WO2019078555A3 - 물푸레나무 추출물을 유효성분으로 포함하는 우울증 및 불안장애의 예방, 개선 또는 치료용 조성물 - Google Patents

물푸레나무 추출물을 유효성분으로 포함하는 우울증 및 불안장애의 예방, 개선 또는 치료용 조성물 Download PDF

Info

Publication number
WO2019078555A3
WO2019078555A3 PCT/KR2018/012074 KR2018012074W WO2019078555A3 WO 2019078555 A3 WO2019078555 A3 WO 2019078555A3 KR 2018012074 W KR2018012074 W KR 2018012074W WO 2019078555 A3 WO2019078555 A3 WO 2019078555A3
Authority
WO
WIPO (PCT)
Prior art keywords
depression
tree extract
composition
ash tree
effective ingredient
Prior art date
Application number
PCT/KR2018/012074
Other languages
English (en)
French (fr)
Other versions
WO2019078555A2 (ko
Inventor
이미영
김유리
박보경
김영화
Original Assignee
한국 한의학 연구원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한국 한의학 연구원 filed Critical 한국 한의학 연구원
Priority to US16/755,338 priority Critical patent/US11253566B2/en
Publication of WO2019078555A2 publication Critical patent/WO2019078555A2/ko
Publication of WO2019078555A3 publication Critical patent/WO2019078555A3/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/322—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pediatric Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 물푸레나무 추출물을 유효성분으로 포함하는 우울증 및 불안장애의 예방, 개선 또는 치료용 조성물에 관한 것으로, 더욱 상세하게는 물푸레나무 추출물을 유효성분으로 포함하는 우울증 또는 불안장애에 효과가 있는 약학적 조성물 또는 건강기능식품 조성물에 관한 것이다. 본 발명의 물푸레나무 추출물은 불안 및 우울증이 유발된 동물모델에서 나타나는 우울 행동 및 활동성 감소를 개선하는 효과가 있으며, 코르티졸의 함량을 감소시키고, 세로토닌의 함량을 증가시킬 뿐만 아니라, 해마 조직에서의 pCERB, BDNF와 mBDNF 단백질 발현량을 증가시키는 효과가 있으므로, 우울증 및 불안장애를 개선하거나 치료하는 건강기능식품 또는 의약품으로 개발하는데 유용하게 사용될 수 있다.
PCT/KR2018/012074 2017-10-16 2018-10-15 물푸레나무 추출물을 유효성분으로 포함하는 우울증 및 불안장애의 예방, 개선 또는 치료용 조성물 WO2019078555A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US16/755,338 US11253566B2 (en) 2017-10-16 2018-10-15 Composition for ameliorating, or treating depression and anxiety disorder comprising Fraxinus rhynchophylla extract as effective ingredient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170134156A KR102041847B1 (ko) 2017-10-16 2017-10-16 물푸레나무 추출물을 유효성분으로 포함하는 우울증 및 불안장애의 예방, 개선 또는 치료용 조성물
KR10-2017-0134156 2017-10-16

Publications (2)

Publication Number Publication Date
WO2019078555A2 WO2019078555A2 (ko) 2019-04-25
WO2019078555A3 true WO2019078555A3 (ko) 2019-06-27

Family

ID=66174085

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/012074 WO2019078555A2 (ko) 2017-10-16 2018-10-15 물푸레나무 추출물을 유효성분으로 포함하는 우울증 및 불안장애의 예방, 개선 또는 치료용 조성물

Country Status (3)

Country Link
US (1) US11253566B2 (ko)
KR (1) KR102041847B1 (ko)
WO (1) WO2019078555A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102170418B1 (ko) * 2018-10-17 2020-10-27 한국 한의학 연구원 프락시누스속 식물 추출물을 유효성분으로 포함하는 수면장애의 예방, 개선 또는 치료용 조성물
KR102537835B1 (ko) * 2020-10-06 2023-05-30 동의대학교 산학협력단 물푸레나무 잎 추출물을 포함하는 항우울 개선 효과가 우수한 동시에, 항스트레스 효과를 나타내는 항우울 및 항스트레스용 조성물
KR20230109992A (ko) * 2022-01-14 2023-07-21 경상국립대학교산학협력단 말차 추출물을 유효성분으로 포함하는 만성스트레스로 인한 우울증 및 불안장애의 예방, 개선 또는 치료용 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004083449A (ja) * 2002-08-26 2004-03-18 Kinji Ishida ストレス緩和用の経口投与組成物
CN103007111A (zh) * 2012-12-27 2013-04-03 青岛华仁信息技术开发有限公司 一种治疗兔腹泻的中药制剂及其制备方法
CN105497528A (zh) * 2014-11-05 2016-04-20 石友爱 一种治疗呼吸***疾病伴发的精神障碍的中药

