the problem that the amount of gas generated sharply decreased after 2 hours and the total amount of gas generated was also small remained.
(その他)
・本発明に適用される次亜塩素酸溶液の酸性度はpH3.5から4.2が好適であるが限定されず、次亜塩素酸溶液の溶液濃度との関係において決定されればよい。例えば、溶液濃度が100ppmである場合に、pH値が小さくなると次亜塩素酸ガスの発生量が多くなる代わりに塩素ガスの発生のリスクが増す。一方、pH値を大きくすると塩素ガス発生のリスクがなくなる代わりに次亜塩素酸ガスの発生が少なくなる。次亜塩素酸溶液の濃度は臭いがしない範囲で適宜決定されればよい。
・実施例1から実施例3は、小型の失活装置の実施例を説明したが、その大きさは限定されない。空気との接液表面積を限定して、空気の旋回により次亜塩素酸溶液を旋回揺動させる失活装置であればよく、建物の空調手段の一部に本発明を適用してもよいことは勿論のことである。
・上記の実施例では、球体形状の失活装置を示したが、次亜塩素酸溶液が旋回揺動されればよく、容器の形状は円筒形状であってもよいことは勿論のことである。 (Other)
-The acidity of the hypochlorous acid solution applied to the present invention is preferably pH 3.5 to 4.2, but is not limited, and may be determined in relation to the solution concentration of the hypochlorous acid solution. For example, when the solution concentration is 100 ppm, when the pH value becomes small, the amount of hypochlorous acid gas generated increases, but the risk of chlorine gas generation increases. On the other hand, when the pH value is increased, the risk of chlorine gas generation is eliminated, but the generation of hypochlorous acid gas is reduced. The concentration of the hypochlorous acid solution may be appropriately determined as long as it does not smell.
-Although Examples 1 to 3 have described examples of a small deactivating device, the size thereof is not limited. Any deactivation device that limits the surface area of contact with air and swirls the hypochlorous acid solution by swirling the air may be used, and the present invention may be applied to a part of the air conditioning means of the building. Of course.
-In the above embodiment, the spherical shape deactivating device is shown, but it goes without saying that the hypochlorous acid solution may be swirled and swung, and the container shape may be cylindrical. ..
・本発明に適用される次亜塩素酸溶液の酸性度はpH3.5から4.2が好適であるが限定されず、次亜塩素酸溶液の溶液濃度との関係において決定されればよい。例えば、溶液濃度が100ppmである場合に、pH値が小さくなると次亜塩素酸ガスの発生量が多くなる代わりに塩素ガスの発生のリスクが増す。一方、pH値を大きくすると塩素ガス発生のリスクがなくなる代わりに次亜塩素酸ガスの発生が少なくなる。次亜塩素酸溶液の濃度は臭いがしない範囲で適宜決定されればよい。
・実施例1から実施例3は、小型の失活装置の実施例を説明したが、その大きさは限定されない。空気との接液表面積を限定して、空気の旋回により次亜塩素酸溶液を旋回揺動させる失活装置であればよく、建物の空調手段の一部に本発明を適用してもよいことは勿論のことである。
・上記の実施例では、球体形状の失活装置を示したが、次亜塩素酸溶液が旋回揺動されればよく、容器の形状は円筒形状であってもよいことは勿論のことである。 (Other)
-The acidity of the hypochlorous acid solution applied to the present invention is preferably pH 3.5 to 4.2, but is not limited, and may be determined in relation to the solution concentration of the hypochlorous acid solution. For example, when the solution concentration is 100 ppm, when the pH value becomes small, the amount of hypochlorous acid gas generated increases, but the risk of chlorine gas generation increases. On the other hand, when the pH value is increased, the risk of chlorine gas generation is eliminated, but the generation of hypochlorous acid gas is reduced. The concentration of the hypochlorous acid solution may be appropriately determined as long as it does not smell.
-Although Examples 1 to 3 have described examples of a small deactivating device, the size thereof is not limited. Any deactivation device that limits the surface area of contact with air and swirls the hypochlorous acid solution by swirling the air may be used, and the present invention may be applied to a part of the air conditioning means of the building. Of course.
-In the above embodiment, the spherical shape deactivating device is shown, but it goes without saying that the hypochlorous acid solution may be swirled and swung, and the container shape may be cylindrical. ..
