WO2019119519A1 - 超声激励装置、方法及*** - Google Patents

超声激励装置、方法及*** Download PDF

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WO2019119519A1
WO2019119519A1 PCT/CN2017/120162 CN2017120162W WO2019119519A1 WO 2019119519 A1 WO2019119519 A1 WO 2019119519A1 CN 2017120162 W CN2017120162 W CN 2017120162W WO 2019119519 A1 WO2019119519 A1 WO 2019119519A1
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ultrasonic
signal
excitation
waveform
ultrasonic excitation
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PCT/CN2017/120162
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English (en)
French (fr)
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邱维宝
孙武
周娟
言文斌
李锦成
郑海荣
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深圳先进技术研究院
中国科学院大学
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
    • G01S15/88—Sonar systems specially adapted for specific applications
    • G01S15/89—Sonar systems specially adapted for specific applications for mapping or imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A61N2007/0026—Stimulation of nerve tissue

Definitions

  • the present invention relates to the field of medical device technology, and in particular to an ultrasonic excitation device, method and system.
  • the traditional neuromodulation method generally uses a single frequency single waveform excitation, such as sine wave or square wave excitation, but the single frequency excitation signal cannot fully exert the performance of the ultrasonic transducer.
  • current device hardware uses a method similar to a direct digital frequency synthesizer to generate an excitation signal, which is less flexible.
  • an object of the present invention is to provide an ultrasonic excitation device, method and system, which can flexibly configure ultrasonic excitation parameters of respective channels to generate an excitation signal of an arbitrary waveform, thereby fully utilizing ultrasonic transduction Performance, better ultrasonic mechanics and thermal effects.
  • a preferred embodiment of the present invention provides an ultrasonic excitation device that includes a waveform generator, a power amplifier, and an ultrasound transducer array.
  • a waveform excitation signal of each channel is generated according to the ultrasonic excitation parameters.
  • the power amplifier is electrically connected to the waveform generator for power amplifying the waveform excitation signal to generate a high voltage driving signal and input to the ultrasonic transducer array.
  • the ultrasonic transducer array is configured to generate ultrasonic waves on respective array elements according to the high voltage driving signal, wherein the ultrasonic transducer array includes a plurality of array elements, and each array element corresponds to one channel.
  • the ultrasonic excitation parameter includes at least one of a waveform shape, a signal frequency, a signal amplitude, and a focus parameter
  • the signal frequency includes a single frequency waveform frequency or a composite frequency waveform frequency
  • the waveform generator includes a communication interface, a signal processor, and an array of digital to analog converters.
  • the signal processor is electrically connected to the communication interface and the digital-to-analog converter array, respectively, for controlling the communication interface to receive an ultrasonic excitation parameter of each channel, and generating a corresponding channel according to the ultrasonic excitation parameter.
  • a waveform excitation signal which is further written into a corresponding digital-to-analog converter in the digital-to-analog converter array to convert the waveform excitation signal into an analog signal and output through the digital-to-analog converter To the power amplifier.
  • the signal processor is further configured to control the communication interface to receive a control parameter, and control the digital-to-analog converter array and the working state of the power amplifier according to the control parameter, where
  • the control parameter includes at least one or a combination of a power amplification factor, a pulse repetition frequency, a transmission control parameter, and an echo reception control parameter.
  • the signal processor comprises a field programmable gate array or a digital signal processor.
  • the signal processor includes:
  • a communication processing unit for controlling the communication interface
  • a beam combining unit for phase delaying a waveform excitation signal to be generated according to a focus parameter.
  • the ultrasonic excitation device further includes an echo acquisition module and an echo imaging module;
  • the echo acquisition module is configured to perform signal processing after acquiring an ultrasonic echo signal detected by the ultrasound transducer array, and convert the processed ultrasonic echo signal into a digital signal;
  • the echo imaging module is electrically connected to the echo collection module, and is configured to perform signal processing on the digital signal according to beamforming parameters to obtain corresponding ultrasonic echo data, and transmit the ultrasonic echo data to The computer device performs ultrasound imaging.
  • the echo acquisition module includes an ultrasound analog front end amplification unit and an analog signal acquisition unit;
  • the ultrasonic analog front end amplification unit is electrically connected to the analog signal acquisition unit, and is configured to send the ultrasonic echo signal to the analog signal acquisition unit for analog-to-digital conversion after preamplification, filtering, and voltage controlled amplification. After that, the digital signal is output.
  • the ultrasonic transducer array includes an excitation probe and an imaging probe;
  • the excitation probe is configured to generate an ultrasonic wave according to a high voltage driving signal
  • the imaging probe is used to detect ultrasound echoes for imaging monitoring.
  • the preferred embodiment of the present invention further provides an ultrasonic excitation method applied to the above ultrasonic excitation device, the method comprising:
  • the waveform generator After obtaining the ultrasonic excitation parameters of the respective channels, the waveform generator generates a waveform excitation signal for each channel according to the ultrasonic excitation parameters, wherein the ultrasonic excitation parameters include a waveform shape, a signal frequency, a signal amplitude, and a focusing parameter. At least one of the signal frequencies comprising a single frequency waveform frequency or a composite frequency waveform frequency;
  • the power amplifier performs power amplification of the waveform excitation signal to generate a high voltage driving signal and input to the ultrasonic transducer array;
  • the ultrasound transducer array generates ultrasound waves on respective array elements according to the high voltage drive signal, wherein the ultrasound transducer array includes a plurality of array elements, each array element corresponding to one channel.
  • a preferred embodiment of the present invention also provides an ultrasonic excitation system including a computer device and the above-described ultrasonic excitation device;
  • the computer device is communicatively coupled to the ultrasonic excitation device for transmitting ultrasonic excitation parameters of each channel to the ultrasonic excitation device;
  • the ultrasonic excitation device generates a corresponding ultrasonic wave based on the ultrasonic excitation parameter, and transmits the ultrasonic echo data to the computer device after acquiring the ultrasonic echo data;
  • the computer device performs ultrasound imaging according to the ultrasound echo data to output a visualization image.
