WO2019130252A3 - Methods and intermediates for preparing deutetrabenazine - Google Patents

Methods and intermediates for preparing deutetrabenazine Download PDF

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Publication number
WO2019130252A3
WO2019130252A3 PCT/IB2018/060678 IB2018060678W WO2019130252A3 WO 2019130252 A3 WO2019130252 A3 WO 2019130252A3 IB 2018060678 W IB2018060678 W IB 2018060678W WO 2019130252 A3 WO2019130252 A3 WO 2019130252A3
Authority
WO
WIPO (PCT)
Prior art keywords
deutetrabenazine
intermediates
preparing
methods
preparation
Prior art date
Application number
PCT/IB2018/060678
Other languages
French (fr)
Other versions
WO2019130252A2 (en
Inventor
Sureshbabu JAYACHANDRA
Veera Venkata Srinivasarao ATTANTI
Rathinapandian JABARAJ
Shivakumar CHANDUPATLA
Srinivas KOMMARAJU
Original Assignee
Mylan Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Laboratories Ltd filed Critical Mylan Laboratories Ltd
Publication of WO2019130252A2 publication Critical patent/WO2019130252A2/en
Publication of WO2019130252A3 publication Critical patent/WO2019130252A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Disclosed is a process for the preparation of deutetrabenazine and intermediates useful in the preparation thereof. Disclosed are also process for making amorphous deutetrabenazine.
PCT/IB2018/060678 2017-12-29 2018-12-28 Methods and intermediates for preparing deutetrabenazine WO2019130252A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN201741047280 2017-12-29
IN201741047280 2017-12-29
IN201841006981 2018-02-23
IN201841006981 2018-02-23

Publications (2)

Publication Number Publication Date
WO2019130252A2 WO2019130252A2 (en) 2019-07-04
WO2019130252A3 true WO2019130252A3 (en) 2019-08-08

Family

ID=65409119

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2018/060678 WO2019130252A2 (en) 2017-12-29 2018-12-28 Methods and intermediates for preparing deutetrabenazine

Country Status (1)

Country Link
WO (1) WO2019130252A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3784238A4 (en) * 2018-04-27 2021-12-29 Hetero Labs Ltd. Process for preparation of ((3r,11br)-1,3,4,6,7,11b-hexahydro-9,10-di(methoxy-d)-3-(2-methylpropyl)-2h-benzo[a]quinolizin-2-one
TW202342470A (en) * 2022-02-15 2023-11-01 逸達生物科技股份有限公司 Crystalline (+)-tetrabenazine
CN116212963B (en) * 2023-02-27 2024-01-09 安徽泽升科技股份有限公司 Preparation method of deuterated methyl iodide

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010044981A2 (en) * 2008-09-18 2010-04-22 Auspex Pharmaceutical ,Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
US20150152099A1 (en) * 2013-12-03 2015-06-04 Auspex Pharmaceuticals, Inc. Methods of manufacturing benzoquinoline compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010044981A2 (en) * 2008-09-18 2010-04-22 Auspex Pharmaceutical ,Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
US20150152099A1 (en) * 2013-12-03 2015-06-04 Auspex Pharmaceuticals, Inc. Methods of manufacturing benzoquinoline compounds

Also Published As

Publication number Publication date
WO2019130252A2 (en) 2019-07-04

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