WO2019066617A3 - 항 c-met 항체 및 이의 용도 - Google Patents

항 c-met 항체 및 이의 용도 Download PDF

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Publication number
WO2019066617A3
WO2019066617A3 PCT/KR2018/011641 KR2018011641W WO2019066617A3 WO 2019066617 A3 WO2019066617 A3 WO 2019066617A3 KR 2018011641 W KR2018011641 W KR 2018011641W WO 2019066617 A3 WO2019066617 A3 WO 2019066617A3
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Prior art keywords
met
same
circulating tumor
antibody
antibodies
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PCT/KR2018/011641
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English (en)
French (fr)
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WO2019066617A2 (ko
WO2019066617A9 (ko
Inventor
신영기
이지혜
김영덕
이재구
이훈석
Original Assignee
서울대학교산학협력단
주식회사 지노바이오
에이비온 주식회사
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Application filed by 서울대학교산학협력단, 주식회사 지노바이오, 에이비온 주식회사 filed Critical 서울대학교산학협력단
Publication of WO2019066617A2 publication Critical patent/WO2019066617A2/ko
Publication of WO2019066617A3 publication Critical patent/WO2019066617A3/ko
Publication of WO2019066617A9 publication Critical patent/WO2019066617A9/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

본 발명은 항 c-Met 항체 및 이의 용도에 관한 것으로, 보다 상세하게는 인간 유래 c-Met 단백질에 특이적으로 결합하는 항체 또는 그 단편, 이의 생산방법, 이를 이용한 c-Met 특이적 검출 방법, 이를 이용한 순환암세포 (Circulating Tumor Cell, CTC) 검출 방법 및 이를 유효성분으로 포함하는 순환암세포 검출용 키트에 관한 것이다. 본 발명의 방법은 c-Met 항체를 검출하고, 항체를 이용하여 혈액 내의 순환암세포를 검출하는 데에 유용하게 이용될 수 있다.
PCT/KR2018/011641 2017-09-29 2018-10-01 항 c-met 항체 및 이의 용도 WO2019066617A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0128286 2017-09-29
KR1020170128286A KR20190038173A (ko) 2017-09-29 2017-09-29 항 c-Met 항체 및 이의 용도

Publications (3)

Publication Number Publication Date
WO2019066617A2 WO2019066617A2 (ko) 2019-04-04
WO2019066617A3 true WO2019066617A3 (ko) 2019-07-04
WO2019066617A9 WO2019066617A9 (ko) 2019-08-15

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ID=65903672

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PCT/KR2018/011641 WO2019066617A2 (ko) 2017-09-29 2018-10-01 항 c-met 항체 및 이의 용도

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KR (1) KR20190038173A (ko)
WO (1) WO2019066617A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
MX2022002886A (es) 2019-09-16 2022-04-06 Regeneron Pharma Proteinas de union met radiomarcadas para la obtencion de imagenes por inmuno-pet.
WO2023204625A1 (ko) * 2022-04-20 2023-10-26 에이비온 주식회사 C-met 발현 ctc를 이용한 유방암 환자의 예후 예측 방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014530201A (ja) * 2011-09-20 2014-11-17 イーライ リリー アンド カンパニー 抗ｃ−Ｍｅｔ抗体
KR20160017918A (ko) * 2014-08-07 2016-02-17 주식회사 파멥신 c-Met 특이적 인간 항체 및 그 제조방법
KR20160037667A (ko) * 2014-09-29 2016-04-06 삼성전자주식회사 폴리펩타이드, 이를 포함하는 항 VEGF 항체 및 항 c-Met/항 VEGF 이중 특이 항체

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014530201A (ja) * 2011-09-20 2014-11-17 イーライ リリー アンド カンパニー 抗ｃ−Ｍｅｔ抗体
KR20160017918A (ko) * 2014-08-07 2016-02-17 주식회사 파멥신 c-Met 특이적 인간 항체 및 그 제조방법
KR20160037667A (ko) * 2014-09-29 2016-04-06 삼성전자주식회사 폴리펩타이드, 이를 포함하는 항 VEGF 항체 및 항 c-Met/항 VEGF 이중 특이 항체

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
COMOGLIO, P. M.: "Drug development of MET inhibitors: targeting oncogene addiction and expedience", NATURE REVIEWS. DRUG DISCOVERY, vol. 7, no. 6, 2008, pages 504 - 516, XP002565003 *
ZHANG, T.: "Development of a Novel c-MET-Based CTC Detection Platform", MOL. CANCER RES., vol. 14, no. 6, 7 March 2016 (2016-03-07) - June 2016 (2016-06-01), pages 539 - 547, XP055623498 *

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Publication number Publication date
WO2019066617A2 (ko) 2019-04-04
WO2019066617A9 (ko) 2019-08-15
KR20190038173A (ko) 2019-04-08

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