  • the present invention has the following beneficial effects:
  • Embodiments of the present invention provide an ultrasonic excitation device, method, and system. After obtaining ultrasonic excitation parameters of each channel by a waveform generator, a waveform excitation signal of each channel is generated, and the power amplifier amplifies the waveform excitation signal to generate a high voltage driving signal. And input to the ultrasound transducer array, the ultrasound transducer array generates ultrasonic waves on the corresponding array elements according to the high voltage driving signal. Therefore, the ultrasonic excitation parameters of each channel can be flexibly configured to generate an excitation signal of an arbitrary waveform, and the excitation signals of each array element in the ultrasonic transducer array can be independently controlled, thereby fully utilizing the performance of the ultrasonic transducer. , to obtain better ultrasonic mechanical effects as well as thermal effects.
  • FIG. 1 is a structural block diagram of an ultrasonic excitation system according to a preferred embodiment of the present invention
  • 2 is a waveform diagram of an excitation signal in an embodiment
  • FIG. 3 is another structural block diagram of an ultrasonic excitation system according to a preferred embodiment of the present invention.
  • FIG. 4 is another structural block diagram of an ultrasonic excitation system according to a preferred embodiment of the present invention.
  • FIG. 5 is another structural block diagram of an ultrasonic excitation system according to a preferred embodiment of the present invention.
  • FIG. 6 is a schematic flow chart of an ultrasonic excitation method according to a preferred embodiment of the present invention.
  • Icons 10 - ultrasonic excitation system; 100 - ultrasonic excitation device; 110 - waveform generator; 112 - communication interface; 114 - signal processor; 1142 - communication processing unit; - Digital to analog converter array; 120 - power amplifier; 130 - ultrasonic transducer array; 140 - echo acquisition module; 142 - ultrasonic analog front end amplification unit; 144 - analog signal acquisition unit; 150 - echo imaging module; - Computer equipment.
  • Ultrasound diagnosis mainly uses ultrasound echo to obtain imaging information of the tissue, providing clinicians with the necessary diagnostic reference.
  • Ultrasound therapy utilizes the mechanical, thermal, and cavitation effects of ultrasound for the treatment of disease. Specifically, it can be divided into high-dose ultrasonic thermal ablation technology and low-dose ultrasonic regulation technology.
  • High-intensity focused ultrasound (HIFU) is a typical ultrasonic thermal ablation technique. HIFU can penetrate the tissue, reach the target area, destroy the tumor in the body, and finally absorb the damaged tumor through the body's own immune system. To achieve the efficacy of non-invasive treatment.
  • ultrasound vascular thrombolysis that is, the use of ultrasound to destroy, dredge blood spots, in order to achieve the purpose of treatment.
  • the blood-brain barrier is a barrier that selectively blocks certain substances from entering the brain between blood vessels and the brain. This is usually beneficial for the protection of the body. However, it also weakens the therapeutic effect of the drug on the patient. Focused ultrasound can temporarily remove the blood-brain barrier, allowing drugs to pass through the barrier to the brain, effectively improving the effectiveness of drug treatment.
  • Ultrasound neuromodulation which stimulates the nerve by ultrasound, causes the nervous system to excite or inhibit, regulates the nerve activity of the organism, and changes the response of the neural circuit, thereby contributing to the treatment of neuropsychiatric diseases.
  • Ultrasound neuromodulation is an effective means by human intervention in the neural circuits of living organisms, and then the study of brain functions (such as cognition, feeling, etc.).
  • the inventors of the present application have found that the commonly used solution is an ultrasound system based on a single-element self-focusing transducer.
  • the advantage of this scheme is that the system complexity is low and easy to implement.
  • the shortcomings are also obvious, such as a single ultrasound focusing mode, and the problem of inaccurate target location.
  • an ultrasound system based on arrayed ultrasonic transducer is proposed. This scheme can flexibly change the focus position of the phased array ultrasonic transducer by means of electronic scanning. The problem is solved by the former.
  • the ultrasonic transducer has a certain bandwidth during the research process, and the excitation signal in the bandwidth has a high electroacoustic conversion efficiency.
  • a novel excitation sequence can be formed, which can be obtained in applications such as opening of the blood-brain barrier, thermal ablation of the focal region, and the like. Better results.
  • currently existing device hardware uses a method similar to a direct digital frequency synthesizer to generate an excitation signal, and it is difficult to compensate for this defect by a software algorithm.
  • the inventors of the present application have long studied and explored the following embodiments for improving the effect of ultrasonic treatment, and the ultrasonic excitation parameters of each channel can be flexibly configured to generate an excitation signal of an arbitrary waveform for an ultrasound transducer array.
  • the excitation signals of each of the array elements can be independently controlled, so that the performance of the ultrasonic transducer can be fully utilized to obtain better ultrasonic mechanical effects and thermal effects.
  • relevant personnel can design new excitation waveforms and excitations. Sequences to achieve a more diverse excitation waveform and focus mode provide a better device basis for ultrasound therapy.
  • the ultrasonic excitation system 10 can include a computer device 200 and an ultrasonic excitation device 100.
  • the computer device 200 is communicatively coupled to the ultrasound excitation device 100 for transmitting ultrasound excitation parameters for each channel to the ultrasound excitation device 100.
  • the ultrasonic excitation device 100 generates a corresponding ultrasonic wave based on the ultrasonic excitation parameter, and transmits the ultrasonic echo data to the computer device 200 after acquiring the ultrasonic echo data.
  • the computer device 200 performs ultrasonic imaging based on the ultrasonic echo data and outputs a visualized image.
  • the computer device 200 may be an electronic device including a hardware, a software or an embedded logic element or a combination of two or more such elements, and capable of executing a suitable implementation or support by the computer device 200.
  • the computer device 200 can be a device having a wireless transceiving function, including indoor or outdoor, handheld, wearable, or in-vehicle devices.
  • the computer device 200 may be a mobile phone, a tablet, a personal computer (PC), a computer with wireless transceiver function, a virtual reality (VR) terminal, and augmented reality ( Augmented Reality, AR) terminal, wireless terminal in Industrial Control, wireless terminal in Self Driving, wireless terminal in Remote Medical, wireless in Smart Grid Terminals, wireless terminals in Transportation Safety, wireless terminals in Smart City, wireless terminals in Smart Home, etc.