・本発明は、高齢者住宅、一般住宅のほか、診療所、病院、学習塾等の種々の用途に適用できることは勿論のことである。例えば、学習塾等の営業時間が短い用途の場合には、4時間程度のガス発生時間であっても運転初期にガスを発生させやすい失活装置を適用すればよく、高齢者用の個室の場合には、就寝時に備えて、長時間ガスを発生させ続ける失活装置を適用すればよい。
・空間の大きさが変われば、それに応じて失活装置の数を変更すればよいこと、容器の大きさを変更すればよいことは勿論のことである。
・今回開示された実施の形態はすべての点で例示であって、制限的なものではないと考えられるべきである。本発明の技術的範囲は、上記した説明に限られず、請求の範囲と均等の意味および範囲内でのすべての変更が含まれることが意図される。 -It goes without saying that the present invention can be applied to various uses such as clinics, hospitals, cram schools, etc., in addition to elderly housing and general housing. For example, in the case of a cram school or the like where the business hours are short, it is sufficient to apply a deactivation device that easily generates gas at the initial stage of operation even if the gas generation time is about 4 hours. In that case, a deactivating device that keeps generating gas for a long time may be applied in preparation for going to bed.
-If the size of the space changes, it goes without saying that the number of deactivating devices should be changed and the size of the container should be changed accordingly.
-The embodiments disclosed this time should be considered to be exemplary in all respects and not restrictive. The technical scope of the present invention is not limited to the above description, and is intended to include all modifications within the meaning and scope equivalent to the claims.
・空間の大きさが変われば、それに応じて失活装置の数を変更すればよいこと、容器の大きさを変更すればよいことは勿論のことである。
・今回開示された実施の形態はすべての点で例示であって、制限的なものではないと考えられるべきである。本発明の技術的範囲は、上記した説明に限られず、請求の範囲と均等の意味および範囲内でのすべての変更が含まれることが意図される。 -It goes without saying that the present invention can be applied to various uses such as clinics, hospitals, cram schools, etc., in addition to elderly housing and general housing. For example, in the case of a cram school or the like where the business hours are short, it is sufficient to apply a deactivation device that easily generates gas at the initial stage of operation even if the gas generation time is about 4 hours. In that case, a deactivating device that keeps generating gas for a long time may be applied in preparation for going to bed.
-If the size of the space changes, it goes without saying that the number of deactivating devices should be changed and the size of the container should be changed accordingly.
-The embodiments disclosed this time should be considered to be exemplary in all respects and not restrictive. The technical scope of the present invention is not limited to the above description, and is intended to include all modifications within the meaning and scope equivalent to the claims.
1,2,3,4…失活装置、
10…上部本体、20…下部本体、
11…モータ、12…円盤、13…空気循環部、14…突設片、
15…軸体、16…散布孔、17…空気取入口、18…空気放散口、
21…攪拌板体、22…泡立たせるような状態 1,2,3,4 ... Inactivation device,
10 ... upper body, 20 ... lower body,
11 ... motor, 12 ... disk, 13 ... air circulation part, 14 ... projecting piece,
15 ... shaft body, 16 ... spray hole, 17 ... air inlet, 18 ... air outlet,
21 ... Stirring plate, 22 ... Foaming state
10…上部本体、20…下部本体、
11…モータ、12…円盤、13…空気循環部、14…突設片、
15…軸体、16…散布孔、17…空気取入口、18…空気放散口、
21…攪拌板体、22…泡立たせるような状態 1,2,3,4 ... Inactivation device,
10 ... upper body, 20 ... lower body,
11 ... motor, 12 ... disk, 13 ... air circulation part, 14 ... projecting piece,
15 ... shaft body, 16 ... spray hole, 17 ... air inlet, 18 ... air outlet,
21 ... Stirring plate, 22 ... Foaming state
Claims (7)
- 容器と空気循環手段とからなるインフルエンザウイルスの失活装置において、
前記容器が、次亜塩素酸溶液の貯留部と、空気循環部と、空気取入口と、空気放出口とを備え、
前記貯留部と前記空気循環部とは、断面形状が円断面形状をなし、夫々が同一軸芯に配され、
前記空気循環手段が、前記同一軸芯の周りに軸動される円盤を有し、
前記貯留部において、前記次亜塩素酸溶液が、前記円盤の軸動に連れて、前記空気と前記次亜塩素酸溶液との面摩擦により、液滴・液体微粒子を発生させない液相状態のまま旋回揺動され、前記次亜塩素酸溶液から前記空気の中に次亜塩素酸ガスが発生され、
前記円盤の軸動による前記空気取入口と前記空気放出口との気圧差により、空気が前記空気循環部の中に導入されると共に前記次亜塩素酸ガスを含んだ空気が前記空気循環部から放出され、前記容器の外部に、水分放出量を抑制させた状態で次亜塩素酸ガスが放出される、
ことを特徴とするインフルエンザウイルスの失活装置。 In an influenza virus inactivating device consisting of a container and air circulation means
The container includes a hypochlorous acid solution storage section, an air circulation section, an air inlet, and an air outlet.
The storage portion and the air circulation portion have a circular cross-sectional shape, and each is arranged on the same axis.
The air circulation means has a disk that is axially driven around the same axis.
