WO2019098759A3 - 형질전환된 인간세포 및 이의 용도 - Google Patents

형질전환된 인간세포 및 이의 용도 Download PDF

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WO2019098759A3
WO2019098759A3 PCT/KR2018/014112 KR2018014112W WO2019098759A3 WO 2019098759 A3 WO2019098759 A3 WO 2019098759A3 KR 2018014112 W KR2018014112 W KR 2018014112W WO 2019098759 A3 WO2019098759 A3 WO 2019098759A3
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cell
transformed
human cell
mhc
transformed human
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PCT/KR2018/014112
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English (en)
French (fr)
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WO2019098759A2 (ko
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임옥재
김문경
이윤정
이지원
양우석
김유영
권영은
최승현
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재단법인 목암생명과학연구소
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Priority to CA3082331A priority Critical patent/CA3082331A1/en
Priority to AU2018367792A priority patent/AU2018367792A1/en
Priority to CN201880074666.8A priority patent/CN111742049A/zh
Priority to JP2020527057A priority patent/JP2021503284A/ja
Priority to SG11202004529XA priority patent/SG11202004529XA/en
Priority to MX2020005235A priority patent/MX2020005235A/es
Application filed by 재단법인 목암생명과학연구소 filed Critical 재단법인 목암생명과학연구소
Priority to EP18877963.1A priority patent/EP3712268A4/en
Priority to US16/764,664 priority patent/US20200407713A1/en
Priority to KR1020207011903A priority patent/KR20200074954A/ko
Publication of WO2019098759A2 publication Critical patent/WO2019098759A2/ko
Publication of WO2019098759A3 publication Critical patent/WO2019098759A3/ko
Priority to IL274691A priority patent/IL274691A/en

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Abstract

본 발명은 형질전환된 인간세포 및 이의 용도에 관한 것으로, 보다 구체적으로 가이드 RNA를 이용한 유전자 발현 억제용 시스템을 이용한 MHC I 세포막 수용체 및 MHC II 세포막 수용체를 코딩하는 유전자가 변형된 세포 및 이의 용도에 관한 것이다. 상기와 같은 형질전환 세포는 생체 내에서도 세포의 치료 효능을 효과적으로 발휘할 수 있으며, 생체 내 면역반응에 의해 제거되지 않는다. 따라서, 상기 면역세포를 유효성분으로 포함하는 조성물은 암, 감염성 질환, 퇴행성 질환 또는 면역 질환 치료에 유용하게 활용될 수 있을 것으로 기대된다.
PCT/KR2018/014112 2017-11-16 2018-11-16 형질전환된 인간세포 및 이의 용도 WO2019098759A2 (ko)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AU2018367792A AU2018367792A1 (en) 2017-11-16 2018-11-16 Transformed human cell and use thereof
CN201880074666.8A CN111742049A (zh) 2017-11-16 2018-11-16 转化的人细胞及其用途
JP2020527057A JP2021503284A (ja) 2017-11-16 2018-11-16 形質転換ヒト細胞およびその使用
SG11202004529XA SG11202004529XA (en) 2017-11-16 2018-11-16 Transformed human cell and use thereof
MX2020005235A MX2020005235A (es) 2017-11-16 2018-11-16 Celula humana transformada y uso de la misma.
CA3082331A CA3082331A1 (en) 2017-11-16 2018-11-16 Transformed human cell and use thereof
EP18877963.1A EP3712268A4 (en) 2017-11-16 2018-11-16 TRANSFORMED HUMAN CELL AND ITS USE
US16/764,664 US20200407713A1 (en) 2017-11-16 2018-11-16 Transformed human cell and use thereof
KR1020207011903A KR20200074954A (ko) 2017-11-16 2018-11-16 형질전환된 인간세포 및 이의 용도
IL274691A IL274691A (en) 2017-11-16 2020-05-14 Transformed human cells inhibited for expression of mhc i and mhc ii cell membrane receptors and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762587068P 2017-11-16 2017-11-16
US62/587,068 2017-11-16