  • This embodiment does not limit the application scenario.
  • the computer device 200 can be used as a host computer to provide an interactive interface for configuring ultrasonic excitation parameters of each channel.
  • the user can configure the ultrasonic excitation parameters of each channel on the interaction interface according to actual conditions to generate related control.
  • Instructions are sent to the ultrasonic excitation device 100, which can generate ultrasonic waves on respective array elements based on ultrasonic excitation parameters of the respective channels.
  • the ultrasonic excitation device 100 may not only obtain the ultrasonic excitation parameters of the respective channels, but also obtain the configuration buttons provided by the ultrasonic excitation device 100 itself, or obtain the information through the remote server.
  • the manner in which the excitation device 100 obtains the ultrasonic excitation parameters is not limited in detail.
  • the ultrasonic excitation device 100 can include a waveform generator 110, a power amplifier 120, and an ultrasound transducer array 130.
  • the waveform generator 110 is configured to obtain ultrasonic excitation parameters of the respective channels, a waveform excitation signal of each channel is generated according to the ultrasonic excitation parameters.
  • the power amplifier 120 is electrically connected to the waveform generator 110 for power amplification of the waveform excitation signal to generate a high voltage driving signal and input to the ultrasonic transducer array 130.
  • the ultrasound transducer array 130 is configured to generate ultrasound waves on respective array elements based on the high voltage drive signals.
  • the ultrasonic excitation parameter may include at least one of a waveform shape, a signal frequency, a signal amplitude, and a focus parameter, the signal frequency including a single frequency waveform frequency or a composite frequency waveform frequency.
  • the ultrasound transducer array 130 can include a plurality of array elements, one for each array element.
  • the ultrasonic excitation parameters can be flexibly configured by the relevant user, so that an excitation signal of an arbitrary waveform can be generated according to the user's needs, and thus the excitation signal for each of the array elements in the ultrasonic transducer array 130 can be performed.
  • the same array element can also be excited by a waveform containing multiple frequencies, each channel waveform is arranged according to a certain rule, and the excitation signal can also be continuous Waves, short pulse waves, and long pulse waves.
  • the performance of the ultrasonic transducer is fully utilized, and better ultrasonic mechanical effects and thermal effects are obtained, so that better effects can be obtained in applications such as blood-brain barrier opening and ultrasonic thermal ablation.
  • relevant personnel can design a new type of excitation waveform and excitation sequence to achieve a more diversified excitation waveform and focusing mode, providing a better equipment basis for ultrasound treatment.
  • the waveform shape may refer to a sine wave, a square wave, and a sinusoidal composite waveform of a plurality of frequencies
  • the signal frequency may refer to a signal change period of the waveform signal, when a plurality of sinusoidal composite waveforms are used. Contains multiple frequencies.
  • pulse wave excitation it is also necessary to configure the repetition frequency of the pulse.
  • the signal amplitude may refer to a range in which the signal voltage fluctuates up and down.
  • the focus parameter may refer to a focus mode of the signal.
  • three typical different excitation waveforms are listed, which are a single-frequency sine wave signal, a single-frequency sine wave and a carrier-modulated signal, and a composite signal of a dual-frequency sine wave.
  • the composite signal type of the dual-frequency sine wave at this time contains a plurality of frequencies.
  • other excitation signals can still be designed according to actual conditions. Only the designed excitation signal needs to be sampled, and the excitation parameters and other control parameters (for example, amplification factor, pulse repetition frequency, etc.) at the corresponding sampling points are calculated.
  • the signal to the waveform generator 110 is sent to synthesize the designed excitation signal.
  • the defect that the conventional method can only generate a single waveform excitation signal can be avoided, the bandwidth of the ultrasonic transducer can be better utilized, and better ultrasonic mechanical effects and thermal effects can be obtained in different applications.
  • the ultrasonic transducer when used to heat the target tissue by using the modulated wave or the dual-frequency sine wave shown in FIG. 2, the temperature rises faster, and the heating time is shortened, such as a blood-brain barrier. Better results can be obtained in applications such as opening, ultrasonic ablation, and the like.
  • the waveform generator 110 may include a communication interface 112, a signal processor 114, and a digital to analog converter array 116.
  • the signal processor 114 is electrically connected to the communication interface 112 and the digital-to-analog converter array 116, respectively, for controlling the communication interface 112 to receive ultrasonic excitation parameters of each channel, and according to the The ultrasonic excitation parameters generate waveform excitation signals for the corresponding channels, and then the waveform excitation signals are written to corresponding digital to analog converters in the digital to analog converter array 116.
  • the digital to analog converter can convert the waveform excitation signal into an analog signal and output to the power amplifier 120. Thereby, the reception of the ultrasonic excitation parameters of each of the channels, the generation of the waveform excitation signal, and the digital-to-analog conversion of the waveform excitation signal can be achieved.
  • the signal processor 114 can include a field programmable gate array or a digital signal processor 114.
  • the signal processor 114 includes a communication processing unit 1142, a logic processing unit 1144, and a beam combining unit 1146.
  • the communication processing unit 1142 is configured to control the communication interface 112
  • the logic processing unit 1144 is configured to generate a waveform excitation signal of each channel according to the ultrasonic excitation parameter, and write the waveform excitation signal into the digital mode
  • the converter array 116 is configured to perform phase delay on the generated waveform excitation signal according to the focus parameter to synthesize a specific sound field, thereby improving the practical application effect.
  • the signal processor 114 is further configured to control the communication interface 112 to receive control parameters, and control the working states of the digital-to-analog converter array 116 and the power amplifier 120 according to the control parameters.
  • the control parameter may include at least one or a combination of a power amplification factor, a pulse repetition frequency, a transmission control parameter, and an echo reception control parameter.
  • the power amplification factor may refer to a multiple of the power amplifier 120 amplifying the excitation signal, and at the same time, the pulse repetition frequency needs to be configured when the pulse wave excitation is employed.