In the storage portion, the hypochlorous acid solution remains in a liquid phase state in which droplets and liquid fine particles are not generated due to surface friction between the air and the hypochlorous acid solution as the disk moves. It is swirled and swung, and hypochlorous acid gas is generated in the air from the hypochlorous acid solution.
Due to the pressure difference between the air inlet and the air outlet due to the axial movement of the disk, air is introduced into the air circulation section and air containing the hypochlorous acid gas is released from the air circulation section. Hypochlorite gas is released to the outside of the container with the amount of water released suppressed.
Influenza virus inactivating device characterized by that. - 前記円盤の中心軸から垂設され、前記次亜塩素酸溶液の中に浸入する軸体を有し、
前記軸体の先端が閉塞されており、
前記軸体の軸動に連れて、前記液相状態のまま、前記次亜塩素酸溶液の中において、前記軸体の周囲に渦流が発生される、
ことを特徴とする請求項1のインフルエンザウイルスの失活装置。 It has a shaft body that is vertically hung from the central shaft of the disk and penetrates into the hypochlorous acid solution.
The tip of the shaft body is blocked,
Along with the axial movement of the shaft body, a vortex is generated around the shaft body in the hypochlorous acid solution while maintaining the liquid phase state.
The inactivating device for influenza virus according to claim 1. - 容器と空気循環手段とからなるインフルエンザウイルスの失活装置において、
前記容器が、次亜塩素酸溶液の貯留部と、空気循環部と、空気取入口と、空気放出口とを備え、
前記貯留部と前記空気循環部とは、断面形状が円断面形状をなし、夫々が同一軸芯に配され、
前記空気循環手段が、前記同一軸芯の周りに軸動される軸体を備えた円盤を有し、
前記軸体が、その内部に筒部を有すると共に前記円盤の中心軸から垂設され、
前記筒部が、逆円錐形状をなし、その上端部の周囲に散布孔を有すると共に下端部が前記次亜塩素酸溶液の中に浸入される開放部を有し、
前記円盤の軸動に連れて、
前記次亜塩素酸溶液が、前記開放部から前記筒部の内壁を伝わって上昇され、前記散布孔から前記容器の内壁に放散されて容器の内面を濡らし、前記貯留部においては、前記空気と前記次亜塩素酸溶液との面摩擦により旋回揺動され、
前記空気循環部に接している次亜塩素酸溶液から前記空気の中に次亜塩素酸ガスが発生され、
前記円盤の軸動による前記空気取入口と前記空気放出口との気圧差により、前記失活装置外の空気が前記空気循環部の中に導入されると共に前記次亜塩素酸ガスを含んだ空気が前記空気循環部から放出され、前記容器の外部に、水分放出量を抑制させた状態で次亜塩素酸ガスを放出させる、
ことを特徴とするインフルエンザウイルスの失活装置。 In an influenza virus inactivating device consisting of a container and air circulation means
The container includes a hypochlorous acid solution storage section, an air circulation section, an air inlet, and an air outlet.
The storage portion and the air circulation portion have a circular cross-sectional shape, and each is arranged on the same axis.
The air circulation means has a disk with a shaft body that is axially moved around the same shaft core.
The shaft body has a tubular portion inside the shaft body and is vertically hung from the central shaft of the disk.
The tubular portion has an inverted conical shape, has a spray hole around the upper end portion thereof, and has an open portion at which the lower end portion is penetrated into the hypochlorous acid solution.
With the axial movement of the disk,
The hypochlorous acid solution is raised from the open portion along the inner wall of the tubular portion, and is dissipated from the spray hole to the inner wall of the container to wet the inner surface of the container. It swirls and swings due to surface friction with the hypochlorous acid solution.
Hypochlorous acid gas is generated in the air from the hypochlorous acid solution in contact with the air circulation portion.
Due to the pressure difference between the air inlet and the air outlet due to the axial movement of the disk, the air outside the deactivating device is introduced into the air circulation section, and the air containing the hypochlorite gas is introduced. Is released from the air circulation portion, and hypochlorite gas is released to the outside of the container in a state where the amount of water released is suppressed.
Influenza virus inactivating device characterized by that. - 前記容器が、上部本体と下部本体とからなる球体とされ、
前記下部本体が、前記貯留部とされ、
前記上部本体が、前記空気循環部とされると共に、前記空気循環手段と、前記空気取入口と、前記空気放出口とを備え、
前記円盤が、天面に突設された放射状に伸びる突設片を有し、
前記円盤の軸動に伴った前記突設片の軸動により、円盤周辺部の気圧が円盤中央部の気圧より高くされ、前記円盤中央部に前記空気取入口から空気が導入され、前記空気放出口に前記円盤周辺部から次亜塩素酸ガスを含んだ空気が放出される、
ことを特徴とする請求項1乃至請求項3のいずれか一項に記載のインフルエンザウイルスの失活装置。 The container is a sphere composed of an upper body and a lower body.