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070103629A (ko) * 2006-04-19 2007-10-24 김용민 비만억제용 조성물
KR20090072858A (ko) * 2007-12-29 2009-07-02 주식회사 하이폭시 진피로부터 분리된 화합물을 유효성분으로 함유하는뇌질환의 예방 및 치료용 조성물
WO2015160226A1 (ko) * 2014-04-17 2015-10-22 주식회사 건강사랑 레드클로버 및 석류의 복합 추출물을 유효성분으로 포함하는 조성물의 여성 갱년기 개선 용도
CN107334863A (zh) * 2017-08-21 2017-11-10 安龙县海子镇祥飞农业综合开发有限公司 一种以蝗虫为原料的保健品及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004083449A (ja) * 2002-08-26 2004-03-18 Kinji Ishida ストレス緩和用の経口投与組成物
CN103007111A (zh) * 2012-12-27 2013-04-03 青岛华仁信息技术开发有限公司 一种治疗兔腹泻的中药制剂及其制备方法
CN105497528A (zh) * 2014-11-05 2016-04-20 石友爱 一种治疗呼吸***疾病伴发的精神障碍的中药

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIM, II HYUK ET AL.: "The Chemical Constituents and Their Pharmacological Activities of Endemic Medicinal Plants in Korea", KOREAN JOURNAL OF PHARMACOGNOSY, vol. 24, no. 3, 1993, pages 197 - 202, XP053013231 *
MARTIN , M. J. ET AL.: "Esculine, Ranitidine and Carbenoxolone: Different Modes of Action on Gastric Mucosa", GENERAL PHARMACOLOGY, vol. 22, no. 6, 1991, pages 1001 - 1004, XP023834179 *

Also Published As

Publication number Publication date
KR20190042350A (ko) 2019-04-24
US11253566B2 (en) 2022-02-22
WO2019078555A2 (ko) 2019-04-25
KR102041847B1 (ko) 2019-11-07
US20200306330A1 (en) 2020-10-01

Similar Documents

Publication Publication Date Title
WO2018084531A3 (ko) 골 질환, 비만 및 지질 관련 대사성 질환의 예방 또는 치료용 조성물
PH12019502058A1 (en) Farnesoid x receptor agonists and uses thereof
WO2019078555A3 (ko) 물푸레나무 추출물을 유효성분으로 포함하는 우울증 및 불안장애의 예방, 개선 또는 치료용 조성물
PH12018502634A1 (en) Topical compositions of apremilast
BRPI0819690B8 (pt) uso de uma composição compreendendo cisteamina ou cistamina, ou um sal farmaceuticamente aceitável das mesmas
PH12021550605A1 (en) Farnesoid x receptor agonists and uses thereof
MX2018002507A (es) Metodo para la inhibicion de la absorcion de lipidos y/o la promocion de excrecion de lipidos usando d-psicosa.
BR112018008186A2 (pt) métodos que utilizam proteína de soro de leite para melhorar ou manter a qualidade muscular
EP3318251A3 (en) Composition for preventing or treating obesity or lipid-related metabolic disease
EA201991374A1 (ru) Водорастворимое производное эпиаллопрегнанолона и его применение
BR112021019262A2 (pt) Uso de ciclo-his-pro (chp) para prevenir, atenuar ou tratar fibrose
MX2023003678A (es) Inhibidores de hidroxiesteroide 17beta- deshidrogenasa 13 (hsd17b13) y usos de estos.
MX2023003677A (es) Inhibidores de hidroxiesteroide 17beta- deshidrogenasa 13 (hsd17b13) y usos de estos.
WO2011055931A3 (ko) 인플루엔자 바이러스 유래 질병의 예방 또는 치료용 조성물
MX2023003675A (es) Inhibidores de hidroxiesteroide 17beta-deshidrogenasa 13 (hsd17b13) y usos de estos.
EP3456337A4 (en) PHARMACEUTICAL COMPOSITION AND FUNCTIONAL HEALTH FOOD COMPRISING AVENANTHRAMIDE C OAT EXTRACT OR DERIVATIVE THEREOF AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION OR TREATMENT OF NEURODEGENERATIVE DISEASE
WO2019022482A3 (ko) 황칠나무 추출물을 유효성분으로 포함하는 섬유화 질환의 예방 또는 치료용 조성물
PH12017500743A1 (en) Tau protein production accelerator, and therapeutic or preventive agent and therapeutic or preventive food composition for diseases caused by tau protein deficiency
ATE447963T1 (de) Verwendung von lavendelöl zur prophylaxe und behandlung von somatisierungsstörungen und von posttraumatischer stresserkrankung
EA201992178A1 (ru) Фармацевтические композиции с высоким содержанием лекарственного средства из среднецепочечных триглицеридов и способы, связанные c ними
WO2018093237A3 (ko) 포름산 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 비만 또는 비만으로 야기된 대사증후군의 예방 또는 치료용 조성물
MX2022004382A (es) Metodos para promover la produccion de scfa por microbiota intestinal.
Kamila et al. Screening of novel polyphyto formulations, a natural remedies for learning and memory enhancing properties in rat
BR112017012909A2 (pt) composição contendo extrato de casca de poria cocos para a prevenção, melhora ou tratamento de distúrbios neurodegenerativos
Ximenes et al. Ethanolic extract of erythrina velutina willd ameliorate schizophrenia-like behavior induced by ketamine in mice

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18869255

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18869255

Country of ref document: EP

Kind code of ref document: A2