  • the emission control parameter and the echo reception control parameter may refer to control parameters when transmitting the excitation signal and receiving the echo signal.
  • the ultrasound transducer array 130 may be a multi-element phased array transducer, which may be planar or curved, and the ultrasound transducer array may be regular. The distribution can also be a random distribution.
  • the ultrasound transducer elements can be ultrasonically stimulated, imaged dual mode transducers.
  • the dual-mode transducer enables real-time imaging to monitor ultrasound-stimulated targets and provides more accurate support for moving ultrasound focus.
  • the ultrasound transducer includes an excitation probe for generating ultrasound waves from a high voltage drive signal and an imaging probe for detecting ultrasound echoes for imaging monitoring.
  • the ultrasonic excitation device 100 may further include an echo acquisition module 140 and an echo imaging module 150.
  • the echo acquisition module 140 is configured to perform signal processing after acquiring the ultrasonic echo signals detected by the ultrasonic transducer array 130, and convert the processed ultrasonic echo signals into digital signals.
  • the echo imaging module 150 is electrically connected to the echo collection module 140, and is configured to perform signal processing on the digital signal according to beamforming parameters to obtain corresponding ultrasonic echo data, and the ultrasonic echo data. Transmission to computer device 200 for ultrasound imaging provides support for user decision making.
  • the echo acquisition module 140 may include an ultrasound analog front end amplification unit 142 and an analog signal acquisition unit 144.
  • the ultrasonic analog front end amplifying unit 142 is electrically connected to the analog signal collecting unit 144, and is configured to send the ultrasonic echo signal to the analog signal collecting unit 144 after preamplification, filtering, and voltage controlled amplification. After analog-to-digital conversion, a digital signal is output. Therefore, through the integration of ultrasonic excitation and echo imaging, the integration degree is better, and the ultrasound image self-guided treatment can be realized.
  • a preferred embodiment of the present invention further provides an ultrasonic excitation method. It can be understood that the steps involved in the ultrasonic excitation method to be described next are described in the above embodiments, and specific The details of the steps can be described with reference to the above embodiments, and only the steps of the ultrasonic excitation method are briefly described below.
  • the method can include:
  • Step S110 after the waveform generator 110 obtains the ultrasonic excitation parameters of the respective channels, the waveform excitation signals of each channel are generated according to the ultrasonic excitation parameters.
  • the ultrasonic excitation parameter includes at least one of a waveform shape, a signal frequency, a signal amplitude, and a focus parameter, and the signal frequency includes a single frequency waveform frequency or a composite frequency waveform frequency.