The lower body is used as the storage unit.
The upper main body is provided with the air circulation unit, the air circulation means, the air intake port, and the air discharge port.
The disk has a projecting piece that extends radially on the top surface and has a projecting piece.
Due to the axial movement of the projecting piece accompanying the axial movement of the disk, the air pressure in the peripheral portion of the disk is made higher than the air pressure in the central portion of the disk, air is introduced into the central portion of the disk from the air intake port, and the air is released. Air containing hypochlorous acid gas is discharged from the periphery of the disk to the outlet.
The influenza virus inactivating device according to any one of claims 1 to 3, wherein the influenza virus is activated. - インフルエンザウイルスの失活方法において、
水平に旋回させた空気との面摩擦により、次亜塩素酸溶液を前記空気に連れて旋回揺動させ、
液滴・液体微粒子を発生させない液相状態のまま、水分放出量を抑えて次亜塩素酸ガスを放散させ、インフルエンザウイルスを失活させる空間に0.007ppm以上の次亜塩素酸ガスを充満させることにより、相対湿度が30%以上50%以下の湿度環境においてもインフルエンザウイルスを失活させることが可能とされている、
ことを特徴とするインフルエンザウイルスの失活方法。 In the method of inactivating influenza virus
Due to the surface friction with the horizontally swirled air, the hypochlorous acid solution is swirled and swung with the air.
Hypochlorous acid gas is released by suppressing the amount of water released while maintaining a liquid phase state that does not generate droplets or liquid fine particles, and the space for inactivating influenza virus is filled with 0.007 ppm or more of hypochlorous acid gas. Thereby, it is possible to inactivate the influenza virus even in a humidity environment where the relative humidity is 30% or more and 50% or less.
A method of inactivating influenza virus, which is characterized by that. - インフルエンザウイルスの失活方法において、
旋回揺動されている前記次亜塩素酸溶液の内部において、前記液相状態のまま、渦流が発生されている、
ことを特徴とする請求項5に記載のインフルエンザウイルスの失活方法。 In the method of inactivating influenza virus
Inside the swirling and oscillating hypochlorous acid solution, a vortex is generated in the liquid phase state.
The method for inactivating an influenza virus according to claim 5, wherein the method is characterized by the above. - 前記水平に旋回された空気の旋回流の径方向内外の気圧差により、前記旋回流の径方向内方部から空気を導入し旋回させ、前記空気に次亜塩素酸ガスを含んだ空気を、前記旋回流の径方向外方部を経由して前記空間に放出させる、
ことを特徴とする請求項5又は請求項6に記載のインフルエンザウイルスの失活方法。 Due to the pressure difference between the inside and outside of the swirling flow of the horizontally swirled air, air is introduced from the inside of the swirling flow in the radial direction and swirled. It is discharged into the space via the radial outer portion of the swirling flow.
The method for inactivating an influenza virus according to claim 5 or 6, wherein the method is characterized by the above.
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010227381A (en) * | 2009-03-27 | 2010-10-14 | Sanyo Electric Co Ltd | Air disinfecting apparatus |
JP2012172923A (en) * | 2011-02-22 | 2012-09-10 | Sharp Corp | Humidifier using electrolytic water |
WO2014170971A1 (en) * | 2013-04-17 | 2014-10-23 | 株式会社Fmi | Chlorine-dioxide-gas generation device and medical-device sterilization box |
JP2018183776A (en) * | 2018-06-19 | 2018-11-22 | マクセルホールディングス株式会社 | Mist generator |
JP2019056514A (en) * | 2017-09-21 | 2019-04-11 | パナソニックIpマネジメント株式会社 | Liquid atomization device and air cleaner or air conditioner using the same |
WO2019188534A1 (en) * | 2018-03-28 | 2019-10-03 | パナソニックIpマネジメント株式会社 | Liquid atomizing device |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010227381A (en) * | 2009-03-27 | 2010-10-14 | Sanyo Electric Co Ltd | Air disinfecting apparatus |
JP2012172923A (en) * | 2011-02-22 | 2012-09-10 | Sharp Corp | Humidifier using electrolytic water |
WO2014170971A1 (en) * | 2013-04-17 | 2014-10-23 | 株式会社Fmi | Chlorine-dioxide-gas generation device and medical-device sterilization box |
JP2019056514A (en) * | 2017-09-21 | 2019-04-11 | パナソニックIpマネジメント株式会社 | Liquid atomization device and air cleaner or air conditioner using the same |
WO2019188534A1 (en) * | 2018-03-28 | 2019-10-03 | パナソニックIpマネジメント株式会社 | Liquid atomizing device |
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