WO2016108206A3 - Processes for preparation of idelalisib and intermediates thereof - Google Patents

Processes for preparation of idelalisib and intermediates thereof Download PDF

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Publication number
WO2016108206A3
WO2016108206A3 PCT/IB2015/060069 IB2015060069W WO2016108206A3 WO 2016108206 A3 WO2016108206 A3 WO 2016108206A3 IB 2015060069 W IB2015060069 W IB 2015060069W WO 2016108206 A3 WO2016108206 A3 WO 2016108206A3
Authority
WO
WIPO (PCT)
Prior art keywords
idelalisib
intermediates
preparation
processes
present application
Prior art date
Application number
PCT/IB2015/060069
Other languages
French (fr)
Other versions
WO2016108206A2 (en
Inventor
Srinivas ORUGANTI
Saikat Sen
Vilas Hareshwar Dahanukar
Rakesh GANORKAR
Ramesh Chakka
Original Assignee
Dr. Reddy’S Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy’S Laboratories Limited filed Critical Dr. Reddy’S Laboratories Limited
Publication of WO2016108206A2 publication Critical patent/WO2016108206A2/en
Publication of WO2016108206A3 publication Critical patent/WO2016108206A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Laser Beam Processing (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present application provides processes for preparation of Idelalisib and intermediates thereof. The present application also provides a process for purification of Idelalisib.
PCT/IB2015/060069 2014-12-31 2015-12-31 Processes for preparation of idelalisib and intermediates thereof WO2016108206A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN6844/CHE/2014 2014-12-31
IN6844CH2014 2014-12-31
IN2493CH2015 2015-05-18
IN2493/CHE/2015 2015-05-18

Publications (2)

Publication Number Publication Date
WO2016108206A2 WO2016108206A2 (en) 2016-07-07
WO2016108206A3 true WO2016108206A3 (en) 2016-08-18

Family

ID=56285111

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/060069 WO2016108206A2 (en) 2014-12-31 2015-12-31 Processes for preparation of idelalisib and intermediates thereof

Country Status (1)

Country Link
WO (1) WO2016108206A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3322708A1 (en) * 2015-07-13 2018-05-23 Synthon BV Method for purifying idelalisib
US10870650B2 (en) 2017-04-24 2020-12-22 Natco Pharma Limited Process for the preparation of amorphous idelalisib
WO2019092253A1 (en) 2017-11-10 2019-05-16 Synthon B.V. Process for preparing idelalisib
CN108409740B (en) * 2018-03-14 2020-05-08 盐城师范学院 Preparation method of Aidallas
WO2019178596A1 (en) 2018-03-16 2019-09-19 Johnson Matthey Public Limited Company Pyridine or n,n-dimethyl acetamide solvated solid state forms of solvated idelalisib, their use and preparation
CN109503430B (en) * 2018-12-29 2021-01-29 浙江东亚药业股份有限公司 O-fluoro-o-imine benzoic acid intermediate compound and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005113556A1 (en) * 2004-05-13 2005-12-01 Icos Corporation Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005113556A1 (en) * 2004-05-13 2005-12-01 Icos Corporation Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
WO2005113554A2 (en) * 2004-05-13 2005-12-01 Icos Corporation Method of preparing 3-phenyl-2-[9h-purin-6-ylamino)-methyl]-3h-quinazolin-4-one and substituted and related compounds

Also Published As

Publication number Publication date
WO2016108206A2 (en) 2016-07-07

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