  • step S120 the power amplifier 120 performs power amplification on the waveform excitation signal to generate a high voltage driving signal and input it to the ultrasonic transducer array 130.
  • step S130 the ultrasonic transducer array 130 generates ultrasonic waves on the corresponding array elements according to the high voltage driving signals.
  • the ultrasound transducer array 130 includes a plurality of array elements, one for each array element.
  • the embodiments of the present invention provide an ultrasonic excitation device, method, and system. After obtaining ultrasonic excitation parameters of each channel by a waveform generator, a waveform excitation signal of each channel is generated, and the power amplifier performs power amplification on the waveform excitation signal. A high voltage drive signal is generated and input to the ultrasonic transducer array, and the ultrasonic transducer array generates ultrasonic waves on the corresponding array elements according to the high voltage drive signal. Therefore, the ultrasonic excitation parameters of each channel can be flexibly configured to generate an excitation signal of an arbitrary waveform, and the excitation signals of each array element in the ultrasonic transducer array can be independently controlled, thereby fully utilizing the performance of the ultrasonic transducer. , to obtain better ultrasonic mechanical effects as well as thermal effects.

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Abstract

一种超声激励装置(100)、方法及***(10)。超声激励装置(100)包括波形发生器(110)、功率放大器(120)以及超声换能器阵列(130)。波形发生器(110)用于获得各个通道的超声激励参数后，根据超声激励参数生成每个通道的波形激励信号。功率放大器(120)与波形发生器(110)电性连接，用于将波形激励信号进行功率放大，生成高压驱动信号并输入给超声换能器阵列(130)。超声换能器阵列(130)用于根据高压驱动信号在相应的阵元上产生超声波，超声换能器阵列(130)包括有多个阵元，每个阵元对应一个通道。由此，可以充分发挥超声换能器的性能，获得更佳的超声力学效应以及热效应。

Description

超声激励装置、方法及***
相关申请的交叉引用
本申请要求于2017年12月22日提交中国专利局的申请号为201711401737.4、名称为“超声激励装置、方法及***”的中国专利申请的优先权，其全部内容通过引用结合在本申请中。
技术领域
本发明涉及医疗器械技术领域，具体而言，涉及一种超声激励装置、方法及***。
背景技术
目前传统的神经调控方法一般采用单一频率单一波形激励，例如正弦波或者方波激励，但是单一频率的激励信号，不能充分发挥超声换能器的性能。并且，当前的设备硬件上多采用类似于直接数字式频率合成器的方法来生成激励信号，这种方法灵活性较差。
发明内容
为了克服现有技术中的上述不足，本发明的目的在于提供一种超声激励装置、方法及***，可以灵活配置各个通道的超声激励参数以产生任意波形的激励信号，从而可以充分发挥超声换能器的性能，获得更佳的超声力学效应以及热效应。
为了实现上述目的，本发明较佳实施例采用的技术方案如下：
本发明较佳实施例提供一种超声激励装置，所述超声激励装置包括波形发生器、功率放大器以及超声换能器阵列。
所述波形发生器用于获得各个通道的超声激励参数后，根据所述超声激励参数生成每个通道的波形激励信号。
所述功率放大器与所述波形发生器电性连接，用于将所述波形激 励信号进行功率放大，生成高压驱动信号并输入给所述超声换能器阵列。
所述超声换能器阵列用于根据所述高压驱动信号在相应的阵元上产生超声波，其中，所述超声换能器阵列包括有多个阵元，每个阵元对应一个通道。
在本发明较佳实施例中，其中，所述超声激励参数包括有波形形状、信号频率、信号幅度和聚焦参数中的至少一种，所述信号频率包括单频率波形频率或者复合频率波形频率。
在本发明较佳实施例中，上述波形发生器包括通讯接口、信号处理器以及数模转换器阵列。
所述信号处理器分别与所述通讯接口和所述数模转换器阵列电性连接，用于控制所述通讯接口接收每个通道的超声激励参数，并根据所述超声激励参数生成对应的通道的波形激励信号，再将所述波形激励信号写入所述数模转换器阵列中对应的数模转换器中，以通过所述数模转换器将所述波形激励信号转换为模拟信号并输出至所述功率放大器。
在本发明较佳实施例中，上述信号处理器还用于控制所述通讯接口接收控制参数，并根据所述控制参数控制所述数模转换器阵列以及所述功率放大器的工作状态，其中，所述控制参数包括功率放大倍数、脉冲重复频率、发射控制参数、回波接收控制参数中的至少一种或者多种组合。
在本发明较佳实施例中，上述信号处理器包括现场可编程门阵列或者数字信号处理器。
在本发明较佳实施例中，上述信号处理器包括：
用于控制所述通讯接口的通讯处理单元；
用于根据所述超声激励参数生成各个通道的波形激励信号，并将 所述波形激励信号写入所述数模转换器阵列的逻辑处理单元；以及
用于根据聚焦参数将产生的波形激励信号进行相位延时的波束合成单元。
在本发明较佳实施例中，上述超声激励装置还包括回波采集模块和回波成像模块；