Publications (2)

Publication Number Publication Date
WO2019098759A2 WO2019098759A2 (ko) 2019-05-23
WO2019098759A3 true WO2019098759A3 (ko) 2019-07-18

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PCT/KR2018/014112 WO2019098759A2 (ko) 2017-11-16 2018-11-16 형질전환된 인간세포 및 이의 용도

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Country Link
US (1) US20200407713A1 (ko)
EP (1) EP3712268A4 (ko)
JP (1) JP2021503284A (ko)
KR (1) KR20200074954A (ko)
CN (1) CN111742049A (ko)
AU (1) AU2018367792A1 (ko)
CA (1) CA3082331A1 (ko)
IL (1) IL274691A (ko)
MX (1) MX2020005235A (ko)
SG (1) SG11202004529XA (ko)
WO (1) WO2019098759A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220005208A (ko) * 2020-07-06 2022-01-13 주식회사 지씨셀 면역원성이 감소된 신규한 이식용 세포
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
AU2021414617A1 (en) 2020-12-31 2023-08-10 Crispr Therapeutics Ag Universal donor cells

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KR20160018425A (ko) * 2014-08-06 2016-02-17 차의과학대학교 산학협력단 조직적합성항원 유전자들의 교정을 통하여 구축한, 면역적합형 세포
JP2016521975A (ja) * 2013-05-15 2016-07-28 サンガモ バイオサイエンシーズ， インコーポレイテッド 遺伝的状態の処置のための方法および組成物
WO2017093969A1 (en) * 2015-12-04 2017-06-08 Novartis Ag Compositions and methods for immunooncology
WO2017106537A2 (en) * 2015-12-18 2017-06-22 Sangamo Biosciences, Inc. Targeted disruption of the mhc cell receptor
WO2017152015A1 (en) * 2016-03-04 2017-09-08 Editas Medicine, Inc. Crispr-cpf1-related methods, compositions and components for cancer immunotherapy

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WO2016073955A2 (en) * 2014-11-06 2016-05-12 President And Fellows Of Harvard College Cells lacking b2m surface expression and methods for allogeneic administration of such cells
AU2016349504B2 (en) * 2015-11-04 2023-02-09 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
CA3009727A1 (en) * 2015-12-28 2017-07-06 Novartis Ag Compositions and methods for the treatment of hemoglobinopathies
WO2017143210A1 (en) * 2016-02-19 2017-08-24 The General Hospital Corporation Methods for generating universal and custom mhc/hla-compatible hematopoietic progenitor cells

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JP2016521975A (ja) * 2013-05-15 2016-07-28 サンガモ バイオサイエンシーズ， インコーポレイテッド 遺伝的状態の処置のための方法および組成物
KR20160018425A (ko) * 2014-08-06 2016-02-17 차의과학대학교 산학협력단 조직적합성항원 유전자들의 교정을 통하여 구축한, 면역적합형 세포
WO2017093969A1 (en) * 2015-12-04 2017-06-08 Novartis Ag Compositions and methods for immunooncology
WO2017106537A2 (en) * 2015-12-18 2017-06-22 Sangamo Biosciences, Inc. Targeted disruption of the mhc cell receptor
WO2017152015A1 (en) * 2016-03-04 2017-09-08 Editas Medicine, Inc. Crispr-cpf1-related methods, compositions and components for cancer immunotherapy

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Publication number Publication date
KR20200074954A (ko) 2020-06-25
CN111742049A (zh) 2020-10-02
CA3082331A1 (en) 2019-05-23
WO2019098759A2 (ko) 2019-05-23
AU2018367792A1 (en) 2020-06-11
EP3712268A2 (en) 2020-09-23
SG11202004529XA (en) 2020-06-29
IL274691A (en) 2020-06-30
US20200407713A1 (en) 2020-12-31
JP2021503284A (ja) 2021-02-12
MX2020005235A (es) 2020-08-24
EP3712268A4 (en) 2022-03-23

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