所述回波采集模块，用于在采集到经由所述超声换能器阵列探测到的超声回波信号后进行信号处理，并将处理后的超声回波信号转换为数字信号；
所述回波成像模块与所述回波采集模块电性连接，用于根据波束合成参数对所述数字信号进行信号处理，得到对应的超声回波数据，并将所述超声回波数据传输给计算机设备进行超声成像。
在本发明较佳实施例中，上述回波采集模块包括超声模拟前端放大单元和模拟信号采集单元；
所述超声模拟前端放大单元与所述模拟信号采集单元电性连接，用于对所述超声回波信号经过前置放大、滤波、压控放大后发送给所述模拟信号采集单元进行模数转换后，输出数字信号。
在本发明较佳实施例中，上述超声换能器阵列包括激励探头和成像探头；
所述激励探头用于根据高压驱动信号产生超声波；
所述成像探头用于在探测超声回波以用于成像监测。
本发明较佳实施例还提供一种超声激励方法，应用于上述的超声激励装置，所述方法包括：
所述波形发生器获得各个通道的超声激励参数后，根据所述超声激励参数生成每个通道的波形激励信号，其中，所述超声激励参数包括有波形形状、信号频率、信号幅度和聚焦参数中的至少一种，所述信号频率包括单频率波形频率或者复合频率波形频率；
所述功率放大器将所述波形激励信号进行功率放大，生成高压驱动信号并输入给所述超声换能器阵列；
所述超声换能器阵列根据所述高压驱动信号在相应的阵元上产生超声波，其中，所述超声换能器阵列包括有多个阵元，每个阵元对应一个通道。
本发明较佳实施例还提供一种超声激励***，所述超声激励***包括计算机设备以及上述的超声激励装置；
所述计算机设备与所述超声激励装置通信连接，用于向所述超声激励装置发送各个通道的超声激励参数；
所述超声激励装置基于所述超声激励参数产生对应的超声波，并在采集到超声回波数据后将所述超声回波数据发送给所述计算机设备；
所述计算机设备根据所述超声回波数据进行超声成像后输出可视化图像。
相对于现有技术而言，本发明具有以下有益效果：
本发明实施例提供一种超声激励装置、方法及***，通过波形发生器获得各个通道的超声激励参数后生成每个通道的波形激励信号，功率放大器将波形激励信号进行功率放大，生成高压驱动信号并输入给超声换能器阵列，超声换能器阵列根据高压驱动信号在相应的阵元上产生超声波。由此，可以灵活配置各个通道的超声激励参数以产生任意波形的激励信号，对于超声换能器阵列中的每一个阵元的激励信号都可以独立控制，从而可以充分发挥超声换能器的性能，获得更佳的超声力学效应以及热效应。
附图说明
为了更清楚地说明本发明实施例的技术方案，下面将对实施例中 所需要使用的附图作简单地介绍，应当理解，以下附图仅示出了本发明的某些实施例，因此不应被看作是对范围的限定，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其它相关的附图。
图1为本发明较佳实施例提供的超声激励***的一种结构框图；
图2为一种实施方式中激励信号的一种波形图；
图3为本发明较佳实施例提供的超声激励***的另一种结构框图；
图4为本发明较佳实施例提供的超声激励***的另一种结构框图；
图5为本发明较佳实施例提供的超声激励***的另一种结构框图；
图6为本发明较佳实施例提供的超声激励方法的一种流程示意图。
图标：10-超声激励***；100-超声激励装置；110-波形发生器；112-通讯接口；114-信号处理器；1142-通讯处理单元；1144-逻辑处理单元；1146-波束合成单元；116-数模转换器阵列；120-功率放大器；130-超声换能器阵列；140-回波采集模块；142-超声模拟前端放大单元；144-模拟信号采集单元；150-回波成像模块；200-计算机设备。
具体实施方式
目前，医学超声技术已经广泛应用于临床诊断与治疗。超声诊断主要是利用超声回波获取组织的影像学信息，为临床医生提供必要的诊断参考。超声治疗则是利用了超声波的力学效应、热效应以及空化效应，用于疾病的治疗。具体而言，又可以分为高剂量的超声热消融技术和低剂量的超声波调控技术。高强度聚焦超声(HIFU)就是一 种典型的超声热消融技术，HIFU可以穿透组织，到达设定的目标区域，用来破坏体内的肿瘤，最后通过机体自身的免疫***吸收掉被破坏的肿瘤，达到无创治疗的功效。低剂量超声治疗主要应用有：超声血管溶栓、基于超声波的血脑屏障开启以及超声神经调控。所谓的超声血管溶栓，即利用超声波来破坏、疏通血斑，以达到治疗的目的。血脑屏障是指在血管和脑之间有选择性地阻止某些物质由血液进入脑的屏障，通常这对于机体的保护，是有益的。但是，同样会削弱药物对病人的治疗效果。而聚焦超声波可以暂时解除血脑屏障，令药物可以穿过屏障到达脑部，有效提高药物治疗的效果。超声神经调控，即通过超声刺激神经，引起神经***兴奋或抑制，调节生物体的神经活动，改变神经环路的响应，从而有助于神经性精神疾病的治疗。超声神经调控，通过人为干预生物活体的神经环路，进而开展大脑机能(如认知、感受等)的研究，而成为一种有效的手段。
目前，经本申请发明人研究发现，常用的方案是基于单阵元自聚焦换能器的超声***，该方案的优势是***复杂度低，便于实施。但是缺点也很明显，如超声聚焦模式单一，刺激靶点定位不准确等问题。为了解决焦点移动、定位困难的问题，基于阵列式超声换能器的超声***被提出，这种方案，采用电子扫描的方式，可以灵活的改变相控阵超声换能器的焦点位置，较好地解决了前者的缺陷。
而实际上，发明人在研究过程中发现超声换能器都有一定的带宽，在该带宽范围内的激励信号都有着较高电声转化效率。经发明人长期研究，发现如果采用两种或多种频率接近的激励信号同时激励超声换能器，形成新型的激励序列，在诸如血脑屏障的打开、聚焦区域的热消融等应用中可以获得更好的效果。但是在当前的现有技术中，多是利用单一的正弦波或者方波激励超声换能器，很难取得这样的效果。并且，当前现有的设备硬件上多采用类似于直接数字式频率合成 器的方法来生成激励信号，很难通过软件算法来补偿这一缺陷。
鉴于上述问题，经本申请发明人长期研究探索，提出下述实施例，用于提高超声治疗的效果，可以灵活配置各个通道的超声激励参数以产生任意波形的激励信号，对于超声换能器阵列中的每一个阵元的激励信号都可以独立控制，从而可以充分发挥超声换能器的性能，获得更佳的超声力学效应以及热效应，在此基础上，相关人员可以设计新型的激励波形与激励序列，从而实现更多元化的激励波形以及聚焦方式，为超声治疗提供更好的设备基础。下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。通常在此处附图中描述和示出的本发明实施例的组件可以以各种不同的配置来布置和设计。
因此，以下对在附图中提供的本发明的实施例的详细描述并非旨在限制要求保护的本发明的范围，而是仅仅表示本发明的选定实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其它实施例，都属于本发明保护的范围。
应注意到：相似的标号和字母在下面的附图中表示类似项，因此，一旦某一项在一个附图中被定义，则在随后的附图中不需要对其进行进一步定义和解释。
请参阅图1，为本发明较佳实施例提供的超声激励***10的一种结构框图。本实施例中，所述超声激励***10可包括计算机设备200以及超声激励装置100。所述计算机设备200与所述超声激励装置100通信连接，用于向所述超声激励装置100发送各个通道的超声激励参数。所述超声激励装置100基于所述超声激励参数产生对应的超声波，并在采集到超声回波数据后将所述超声回波数据发送给所述计算机设备200。所述计算机设备200根据所述超声回波数据进行超 声成像后输出可视化图像。
本实施例中，所述计算机设备200可以是包括硬体、软体或内嵌逻辑元件或者两个或多个此类元件的组合的电子装置，并能够执行由计算机设备200实施或支援的合适的功能。所述计算机设备200可以是一种具有无线收发功能的设备，包括室内或室外、手持、穿戴或车载设备。例如，所述计算机设备200可以是手机(Mobile Phone)、平板电脑(Pad)、个人电脑(Personal Computer，PC)、带无线收发功能的电脑、虚拟现实(Virtual Reality，VR)终端、增强现实(Augmented Reality，AR)终端、工业控制(Industrial Control)中的无线终端、无人驾驶(Self Driving)中的无线终端、远程医疗(Remote Medical)中的无线终端、智能电网(Smart Grid)中的无线终端、运输安全(Transportation Safety)中的无线终端、智慧城市(Smart City)中的无线终端、智慧家庭(Smart Home)中的无线终端等等。本实施例对应用场景不做限定。
具体地，所述计算机设备200可作为上位机，提供用于配置各个通道的超声激励参数的交互界面，用户可以根据实际情况需要在该交互界面配置各个通道的超声激励参数，以生成相关的控制指令发送至所述超声激励装置100，所述超声激励装置100可基于各个通道的超声激励参数在相应的阵元上产生超声波。
值得说明的是，所述超声激励装置100也可以不仅限于上述方式获得各个通道的超声激励参数，也可通过超声激励装置100本身提供的配置按键获得，或者通过远程服务器获得，本实施例对超声激励装置100获得超声激励参数的方式不作详细限制。
下面以所述超声激励装置100通过作为上位机的计算机设备200获得超声激励参数为例，对所述超声激励装置100的结构进行详述。如图1所示，所述超声激励装置100可以包括波形发生器110、功率 放大器120以及超声换能器阵列130。所述波形发生器110用于获得各个通道的超声激励参数后，根据所述超声激励参数生成每个通道的波形激励信号。所述功率放大器120与所述波形发生器110电性连接，用于将所述波形激励信号进行功率放大，生成高压驱动信号并输入给所述超声换能器阵列130。所述超声换能器阵列130用于根据所述高压驱动信号在相应的阵元上产生超声波。
详细地，所述超声激励参数可包括有波形形状、信号频率、信号幅度和聚焦参数中的至少一种，所述信号频率包括单频率波形频率或者复合频率波形频率。所述超声换能器阵列130可包括多个阵元，每个阵元对应一个通道。在本实施例中，所述超声激励参数可以由相关用户灵活配置，从而可以根据用户需要产生任意波形的激励信号，因此对于超声换能器阵列130中的每一个阵元的激励信号都可以进行独立控制，例如可为同频率波形，也可为不同频率波形，同一阵元也可以用含有多个频率的波形进行激励，每通道波形按照一定规则进行时序排列，所述激励信号还可以采用连续波、短脉冲波以及长脉冲波。如此，充分发挥了超声换能器的性能，获得更佳的超声力学效应以及热效应，使得在诸如血脑屏障打开、超声热消融等应用中可以获得更佳的效果。在此基础上，相关人员可以设计新型的激励波形与激励序列，从而实现更多元化的激励波形以及聚焦方式，为超声治疗提供更好的设备基础。
其中，所述波形形状可以是指正弦波、方波以及多种频率正弦合成后的波形，所述信号频率可以是指该波形信号的信号变化周期，当采用多种正弦复合后的波形时可包含多种频率。另外，如果采用脉冲波激励还需要配置脉冲的重复频率。所述信号幅度可以是指指信号电压上下波动的范围。所述聚焦参数可以是指信号的聚焦方式。
例如，在图2所示的波形图中，列举了三种典型的不同激励波形， 分别是单频率正弦波信号、单频率正弦波与载波调制后的信号以及双频率正弦波的合成信号，当采用多种正弦复合后的波形时，此时该双频率正弦波的合成信号种包含多种频率。在实际应用中，仍然可以根据实际情况设计其它激励信号，只需要对设计的激励信号进行采样，计算出对应采样点处的激励参数和其它控制参数(例如，放大倍数、脉冲重复频率等)下发到波形发生器110即可合成出所设计的激励信号。由此，可以避免传统方法只能产生单一波形激励信号的缺陷，更好地利用超声换能器的带宽，能够在不同的应用中获得更好的超声力学效应以及热效应。而在实际应用场景中，通过采用图2中所示的调制波或者双频正弦波激励所述超声换能器给目标组织加热时，温度上升更快，加热时间减短，在诸如血脑屏障打开、超声热消融等应用中可以获得更佳的效果。
下面对所述波形发生器110的结构进行说明，请参阅图3，所述波形发生器110可包括通讯接口112、信号处理器114以及数模转换器阵列116。详细地，所述信号处理器114分别与所述通讯接口112和所述数模转换器阵列116电性连接，用于控制所述通讯接口112接收每个通道的超声激励参数，并根据所述超声激励参数生成对应的通道的波形激励信号，接着再将所述波形激励信号写入所述数模转换器阵列116中对应的数模转换器中。所述数模转换器可将所述波形激励信号转换为模拟信号并输出至所述功率放大器120。由此，可以实现对所述每个通道的超声激励参数的接收、波形激励信号的生成以及波形激励信号的数模转换。
在一种实施方式中，所述信号处理器114可以包括现场可编程门阵列或者数字信号处理器114。
在一种实施方式中，所述信号处理器114包括通讯处理单元1142、逻辑处理单元1144以及波束合成单元1146。所述通讯处理单 元1142用于控制所述通讯接口112，所述逻辑处理单元1144用于根据所述超声激励参数生成各个通道的波形激励信号，并将所述波形激励信号写入所述数模转换器阵列116，所述波束合成单元1146用于根据聚焦参数将产生的波形激励信号进行相位延时，以合成特定声场，提高实际应用效果。
在一种实施方式中，所述信号处理器114还用于控制所述通讯接口112接收控制参数，并根据所述控制参数控制所述数模转换器阵列116以及所述功率放大器120的工作状态。所述控制参数可以包括功率放大倍数、脉冲重复频率、发射控制参数、回波接收控制参数中的至少一种或者多种组合。所述功率放大倍数可以是指所述功率放大器120放大激励信号的倍数，同时，当采用脉冲波激励需要配置脉冲重复频率。发射控制参数、回波接收控制参数可以是指在发射激励信号时和接收回波信号的控制参数。
在一种实施方式中，所述超声换能器阵列130可以为多阵元的相控阵换能器，可以为平面型也可以为弧面型，超声换能器阵元可以是有规则的分布也可以是随机分布。此外，超声换能器阵元可以采用超声刺激、成像双模换能器。双模换能器可以实现实时成像监测超声刺激靶点的功能，为移动超声聚焦焦点提供更精准的支持。在这一情形下，所述超声换能器包括激励探头和成像探头，所述激励探头用于根据高压驱动信号产生超声波，所述成像探头用于在探测超声回波以用于成像监测。
进一步地，在探测到超声回波的基础上，请参阅图4，所述超声激励装置100还可以包括回波采集模块140和回波成像模块150。具体地，所述回波采集模块140，用于在采集到经由所述超声换能器阵列130探测到的超声回波信号后进行信号处理，并将处理后的超声回波信号转换为数字信号。所述回波成像模块150与所述回波采集模块 140电性连接，用于根据波束合成参数对所述数字信号进行信号处理，得到对应的超声回波数据，并将所述超声回波数据传输给计算机设备200进行超声成像，从而为用户决策提供支持。
更为具体地，请参阅图5，所述回波采集模块140可包括超声模拟前端放大单元142和模拟信号采集单元144。所述超声模拟前端放大单元142与所述模拟信号采集单元144电性连接，用于对所述超声回波信号经过前置放大、滤波、压控放大后发送给所述模拟信号采集单元144进行模数转换后，输出数字信号。由此，通过超声激励与回波成像一体化，集成度更好，能够实现超声图像自引导治疗。
进一步地，请参阅图6，本发明较佳实施例还提供一种超声激励方法，可以理解的是，接下来要描述的超声激励方法中涉及的步骤在上面实施例中已经描述过，具体各个步骤的详尽内容可参照上面的实施例描述，下面仅对超声激励方法执行步骤进行简要说明。所述方法可以包括：
步骤S110，所述波形发生器110获得各个通道的超声激励参数后，根据所述超声激励参数生成每个通道的波形激励信号。
所述超声激励参数包括有波形形状、信号频率、信号幅度和聚焦参数中的至少一种，所述信号频率包括单频率波形频率或者复合频率波形频率。
步骤S120，所述功率放大器120将所述波形激励信号进行功率放大，生成高压驱动信号并输入给所述超声换能器阵列130。
步骤S130，所述超声换能器阵列130根据所述高压驱动信号在相应的阵元上产生超声波。
所述超声换能器阵列130包括有多个阵元，每个阵元对应一个通道。
综上所述，本发明实施例提供一种超声激励装置、方法及***， 通过波形发生器获得各个通道的超声激励参数后生成每个通道的波形激励信号，功率放大器将波形激励信号进行功率放大，生成高压驱动信号并输入给超声换能器阵列，超声换能器阵列根据高压驱动信号在相应的阵元上产生超声波。由此，可以灵活配置各个通道的超声激励参数以产生任意波形的激励信号，对于超声换能器阵列中的每一个阵元的激励信号都可以独立控制，从而可以充分发挥超声换能器的性能，获得更佳的超声力学效应以及热效应。
需要说明的是，在本文中，术语"包括"、"包含"或者其任何其它变体意在涵盖非排它性的包含，从而使得包括一系列要素的过程、方法、物品或者设备不仅包括那些要素，而且还包括没有明确列出的其它要素，或者是还包括为这种过程、方法、物品或者设备所固有的要素。在没有更多限制的情况下，由语句"包括一个……"限定的要素，并不排除在包括所述要素的过程、方法、物品或者设备中还存在另外的相同要素。
对于本领域技术人员而言，显然本发明不限于上述示范性实施例的细节，而且在不背离本发明的精神或基本特征的情况下，能够以其它的具体形式实现本发明。因此，无论从哪一点来看，均应将实施例看作是示范性的，而且是非限制性的，本发明的范围由所附权利要求而不是上述说明限定，因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。不应将权利要求中的任何附图标记视为限制所涉及的权利要求。

Claims (10)

  1. 一种超声激励装置，其特征在于，所述超声激励装置包括波形发生器、功率放大器以及超声换能器阵列；
    所述波形发生器配置成获得各个通道的超声激励参数后，根据所述超声激励参数生成每个通道的波形激励信号；
    所述功率放大器与所述波形发生器电性连接，用于将所述波形激励信号进行功率放大，生成高压驱动信号并输入给所述超声换能器阵列；
    所述超声换能器阵列配置成根据所述高压驱动信号在相应的阵元上产生超声波，其中，所述超声换能器阵列包括有多个阵元，每个阵元对应一个通道。
  2. 根据权利要求1所述的超声激励装置，其特征在于，其中，所述超声激励参数包括有波形形状、信号频率、信号幅度和聚焦参数中的至少一种，所述信号频率包括单频率波形频率或者复合频率波形频率。
  3. 根据权利要求1所述的超声激励装置，其特征在于，所述波形发生器包括通讯接口、信号处理器以及数模转换器阵列；
    所述信号处理器分别与所述通讯接口和所述数模转换器阵列电性连接，用于控制所述通讯接口接收每个通道的超声激励参数，并根据所述超声激励参数生成对应的通道的波形激励信号，再将所述波形激励信号写入所述数模转换器阵列中对应的数模转换器中，以通过所述数模转换器将所述波形激励信号转换为模拟信号并输出至所述功率放大器。
  4. 根据权利要求3所述的超声激励装置，其特征在于，所述信号处理器还配置成控制所述通讯接口接收控制参数，并根据所述控制参 数控制所述数模转换器阵列以及所述功率放大器的工作状态，其中，所述控制参数包括功率放大倍数、脉冲重复频率、发射控制参数和回波接收控制参数中的至少一种或者多种组合。
  5. 根据权利要求3所述的超声激励装置，其特征在于，所述信号处理器包括：
    用于控制所述通讯接口的通讯处理单元；
    用于根据所述超声激励参数生成各个通道的波形激励信号，并将所述波形激励信号写入所述数模转换器阵列的逻辑处理单元；以及
    用于根据聚焦参数将产生的波形激励信号进行相位延时的波束合成单元。
  6. 根据权利要求1所述的超声激励装置，其特征在于，所述超声激励装置还包括回波采集模块和回波成像模块；
    所述回波采集模块，配置成在采集到经由所述超声换能器阵列探测到的超声回波信号后进行信号处理，并将处理后的超声回波信号转换为数字信号；
    所述回波成像模块与所述回波采集模块电性连接，用于根据波束合成参数对所述数字信号进行信号处理，得到对应的超声回波数据，并将所述超声回波数据传输给计算机设备进行超声成像。
  7. 根据权利要求6所述的超声激励装置，其特征在于，所述回波采集模块包括超声模拟前端放大单元和模拟信号采集单元；
    所述超声模拟前端放大单元与所述模拟信号采集单元电性连接，用于对所述超声回波信号经过前置放大、滤波和压控放大后发送给所述模拟信号采集单元进行模数转换后，输出数字信号。
  8. 根据权利要求1所述的超声激励装置，其特征在于，所述超声换能器阵列包括激励探头和成像探头；
    所述激励探头配置成根据高压驱动信号产生超声波；
    所述成像探头配置成探测超声回波以用于成像监测。
  9. 一种超声激励方法，应用于权利要求1-8中任意一项所述的超声激励装置，其特征在于，所述方法包括：
    所述波形发生器获得各个通道的超声激励参数后，根据所述超声激励参数生成每个通道的波形激励信号，其中，所述超声激励参数包括有波形形状、信号频率、信号幅度和聚焦参数中的至少一种，所述信号频率包括单频率波形频率或者复合频率波形频率；
    所述功率放大器将所述波形激励信号进行功率放大，生成高压驱动信号并输入给所述超声换能器阵列；
    所述超声换能器阵列根据所述高压驱动信号在相应的阵元上产生超声波，其中，所述超声换能器阵列包括有多个阵元，每个阵元对应一个通道。
  10. 一种超声激励***，其特征在于，所述超声激励***包括计算机设备以及权利要求1-8中任意一项所述的超声激励装置；
    所述计算机设备与所述超声激励装置通信连接，用于向所述超声激励装置发送各个通道的超声激励参数；
    所述超声激励装置基于所述超声激励参数产生对应的超声波，并在采集到超声回波数据后将所述超声回波数据发送给所述计算机设备；
    所述计算机设备根据所述超声回波数据进行超声成像后输出可视化图像。
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